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| 1 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 2 | Isolation of a Novel Lodging Resistance QTL Gene Involved in Strigolactone Signaling and Its Pyramiding with a QTL Gene Involved in Another Mechanism显示文摘住宿是到达到增加的庄稼生产率的一个主要障碍。在一次尝试到在米饭为灰煤杆力量理解机制,我们孤立一个有效量的特点地点( QTL ),强壮的 CULM3 ( SCM3 ),哪个与米饭 TEOSINTE BRANCHED1 ( OsTB1 )相同的原因的基因,基因以前报导了断然控制发信号的 strigolactone ( SL )。带 SCM3 的一根 near-isogenic 线(无) 证明尽管有期望的减少,提高的灰煤杆力量和增加的小穗状花小穗在 tiller 数字数,显示 SL 也有在提高灰煤杆力量和小穗状花小穗数字的一个积极角色。我们生产了带 SCM3 和 SCM2 的一根节节上升的线,编码涉及圆锥花序开发的 APO1 的另一 QTL。NIL-SCM2+SCM3 比 NIL-SCM2 和 NIL-SCM3 和这些 QTL 的添加剂效果引起的一个增加的小穗状花小穗数字显示出强壮得多的灰煤杆。我们讨论没有为繁殖导致有害特点,利用这些强壮的灰煤杆 QTL 的合适的等位基因的重要性。 | Kenji Yano Taiichiro Ookawa Koichiro Aya Yusuke Ochiai Tadashi Hirasawa Takeshi Ebitani Takeshi Takarada Masahiro Yano Toshio Yamamoto Shuichi Fukuoka Jianzhong Wu Tsuyu Ando Reynante Lacsamana Ordonio Ko Hirano Makoto Matsuoka | 2015 | Molecular Plant2015，8，2： | 12 |
| 3 | 什么是腕管综合征的真正内镜手术?——18年5880例临床经验(英文)显示文摘腕管综合征是常见的卡压性周围神经病变,由正中神经在腕管内受到卡压引起。它的手术治疗方法在于从掌侧切开腕管,减压正中神经。术式有最初非开放的盲切手术、开放手术、以及利用内镜手术(主要分为单切口和双切口法两类)等。笔者在1986年首创了应用USE(universalsubcutaneousendoscope)系统单切口法治疗腕管综合征,力求创伤最小、最安全的手术方式。USE系统由透明闭锁外套管和30°斜视内镜组成。这是真正意义上的内镜手术,与内镜辅助下的手术在视野、绝对禁忌证等多方面都不同。笔者术中在局麻下,透过透明外套管在内镜直视下在腕管内用钩刀或改良方法于腕管外用推刀彻底切断腕横韧带和DHFFR(distalholdfastfibersoftheflexorretinaculum),达到腕管开放减压的目的,并可于术中通过透光实验及腕管压力测定等方法判断腕管是否完全开放以保证手术效果。另外,笔者还在腕管综合征的诊断方面,新创一种神经诱发体征,命名为OkutsuTest。它的阳性率高于PhalenTest,而且在正常人群中没有发现假阳性。然而最准确的腕管综合征诊断方法是腕管压力测定。通过正常对照,确定在腕管综合征术前休息位腕管内压力高于15mmHg,握拳位是腕管内压力高于135mmHg的诊断指标。采用腕管压力测定可以不仅可以用于诊断。 | 奥津一郎 IkkiHamanaka Aya Yoshida 史其林 | 2005 | 中国微创外科杂志2005，5，5： | 11 |
| 4 | Study of the degradation behavior and the biocompatibility of Mg-0.8Ca alloy for orthopedic implant applications显示文摘Mg-Ca alloys have recently attracted great attention towards the research in the field of orthopedic biodegradable implants.This study presents an in vitro degradation assessment of Mg-0.8Ca(0.8 wt.%of Ca)alloy in Hank’s balanced salt solution(HBSS).Immersion,hydrogen evolution and electrochemical behavior was studied as well as the cytotoxicity of the degradation products.Morphology and phase composition of the corrosion products were studied using SEM,EDX and XRD techniques.Degradation in HBSS resulted in the formation of the needle-shaped carbonated hydroxyapatite which was similar to the biological apatite in the human bone.Degradation kinetics showed that Mg-0.8Ca alloy had approximately 3-fold faster degradation rate than the pure Mg(1.08±0.38 mm/year for Mg-0.8Ca and 0.35±0.17 mm/year for pure Mg),as observed in two independent experiments.Both,pure Mg and Mg-0.8Ca alloy were biocompatible,generating no cytotoxic degradation products against human-derived HEK 293 cells.Thus,the Mg-0.8Ca alloy was found to be a promising biodegradable implant in terms of bioactivity and compatibility with human cell lines.Depending on the application of the implant and the estimated healing time of the bone,the desired degradation rate of an implant can be controlled by the Mg-Ca composition of such alloys. | Aya Mohamed Ahmed MEl-Aziz Hans-Georg Breitinger | 2019 | Journal of Magnesium and Alloys2019，7，2： | 9 |
| 5 | Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis显示文摘Hepatocellular carcinoma(HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs(lncRNAs) are RNAs with a length greater than 200 nucleotides that do not encode proteins. lncRNAs can regulate gene expression and protein synthesis in several ways by interacting with DNA, RNA and proteins in a sequence specific manner. They could regulate cellular and developmental processes through either gene inhibition or gene activation. Many studies have shown that dysregulation of lncRNAs is related to many human diseases such as cardiovascular diseases, genetic disorders, neurological diseases, immune mediated disorders and cancers. However, the study of lncRNAs is challenging as they are poorly conserved between species, their expression levels aren't as high as that of m RNAs and have great interpatient variations. The study of lncRNAs expression in cancers have been a breakthrough as it unveils potential biomarkers and drug targets for cancer therapy and helps understand the mechanism of pathogenesis. This review discusses many long non-coding RNAs and their contribution in HCC, their role in development, metastasis, and prognosis of HCC and how to regulate and target these lncRNAs as a therapeutic tool in HCC treatment in the future. | Aya El Khodiry Menna Afify Hend M El Tayebi | 2018 | World Journal of Gastroenterology2018，24，5： | 9 |
| 6 | Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. | Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 7 | Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody显示文摘AIM To investigate near-infrared photoimmunotherapeutic effect mediated by an anti-tissue factor(TF) antibody conjugated to indocyanine green(ICG) in a pancreatic cancer model.METHODS Near-infrared photoimmunotherapy(NIR-PIT) is a highly selective tumor treatment that utilizes an antibody-photosensitizer conjugate administration, followed by NIR light exposure. Anti-TF antibody 1849-ICG conjugate was synthesized by labeling of rat IgG2 b anti-TF monoclonal antibody 1849(anti-TF 1849) to a NIR photosensitizer,ICG. The expression levels of TF in two human pancreatic cancer cell lines were examined by western blotting. Specific binding of the 1849-ICG to TF-expressing BxPC-3 cells was examined by fluorescence microscopy. NIR-PITinduced cell death was determined by cell viability imaging assay. In vivo longitudinal fluorescence imaging was used to explore the accumulation of 1849-ICG conjugate in xenograft tumors. To examine the effect of NIRPIT, tumor-bearing mice were separated into 5 groups:(1) 100 μg of 1849-ICG i.v. administration followed by NIR light exposure(50 J/cm2) on two consecutive days(Days 1 and 2);(2) NIR light exposure(50 J/cm2) only on two consecutive days(Days 1 and 2);(3) 100 μg of 1849-ICG i.v. administration;(4) 100 μg of unlabeled antiTF 1849 i.v. administration; and(5) the untreated control. Semiweekly tumor volume measurements, accompanied with histological and immunohistochemical(IHC) analyses of tumors, were performed 3 d after the 2nd irradiation with NIR light to monitor the effect of treatments. RESULTS High TF expression in BxPC-3 cells was observed via western blot analysis, concordant with the observed preferential binding with intracellular localization of 1849-ICG via fluorescence microscopy. NIR-PIT-induced cell death was observed by performing cell viability imaging assay. In contrast to the other test groups, tumor growth was significantly inhibited by NIR-PIT with a statistically significant difference in relative tumor volumes for 27 d after the treatment start date [2.83 ± 0.38(NIR-PIT) vs 5.42 ± 1.61(Untreated), vs 4.90 ± 0.87(NIR), vs 4.28 ±1.87(1849-ICG), vs 4.35 ± 1.42(anti-TF 1849), at Day 27, P < 0.05]. Tumors that received NIR-PIT showed evidence of necrotic cell death-associated features upon hematoxylin-eosin staining accompanied by a decrease in Ki-67-positive cells(a cell proliferation marker) by IHC examination.CONCLUSION The TF-targeted NIR-PIT with the 1849-ICG conjugate can potentially open a new platform for treatment of TF-expressing pancreatic cancer. | Winn Aung Atsushi B Tsuji Aya Sugyo Hiroki Takashima Masahiro Yasunaga Yasuhiro Matsumura Tatsuya Higashi | 2018 | World Journal of Gastroenterology2018，24，48： | 7 |
| 8 | Effect of fibre orientations on the mechanical properties of kenaf–aramid hybrid composites for spall-liner application显示文摘This paper presents the effect of kenaf fibre orientation on the mechanical properties of kenaf–aramid hybrid composites for military vehicle's spall liner application. It was observed that the tensile strength of woven kenaf hybrid composite is almost 20.78% and 43.55% higher than that of UD and mat samples respectively. Charpy impact strength of woven kenaf composites is 19.78% and 52.07% higher than that of UD and mat kenaf hybrid composites respectively. Morphological examinations were carried out using scanning electron microscopy. The results of this study indicate that using kenaf in the form of woven structure could produce a hybrid composite material with high tensile strength and impact resistance properties. | R.YAH AYA S.M.SAPUAN M.JAWAID Z.LEMAN E.S.ZAINUDIN | 2016 | Defence Technology(防务技术)2016，12，1： | 7 |
| 9 | Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration显示文摘The objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by loading.In trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration. | Aya Shibamoto Toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki | 2018 | International Journal of Oral Science2018，10，1： | 7 |
| 10 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 5 |
| 11 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 12 | Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography显示文摘Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms.However,capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo.Here we demonstrate a novel optical imaging system,dual-band dual-scan inverse spectroscopic optical coherence tomography(D2-ISOCT),that,for the first time,can simultaneously obtain the following metrics in vivo using endogenous contrast:(1)capillary-level oxygen saturation and arteriolar-level blood flow rates,oxygen delivery rates,and oxygen metabolic rates;(2)spatial characteristics of tissue structures at length scales down to 30 nm;and(3)morphological images up to 2mm in depth.To illustrate the capabilities of D2-ISOCT,we monitored alterations to capillaries and the surrounding pericapillary tissue(tissue between the capillaries)in the healing response of a mouse ear wound model.The obtained microvascular and ultrastructural metrics corroborated well with each other,showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool. | Rongrong Liu James A.Winkelmann Graham Spicer Yunxiao Zhu Aya Eid Guillermo A.Ameer Vadim Backman Ji Yi | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 13 | Identification of sources of lead in the atmosphere by chemical speciation using X-ray absorption near-edge structure(XANES) spectroscopy显示文摘Sources of Pb pollution in the local atmosphere together with Pb species, major ions, and heavy metal concentrations in a size-fractionated aerosol sample from Higashi-Hiroshima(Japan) have been determined by X-ray absorption near-edge structure(XANES) spectroscopy, ion chromatography, and ICP-MS/AES, respectively. About 80% of total Pb was concentrated in fine aerosol particles. Lead species in the coarse aerosol particles were PbC2O4, 2PbCO3·Pb(OH)2, and Pb(NO3)2, whereas Pb species in the fine aerosol particles were PbC2O4, PbSO4, and Pb(NO3)2. Chemical speciation and abundance data suggested that the source of Pb in the fine aerosol particles was different from that of the coarse ones. The dominant sources of Pb in the fine aerosol particles were judged to be fly ash from a municipal solid waste incinerator and heavy oil combustion. For the coarse aerosol particles, road dust was considered to be the main Pb source. In addition to Pb species, elemental concentrations in the aerosols were also determined. The results suggested that Pb species in size-fractionated aerosols can be used to identify the origin of aerosol particles in the atmosphere as an alternative to Pb isotope ratio measurement. | Kohei Sakata Aya Sakaguchi Masaharu Tanimizu Yuichi Takaku Yuka Yokoyama Yoshio Takahashi | 2014 | Journal of Environmental Sciences2014，26，2： | 4 |
| 14 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 4 |
| 15 | 超低频地磁异常与2000年日本伊豆诸岛震群的关系显示文摘通过研究电磁现象与大地震的联系有助于建立监测地壳运动(如地震、火山喷发)的电磁方法.在地震的紧急预报中,超低频(ULF)地磁的方法是最有前途的方法之一.本文将一种主要分量分析的新方法应用在了与2000年日本伊豆诸岛震群有关的ULF地磁资料的研究中.这次震群活动始于2000年6月26日,同年9月结束.在这次地震活动中,观测到5次震级超过6级的大地震(分别发生在7月1日、8日、15日、30日和8月18日).在此期间,我们的超低频地磁观测站幸运地记录下了数据,其中有三个观测站相距很近(大约5 km的距离),距地震中心大约80~100 km.因为我们可以在正交分解的基础上,用主要分量分析法将一些噪声分辨出来,所以我们把主要分量分析法用在了超低频地磁水平方向的NS分量中.我们研究了主要分量分析法结果中本征值和本征矢量的临时变化,这些结果总结如下.第一主要分量是源于日地交互作用影响的信号,如:地磁脉动.第一主要分量的本征矢量的变化说明这种信号在整个分析过程中非常稳定.第二主要分量中混有当地的人为的噪音.而最小的第三分量出现在伊豆半岛当地的子夜,在大地震前几天,第三本征值明显地增加.大约在震群活动开始前三个月,第三本征值的水平有微小增强.相应地,在信号的子空间中本征矢量方向的模式同时改变,在震群活动后又恢复到了其原来的水平.这些特征可能与大地震有关.最后我们强调主要分量分析的方法是目前监测地壳活动最有前途的方法. | Katsumi Hattori Aya Serita Kaoru Gotoh Chie Yoshino Makoto Harada Nobuhiro Isezaki Masashi Hayakawa 辛长江 | 2005 | 国际地震动态2005，，11： | 4 |
| 16 | Removal of arsenite by reductive precipitation in dithionite solution activated by UV light显示文摘This study investigates the removal of arsenite(As(III)) from water using dithionite activated by UV light. This work evaluated the removal kinetics of As(III) under UV light irradiation as affected by dithionite dose and light intensity, and characterized the nature of the precipitated solids using XPS and SEM-EDS. Photolysis of dithionite was observed by measuring dithionite concentration using UV absorbance at 315 nm. This study also investigated the effect of UV light path length on soluble As concentrations to understand resolubilization mechanisms. Total soluble As concentrations were observed to decrease with reaction time due to reduction of arsenite to form solids having a yellow-orange color.The removal mechanism was found to be reductive precipitation that formed solids of elemental arsenic or arsenic sulfide. However, these solids were observed to resolubilize at later times after dithionite had been consumed. Resolubilization of As was prevented and additional As removal was obtained by frequent dosing of dithionite throughout the experiment. As(III) removal is attributed to photolysis of dithionite by UV light and production of reactive radicals that reduce As(III) and convert it to solid forms. | Bahngmi Jung Aya Safan Yuhang Duan Vishakha Kaushik Bill Batchelor Ahmed Abdel-Wahab | 2018 | Journal of Environmental Sciences2018，30，12： | 3 |
| 17 | Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication显示文摘 | Paul Lochhead Aya Kuchiba Yu Imamura Xiaoyun Liao Mai Yamauchi Reiko Nishihara Zhi Rong Qian Teppei Morikawa Jeanne Shen Jeffrey A. Meyerhardt Charles S. Fuchs Shuji Ogino | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 3 |
| 18 | Laparoscopic-extracorporeal surgery performed with a fixation device for adnexal masses complicating pregnancy: Report of two cases显示文摘The potential complications associated with an adnexal mass discovered during early pregnancy call for surgical treatment. Ideally, surgery is performed after gestational week 12, but uterine expansion after the first trimester makes surgery difficult. We report two pregnancies complicated by adnexal masses for which we used an organ fixation device for safe performance of single-site umbilical laparoscopic surgery. Pelvic magnetic resonance imaging depicted a dichorionic, diamniotic twin pregnancy and 60-mm right adnexal mass in the first patient and bilateral adnexae in the second. All three masses were suspected mature cystic teratomas. Both patients underwent laparoscopic surgery during gestational week 14. With use of an organ fixation device, traction was applied until the mass reached the umbilicus; tumor resection was performed extracorporeally. In the second patient, the second mass was simply aspirated because adhesions were encountered. Our single-site laparoscopicextracorporeal technique proved to be a safe approach to an otherwise high-risk situation. | Hanako Kasahara Iwaho Kikuchi Aya Otsuka Yoko Tsuzuki Michio Nojima Koyo Yoshida | 2017 | World Journal of Methodology2017，7，4： | 3 |
| 19 | Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma显示文摘A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or α-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor(PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary car-cinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease. | Sohsuke Yamada Atsunori Nabeshima Hirotsugu Noguchi Aya Nawata Hisae Nishii Xin Guo Ke-Yong Wang Masanori Hisaoka Toshiyuki Nakayama | 2015 | World Journal of Gastroenterology2015，21，4： | 2 |
| 20 | Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report显示文摘A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests. | Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada | 2018 | World Journal of Gastroenterology2018，24，2： | 2 |
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