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| 1 | 纳米定位测量机操作测量结果(英文)显示文摘伊尔梅瑙工业大学过程测量和传感技术研究所研制了三维纳米定位和测量机 (NPMM ) .阿贝无偏设计使得该机器异常精确 .在整个 2 5mm× 2 5mm× 5mm的定位和测量域内 ,干涉测长系统分辨力可达 0 .1nm ,不确定度达 5~ 10nm .提供了纳米定位测量机的基本信息 ,介绍其操作模式 。 | JAGER Gerd GRUNWALD Rainer MANSKE Eberhard HAUSOTTE Tino FUβL Roland | 2004 | 纳米技术与精密工程2004，2，2： | 14 |
| 2 | 炎症和老化在年龄相关性黄斑变性和葡萄膜黑色素瘤中的作用显示文摘许多眼科疾病在中老年人群中的患病率高于其他年龄组,随着全球老龄化社会的到来,眼科医师面临着年龄相关性眼病疾病谱迅速扩大的挑战,加强年龄相关性眼病的预防对于中老年人的健康有着重要意义。因此,了解年龄相关性黄斑变性(AMD)、青光眼和葡萄膜黑色素瘤易在老年人中发病的原因至关重要。我们先前的动物实验研究表明,正常的老化过程伴随着炎症反应,这种反应增加了眼部疾病发病的风险,而加重炎症反应的环境因素是吸烟。目前已发现炎症参与AMD的发病和进展,并且可能在青光眼、葡萄膜黑色素瘤的病理过程中发挥作用,巨噬细胞和淋巴细胞增加了肿瘤转移的风险。一些实验研究也表明,巨噬细胞在脉络膜/视网膜炎症、眼内肿瘤等疾病中发挥关键作用。巨噬细胞分为M1型和M2型,前者刺激特异性免疫反应,后者可刺激血管的生成。在机体老化过程中,M1型的功能可以向M2型转化,从而可能促进AMD和肿瘤的进展。深入研究巨噬细胞的特性有助于老化过程的干预和年龄相关性眼病的预防。 | Martine J. Jager L. Ho L. V. Ly | 2013 | 中华实验眼科杂志2013，31，1： | 5 |
| 3 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 4 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 5 | CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes显示文摘AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models.METHODS:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced apoptosis.Liver injury was assessed by measurement of serum transaminases and histological analysis.Apoptosis induction was quantified by cleaved PARP staining and Western blotting of activated caspases.Nuclear factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were assessed.Primary Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand Jo2.Cell viability was analyzed by MTT-assay.RESULTS:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB signaling.In both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis sensitivity.After D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT mice.In addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,respectively.Inhibition of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell death.CONCLUSION:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling. | Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 6 | Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis显示文摘BackgroundTranscatheter 大动脉的阀门培植(TAVI ) 与严重征兆的大动脉的狭窄为病人成为了标准治疗(作为) 为外科的大动脉的阀门代替在很高的风险考虑了。这亚学习的目的是评估长期的(> 4 年) 在 octogenarians 的生活(QoL ) 的健康相关的质量经历了 TAVI.MethodsA 单个中心在在 TAVI 以后经历了框架分析评价 4 年的二十个病人的观察登记。健康相关的 QoL 被评估,用短 Form-36 ( SF-36 ),吗 EuroQoL-5D ( EQ-5D )和 questionnaires.ResultsThe 平均数 SF-36 subscale 在后续获得的视觉类似物分数(EQ管)是物理的工作 40.8 ????????????????????????????搠?潮潶???吗?湡楧灯慬瑳?????????愠杮潩牧灡票?€ 敦潭潲潰汰瑩慥???????????????愠桴牥'啼蠹溃浚? | Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J Lenzen Peter PT de Jaegere | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 7 | Solvent Microextraction of Chlorinated Pesticides显示文摘 | Jager L S de Andrews A R J | 1999 | Chromatographia1999，50，： | 2 |
| 8 | Development of a Rapid Screening Technique for Organochlorine Pesticides Using Solvent Microextraction And fast Gas Chromatography显示文摘 | Jager L S de Andrews A R J | 2000 | Analyst2000，125，： | 2 |
| 9 | Endoscopic ultrasonography for the evaluation of smooth muscle tumors in the upper gastrointestinal tract: an experience with 42 cases显示文摘 | Tio TL Tytgat GNJ Den Hartog Jager FCA | 1990 | Gastrointest Endosc1990，36，4： | 2 |
| 10 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 11 | Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy显示文摘 | Robert Loos Giovanni Locoro Tania Huber Jan Wollgast Eugen H. Christoph Alfred de Jager Bernd Manfred Gawlik Georg Hanke Gunther Umlauf José-Manuel Zaldívar | 2007 | Chemosphere2007，，2： | 2 |
| 12 | Upper intestinal and biliary tract endoprosthesis显示文摘 | G. N. J. Tytgat J. F. W. M. Bartelsman F. C. A. Hartog Jager K. Huibregtse E. M. H. Mathus-Vliegen | 1986 | Digestive Diseases and Sciences1986，，9： | 2 |
| 13 | Relationships between fruit nutrients and concentration of flavonoids and chlorogenic acid in Elstar apple skin显示文摘 | AWAD M A de JAGER A | 2002 | Sci Hortic2002，92，34： | 1 |
| 14 | Advances in low temperature Fischer-Tropsch synthesis显示文摘 | Jager B Espinoza R L | 1995 | Catal Today1995，，23： | 1 |
| 15 | Blockage of intermediate conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro 显示文摘 | Jager H Dreker T Buck A Giehl K Gress T Grissmer S | 2004 | Mol Pharmacol2004，65，： | 1 |
| 16 | Dynamic turboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate:correlation with histopathologic results显示文摘 | Jager G J Ruijter E T G Van de Kaa C A | 1997 | Radiology1997，203，： | 1 |
| 17 | Challenges to the development of antigenspecific breast cancer vaccines 显示文摘 | Scanlan MJ Jager D | 2001 | Breast Cancer Res2001，3，2： | 1 |
| 18 | Contrast enhancement of the cerebrospinal fluid on MRI in two cases of spirochaetal meningitis显示文摘 | Good CD Jager HR | 2000 | Neuroradiology2000，42，6： | 1 |
| 19 | Comparison of serum S-100protein level following stroke and traumatic brain injury显示文摘 | Elting JW Jager AE Teelken AW | 2000 | J Neurol Sci2000，181，12： | 1 |
| 20 | Efficacy and safety of APSAC in the treatment of acute myocardial infarction显示文摘 | Machraoui A Jager D Barmeyer J | 1992 | Eur Heart J1992，13，6： | 1 |
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