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| 1 | Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis显示文摘AIM: To analyze hepatocellular carcinoma(HCC) patients with portal vein tumor thrombosis(PVTT) using the tumor-node-metastasis(TNM) staging system.METHODS: We retrospectively analyzed 372 patients with HCC who underwent hepatectomy between 1980 and 2009.We studied the outcomes of HCC patients with PVTT to evaluate the American Joint Committee on Cancer TNM staging system(7th edition) for stratifying and predicting the prognosis of a large cohort of HCC patients after hepatectomy in a single-center.Portal vein invasion(vp) 1 was defined as an invasion or tumor thrombus distal to the second branch of the portal vein,vp2 as an invasion or tumor thrombus in the second branch of the portal vein,vp3 as an invasion or tumor thrombus in the first branch of the portal vein,and vp4 as an invasion or tumor thrombus in the portal trunk or extending to a branch on the contralateral side.RESULTS: The cumulative 5-year overall survival(5yr OS) and 5-year disease-free survival(5yr DFS) rates of the 372 patients were 58.3% and 31.3%,respectively.The 5yr DFS and 5yr OS of vp3-4 patients(n = 10) were 20.0%,and 30.0%,respectively,which was comparable with the corresponding survival rates of vp1-2 patients(P = 0.466 and 0.586,respectively).In the subgroup analysis of patients with macroscopic PVTT(vp2-4),the OS of the patients who underwent preoperative transarterial chemoembolization was comparable to that of patients who did not(P = 0.747).There was a significant difference in the DFS between patients with stage Ⅰ HCC and those with stage Ⅱ HCC(5yr DFS 39.2% vs 23.1%,P < 0.001); however,theDFS for stage Ⅱ was similar to that for stage Ⅲ(5yrD FS 23.1% vs 13.8%,P = 0.330).In the subgroup analysis of stage Ⅱ-Ⅲ HCC(n = 148),only alpha-fetoprotein(AFP) > 100 mg/dL was independently associated with DFS.CONCLUSION: Hepatectomy for vp3-4 HCC results in a survival rate similar to hepatectomy for vp1-2.AFP stratified the stage Ⅱ-Ⅲ HCC patients according to prognosis. | Yusuke Yamamoto Hisashi Ikoma Ryo Morimura Katsutoshi Shoda Hirotaka Konishi Yasutoshi Murayama Shuhei Komatsu Atsushi Shiozaki Yoshiaki Kuriu Takeshi Kubota Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Chouhei Sakakura Toshiya Ochiai Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，1： | 9 |
| 2 | Characteristics of ammonium removal by heterotrophic nitrification-aerobic denitrification by Alcaligenes faecalis No. 4显示文摘 | Hung-Soo Joo Mitsuyo Hirai Makoto Shoda | 2005 | Journal of Bioscience and Bioengineering2005，，2： | 5 |
| 3 | Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma显示文摘Synovial sarcoma(SS) is genetically characterized by chromosomal translocation, which generates SYT-SSX fusion transcripts. Although SS can occur in any body part, primary gastric SS is substantially rare. Here we describe a detection of the fusion gene sequence of gastric SS in plasma cell-free DNA(cf DNA). A gastric submucosal tumor was detected in the stomach of a 27-year-old woman and diagnosed as SS. Candidate intronic primers were designed to detect the intronic fusion breakpoint and this fusion sequence was confirmed in intron 10 of SYT and intron 5 of SSX2 by genomic polymerase chain reaction(PCR) and direct sequencing. A locked nucleic acid(LNA) probe specificto the fusion sequence was designed for detecting the fusion sequence in plasma and the fusion sequence was detected in preoperative plasma cfD NA, while not detected in postoperative plasma cfD NA. This technique will be useful for monitoring translocation-derived diseases such as SS. | Shinpei Ogino Hirotaka Konishi Daisuke Ichikawa Junichi Hamada Katsutoshi Shoda Tomohiro Arita Shuhei Komatsu Atsushi Shiozaki Kazuma Okamoto Sanae Yamazaki Satoru Yasukawa Eiichi Konishi Eigo Otsuji | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 4 | Piggery wastewater treatment using Alcaligenes faecalis strain No. 4 with heterotrophic nitrification and aerobic denitrification显示文摘 | Hung-Soo Joo Mitsuyo Hirai Makoto Shoda | 2006 | Water Research2006，，16： | 2 |
| 5 | Characteristics of ammonium removal by heterotrophic nitrification-aerobic denitrification by Alcaligenes faecalis No. 4显示文摘 | Hung-Soo Joo Mitsuyo Hirai Makoto Shoda | 2005 | Journal of Bioscience and Bioengineering2005，，2： | 2 |
| 6 | Second stage production of iturin A by induced germination of Bacillus subtilis RB14显示文摘 | Mohammad Shahedur Rahman Takashi Ano Makoto Shoda | 2006 | Journal of Biotechnology2006，，4： | 2 |
| 7 | A cognitive-affective system theory of personality: re-conceptualizing sit-ation, dispositions, dynamics, and invariance in personality structure显示文摘 | Mischel W Shoda Y | 1995 | Psychological review1995，，102： | 1 |
| 8 | Effect of temperature change and aeration on the production of antifungal peptide anti- biotic iturin by Bacillus subtilis NB22 in liquid cultiva- tion显示文摘 | Ohno A Ano T Shoda M | 1993 | Journal of Fermentations and Bioengineering1993，75，6： | 1 |
| 9 | Alterations of bile acid composition in gallstones, bile and live of patients with hepatolithiesis and the etiological significante显示文摘 | Shoda J Tanaka N He B | 1993 | Dig Dis Sci1993，38，11： | 1 |
| 10 | Cloning,sequencing,and characterization of the iturin A operon显示文摘 | Tsuge K Aldyama T Shoda M | 2001 | Journal of Bacteriology2001，183，21： | 1 |
| 11 | Development of selective, visible light-excitable, fluorescent magnesium ion probes with a novel fluorescence switching mecha- nism 显示文摘 | Shoda T Kikuchi K Kojima H | 2003 | Analyst2003，128，6： | 1 |
| 12 | Cloning of cD-NA encoding bovine interleukin 18 and analysis of IL-18 expression in maerophages and its IFN-gamma-in-ducing activity显示文摘 | Shoda D S Zarlega M | 1999 | J Interf Cytokine Res1999，19，： | 1 |
| 13 | IL-17B and IL-17C are as-sociated with TNF-alpha production and contribute to the exacerba-tion of inflammatory arthritis显示文摘 | Yamaguchi Y Fujio K Shoda H | 2007 | J Immunol2007，179，10： | 1 |
| 14 | Comparison of the biological H2S removal characteristics among four inorganic packing materials显示文摘 | Hirai M Kamaraoto M Yanl M Shoda M | 2001 | Journal of Bioscience and Bioengineering2001，91，4： | 1 |
| 15 | Mapping and ablation of idiopathic ventricular fibrillation显示文摘 | Haissaguerre M Shoda M Jais P | 2002 | Circulation2002，106，： | 1 |
| 16 | Developmental and dynamic canal stenosis as radiologic factors affecting surgical results of anterior cervical fusion for myelopathy 显示文摘 | Shoda E Sumi M Kataoka O | 1999 | Spine1999，24，4： | 1 |
| 17 | Recent advance in bacterial cellulose production显示文摘 | Shoda M Sugano Y | 2005 | Biotechnology and Bioprocess Engineering2005，10，1： | 1 |
| 18 | Isolation of a gene essential for biosynthesis of the lipopeptide antibiotics plipastatin B1 and surfactin in Bacillus subtilis YB8显示文摘 | Tsuge K Ano T Shoda M | 1996 | Arch Microbiol1996，165，： | 1 |
| 19 | Molecular packing analysis of benzene crystals, Part 2: Prediction of experimental crystal structure polymorphs at low and high pressure 显示文摘 | SHODA T YAMAHARA K OKAZAKI K | 1995 | J Mol Struct1995，333，： | 1 |
| 20 | Rate of composting of dewatered sewage sludge in continuously mixed isothermal reactor 显示文摘 | BACH P D SHODA M KUBOTA H | 1984 | Journal of Fermentation Technology1984，62，： | 1 |
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