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| 1 | 药物涂层球囊治疗急性冠脉综合征的系统评价显示文摘目的:系统评价急性冠脉综合征患者应用药物涂层球囊的疗效和安全性。方法:计算机检索Pubmed、Cochrane图书馆、EMbase、中国知网、万方数据库和中国生物医学数据库,由2名研究员独立按照纳入排除标准进行文献筛选和资料提取。结果:纳入DEB-AMI、Besic KM等、PEBSI共3项随机对照研究,其药物涂层球囊联合裸金属支架治疗的靶病变血运重建率分别为23.9%、19.5%、1.8%,主要不良心脏事件率分别为23.9%、24.4%、3.6%。此外纳入PAPPA、Ho HH等、Mahmood Zuhdi AS等、Nanolute共4篇队列研究,单纯药物涂层球囊治疗的靶病变血运重建率分别为3%、0、1.2%、5.2%。结论:药物涂层球囊可作为急性冠脉综合征的有效治疗方案,但其最佳治疗方案尚需更多大样本随机研究数据支持。 | 庞思 陈忠 朱孔博 何砚如 Gondo Esther Kema Hawa 章晓国 童嘉毅 马根山 陈立娟 | 2018 | 东南大学学报(医学版)2018，37，1： | 3 |
| 2 | A Rapid and Simple Approach to Preparation of Monoclonal Antibody Based on DNA Immunization显示文摘Inoculation with purified specific protein is usually the first step for preparation of monoclonal antibody (mAb).But it is quite difficult to obtain pure proteins especially with natural structures. Here we attempt to replace the protein inoculation with DNA immunization in the preparation of mAb. The eukaryotic expression vectors pcDNA3-PreS2/S and pVAX-PreS2/S encoding the HBV M protein were constructed and prepared for DNA immunization. Female BALB/c mice developed a well antibody response to the target antigen after muscle injection with corresponding plasmids. The mice with effective antibodies induced were used for preparation of mAb. We found the mice immunized with three administrations of pcDNA3-PreS2/S and boosted by intrasplenic injection with the same plasmid could be exploited for preparation of mAb. And positive hybridoma cell 2D3 that can secrete specific mAb was cloned and analyzed. Our studies demonstrate that gene immunization may provide a convenient and efficient way to prepare mAbs. | YiNi KeMa JingNi XiujuanZheng YingWang SidongXiong | 2004 | Cellular & Molecular Immunology2004，1，4： | 3 |
| 3 | Obstructive sleep apnea therapy显示文摘 | H~kema A Stegenga B Wijkstra PJ | 2008 | J Dent Res2008，87，9： | 1 |
| 4 | Intraspecific com- parison and annotation of two complete mitochondrial genome sequences from the plant pathogenic fungus MycosphaereUa graminicola 显示文摘 | TORRIANI S F F GOODWIN S B KEMA G H J | | Fungal genetics and biology0，45，5： | 1 |
| 5 | Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma显示文摘 | DE JONG R A KEMA I P BOERMA A | 2012 | Gynecolc Oncol2012，126，3： | 1 |
| 6 | Characterization of the durable resistance to yellow rust in old winter wheat culti vars in the Netherlands显示文摘 | Dijk P Parlevliet J E Kema G H J | 1988 | Euphytica1988，38，2： | 1 |
| 7 | Clinical chemistry of semtonin and metabolites显示文摘 | Kema IP De Vries EGE Muskiet FAJ | 2000 | J Chromatogr B2000，747，： | 1 |
| 8 | Clinical chemistry of serotonin metabolites显示文摘 | Kema I P De Vries E G E Muskiet F A J | 2000 | J Chrom B2000，747，： | 1 |
| 9 | Clinical chemistry of serotonin and metabolites 显示文摘 | Kema IP Vries EG Muskiet FA | 2000 | J Chromatogr B Biomed Sci Appl2000，，： | 1 |
| 10 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 11 | psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients a critical review of the literature显示文摘 | de Jonge P Rosmalen JG Kema IP | 2010 | Neurosci Biobehav Rev2010，35，1： | 1 |
| 12 | Platelet serotonin levels in pervasive developmental disorders and mental retardation:diagnostic group differences,withingroup distribution,and behavioral correlates显示文摘 | MULDER EJ ANDERSON GM KEMA IP | 2004 | J Am Acad Child Adolesc Psychiatry2004，43，： | 1 |
| 13 | Pressure estimation in vacuum circuit breakers显示文摘 | Damstra G C Kema N V | 1995 | IEEE ''Transactions on Dielectrics and Electrical Insulation1995，2，2： | 1 |
| 14 | Clinical chemistry of serotonin and metabolites显示文摘 | Kema IP de Vries EG Muskiet FA | 2000 | J Chromatogr B Biomed Sci Appl2000，747，12： | 1 |
| 15 | Psychophy-siological biomarkers explaining the association between depression and prognosis in coronary artery patients:a critical review of the literature显示文摘 | Jonge P Rosmalen JGM Kema IP | 2010 | Neurosci Biobehav Rev2010，35，1： | 1 |
| 16 | Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results显示文摘 | Koopmans KP Neels ON Kema IP | 2009 | Crit Rev Oncol Hematol2009，71，3： | 1 |
| 17 | Tryptophan as a Link between Psychopathology and Somatic States 显示文摘 | Russo S Kema IP Fokkema MR | 2003 | Psychosom Med2003，65，4： | 1 |
| 18 | Prognostic role of in- doleamine 2,3-dioxygenase in endometrial carcinoma显示文摘 | de Jong RA Kema IP Boerma A | 2012 | Gynecol Oncol2012，126，3： | 1 |
| 19 | Tryptophan as a link between psychopathology and somatic states显示文摘 | Russo S Kema IP Fokkema MR | 2003 | Psychosomatic Medicine2003，65，4： | 1 |
| 20 | Catechol-omethyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response 显示文摘 | Jabbi M Kema I P van der Pompe G | 2007 | Psychiatr Genet2007，17，3： | 1 |
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