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| 1 | Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis显示文摘AIM: To evaluate the effi cacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP). METHODS: We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulf illed clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy (non-CRAI). CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate (2400 mg/d) was continuously administered for 3 to 5 d. The clinical outcome including serum infl ammation-related parameters were examined. RESULTS: The duration of abdominal pain in the CRAI group was 1.9 ± 0.26 d, whereas that in the non-CRAI group was 4.3 ± 0.50. The duration of SIRS in the CRAI group was 2.2 ± 0.22 d, whereas that in the non- CRAI group was 3.2 ± 0.28. Abdominal pain and SIRS disappeared signifi cantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization signifi cantly differed between the CRAI and non-CRAI groups, 53.3 ± 7.9 d and 87.4 ± 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group. CONCLUSION: The present results suggest that CRAI using gabexate mesilate was effective against SAP. | Yoshifumi Ino Yoshiyuki Arita Tetsuro Akashi Toshinari Kimura Hisato Igarashi Takamasa Oono Masayuki Furukawa Ken Kawabe Keiichiro Ogoshi Jiro Ouchi Toshihiko Miyahara Ryoichi Takayanagi Tetsuhide Ito | 2008 | World Journal of Gastroenterology2008，14，41： | 20 |
| 2 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 3 | Advanced diffusion magnetic resonance imaging in patients with Alzheimer’s and Parkinson’s diseases显示文摘The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings;however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively. | Koji Kamagata Christina Andica Taku Hatano Takashi Ogawa Haruka Takeshige-Amano Kotaro Ogaki Toshiaki Akashi Akifumi Hagiwara Shohei Fujita Shigeki Aoki | 2020 | Neural Regeneration Research2020，15，9： | 11 |
| 4 | 聚N-异丙基丙烯酰胺-丙烯酸共聚微凝胶与Tb(Ⅲ)相互作用的研究显示文摘 | 肖雨亭 陈明清 陆天虹 MITSURU Akashi 黄晓华 | 2005 | 高分子学报2005，15，3： | 10 |
| 5 | Tb(Ⅲ)与PNIPAM接枝核壳纳米微球相互作用的研究显示文摘利用透射电镜、X射线光电子能谱、动态激光光散射和荧光光谱技术对Tb(Ⅲ)与聚N-异丙基丙烯酰胺(PNIPAM)接枝核壳纳米微球PNIPAM-g-P(NIPAM-co-St)(PNNS)的相互作用进行了研究.结果表明:Tb(Ⅲ)和热敏性的核壳纳米微球PNNS有显著的相互作用.其一,Tb(Ⅲ)可与PNNS中酰胺基团上的氧原子配位形成微球配合物Tb(Ⅲ)-PNNS;其二,Tb(Ⅲ)-PNNS微球配合物兼具热敏性;其三,该配合物在545nm处的荧光强度较Tb(Ⅲ)增大了233倍,Tb(Ⅲ)与PNNS分子间能量传递达到50%,当Tb(Ⅲ)质量分数为12%时荧光强度最大. | 殷伟庆 陈明清 陆天虹 MITSURU Akashi 黄晓华 | 2006 | 化学学报2006，64，20： | 9 |
| 6 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 7 | Preparation and Characterization of Polymeric Microspheres Having Isotactic Poly(methacrylic acid) on Their Surfaces显示文摘A poly( tert -butyl methacrylate)(PBMA) macromonomer was synthesized by anionic polymerization with bis(2,6-di- t -butyl phenoxy) methyl aluminum [MeAl(ODBP)2] as the initiator and trimethylsilylmethacrylate(TMSMA) as the end capping agent in dry THF. Then, a poly(methacrylic acid)(PMAA) macromonomer was obtained by means of hydrolysis reaction from the PBMA macromonomer in the presence of hydrochloric acid. The structures of the PBMA macromonomer were characterized by using 1H NMR. It was found that the resulted PBMA macromonomer has highly isotactic properties and the PMAA macromonomer has an end vinyl group on per polymer chain. The monodisperse polymeric microspheres, which consisted of polystyrene cores and PMAA branches on their surfaces, were prepared by the dispersion copolymerization of styrene with the PMAA macromonomer in an ethanol/water mixed solvent. It was found that the concentration of the PMAA macromonomer would affect the microsphere formation, the morphology and its size in the copolymerization system. | CHEN Ming-qing 1** , LIU Xiao-ya 1, YANG Cheng 1 and AKASHI Mitsuru 21. School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, P. R. China 2. Department of Applied Chemistry and Chemical Engineering, Faculty of Engi | 2002 | Chemical Research in Chinese Universities2002，18，1： | 6 |
| 8 | 铽-聚N-乙烯基乙酰胺体系中镧钆掺杂稀土配合物谱学研究显示文摘在乙醇溶液中合成了掺杂镧和钆的铽-聚N-乙烯基乙酰胺(PNVA)的掺杂稀土配合物,并通过红外光谱、紫外光谱、XPS光电子能谱和荧光光谱研究了该配合物的光谱性质。结果表明:掺杂稀土配合物中的稀土离子都与高分子配体PNVA产生配位作用。配合物的最佳激发波长为303 nm;在此波长激发下,配合物发出较强铽的特征荧光,说明非荧光稀土离子(La3+和Gd3+)对Tb3+离子的发光有显著的增强作用,而对Tb3+的发射峰位影响不大。 | 孙勇 陈明清 陆天虹 Mitsuru Akashi 黄晓华 | 2006 | 光谱学与光谱分析2006，26，4： | 5 |
| 9 | Thermosensitive Particles with Unusual Morphology Prepared by Dispersion Copolymerization显示文摘The monodispersed polymeric particles with an unusual structure were prepared by the dispersion copolymerization of acrylonitrile/styrene(AN/St) in mixed solvents of ethanol/water by using the poly(N-isopropylacrylamide) (PNIPAAm) macromonomer as a reaction stabilizer. It was found that the AN monomer plays a key role in the formation of the particles with special morphology analyzed via scanning electron microscopy(SEM). The reaction parameters have remarkable influences on the particle size and morphology. The particles possess a thermosensitive property according to the result of laser light scattering(LLS). | CHEN Ming-qing YUAN Yan-hua LIU Xiao-ya YANG Cheng KANEKO Tatsuo AKASHI Mitsuru | 2005 | Chemical Research in Chinese Universities2005，21，6： | 3 |
| 10 | Increase in medium-size rainfall events will enhance the C-sequestration capacity of biological soil crusts显示文摘Biological soil crusts(BSCs) play important roles in the carbon(C) balance in arid regions. Net C balance of BSCs is strongly dependent on rainfall and consequent activation of microbes in the BSCs. The compensation-rainfall size for BSCs(the minimum rainfall amount for a positive net C balance) is assumed to be different with BSCs of different developmental stages. A field experiment with simulated rainfall amount(SRA) of 0, 1, 5, 10, 20, and 40 mm was conducted to examine the C fluxes and compensation-rainfall size of BSCs in different parts of fixed dunes in the ecotone between the Badain Jaran Desert and the Minqin Oasis. We found algae-lichen crust on the interdunes and crest, algae crust on the leeward side, and lichen-moss crust on the windward. Even a small rainfall(1 mm) can activate both photosynthesis and respiration of all types of BSCs. The gross ecosystem production, ecosystem respiration, and net ecosystem exchange were significantly affected by SRA, hours after the simulated rainfall, position on a dune, and their interactions. The rapid activation of photosynthesis provides a C source and therefore could be responsible for the increase of C efflux after each rewetting. C-uptake and-emission capacity of all the BSCs positively correlated with rainfall size, with the lowest C fluxes on the leeward side. The compensation rainfall for a net C uptake was 3.80, 15.54, 8.62, and 1.88 mm for BSCs on the interdunes, the leeward side, the crest, and the windward side, respectively. The whole dune started to show a net C uptake with an SRA of 5 mm and maximized with an SRA of about 30 mm. The compensation-rainfall size is negatively correlated with chlorophyll content. Our results suggest that BSCs will be favored in terms of C balance, and sand dune stabilization could be sustained with an increasing frequency of 5-10 mm rainfall events in the desert-oasis transitional zone.- | CuiHua Huang Fei Peng Itaru Shibata Jun Luo Xian Xue Kinya Akashi Atsushi Tsunekawa Tao Wang | 2019 | Research in Cold and Arid Regions2019，11，1： | 2 |
| 11 | MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4显示文摘 | Shimazu R Akashi S Ogata H | 1999 | J Exp Med1999，189，11： | 2 |
| 12 | Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα显示文摘 | Pu Zhang Junko Iwasaki-Arai Hiromi Iwasaki Maris L. Fenyus Tajhal Dayaram Bronwyn M. Owens Hirokazu Shigematsu Elena Levantini Claudia S. Huettner Julie A. Lekstrom-Himes Koichi Akashi Daniel G. Tenen | 2004 | Immunity2004，，6： | 2 |
| 13 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 14 | 由日本专利应用看热喷涂技术在钢铁业中的发展趋势显示文摘从日本专利局20年(FY1990~FY2009)来申请的专利情况,可以看出日本钢铁领域热喷涂技术的发展趋势。以C23C4/00为分类号进行国际专利检索(IPC检索关键词:喷涂熔融态涂层材料),对8家专利局(日本,美国,欧洲,中国,韩国,俄罗斯,巴西和印度)共15,082篇专利进行检索,各局提交的专利申请比例如下:日本(39%)、美国(22%)、欧洲(17%)、中国(9%)、韩国(6%)、俄罗斯(3%)、巴西(3%)和印度(1%),本文中所引用的数据来自商业数据库。日本关于热喷涂技术申请的专利数量4,369篇(C23C4/00)。根据日本主要钢铁公司提供的数据,钢铁行业的专利比例占所有工业领域的13%。这些专利分为以下几类:(1)涂层在钢铁生产线中的应用;(2)涂层能达到的性能和作用;(3)涂层材料。本文讨论了热喷涂技术在日本钢铁业的现状和未来的发展趋势。 | Y.Namba K.Tani Akashi/J 王梦雨(译) 崔颖(校) | 2012 | 热喷涂技术2012，4，2： | 2 |
| 15 | WRF Environment Assessment in Guangzhou City with an Extracted Land-use Map from the Remote Sensing Data in 2000 as an Example显示文摘Mesoscale urban environment forecast combined with WRF is a current frontier in international academic. Taking Guangzhou as an example,the new land-use model presented by the present authors,the existing USGS and MODIS models in WRF were firstly compared to the remote sensing model in this article.The comparison result shows that the land-use model presented by the authors has the highest similarity with the remote sensing data. Secondly,the new land-use model was used to replace the defaulted land-use data in WRF for simulation. By comparing this simulation results with the WRF results using the defaulted USGS and MODIS model,it was showed that the geographic models have a great impact on the mesoscale environment forecast result. Also,the geographic information model presented in this article shows the best accuracy when comparing with the observation data. Results in this study are going to be an important reference in the contemporary international forefront of mesoscale urban environment studies by WRF. | Yuan Li Ye-Hao Song Akashi Mochida Tsubasa Okaze | 2014 | Journal of Harbin Institute of Technology(New Series)2014，21，5： | 2 |
| 16 | Obstruction of st jude medical valves in the aortic position: histology and immunohistochemistry of pannus显示文摘 | Hideki Teshima Nobuhiko Hayashida Hirohisa Yano Masaru Nishimi Eiki Tayama Shuji Fukunaga Hidetoshi Akashi Takemi Kawara Shigeaki Aoyagi | 2003 | The Journal of Thoracic and Cardiovascular Surgery2003，，2： | 2 |
| 17 | Long-term outcomes after a variety of video-assisted thoracoscopic lobectomy approaches for clinical stage IA lung cancer: A multi-institutional study显示文摘 | Norihisa Shigemura Akinori Akashi Soichiro Funaki Tomoyuki Nakagiri Masayoshi Inoue Noriyoshi Sawabata Hiroyuki Shiono Masato Minami Yukiyasu Takeuchi Meinoshin Okumura Yoshiki Sawa | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，3： | 2 |
| 18 | Effect of endog enous and exogenous nitric oxide on endothelin-I produc tion in cultured vascular endothelial cell显示文摘 | Mitsutomi N Akashi C Odigiri J | 1999 | Eur J Pharmacol1999，364，1： | 1 |
| 19 | Preparation of BaTi2O5 single crystal by a floating zone method显示文摘 | Akashi T Iwata H Goto T | 2003 | Mater Trans2003，44，： | 1 |
| 20 | Prospective isolation of human clonogenic common myeloid progenitors 显示文摘 | Manz MG Miyamoto T Akashi K | 2002 | Proc Nad Acad Sci USA2002，99，11： | 1 |
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