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| 1 | 肝癌高发区不同饮用水类型中微囊藻毒素含量调查显示文摘为了解肝脏促癌剂微囊藻毒素(MC)在肝癌高发区饮用水中的污染情况,于1992至1993年对江苏海门居民饮用水中藻类及其产生的MC进行了检测,经鉴定在海门沟河水中颤藻是目前已被证明能产生MC的最常见的藻属;在65个水样中有2份经高效液相和液相色谱/质谱分析确定含有MC。进一步于1994年7月在江苏海门采集不同饮用水源共989份,采用高敏感度酶联免疫方法测定MC含量。结果在沟塘水、河水、浅井水和深井水中MC的阳性率(>50pg/ml)分别为17.3%,31.9%,4.3%,0.0%;阳性样本中MC平均含量分别为101,160,68,0。在沟塘水和河水中MC的阳性率和阳性样本中的平均含量均显著大于浅井水和深井水,提示应对饮用水中MC与肝癌的关系作进一步研究。 | 陈刚 俞顺章 卫国荣 陈公超 徐小英 黄裕华 Ken-ichi Harada Yoshio Ueno | 1996 | 中华预防医学杂志1996，30，1： | 59 |
| 2 | 2500年来艾比湖的环境演变信息显示文摘通过对艾比湖缘 1.8m浅孔的沉积相和孢粉组合 ,结合14 C测年资料分析 ,指出近 2 5 0 0年来艾比湖的沉积环境总体是比较稳定的 ,但由于气候波动引起艾比湖水位曾发生较明显的变化。约在公元前 30 0~ 4 0 0年 ,是艾比湖面积缩小时期 ;约公元前 30 0~公元 30 0年 ,即东周末至西晋 ,是艾比湖水位较高时期 ;约公元 30 0~ 14 0 0年 ,即东晋至 15世纪初 ,是艾比湖的高水位时期 ;约 15世纪初至 17世纪中是艾比湖的水位下降期 ,但水位比现代仍然高 ;约 17世纪中至 19世纪初的小冰期是艾比湖的水位上升期。 | 阎顺 穆桂金 远藤邦彦 Nobuhiko Handa Masao Uchida Naomi Harada | 2003 | 干旱区地理2003，26，3： | 55 |
| 3 | A PERIODICALLY LOCALIZED TRAVELING WAVE STATE OF BINARY FLUID CONVECTION WITH HORIZONTAL FLOWS显示文摘In this paper, the convection structure in a rectangular channel with a horizontal flow was studied for the aspect ratio Γx=12 and the separation ratio ψ=-0.11. Our simulations were preformed by solving the hydrodynamic equations using the SIMPLE method. In the system of binary fluid convection with a horizontal flow, a Periodically Localized Traveling Wave (PLTW) state was found. It has similar behavior to classical Rayleigh-Benard convection in a binary fluid mixture, but the region and wave number of convection change periodically with time. The instability of PLTW depends on the Rayleigh number r and the intensity of horizontal flows Re for given ψ. Thus, the PLTW convection results from the competition between the horizontal flow and the counter-propagating wave near the onset of convection. | NING Li-zhong QI Xin HARADA Yoshifumi YAHATA Hideo | 2006 | Journal of Hydrodynamics2006，18，2： | 37 |
| 4 | Pathological classification of intrahepatic cholangiocarcinoma based on a new concept显示文摘Intrahepatic cholangiocarcinoma (ICC) arises from the lining epithelium and peribiliary glands of the intrahepatic biliary tree and shows variable cholangiocytic dif-f-e-re-ntiation. To date-,ICC was large-ly classifie-d into adenocarcinoma and rare variants. Herein,we propose to subclassify the former,based on recent progress in the-study of-ICC including the-gross classification and hepatic progenitor/stem cells and on the pathological similarities between biliary and pancreatic neoplasms. That is,ICC is classifiable into the conventional (bile duct) type,the bile ductular type,the intraductal neoplasm type and rare variants. The conventional type is further divided into the small duct type (peripheral type) and large bile duct type (perihilar type). The former is a tubular or micropapillary adenocarcinoma while the latter involves the intrahepatic large bile duct. Bile ductular type resembles proliferated bile ductules and shows a replacing growth of the hepatic parenchyma.Hepatic progenitor cell or stem cell phenotypes such as neural cell adhesion molecule expression are frequently expressed in the bile ductular type. Intraductal type includes papillary and tubular neoplasms of the bile duct (IPNBs and ITNBs) and a superficial spreading type. IPNB and ITNB show a spectrum from a preneoplastic borderline lesion to carcinoma and may have pancreatic counterparts. At invasive sites,IPNB is associated with the conventional bile duct ICC and mucinous carcinoma. Biliary mucinous cystic neoplasm with ovarian-like stroma in its wall is different from IPNB,particularly IPNB showing cystic dilatation of the affected ducts. Rare variants of ICC include squamous/adenosquamous cell carcinoma,mucinous/signet ring cell carcinoma,clear cell type,undifferentiated type,neuroendocrine carcinoma and so on. This classification of-ICC may ope-n up a ne-w fie-ld of-re-se-arch of-ICC and contribute-to the-clini cal approach to ICC. | Yasuni Nakanuma Yasunori Sato Kenichi Harada Mokoto Sasaski Hiroko Ikeda | 2010 | World Journal of Hepatology2010，2，12： | 34 |
| 5 | Helicobacter pylori and oral pathology:Relationship with the gastric infection显示文摘Helicobacter pylori(H.pylori)has been found in the oral cavity and stomach,and its infection is one of the most frequent worldwide.We reviewed the literature and conducted a Topic Highlight,which identified studies reporting an association between H.pylori-infection in the oral cavity and H.pylori-positive stomach bacterium.This work was designed to determine whether H.pylori is the etiologic agent in periodontal disease,recurrent aphthous stomatitis(RAS),squamous cell carcinoma,burning and halitosis.Record selection focused on the highest quality studies and meta-analyses.We selected 48 articles reporting on the association between saliva and plaque and H.pylori-infection.In order to assess periodontal disease data,we included 12 clinical trials and 1 meta-analysis.We evaluated 13 published articles that addressed the potential association with RAS,and 6 with squamous cell carcinoma.Fourteen publications focused on our questions on burning and halitosis.There is a close relation between H.pylori infection in the oral cavity and the stomach.The mouth is the first extra-gastric reservoir.Regarding the role of H.pylori in the etiology of squamous cell carcinoma,no evidence is still available. | Isabel Adler Andrea Muio Silvia Aguas Laura Harada Mariana Diaz Adriana Lence Mario Labbrozzi Juan Manuel Muio Boris Elsner Alejandra Avagnina Valeria Denninghoff | 2014 | World Journal of Gastroenterology2014，20，29： | 21 |
| 6 | 葛枣猕猴桃组织培养中的器官形成与植株再生显示文摘以葛枣猕猴桃(Actinidiapolygama)的叶柄为外植体,通过愈伤组织的形成产生不定芽从而建立了高效的再生系统。在附加蔗糖(30g/L),琼脂(8g/L)和植物生长调节物质IBA(0、0.01、1、10μmol/L)与CPPU(0、0.1、1μmol/L)的全组合培养基中,IBA和CPPU对愈伤组织的形成有促进作用。不定芽从叶柄形成的愈伤组织表层分化出来,CPPU对不定芽的分化有良好的促进效果,而高浓度的IBA对不定芽的分化有抑制作用。将分化的枝芽转移至含有1μmol/LNAA的BW培养基上,40d后发根率为100%,并长成健康植株。 | 刘永立 兰大伟 毕静华 陈超 Takashi Harada | 2005 | 果树学报2005，22，3： | 20 |
| 7 | TRANSITION OF CONVECTIVE PATTERNS IN A RECTANGULAR CELL显示文摘In this paper our interest is focussed on the behavior in the transition of the Traveling Wave (TW) convective patterns along the nonlinear branch in a rectangular cell of Γ=12 for ψ=-0.11. Our numerical simulations were performed by solving the two-dimensional hydrodynamic equations using the SIMPLE method. Three types of convection patterns appearing in the nonlinear branch of the bifurcation diagram were observed. In particular, the undulation TW state in the rectangular cell was obtained, and the hysteresis in the transition from the TW State to the Stationary Overturning Convection (SOC) was verified. | Ning Li-zhong Institute of Hydraulic Engineering, Xi’an University of Technology, Xi’an 710048, China Department of Engineering, Nitto Co. Ltd., Ikebukuro 2-77-5, Toushima-ku, Tokyo 171-0014, Japan Yoshifumi Harada Department of Applied Physics, Fac | 2001 | Journal of Hydrodynamics2001，13，4： | 20 |
| 8 | Leaching of phosphorus from incinerated sewage sludge ash by means of acid extraction followed by adsorption on orange waste gel显示文摘Ashes from sewage sludge incineration have a high phosphorus content, approximately 8% (W/W), which indicates a potential resource of the limiting nutrient. Incineration of sewage sludge with subsequent recovery of phosphorus is a relatively new sludge treatment technique. In this article, the leaching of phosphorus by using sulfuric acid as well as hydrochloric acid by means of several batch experiments was presented. At the same time a selective recovery of phosphorus by adsorption was also discussed. The effects of acid concentration, temperature and time on extraction were studied. The phosphorus leaching increased with the increase in acid concentration and temperature. Kinetic studies showed that the complete leaching of phosphorus took place in less than 4 h. Selective adsorption of phosphorus by using orange waste gel provided a hint for recovery of this natural resource, which eventually could meet the ever-increasing requirement for phosphorus. The overall results indicated that the incinerated sewage sludge ash can be treated with acid to efficiently recover phosphorus and thus can be considered a potentially renewable source of phosphorus. | Biplob Kumar Biswas Katsutoshi Inoue Hiroyuki Harada Keisuke Ohto Hidetaka Kawakita | 2009 | Journal of Environmental Sciences2009，21，12： | 20 |
| 9 | Novel strategies for the treatment of inflammatory bowel disease: Selective inhibition of cytokines and adhesion molecules显示文摘煽动性的肠疾病(IBD ) 的病原学还没被澄清了,非明确地减少发炎和免疫的抑制免疫力的代理人为 IBD 在常规治疗被使用了。证据显示在 IBD 的内脏的粘膜免疫的 dysregulation 引起煽动性的 cytokines 和受动器白血球的交通国王的生产过剩进肠,因此导致不受管束的肠的发炎。在 IBD 的致病的理解的如此的最近的进展创造了明确地禁止涉及煽动性的串联的分子的新奇生物制品疗法的一个最近的趋势。为如此的处理的主要目标是煽动性的 cytokines 和他们的受体,和粘附分子。妄想的 anti-TNF-alpha 单音的同种细胞的抗体, infliximab,为 CD 成为了标准治疗,它也是可能的为 UC 有益。几 anti-TNF 试剂被开发了,但是他们中的大多数似乎不象 infliximab 一样有效。人性化的 anti-TNF 单音的同种细胞的抗体, adalimumab 可能为输了的病人的治疗是有用的应答的海角或发达不耐到 infliximab。对 IL-12 p40 和 IL-6 受体的抗体能是为 IBD 的其他的新 anti-cytokine 治疗。Anti-interferon-gamma 和 anti-CD25 治疗被开发,但是这些代理人的利益还没被建立了。进肠的白细胞移行的选择堵住似乎是一条好途径。对 alpha4 integrin 和 alpha4beta7 integrin 的抗体为 IBD 显示出利益。细胞间的粘附分子 1 的 Antisense oligonucleotide (ICAM-1 ) 可能为 IBD 是有效的。如此的混合物的临床的试用最近也被报导了或当前是在进行之中的。在这篇文章,我们为 IBD 考察如此的新奇生物制品疗法的功效和安全。 | Kazuhiko Nakamura Kuniomi Honda Takahiro Mizutani Hirotada Akiho Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，29： | 18 |
| 10 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 11 | 广东五种菊头蝠的核型分析显示文摘本文用蝙蝠的新鲜肺组织和尾椎进行组织培养,然后在光学显微镜下计数30个染色体分散良好的中期分裂相细胞,并进行摄影、剪贴和测量。分析了广东地区5种菊头蝠的核型,即小菊头蝠的核型为2n =6 2 ,FN =6 0 ;角菊头蝠的核型为2n =6 2 ,FN =6 0 ;中菊头蝠的核型为2n =6 2 ,FN =6 0 ;大耳菊头蝠的核型为2n =6 2 ,FN =6 0 ;中华(栗黄)菊头蝠的核型为2n =36 ,FN =6 0。大耳菊头蝠的核型为首次报道。角菊头蝠和中菊头蝠的核型与前人报道的结果基本相同。中华(栗黄)菊头蝠的核型(2n =36 )与张维道报道的鲁氏菊头蝠相同,而与印度和斯里兰卡产R rouxii的核型2n =5 6迥异。 | 吴毅 Masashi HARADA | 2005 | 兽类学报2005，25，2： | 11 |
| 12 | NUMERICAL SIMULATION OF TRAVELING WAVE CONVECTION IN A WEAKLY NONLINEAR REGIME显示文摘This paper presents a simulational result on a blinking traveling wave (BTW) state in binary fluid convection in a rectangular cell. The numerical simulations were made using the two dimensional perturbation equations of full hydrodynamic equations. We found for the first time that the BTW or sloshing traveling wave state is a type of modulated traveling wave (MTW) generated by the motion of a source defect which originates from the reflection effect at the end walls and depends on the reduced Rayleigh number r. Comparison with the localized traveling wave (LTW) shows that the BTW is convective patterns on a weakly nonlinear branch with a small amplitude and the LTW is those on a full nonlinear branch whth a large amplitude. They have different dynamical behaviour. A discontinuous jump from the BTW branch to the stable LTW branch takes place as the oscillatory period lengthens and the amplitude grows above the upper critical value of the BTW. | Ning, Lizhong Yashifumi, Harada Hideo, Yahata | 2000 | Journal of Hydrodynamics2000，12，2： | 11 |
| 13 | Prognosis of ulcerative colitis differs between patients with complete and partial mucosal healing, which can be predicted from the platelet count显示文摘AIM:To determine the difference in clinical outcome between ulcerative colitis(UC)patients with Mayo endoscopic subscore(MES)0 and those with MES 1.METHODS:UC patients with sustained clinical remission of 6 mo or more at the time of colonoscopy were examined for clinical outcomes and the hazard ratios of clinical relapse according to MES.Parameters,including blood tests,to identify predictive factors for MES 0and slight endoscopic recurrence in clinically stablepatients were assessed.Moreover,a receiver operating characteristic curve was generated,and the area under the curve was calculated to indicate the utility of the parameters for the division between complete and partial mucosal healing.All P values were two-sided and considered significant when less than 0.05.RESULTS:A total of 183 patients with clinical remission were examined.Patients with MES 0(complete mucosal healing:n=80,44%)were much less likely to relapse than those with MES 1(partial mucosal healing:n=89,48%)(P<0.0001,log-rank test),and the hazard ratio of risk of relapse in patients with MES 1 vs MES0 was 8.17(95%CI:4.19-17.96,P<0.0001).The platelet count(PLT)<26×104/μL was an independent predictive factor for complete mucosal healing(OR=4.1,95%CI:2.15-7.99).Among patients with MES 0 at the initial colonoscopy,patients of whom colonoscopy findings shifted to MES 1 showed significant increases in PLT compared to those who maintained MES 0(3.8×104/μL vs-0.6×104/μL,P<0.0001).CONCLUSION:The relapse rate differed greatly between patients with complete and partial mucosal healing.A shift from complete to partial healing in clinically stable UC patients can be predicted by monitoring PLT. | Asuka Nakarai Jun Kato Sakiko Hiraoka Toshihiro Inokuchi Daisuke Takei Yuki Moritou Mitsuhiro Akita Sakuma Takahashi Keisuke Hori Keita Harada Hiroyuki Okada Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，48： | 11 |
| 14 | Evolution of gastric surgery techniques and outcomes显示文摘Surgical management of gastric cancer improves survival.However,for some time,surgeons have had diverse opinions about the extent of gastrectomy.Researchers have conducted many clinical studies,making slow but steady progress in determining the optimal surgical approach.The extent of lymph node dissection has been one of the major issues in surgery for gastric cancer.Many trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 dissection.However,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 dissection.In 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional surgery.Gastrectomy with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 dissection.Now,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of splenectomy.Furthermore,the feasibility and safety of laparoscopic gastrectomy are well established.Survival and quality of life are increasingly recognized as the most important endpoints.In this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients. | Hironori Shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo Kazuto Harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani | 2016 | Chinese Journal of Cancer2016，35，8： | 9 |
| 15 | Diffusion-weighted imaging of the liver:Current applications显示文摘Diffusion-weighted imaging(DWI) of the liver can be performed using most commercially available machines and is currently accepted in routine sequence. This sequence has some potential as an imaging biomarker for fibrosis, tumor detection/characterization, and following/predicting therapy. To improve reliability including accuracy and reproducibility, researchers have validated this new technique in terms of image acquisition, data sampling, and analysis. The added value of DWI in contrastenhanced magnetic resonance imaging was established in the detection of malignant liver lesions. However, some limitations remain in terms of lesion characterization and fibrosis detection. Furthermore, the methodologies of image acquisition and data analysis have been inconsistent. Therefore, researchers should make every effort to not only improve accuracy and reproducibility but also standardize imaging parameters. | Kazuhiro Saito Yu Tajima Taiyo L Harada | 2016 | World Journal of Radiology2016，8，11： | 8 |
| 16 | A predictive factor for the response to S-1 plus cisplatin in gastric cancer显示文摘AIM:To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin(CDDP)chemotherapy in gastric cancer.METHODS:We measured the protein expression levels of thymidylate synthase(TS),dihydropyrimidine dehydrogenase(DPD),and orotate phosphoribosyltrans-ferase(OPRT)in advanced gastric cancer.Before S-1/CDDP chemotherapy,tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent assay.The chemo-therapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP chemotherapy.The effects are a predictive factor for the response to S-1/CDDP chemotherapy inpatients with advanced gastric cancer,as evaluated by endoscopic biopsy over time.RESULTS:The protein expression level of TS was significantly higher(P<0.05)in the tumor than in the normal tissue,and significantly lower(P<0.05)in the responders than in the non-responders.We were able to evaluate the correlation between changes in the protein expression levels of TS,DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than twice.In the responders,the protein expression level of TS was<40 ng/mg protein.However,there were significant increases in the protein expression levels of TS(P<0.01)and DPD(P<0.05)after chemotherapy in 3 patients.In these cases,the patient assessment changed from'responder'to'non-responder'.In the non-responders,the protein expression level of TS was>40 ng/mg protein.CONCLUSION:We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer. | Ikuko Miyazaki Takashi Kawai Youji Harada Fuminori Moriyasu | 2010 | World Journal of Gastroenterology2010，16，36： | 8 |
| 17 | Comparison of antimony behavior with arsenic under various soil redox conditions显示文摘 | Satoshi Mitsunobu Teppei Harada Yoshio Takahashi | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 7 |
| 18 | Recent advances in photodynamic diagnosis of gastriccancer using 5-aminolevulinic acid显示文摘Photodynamic diagnosis based on 5-aminolevulinic acidinduced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative realtime fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma. | Noriaki Koizumi Yoshinori Harada Takeo Minamikawa Hideo Tanaka Eigo Otsuji Tetsuro Takamatsu | 2016 | World Journal of Gastroenterology2016，22，3： | 7 |
| 19 | 日本新建筑标准的结构抗火设计显示文摘本文的目的是为了说明1998~2000期间日本建筑规程(日本建筑标准)以及相关技术标准的修订。考虑了功能要求后,规程修订趋向于以性能为主。在抗火这一章节中,功能要求指的是在发生火灾时防止结构倒塌以及火势向其他隔间的蔓延,同时还包括防止火势由失火建筑物内部向周围建筑的扩散。为了满足功能上的要求,我们提供了三种方法(A、B、C)。方法A是传统的设计方法,即建筑框架及隔墙采用防火构件。相对于方法A,新近引进了以考虑性能为主的方法B。在方法B中,由一系列设计公式计算出指定部分发生火灾可能产生的后果、结构和边界部分的热反应、构件破坏的临界时间。设计公式应足够简单,以便于建筑工程师和有关官员的使用。由方法B计算出的结果通常是保守的。方法C是一个框架,用最先进的设计方法。规程没有指定采用的设计方法,但是工程上火灾和结构分析的结果只有在全面地考证后才能被行业接受。 | Kazunori Harada | 2003 | 建筑钢结构进展2003，5，2： | 7 |
| 20 | Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy显示文摘BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano | 2019 | World Journal of Gastroenterology2019，25，4： | 6 |
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