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| 1 | 中国:推进高效、包容可持续的城镇化显示文摘中国城镇化有力支持了经济的高速增长和快速转型,成功避免了大规模的城市贫困、失业和贫民窟,但压力也开始显现。中国领导人高度关注这些挑战,倡导新型城镇化的道路模式,以适应新的发展目标。新型城镇化模式需要政府重新定位,实现更高质量的增长。本报告提出构建新型城镇化模式的六大优先领域:一是改革土地管理制度;二是改革户籍制度,实现基本公共服务均等化,促进具备技能的劳动者自由流动;三是将城市融资建立在更可持续的基础之上,同时建立有效约束地方政府的财政纪律;四是改革城市规划和设计;五是应对环境压力;六是改善地方政府治理。本报告提出的政策议程是全面的,需要确定优先序。最为迫切的问题是土地方面的议程;其次,政府需要关注各种形式的地方政府性债务;最后,在全面铺开以市场为基础的城乡土地转化之前,需要开展更多试点。其他改革也应尽快提出落实改革议程的全面规划并建立监测督促机制。 | 国务院发展研究中心和世界银行联合课题组 李伟 Sri Mulyani Indrawati 刘世锦 韩俊 Klaus Rohland Bert Hofman 侯永志 Mara Warwick Chorching Goh 何宇鹏 刘培林 卓贤 | 2014 | 管理世界2014，30，4： | 166 |
| 2 | 文化生态理念下的历史街区保护与更新研究--以武汉市青岛路历史街区为例显示文摘在全球化及在全球可持续发展理念及'人本主义'思想影响下,如何在保护历史街区的前提下延续城市文脉、提升区域的活力、创造与时代背景相融合的新文化,仍然是当前历史街区保护与更新需要重点研究的课题。武汉市青岛路历史街区保护与更新规划基于文化生态理念,从物质文化形态层面、文化与社会经济层面及文化价值与社会民生层面提出规划重点。 | 黄焕 Bert Smolders Jos Verweij | 2010 | 规划师2010，26，5： | 34 |
| 3 | Targeted therapy for advanced gastric cancer: A review of current status and future prospects显示文摘In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC. | Ozkan Kanat Bert O'Neil Safi Shahda | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 4 | 中国:推进高效、包容、可持续的新型城镇化显示文摘如何开拓新型城镇化之路,是中国当前和今后面临的新挑战。为此,国务院发展研究中心和世界银行围绕这一主题联合开展了一项大型研究。这项有100余位专家学者参与的研究从2012年初冬开始,到2014年初春竣工,历时一年多,研究成果包括题为《中国:推进高效、包容、可持续的城镇化》的总报告和与之相关的七个专题报告,共50余万字。该项研究全面系统地阐述和分析了中国城镇化取得的成就和面临的挑战,对城镇化进程中迫切需要实施的改革提出了具有可操作性的政策建议,建言中国要推进高效、包容、可持续的城镇化,同时描述了改革情境下2030年的中国城镇化格局。今年3月25日,以该项研究报告为主题的国际研讨会在北京召开,与会者对报告给予了高度评价。研讨会后,课题组还将根据与会部门和专家的意见进一步完善报告。4月11日,亦即世行春季年会在华盛顿召开期间,将举办这项研究成果的正式发布会。兹将该总报告摘要刊出,以飨读者。 | 国务院发展研究中心和世界银行联合课题组 李伟 Sri Mulyani Indrawat 刘世锦 韩俊 Klaus Rohland Bert Hofman | 2014 | 中国经济报告2014，0，4： | 13 |
| 5 | Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor显示文摘SRC-3/AIB1 (在乳癌 1 的类固醇受体激活剂 3/amplified ) 是在癌症病人贡献药抵抗和差的没有疾病的幸存的发展的真 oncogene。Autophagy 也是让肿瘤 suppressor 工作的重要房间死亡机制。在这研究,我们识别了巨噬细胞移植禁止的因素(MIF ) 作为 SRC-3 的新奇目标基因并且在房间幸存表明了它的重要性。明确地,我们证明 MIF 是 autophagic 房间死亡的强壮的 suppressor。我们进一步证明接着, MIF 的抑制导致了 autophagic 房间死亡,提高了 chemosensitivity 并且禁止了在一个异种皮移植老鼠 tumorigenesis 模型的 tumorigenesis。我们的学习证明 MIF 表示的那条规定和 autophagic 房间死亡的抑制是 SRC-3 由贡献增加的 chemoresistance 和 tumorigenicity 的有势力机制。 | Mei-Yi Wu Junjiang Fu Jianming Xu Bert W O'MaUey Ray-Chang Wu | 2012 | Cell Research2012，22，6： | 12 |
| 6 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 7 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 8 | 开放式创新网络形成及演化的探索性案例研究显示文摘企业如何在战略阶段演进中构建与战略网络与商业生态系统相互融合与共同演化的开放式创新网络,已成为开放式创新能否取得成效的关键。本文揭示了开放式创新网络与战略网络、商业生态系统的关联性及内在逻辑,运用探索性案例研究方法,以'每20分钟产生一项专利'的荷兰埃因霍芬高科技园区为研究对象,将园区开放式创新网络形成及演化3阶段的开放式创新网络概括为'1+0'、'1+N'、'N+N'3种形式,得出开放式创新网络的形成及演化取决于战略网络的类型和动态变化趋势以及商业生态系统中核心物种的生态位进化。 | 彭华涛 Bert Sadowski | 2014 | 科研管理2014，35，8： | 10 |
| 9 | 自行车通勤方式文献综述显示文摘无论对通勤者个人还是整个社会,自行车通勤方式要优于其他出行方式。尽管如此,很大一部分通勤者还是放弃了自行车方式。为巩固自行车通勤激励政策的理论基础,研究了影响人们选择自行车通勤方式的决定因素;由于许多自行车通勤者并不是每天都骑车上下班,所以也考虑了其日常出行方式选择情况,以使用频率表示。为明确上述决定因素对自行车通勤的影响,对现有文献进行了广泛研究,发现现有文献对许多决定因素的阐述,并未遵循出行方式选择的传统研究方法及模型,这表明对自行车使用的影响与预测还应以其他知识为基础,而不仅仅是现有的机动车交通模型。 | Eva Heinen Bert van Wee Kees Maat 高海欣 马祥禄 | 2011 | 城市交通2011，9，2： | 8 |
| 10 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 11 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 12 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 13 | 超高效液相色谱/电喷雾串联质谱(UPLC/MS/MS)分析全氟代化合物(PFCs)显示文摘 | Antonietta Gledhill Anna Karman Ingrid Ericson Bert van Bavel Gunilla Linstrom Gordon Kearney | 2007 | 环境化学2007，26，5： | 6 |
| 14 | OMEGAlap条并卷机技术为精梳准备带来质的飞跃显示文摘条并卷机OMEGAlap E 35——Rieter(立达)全新的精梳准备设备采用创新的Ω形状成卷技术,此工艺可生产更均匀的棉卷品质,产量可提高50%。 | Bert Rusch Anja Knick | 2007 | 纺织导报2007，，3： | 5 |
| 15 | Influence of Sludge Incineration Ash on Ryegrass Growth and Soil Phosphorus Status显示文摘Phosphorus(P) is a limited resource that could be depleted. Consequently, recycling the P contained in sewage sludge, including sewage sludge incineration ash(SIA), from wastewater treatment plants is a possibility to be explored. A greenhouse experiment using annual ryegrass(Lolium multiflorum L.) was performed with an experimental design of three completely randomized blocks of two soils and 29 treatments: one control without P and two levels of 9 and 26 kg total P ha^(-1) from 14 different sources: twelve SIAs(not contaminated by trace metals) from the US and Canada, one commercial synthetic fertilizer(triple superphosphate(TSP)), and one commercial rock phosphate(RP). Higher ryegrass biomass levels were achieved at the higher fertilization rate(26 kg total P ha^(-1))and when using the SIAs with the highest P solubility percentage(PSP)(≥ 54% of total P). The biomass increases following SIA application were as high as 29% and 59% more than the control for the sandy loam and clayey soil, respectively, but 40% less than in TSP for both soils. A similar behavior was observed for P uptake, with a maximum increase of 26% for the clayey soil, and 165% for the sandy loam soil. The ryegrass biomass and P uptake increases due to SIA application were larger than those due to RP application in the clayey soil, but similar to those in the sandy loam soil. The SIAs with a PSP of ≥ 54% significantly increased soil available P stocks and saturation. According to our findings, we conclude that the SIAs from municipal and agrifood industries have a potential for P agricultural recycling, but their efficiencies vary. | Claude-Alla JOSEPH Lotfi KHIARI Jacques GALLICHAND Marc HBERT Ned BEECHER | 2019 | Pedosphere2019，29，1： | 4 |
| 16 | The Need of Industry to Go FAIR显示文摘The industry sector is a very large producer and consumer of data,and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services.As many of the data sources needed are distributed and outside the company,FAIR data will have a major impact,both by reducing the existing internal data silos and by enabling the efficient integration with external(public and commercial)data.Many companies are still in the early phases of internal data”FAIRification”,providing opportunities for SMEs and academics to apply and develop their expertise on FAIR data in collaborations and public-private partnerships.For a global Internet of FAIR Data&Services to thrive,also involving industry,professional tools and services are essential.FAIR metrics and certifications on individuals,data,organizations,and software,must ensure that data producers and consumers have independent quality metrics on their data.In this opinion article we reflect on some industry specific challenges of FAIR implementation to be dealt with when choices are made regarding”Industry GOing FAIR”. | Herman van Vlijmen Albert Mons Arne Waalkens Wouter Franke Arie Baak Gerbrand Ruiter Christine Kirkpatrick Luiz Olavo Bonino da Silva Santos Bert Meerman Renger Jellema Derk Arts Martijn Kersloot Sebastiaan Knijnenburg Scott Lusher Rudi Verbeeck Jean-Marc Neefs | 2020 | Data Intelligence2020，2，1： | 4 |
| 17 | The presence of a cytopathologist increases the diagnostic accuracy of endoscopic ultrasound‐guided fine needle aspiration cytology for pancreatic adenocarcinoma: a meta‐analysis显示文摘 | S. Hébert‐Magee S. Bae S. Varadarajulu J. Ramesh A. R. Frost M. A. Eloubeidi I. A. Eltoum | 2013 | Cytopathology2013，，3： | 4 |
| 18 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 19 | Urban Physics: Effect of the micro-climate on comfort, health and energy demand显示文摘 | Peter Moonen Thijs Defraeye Viktor Dorer Bert Blocken Jan Carmeliet | 2012 | Frontiers of Architectural Research2012，1，3： | 4 |
| 20 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
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