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| 1 | 论岩土材料屈服准则的基本特性和创新显示文摘从岩土材料的基本力学性能出发,讨论岩土材料屈服准则的基本特性和屈服准则的创新。根据国内外学者的大量实验结果,岩土材料屈服准则的基本特性为:拉压异性(SD)效应、正应力效应、静水应力效应、中间主应力效应、中间主剪应力效应、双剪应力正应力效应、双剪应力围压效应、应力角效应(应力偏张量第三不变量效应)和屈服面的外凸性。屈服准则应该满足这些基本特性,Tresca准则不符合这些条件,Mohr-Coulomb理论只能够满足部分条件,Drucker-Prager准则不能满足应力角效应。屈服准则的创新应该满足科学创新的3个要素:(1)新,前所未有;(2)比原来的准则更好;(3)能够实施、便于实际应用。总结各种力学单元体模型的发展,并以一个新的力学模型为依据,对统一强度理论补充一个拉伸破坏条件,它类似于Mohr-Coulomb准则的拉伸截断。从而将统一强度理论扩展到三向拉伸区,更能适用于岩土材料和岩土工程,也使统一强度理论在理论上更趋完整。 | 俞茂宏 刘继明 ODA Yoshiya 高江平 | 2007 | 岩石力学与工程学报2007，26，9： | 22 |
| 2 | Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis显示文摘The main purpose of treatment of rheumatoid arthritis(RA) with disease modifying antirheumatic drugs(DMARDs) is to control activation of lymphocytes,although some patients do not respond adequately to such treatment. Among various mechanisms of multidrug resistance, P-glycoprotein(P-gp), a member of ATP-binding cassette transporters, causes drugresistance by efflux of intracellular drugs. Certain stimuli,such as tumor necrosis factor-α, activate lymphocytes and induce P-gp expression on lymphocytes, as evident in active RA. Studies from our laboratories showed spontaneous nuclear accumulation of human Y-boxbinding protein-1, a multidrug resistance 1 transcription factor, in unstimulated lymphocytes, and surface overexpression of P-gp on peripheral lymphocytes of RA patients with high disease activity. The significant correlation between P-gp expression level and RA disease activity is associated with active efflux of drugs from the lymphocyte cytoplasm and in drugresistance.However, the use of biological agents that reduce P-gp expression as well as P-gp antagonists(e.g., cyclosporine) can successfully reduce the efflux of corticosteroids from lymphocytes in vitro, suggesting that both types of drugs can be used to overcome drug-resistance and improve clinical outcome. We conclude that lymphocytes activated by various stimuli in RA patients with highly active disease acquire P-gpmediated multidrug resistance against corticosteroids and probably some DMARDs, which are substrates of P-gp. Inhibition/reduction of P-gp could overcome such drug resistance. Expression of P-gp on lymphocytes is a promising marker of drug resistance and a suitable therapeutic target to prevent drug resistance in patients with active RA. | Shizuyo Tsujimura Yoshiya Tanaka | 2015 | World Journal of Experimental Medicine2015，5，4： | 8 |
| 3 | Hepatitis B virus reactivation with a rituximab-containing regimen显示文摘Rituximab is currently used not only in the treatment of B-cell lymphoma but also for various other diseases, including autoimmune diseases, post-transplant graft vs host disease, and rejection following kidney transplants. Due to rituximab's widespread use, great progress has been made regarding research into complications that arise from its use, one of the most serious being the reactivation of hepatitis B virus(HBV), and efforts continue to establish guidelines for preventive treatment against this occurrence. This report discusses preventive measures against rituximab-induced HBV reactivation and future objectives. | Yutaka Tsutsumi Yoshiya Yamamoto Shinichi Ito Hiroyuki Ohigashi Souichi Shiratori Hirohito Naruse Takanori Teshima | 2015 | World Journal of Hepatology2015，7，21： | 5 |
| 4 | Treatment of colorectal carcinoids:A new paradigm显示文摘It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，5： | 5 |
| 5 | Study on the applicability of frequency spectrum of micro-tremor and dynamic characteristics of surface ground in Asia area显示文摘The dynamic characteristics of ground soil using micro-tremor observation in Asia (Zushi and Ogasawara (Japan), Xi’an (China), Manila (Philippines), and Gujarat (India)) are studied. Ground micro-tremor signals were observed and analyzed by fast Fourier transform method (FFT). The response of ground soil to frequency of ground micro-tremor is revealed, and func- tions with frequency-dependence and frequency-selection of micro-tremor for different foundation soil strata are also researched. The horizontal to vertical spectral ratio (H/V, Nakamura technique) of micro-tremor observed at the surface ground was used to evaluate the site’s predominant period. This paper also discusses the application of micro-tremor on site safety evaluation, and gives the observed calculation results obtained at multiple points. The experimental foundation and the deduction process of the method are described in detail. Some problems of the method are pointed out. Potential use of the technique’s good expandable nature makes it a useable means for preventing and reducing disaster’s harmful effects. | CHE Ai-lan IWATATE Takahiro ODA Yoshiya GE Xiu-run | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，11： | 5 |
| 6 | 有包含 rituximab 政体的肝炎 B 病毒复活显示文摘 Rituximab is recognized as a useful drug for the treatment of B-cell non-Hodgkin’s lymphoma and its use has been extended to such diseases as idiopathic thrombocytopenic purpura,thrombotic thrombocytopenic purpura,chronic rheumatoid arthritis and ANCA-associated vasculitides.One serious complication associated with its use is the reactivation of hepatitis B virus and the search for methods to prevent this occurrence has resulted in the rapid accumulation of knowledge.In this review,we discuss case analyses from our department and other groups and outline the current knowledge on the topic and the remaining issues. | Yutaka Tsutsumi Yoshiya Yamamoto Joji Shimono Hiroyuki Ohhigashi Takanori Teshima | 2013 | World Journal of Hepatology2013，5，11： | 4 |
| 7 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 8 | Preoperative chemoradiation and extended pelvic lymphadenectomy for rectal cancer:Two distinct principles显示文摘Extended pelvic lymphadenectomy(EPL) with total mesorectal excision(TME) has been reported to provide oncological benefit in lower rectal cancer in Japan.In Western countries EPL is not widely accepted because of frequent morbidity but instead preoperative chemoradiation(CRT) followed by TME has been established as a standard treatment for decreasing local recurrence.Recently,several studies have focused on the comparison between these two distinct therapeutic approaches in Western countries and Japan.A study comparing Dutch trial data and Japanese data revealed that EPL and RT are almost equivalent in decreasing local recurrence in lower rectal cancer as compared with TME alone.Considering that almost 45 survival can be achieved by EPL even in the presence of metastatic lateral lymph nodes(LLNs),EPL performed by experienced surgeons definitely contributes to decrease local recurrence.On the other hand,a randomized controlled trial in Japan that compared EPL with conventional TME following preoperative RT revealed that EPL is associated with a higher frequency of sexual and urinary dysfunction without oncological benefits in the presence of preoperative RT.On this point,preoperative CRT followed by conventional TME without EPL would be a better therapeutic approach in patients without evident metastatic LLNs.For future treatment,it would be desirable to have a narrower indication for EPL using full advantage of recent improvement in image diagnosis.Although objective comparison of these two principles between Japan and the West is difficult due to differences in patient groups,further studies would lead to the next great step towards future improvement in treating lower rectal cancer. | Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 9 | Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse显示文摘 | Sunil R. Hingorani Emanuel F. Petricoin Anirban Maitra Vinodh Rajapakse Catrina King Michael A. Jacobetz Sally Ross Thomas P. Conrads Timothy D. Veenstra Ben A. Hitt Yoshiya Kawaguchi Don Johann Lance A. Liotta Howard C. Crawford Mary E. Putt Tyler Jacks | 2003 | Cancer Cell2003，，： | 2 |
| 10 | Safety and Feasibility of Laparoscopic Intersphincteric Resection for Very Low Rectal Cancer显示文摘 | Yoshiya Fujimoto Takashi Akiyoshi Hiroya Kuroyanagi Tsuyoshi Konishi Masashi Ueno Masatoshi Oya Toshiharu Yamaguchi | 2010 | Journal of Gastrointestinal Surgery2010，，4： | 2 |
| 11 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi Kazuhiro Kami Daisuke Ito Koji Fujimoto Yoshiya Kawaguchi Michihiko Wada Masafumi Kogire Ryo Hosotani Masayuki Imamura Shinji Uemoto | 2007 | World Journal of Surgery2007，，： | 2 |
| 12 | One-step reconstruction of the right inferior hepatic veins using auto-venous grafts in living donor liver transplantation显示文摘 | Toru Ikegami Ken Shirabe Shohei Yoshiya Yuji Soejima Tomoharu Yoshizumi Hideaki Uchiyama Takeo Toshima Takashi Motomura Yoshihiko Maehara | 2013 | Surgery Today2013，，7： | 2 |
| 13 | Short-Term Outcomes of Laparoscopic Colectomy for Transverse Colon Cancer显示文摘 | Takashi Akiyoshi Hiroya Kuroyanagi Yoshiya Fujimoto Tsuyoshi Konishi Masashi Ueno Masatoshi Oya Toshiharu Yamaguchi | 2010 | Journal of Gastrointestinal Surgery2010，，5： | 2 |
| 14 | Pressure-Induced Metallization and Structural Phase Transition in the Quasi-One-Dimensional TlFeSe2显示文摘We report a comprehensive high-pressure study on the monoclinic TIFeSe2 single crystal,which is an antiferromagnetic jnsulator with quasi-one-dimensional crystal structure at ambient pressure.It is found that TIFeSe2 undergoes a pressure-induced structural transformation from the monoclinic phase to an orthorhombic structure above Pc≈13 GPa,accompanied with a large volume collapse of ΔV/V0=8.3%.In the low-pressure monoclinic phase,the insulating state is easily metallized at pressures above 2 GPa;while possible superconductivity with Tconset^2 K is found to emerge above 30 GPa in the high-pressure phase.Such a great tunability of TIFeSe2 under pressure indicates that the ternary AFeSe2 system(A=Tl,K,Cs,Rb) should be taken as an important platform for explorations of interesting phenomena such as insulator-metal transition,dimensionality crossover,and superconductivity. | 刘子儀 董庆新 单鹏飞 王义炎 戴建洪 Rajesh Jana 陈科宇 孙建平 王铂森 于晓辉 刘广同 Yoshiya Uwatoko 隋郁 杨槐馨 陈根富 程金光 | 2020 | Chinese Physics Letters2020，37，4： | 2 |
| 15 | Prognostic Implication of Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer显示文摘 | Ryuichiro Doi MD Kazuhiro Kami MD Daisuke Ito MD Koji Fujimoto MD Yoshiya Kawaguchi MD Michihiko Wada MD Masafumi Kogire MD Ryo Hosotani MD Masayuki Imamura MD Shinji Uemoto MD | 2007 | World Journal of Surgery2007，，1： | 2 |
| 16 | Cubic anvil cell apparatus for high-pressure and low-temperature physical property measurements显示文摘We will build a cubic anvil cell(CAC) apparatus for high-pressure and low-temperature physical property measurements in the synergic extreme condition user facility(SECUF). In this article, we first introduce the operating principle, the development history, and the current status of the CAC apparatus, and subsequently describe the design plan and technical targets for the CAC in SECUF. We will demonstrate the unique advantages of CAC, i.e., excellent pressure homogeneity and large hydrostatic pressure capacity, by summarizing our recent research progresses using CAC. Finally, we conclude by providing some perspectives on the applications of CAC in the related research fields. | 程金光 王铂森 孙建平 Yoshiya Uwatoko | 2018 | Chinese Physics B2018，27，7： | 2 |
| 17 | Bacterial Sepsis after Living Donor Liver Transplantation: The Impact of Early Enteral Nutrition显示文摘 | Toru Ikegami Ken Shirabe Shohei Yoshiya Tomoharu Yoshizumi Mizuki Ninomiya Hideaki Uchiyama Yuji Soejima Yoshihiko Maehara | 2012 | Journal of the American College of Surgeons2012，，3： | 2 |
| 18 | Electrohydraulic lithotripsy and rendezvous nasal endoscopic cholangiography for common bile duct stone: A case report显示文摘BACKGROUND In patients with large stones in the common bile duct(CBD),advanced treatment modalities are generally needed.Here,we present an interesting case of a huge CBD stone treated with electrohydraulic lithotripsy(EHL)by the percutaneous approach and rendezvous endoscopic retrograde cholangiography(ERC)using a nasal endoscope.CASE SUMMARY A 91-year-old woman underwent ERC for a symptomatic large CBD stone with a diameter of 50 mm.She was referred to our institution after the failure of lithotomy by ERC,and after undergoing percutaneous transhepatic biliary drainage.We attempted to fragment the stone by transhepatic cholangioscopy using EHL.However,the stones were too large and partly soft clay-like for lithotripsy.Next,we attempted lithotomy with ERC and cholangioscopy by the rendezvous technique using a nasal endoscope and achieved complete lithotomy.No complication was observed at the end of this procedure.CONCLUSION Cholangioscopy by rendezvous technique using a nasal endoscope is a feasible and safe endoscopic method for removing huge CBD stones. | Koichi Kimura Kensuke Kudo Tomoharu Yoshizumi Takeshi Kurihara Shohei Yoshiya Yohei Mano Kazuki Takeishi Shinji Itoh Noboru Harada Toru Ikegami Tetsuo Ikeda | 2019 | World Journal of Clinical Cases2019，7，10： | 2 |
| 19 | Medial collateral ligament reconstruction using autogenous hamstring tendons technique and results in initial cases 显示文摘 | Yoshiya S Kuroda R | 2005 | Am J Sports Med2005，33，： | 1 |
| 20 | The extinction of genetic resources of Asian wild rice, Oryza rufipogon Griff.: A case study in Thailand显示文摘 | Masahiro Akimoto Yoshiya Shimamoto Hiroko Morishima | 1999 | Genetic Resources and Crop Evolution1999，，4： | 1 |
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