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| 1 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 2 | ROS signaling: the new wave?显示文摘 | Ron Mittler Sandy Vanderauwera Nobuhiro Suzuki Gad Miller Vanesa B. Tognetti Klaas Vandepoele Marty Gollery Vladimir Shulaev Frank Van Breusegem | 2011 | Trends in Plant Science2011，，6： | 3 |
| 3 | Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol显示文摘 | Anke M. J. Kuijpers Boj Mirck Arend G. J. Aalbers Simon W. Nienhuijs Ignace H. J. T. Hingh Martinus J. Wiezer Bert Ramshorst Robert J. Ginkel Klaas Havenga Andreas J. Bremers Johannes H. W. Wilt Elisabeth A. Velde Vic J. Verwaal | 2013 | Annals of Surgical Oncology2013，，13： | 2 |
| 4 | Ultra-high performance liquid chromatography–tandem mass spectrometry in high-throughput confirmation and quantification of 34 anabolic steroids in bovine muscle显示文摘 | Lynn Vanhaecke Julie Vanden Bussche Klaas Wille Karen Bekaert Hubert F. De Brabander | 2010 | Analytica Chimica Acta2010，，1： | 2 |
| 5 | Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death显示文摘 | Sandra Dunning Atta ur Rehman Marjolein H. Tiebosch Rebekka A. Hannivoort Floris W. Haijer Jannes Woudenberg Fiona A.J. van den Heuvel Manon Buist-Homan Klaas Nico Faber Han Moshage | 2013 | BBA - Molecular Basis of Disease2013，，： | 2 |
| 6 | Partial,matrix excision or segmental phenolization for ingrowing toenails显示文摘 | GERRITSMA BLEEKER C L KLAASE J M GEELKERKEN R H | | 0，，03： | 1 |
| 7 | Automatic generation of octree-based three-dimensional discretizations for Partition of Unity methods显示文摘 | O. Klaas M. S. Shephard | 2000 | Computational Mechanics (-)2000，，2： | 1 |
| 8 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 9 | Partial matrix excision or segmental phenolization for ingrowing toenails显示文摘 | Gerritsma-Bleeker CL Klaase JM Geelkerken RH | 2002 | Arch Surg2002，137，3： | 1 |
| 10 | Abdominoperineal Resection via Total Mesorectal Excision and Autonomic Nerve Preservation for Low Rectal Cancer显示文摘 | Warren E. Enker Klaas Havenga Tatyana Polyak Howard Thaler Millicent Cranor | 1997 | World Journal of Surgery1997，，7： | 1 |
| 11 | Assessment of Median Nerve with MR Neurography by Using Diffusion-Tensor Imaging: Normative and Pathologic Diffusion Values显示文摘 | Roman Guggenberger Daniel Markovic Patrick Eppenberger Avneesh Chhabra Andreas Schiller Daniel Nanz Klaas Prüssmann Gustav Andreisek | 2012 | Radiology2012，，1： | 1 |
| 12 | Systematic clinical examinations for identification of latent udder health types in Danish dairy herds显示文摘 | Klaas I C Enevoldsen C Vaarst M | | 0，，05： | 1 |
| 13 | Comparison between the use of whole blood versus a diluted perfusate in regional isolated perfusion by continuous monitoring of transcutaneous oxygen tension:a pilot study 显示文摘 | Klaase JM Kroon BB van Slooten GW | 1994 | J Invest Surg1994，7，： | 1 |
| 14 | Size, spillovers and soft budget constraints显示文摘 | Ernesto Crivelli Klaas Staal | 2013 | International Tax and Public Finance2013，，2： | 1 |
| 15 | Crosslinked polymer materials for nonlinear optics I :UV-cured acrylic monomers bearing azobenzene dyes显示文摘 | Booger J A F Klaase P T A de Vlieger J J | 1994 | Macromolecules1994，27，： | 1 |
| 16 | Initial Demonstration of in Vivo Tracing of Axonal Projections in the Macaque Brain and Comparison with the Human Brain Using Diffusion Tensor Imaging and Fast Marching Tractography显示文摘 | Geoffrey J.M. Parker Klaas E. Stephan Gareth J. Barker James B. Rowe David G. MacManus Claudia A.M. Wheeler-Kingshott Olga Ciccarelli Richard E. Passingham Rachel L. Spinks Roger N. Lemon Robert Turner | 2002 | Neuroimage2002，，4： | 1 |
| 17 | Troponin I troponin T CKMB- activity and CKMB- mass as markers for the detection of myocardial contusion in patients who experienced blunt trauma显示文摘 | I SWAANENBURG JC KLAASE JM DEJONGSTE MJ | 1998 | Clin Chim Acta1998，272，9： | 1 |
| 18 | An analysis of alignment and integral based kernels for machine learning from vessel trajectories显示文摘 | Gerben Klaas Dirk de Vries Maarten van Someren | 2014 | Expert Systems With Applications2014，，： | 1 |
| 19 | Heterotop icgastric mucosa of the cervical esophagus:a case of high-grade dysplasia treated with argon plasma coagulation and a case of adenocarcinoma显示文摘 | Klaase JM LemaireLC RauwsEA | 2001 | Gastrointest Endosco2001，53，4： | 1 |
| 20 | Comparison between the use of whole blood versus a diluted perfusion in regional isolated perfusion by continuous monitoring of transeutaneous oxygen tension: a pilot study 显示文摘 | KLAASE J M KROON B B VAN SLOOTEN G W | 1994 | J Jnvest Surg1994，7，3： | 1 |
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