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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology显示文摘 | J. Arends G. Bodoky F. Bozzetti K. Fearon M. Muscaritoli G. Selga M.A.E. van Bokhorst-de van der Schueren M. von Meyenfeldt G. Zürcher R. Fietkau E. Aulbert B. Frick M. Holm M. Kneba H.J. Mestrom A. Zander | 2006 | Clinical Nutrition2006，，2： | 6 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | ESPEN Guidelines on Parenteral Nutrition: Non-surgical oncology显示文摘 | F. Bozzetti J. Arends K. Lundholm A. Micklewright G. Zurcher M. Muscaritoli | 2009 | Clinical Nutrition2009，，4： | 3 |
| 5 | Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol显示文摘 | Anke M. J. Kuijpers Boj Mirck Arend G. J. Aalbers Simon W. Nienhuijs Ignace H. J. T. Hingh Martinus J. Wiezer Bert Ramshorst Robert J. Ginkel Klaas Havenga Andreas J. Bremers Johannes H. W. Wilt Elisabeth A. Velde Vic J. Verwaal | 2013 | Annals of Surgical Oncology2013，，13： | 2 |
| 6 | AC loss and contact resistance in highly flexible rebco cable for fusion applications显示文摘High Temperature Superconductor(HTS)materials can operate at higher magnetic fields up to 20 T with high critical current and higher operating temperature,compared to low temperature superconductors(LTS).A Highly Flexible REBCO Cable(HFRC)is introduced at the Institute of Plasma Physics,Chinese Academy of Sciences(ASIPP);a cabling method that is suitable for REBCO HTS tape having anisotropic material properties in its thin REBCO layer.This type of HTS superconducting cable shows high potential for applications in nuclear fusion.The alternating currents and magnetic fields in tokamak type of fusion magnets,cause AC power losses in such cables,which can provoke instability of the conductor by induced currents and increase the temperature.As a first step in characterizing the electromagnetic(EM)performance of an HFRC cable,the AC loss and contact resistance of the HFRC prototype cable were measured at the University of Twente.The measurements were done in liquid helium(4.2 K)with AC magnetic fields,applied perpendicular to the cable's long axis.The AC loss was measured simultaneously by a calibrated gas flow calorimeter utilizing the helium boil-off method,and by the magnetization method using pick-up coils.For the applied test conditions,no coupling loss could be distinguished as a part of the overall AC loss.It is suggested that this might be explained by the shielding of the conductor interior from the applied magnetic field by the outer tape layer due to the high critical current density of the REBCO tape,leading to a high penetration field. | Zichuan Guo Jinggang Qin R.Lubkemann Keyang Wang Huan Jin Guanyu Xiao Jiangang Li Chao Zhou Arend Nijhuis | 2022 | Superconductivity2022，，2： | 2 |
| 7 | Impact of age on transcatheter aortic valve implantation outcomes:a comparison of patients aged≤ 80 years versus patients > 80 years显示文摘 | Frank van der Kley Philippe J van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen Jeroen J Bax Martin J Schalij Victoria Delgado | 2016 | Journal of Geriatric Cardiology2016，13，1： | 2 |
| 8 | Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection显示文摘 | Matthew J. Everly Jason J. Everly Brian Susskind Paul Brailey Lois J. Arend Rita R. Alloway Prabir Roy-Chaudhury Amit Govil Gautham Mogilishetty Adele H. Rike Michael Cardi George Wadih Amit Tevar E Steve Woodle | 2008 | Transplantation2008，，12： | 2 |
| 9 | Capillary density and retinal diameter measurements and their impact on altered retinal circulation in glaucoma:a digital fluorescein angiographic study显示文摘 | Arend O Remky A Plange N | 2002 | Br J Ophthalmol2002，86，4： | 2 |
| 10 | Human papillomavirus type 18 is associated with less apoptosis in fibro blast tumours than human papillornavirus type 16显示文摘 | Arends MJ Wyllie AH Bird CC | 2005 | Br J cancer2005，72，3： | 1 |
| 11 | Pseudophosphorylation of tau p rotein alters its ability for self-aggregation显示文摘 | Haase C Stieler J Arend TT | 2004 | J Neurochem2004，88，： | 1 |
| 12 | Comparison of two interferon-γassays and tuberculin skin test for tracing tuberculosis contacts显示文摘 | Arend SM Thijsen SFT Leyten EMS | 2007 | Am J Respir Crit Care Med2007，175，： | 1 |
| 13 | Apoptosis:mechanisms and roles in patholog显示文摘 | Arends M Wyllie JAJ | 1991 | Int Rev Exp Pathol1991，32，： | 1 |
| 14 | Characterization of proteolysis during the ripening of semi-dry fermented sausages显示文摘 | Hughes MC Kerry JP Arend EK | 2002 | Meat Science2002，，62： | 1 |
| 15 | Metronomic antiangiogenic therapy with capecitabine and celecoxib in advanced tumor patients-results of a phase Ⅱ study显示文摘 | Steinbild S Arends J Medinger M | 2007 | Onkologie2007，30，12： | 1 |
| 16 | Baseline predictors of response to TNF-a blocking therapy in ankylosing spondylitis显示文摘 | Arends S | 2012 | Curt Opin Rheumatol2012，24，3： | 1 |
| 17 | Impact of problem- based,active learning on graduation rates for 10 generations of Dutch medical students显示文摘 | Schmidt HG Cohen-Schotanus J Arends LR | 2009 | Med Educat2009，43，2： | 1 |
| 18 | Cytokeratin 17 andP63 are markers of the HPV target cell,t he cervical stemcell显示文摘 | Martens JE Arends J Linden P | | 0，，02： | 1 |
| 19 | A phase II study ofraltitrexed and gemcitabine in patients with advanced pancreatic carcinoma显示文摘 | Arends J J Sleeboom HP Leys MB | 2005 | Br J Cancer2005，92，3： | 1 |
| 20 | Bivariate ran- dom effects meta-analysis of ROC curves显示文摘 | Arends LR Hamza TH van Houwelingen JC | 2008 | Medical Decision Making2008，28，5： | 1 |
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