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| 1 | Comparative epidemiology of gastric cancer between Japan and China显示文摘AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and China.METHODS:A comprehensive literature search of the PubMed database was performed.The relevant literature published in China was also been cited.Data on incidence and mortality rates in 2008 were obtained from the Cancer Mondial database,published by International Agency for Research on Cancer at http://gffzzdff0249c86de468fhqwqc06nw5ou96kbc.ffgz.tsg.suse.edu.cn/.RESULTS:Gastric cancer remains a significant publichealth burden in both Japan and China.The prevalence of Helicobacter pylori(H.pylori)colonization is high in the adult populations of both countries.Accumulating evidence from intervention studies in both countries has shown the effectiveness of H.pylori eradication in reduc-ing gastric cancer incidence.There are differences,however,in many aspects of gastric cancer,including patterns of incidence and mortality,trends in the prevalence of H.pylori infection,H.pylori strains,the magnitude of risk of gastric cancer related to H.pylori infection,and associations with dietary habits.Compared with China,Japan has seen a more rapid decline in H.pylori infection among adolescents.While Japanese cohort studies have dominated the literature concerning the associations between gastric cancer and dietary habits,numerous case-control studies in China suggest a positive association between a high intake of preserved fish and vegetables and gastric cancer risk.There is a need for a multidisciplinary research approach to understand the interactions between various strains of H.pylori,host factors,and other lifestyle and environmental factors in gastric carcinogenesis in both countries.CONCLUSION:The shared high incidence of gastric cancer and high prevalence of H.pylori,as well as differences in many aspects of gastric cancer,provide an excellent opportunity to establish Sino-Japanese collaborations. | Yingsong Lin Junko Ueda Shogo Kikuchi Yukari Totsuka Wen-Qiang wei You-Lin Qiao Manami Inoue | 2011 | World Journal of Gastroenterology2011，17，39： | 64 |
| 2 | 马尾松幼苗对SO_2慢性伤害的反应显示文摘马尾松 (Pinus massonianas L amb.)幼苗暴露在 SO2 浓度分别为 0 .0 mg/ m3、0 .2 mg/ m3、0 .4 m g/ 3的 3个开顶式熏气室中 6 0昼夜。在 SO2 浓度 0 .2 mg/ m3处理组 ,马尾松苗与对照组无显著差异。在 SO2 浓度 0 .4 mg/ m3处理组 ,马尾松针叶气孔细胞、针叶颜色、根系形态、根毛数量出现异常 ;类胡萝卜素含量下降 35 % ,针叶含硫量增加 2 2 5 % ,从针叶渗出的钾离子量比对照增加 185 % ,光合速率下降 9.5 % ,蒸腾速率增加 13.6 % ,干重下降 15 .4 % ,相对生长速率下降 2 .7m g/ (g· d) | 唐鸿寿 Masatoshi Aoki Tsumugu Totsuka | 2005 | 生态学报2005，25，2： | 4 |
| 3 | Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model显示文摘AIM: To evaluate the effect of ANP on warm I/R injury in a porcine THVE model. METHODS: Miniature pigs (mini-pigs) weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP (0.1 μg/kg per min) was administered to the ANP group (n = 7), and vehicle was administered to the control group (n = 7). Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood ? ow (HTBF) was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups. RESULTS: The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were signifi cantly different between the two groups (60 min: 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 < 0.05, 120 min: 673.6 ± 148.2 vs 281.1 ± 44.8, P = 0.004 < 0.01). No signifi cant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not signif icant. A signifi cantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the controlgroup (0 min: 2.92 ± 1.1 vs 6.38 ± 1.1, P = 0.011 < 0.05).Histological tissue damage was milder in the ANP group than in the control group. CONCLUSION: Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model. | Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 4 | SO_2暴露方式与油松生长的关系显示文摘苗龄为 87d的油松 (PinustabulaeformisCarr )于 2 0 0 2 0 7 0 1~ 0 8 2 9在 3个处理组进行SO2 暴露实验 6 0昼夜 ,处理 1和处理 2在 2 4h中SO2 浓度分别为 0 1mg·m-3 和 0 2mg·m-3 ,处理 3每日 6hSO2 浓度为 0 5mg·m-3 ,18hSO2 浓度为 0 1mg·m-3 .经SO2 暴露后 ,处理 1油松针叶气孔保卫细胞、针叶颜色未见异常 ;叶绿素含量、类胡萝卜素含量、光合速率、蒸腾速率、单株干重、相对生长速率与对照组无显著差异 ;但针叶含硫量比对照增加 17% ,从针叶渗出的钾离子量比对照增加 2 2 % .处理 2油松气孔保卫细胞、针叶颜色未见异常 ;叶绿素含量、光合速率、蒸腾速率与对照组无显著差异 ;类胡萝卜素含量下降5 % ,针叶含硫量增加 92 % ,从针叶渗出的钾离子量比对照增加 6 7% ,单株干重下降 4 5 % ,相对生长速率下降 0 6mg·(g·d) -1.处理 3油松气孔保卫细胞、针叶颜色发现异常 ;叶绿素含量与对照组相似 ,但类胡萝卜素含量下降 2 1% ,含硫量增加 10 4 % ,从针叶渗出的钾离子量比对照增加 89% ,光合速率下降 5 % ,蒸腾速率增加 8% ,单株干重下降 7 6 % ,相对生长速率下降 1 3mg·(g·d) -1. | 唐鸿寿 AOKI Masatoshi TOTSUKA Tsumugu | 2005 | 环境科学2005，26，1： | 3 |
| 5 | Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease显示文摘 | Takanori Kanai Yasuhiro Nemoto Nobuhiko Kamada Teruji Totsuka Tadakazu Hisamatsu Mamoru Watanabe Toshifumi Hibi | 2009 | Current Opinion in Gastroenterology2009，，4： | 2 |
| 6 | Association Between Serum Uric Acid and Development of Type 2 Diabetes显示文摘 | Kodama Satoru Saito Kazumi Yachi Yoko Asumi Mihoko Sugawara Ayumi Totsuka Kumiko Saito Aki Sone Hirohito | 2009 | Diabetes Care2009，，： | 2 |
| 7 | Experimentally determined sequence requirement of ACGT-containing abscisic acid response element显示文摘 | Hattori T Totsuka M Hobo T | 2002 | Plant and Cell Physiology2002，43，1： | 1 |
| 8 | Blockade of B7-H1 suppresses the devdopment of chronic intestinal inflammation显示文摘 | Kanai T Totsuka T Uraushihara K | 2003 | J Immunol2003，171，8： | 1 |
| 9 | Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems显示文摘 | Kato T Totsuka Y Ishino K | 2013 | Nanotoxicology2013，7，： | 1 |
| 10 | Dietary nucleotides increase themueosal IgA response and the secretion of transform- ing growth factor t3 from intestinal epithelial cells in mice显示文摘 | Nagafuchi S totsuka M hachimura S | 2002 | Cy- totechnology2002，40，： | 1 |
| 11 | Influence of high donorserum sodium levels on early postoperative graft function in human liver transplantation:effect of correction of donor hypernatremia显示文摘 | Totsuka E Dodson F Urakami A | 1999 | Liver Transpl Surg1999，5，5： | 1 |
| 12 | Dietary nucleotides can up-regulate antigen-specific Thl immune responses and suppress antigen-specific lgE responses in mice 显示文摘 | Nagafuchi S hachimura S totsuka M | 2000 | Internation- al Archives of Allergy and Immunology2000，122，： | 1 |
| 13 | Changes in bone mineral density in rat adjuvant arthritis 显示文摘 | Toshiki T Tsao P W Totsuka R | 1997 | Clin Immunol Immunopathol1997，84，： | 1 |
| 14 | The development of colitogenic CD4 ( + ) T ceils is regulated by IL-7 in collabora- tion with NK cell function in a murine model of colitis 显示文摘 | Yamaji O Nagaishi T Totsuka T | 2012 | J Immunol2012，188，6： | 1 |
| 15 | Candida albicans and Saccharomycns cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid显示文摘 | Totsuka M Kaminogawa S | 2004 | FEMS Immunol Med Microbiol2004，41，3： | 1 |
| 16 | A Functional Single Nucleotide Polymorphism in Mucin 1 , at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer显示文摘 | Norihisa Saeki Akira Saito Il Ju Choi Keitaro Matsuo Sumiko Ohnami Hirohiko Totsuka Suenori Chiku Aya Kuchiba Yeon–Su Lee Kyong–Ah Yoon Myeong–Cherl Kook Sook Ryun Park Young–Woo Kim Hideo Tanaka Kazuo Tajima Hiroshi Hirose Fumihiko Tanioka Yoshihiro Mats | 2011 | Gastroenterology2011，，3： | 1 |
| 17 | Inhibitory effect of fluvastatin, an HMG-CoA reduetase inhibitor, on the expression of adhesion molecules on human monoeyte cell line 显示文摘 | Niwa S Totsuka T Hayashi S | 1996 | Int J Immunopharmacol1996，18，11： | 1 |
| 18 | Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs显示文摘 | Akao T Takeyoshi I Totsuka O | 2006 | J Heart Lung Transplant2006，25，8： | 1 |
| 19 | Blockade of B7-H1 suppresses the development of chronic interstinal inflammation显示文摘 | Kanai T Totsuka T Uraushihara K | 2003 | J Immunol2003，171，8： | 1 |
| 20 | Inhibitory effects of antioxi-dants on formation of heterocyclic amines显示文摘 | OGURI A SUDA M TOTSUKA Y | 1998 | Mutation Research-Funda- mental and Molecular Mechanisms of Mutagenesis1998，402，12： | 1 |
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