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| 1 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 2 | NO-1886降低脂负荷新西兰兔血清甘油三酯和游离脂肪酸显示文摘目的观察NO1886(ibrolipim)对脂肪餐后血脂水平的影响。方法将25只♂新西兰兔随机分为5组正常对照组、脂负荷组、脂负荷+NO1886(05g·kg-1)组、脂负荷+NO1886(10g·kg-1)组、脂负荷+NO1886(15g·kg-1)组;分别在给予20%脂肪乳和相应剂量NO1886前后第1、2、4、6、8、24h从兔耳缘静脉采血,离心收集血清,测定血清甘油三酯和游离脂肪酸。结果NO1886能有效地降低脂负荷后新西兰兔血清甘油三酯和游离脂肪酸水平,呈剂量依赖性,并能使游离脂肪酸恢复到正常。结论NO1886具有调节脂肪餐后血脂水平的作用。 | 张弛 肖俊霞 席守民 张秋菊 王宗保 Kusunoki M Tsutsumi K 尹卫东 | 2005 | 中国药理学通报2005，21，3： | 6 |
| 3 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 4 | Prognostic Significance of Host- and Tumor-Related Factors in Patients with Gastric Cancer显示文摘 | Yasuhiko Mohri Kouji Tanaka Masaki Ohi Takeshi Yokoe Chikao Miki Masato Kusunoki | 2010 | World Journal of Surgery2010，，2： | 3 |
| 5 | Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer显示文摘 | Yasuhiko Mohri Yasuhiro Inoue Koji Tanaka Junichirou Hiro Keiichi Uchida Masato Kusunoki | 2013 | World Journal of Surgery2013，，11： | 3 |
| 6 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 7 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa Koji Tanaka Yuji Toiyama Takeshi Yokoe Yoshinaga Okugawa Yasuhiro Ioue Chikao Miki Masato Kusunoki | 2009 | Annals of Surgical Oncology2009，，： | 2 |
| 8 | Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma显示文摘AIM: A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis (UC). We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication.METHODS: Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninfliamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs.RESULTS: Two genes showing 2.5-fold decreased expression with significance set at in UC samples were bomeo box a4 (HOXa4) and mads box transcription enhancer factor 2, polypeptide B (MEF2b). RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma.CONCLUSION: It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao Miki Masato Kusunoki | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 9 | Variable-precision dominance-based rough set approach and attribute reduction显示文摘 | Masahiro Inuiguchi Yukihiro Yoshioka Yoshifumi Kusunoki | 2009 | International Journal of Approximate Reasoning2009，，： | 2 |
| 10 | Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy显示文摘 | Susumu Saigusa MD Koji Tanaka MD Yuji Toiyama MD Takeshi Yokoe MD Yoshinaga Okugawa MD Yasuhiro Ioue MD PhD Chikao Miki MD PhD Masato Kusunoki MD PhD | 2009 | Annals of Surgical Oncology2009，，12： | 2 |
| 11 | Single‐incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum显示文摘 | Masaki Ohi Hiromi Yasuda Yoshito Ishino Masaki Katsurahara Susumu Saigusa Kyosuke Tanaka Koji Tanaka Yasuhiko Mohri Yasuhiro Inoue Keiichi Uchida Masato Kusunoki | 2013 | Asian J Endosc Surg2013，，4： | 2 |
| 12 | H. pylori eradication did not improve dysregulation of specific oncogenic miRNAs in intestinal metaplastic glands显示文摘 | Akiko Shiotani Noriya Uedo Hiroyasu Iishi Takahisa Murao Tomoko Kanzaki Yoshiki Kimura Tomoari Kamada Hiroaki Kusunoki Kazuhiko Inoue Ken Haruma | 2012 | Journal of Gastroenterology2012，，9： | 2 |
| 13 | Clinical Effect of Addition of Beraprost Sodium to Pioglitazone Treatment on the Blood Glucose Levels in Patients with Type 2 Diabetes Mellitus显示文摘 | T. Chen M. Kusunoki D. Sato H. Tsutsui T. Nakamura T. Miyata Y. Oshida | 2013 | Exp Clin Endocrinol Diabetes2013，，： | 2 |
| 14 | Analysis of somatic mutation frequency among persons exposed radiation from the Chemoby nuclear power plant accident 显示文摘 | Seyama T Akiyama M Kusunoki Y | 1993 | RadiatRes1993，34，： | 1 |
| 15 | Effect of the amount of γ′ and oxide content on the secondary recrystallization temperature of Ni-base superalloy显示文摘 | SUNMINO K KAWASAKI Y | 1990 | Metal Trans1990，21，3： | 1 |
| 16 | The lipoprotein lipase activator, NO-1886, suppresses fal accumulation and insulin resistance in rats fed a high-fat diet显示文摘 | KUSUNOKI M HARA T TSUTSUMI K | 2000 | Diabetologia2000，43，7： | 1 |
| 17 | Somatic - cell mutations as a possible predictor of cancer risk 显示文摘 | AKIYAMA M UMEKI S KUSUNOKI Y | 1995 | Health Phys1995，68，5： | 1 |
| 18 | Glycerol conversion in the aqueous solution under hydrogen over Ru/C + an ion-exchange resin and its reaction mecha- nism 显示文摘 | Miyazawa T Kusunoki Y Kunimori K | 2006 | Journal of Catalysis2006，240，2： | 1 |
| 19 | Selective synthesis of zigzag-type aligned carbon nanotubes on SiC (000-1) wafers 显示文摘 | Kusunoki M Suzuki T Honjo C | 2002 | Chemical Physics Letters2002，366，： | 1 |
| 20 | Scintigraphic assessment of double tract reconstruction after total gastrectomy 显示文摘 | Fujiwara Y Kusunoki M Nakagawa K | 1998 | Dig Surg1998，15，5： | 1 |
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