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| 1 | Portal hypertensive colopathy in patients with liver cirrhosis显示文摘AIM: In patients with liver cirrhosis and porlal hypertension, portal hypertensive colopathy is thought to be an important cause of lower gastrointestinal hemorrhage. In this study, we evaluated the prevalence of colonic mucosal changes in patients with liver cirrhosis and its clinical significance. METHODS: We evaluated the colonoscopic findings and liver function of 47 patients with liver cirrhosis over a 6-year period. The main cause of liver cirrhosis was post-viral hepatitis (68%) related to hepatitis B (6%) or C (62%)infection. All patients underwent upper gastrointestinal endoscopy to examine the presence of esophageal varices, cardiac varices, and congestive gastropathy, as well as a full colonoscopy to observe changes in colonic mucosa. Portal hypertensive colopathy was defined endoscopically in patients with vascular ectasia, redness, and blue vein. Vascular ectasia was classified into two types: type 1, solitary vascular ectasia; and type 2, diffuse vascular ectasia.RESULTS: Overall portal hypertensive colopathy was present in 31 patients (66%), including solitary vascular ectasia in 17 patients (36%), diffuse vascular ectasia in 20 patients (42%), redness in 10 patients (21%) and blue vein in 6 patients (12%). As the Child-Pugh class increased in severity, the prevalence of portal hypertensive colopathy rose. Child-Pugh class B and C were significantly associated with portal hypertensive colopathy. Portal hypertensive gastropathy, esophageal varices, ascites and hepatocellular carcinoma were not related to occurrence of portal hypertensive colopathy. Platelet count was significantly associated with portal hypertensive colopathy, but prothrombin time, serum albumin level, total bilirubin level and serum ALT level were not related to occurrence of portal hypertensive colopathy. CONCLUSION: As the Child-Pugh class worsens and platelet count decreases, the prevalence of portal hypertensive colopathy increases in patients with liver cirrhosis. A colonoscopic examination in patients with liver cirrhosis is indicated, especially those with worsening Child-Pugh class and/or decreasing platelet count, to prevent complications such as lower gastrointestinal bleeding. | Keiichi Ito Katsuya Shiraki Takahisa Sakai Hitoshi Yoshimura Takeshi Nakano | 2005 | World Journal of Gastroenterology2005，11，20： | 19 |
| 2 | Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines显示文摘AIM The single nucleotide polymorphism(SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn's disease. Meanwhile, three additional genetic variants of NUDT15 were reported in patients with acute lymphoblastic leukemia. We evaluated the effects of these additional genetic variants of NUDT15 in patients with inflammatory bowel disease(IBD) treated with thiopurines.METHODS Ninety-six Japanese patients with IBD were enrolled. Genotyping for the NUDT15 and TPMT genes was performed using Custom Taq Man SNP genotyping assays or Sanger sequencing. The changes in white blood cell(WBC) count, mean corpuscular volume(MCV), platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT, and ESR were evaluated.RESULTS Genetic variants of exon 1 and exon 3 of NUDT15 were identified in 24 of 96 patients(25.0%). C.52G > A and c.36_37 insG GAGTC in exon 1 were found in three patients each. All three patients with c.36_37 insG GAGTC in exon 1 were heterozygotes of p.Arg139 Cys in exon 3. Eighteen patients had p.Arg139 Cys in exon 3 alone. The WBC count gradually decreased after initiation of thiopurine treatment in the mutated cases(n = 24), and was significantly lower at 6, 8, 10, and 16 wk(P = 0.0271, 0.0037, 0.0051, and 0.0185, respectively). The WBC counts were also evaluated in patients with and without prednisolone treatment. In the patients with prednisolone treatment, the WBC count tended to show a greater decrease in the mutated cases, with significant differences at 8 and 10 wk(P = 0.012 and 0.029, respectively). In the patients without prednisolone treatment, the WBC count was significantly lower at 2, 4, 8, and 14 wk in mutated cases(P = 0.0196, 0.0182, 0.0237 and 0.0241, respectively). MCV increased after starting thiopurine treatment in the mutated cases, and was significantly higher at 10 wk(P = 0.0085). Platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT and ESR did not differ significantly between the wildtype and mutated cases. TPMT mutations were not found in any of the patients.CONCLUSION Mutations in exon 1 of NUDT15 also affect thiopurineinduced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia in more detail, investigation of SNPs in both exon 1 and exon 3 of NUDT15 is needed. | Yuichiro Kojima Yosuke Hirotsu Wataru Omata Makoto Sugimori Shinya Takaoka Hiroshi Ashizawa Keiko Nakagomi Dai Yoshimura Kenji Hosoda Yoji Suzuki Hitoshi Mochizuki Masao Omata | 2018 | World Journal of Gastroenterology2018，24，4： | 3 |
| 3 | Immunotherapy of solid cancer using dendritic cells pulsed with the HLA-A24-restricted peptide of carcinoembryonic antigen显示文摘 | Tsuyoshi Itoh Yuji Ueda Ichiro Kawashima Ikuei Nukaya Hitoshi Fujiwara Nobuaki Fuji Tetsuro Yamashita Tetsunori Yoshimura Kaori Okugawa Tomoko Iwasaki Mitsuko Ideno Kazutoh Takesako Masakazu Mitsuhashi Kunzo Orita Hisakazu Yamagishi | 2002 | Cancer Immunology,Immunotherapy2002，，2： | 2 |
| 4 | Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural he art disease显示文摘 | Masao Takemoto Hitoshi Yoshimura Yurika Ohba | 2005 | Am Coll Cardiol2005，45，： | 1 |
| 5 | Frontal Meningioma Incidentally Detected in the Routine Preoperative Assessment of Tongue Cancer: A Case Report and Literature Review显示文摘 | Kazuo Sano Ryuhei Kitai Hitoshi Yoshimura Seigo Ohba | 2013 | Journal of Oral and Maxillofacial Surgery2013，，12： | 1 |
| 6 | Prognostic Factor Analysis in Pars Plana Vitrectomy for Retinal Detachment Attributable to Macular Hole in High Myopia: A Multicenter Study显示文摘 | Hideo Nakanishi Shoji Kuriyama Isao Saito Morio Okada Mihori Kita Yasuo Kurimoto Hideya Kimura Hitoshi Takagi Nagahisa Yoshimura | 2008 | American Journal of Ophthalmology2008，，2： | 1 |
| 7 | Diagnostic accuracy of the 13 C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study显示文摘 | Seiichi Kato Kyoko Ozawa Mutsuko Konno Hitoshi Tajiri Norikazu Yoshimura Toshiaki Shimizu Takuji Fujisawa Daiki Abukawa Takanori Minoura Kazuie Iinuma | 2002 | The American Journal of Gastroenterology2002，，： | 1 |
| 8 | Entrapment of the inferior horns of the lateral ventricle with enlargement of the bilateral choroid plexus显示文摘 | Ryosuke Ogura Junichi Yoshimura Masakazu Sano Shouichi Kawasaki Kenichi Nishiyama Kouichirou Okamoto Hitoshi Takahashi Yukihiko Fujii Akiyoshi Kakita | 2014 | Neuropathology2014，，2： | 1 |
| 9 | Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease显示文摘 | Masao Takemoto Hitoshi Yoshimura Yurika Ohba Yasuharu Matsumoto Umpei Yamamoto Masahiro Mohri Hideo Yamamoto Hideki Origuchi | 2005 | Journal of the American College of Cardiology2005，，8： | 1 |
| 10 | A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese显示文摘 | Michihiro Yoshimura H. Yasue Masafumi Nakayama Yukio Shimasaki Hitoshi Sumida Seigo Sugiyama Kiyotaka Kugiyama Hisao Ogawa Yoshihiro Ogawa Yoshihiko Saito Yoshihiro Miyamoto Kazuwa Nakao | 1998 | Human Genetics1998，，1： | 1 |
| 11 | Multicenter Study of Short- and Long-Term Outcomes of Laparoscopic Palliative Resection for Incurable, Symptomatic Stage IV Colorectal Cancer in Japan显示文摘 | Tomonori Akagi Masafumi Inomata Seigo Kitano Koya Hida Yoshiharu Sakai Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Masahiko Watanabe | 2013 | Journal of Gastrointestinal Surgery2013，，4： | 1 |
| 12 | A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese显示文摘 | Michihiro Yoshimura H. Yasue Masafumi Nakayama Yukio Shimasaki Hitoshi Sumida Seigo Sugiyama Kiyotaka Kugiyama Hisao Ogawa Yoshihiro Ogawa Yoshihiko Saito Yoshihiro Miyamoto Kazuwa Nakao | 1998 | Human Genetics1998，，1： | 1 |
| 13 | Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss显示文摘 | Nobuaki Ozawa Tetsuo Maruyama Takashi Nagashima Masanori Ono Toru Arase Hitoshi Ishimoto Yasunori Yoshimura | 2008 | Fertility and Sterility2008，，4： | 1 |
| 14 | Open Versus Laparoscopic Resection of Primary Tumor for Incurable Stage IV Colorectal Cancer: A Large Multicenter Consecutive Patients Cohort Study显示文摘 | Koya Hida Suguru Hasegawa Yousuke Kinjo Kenichi Yoshimura Masafumi Inomata Masaaki Ito Yosuke Fukunaga Akiyoshi Kanazawa Hitoshi Idani Yoshiharu Sakai Masahiko Watanabe | 2012 | Annals of Surgery2012，，5： | 1 |
| 15 | Increased plasma levels of B-type natriuretic peptide in patients with unstable angina显示文摘 | Koichi Kikuta Hirofumi Yasue Michihiro Yoshimura Etsuo Morita Hitoshi Sumida Hideji Kato Kiyotaka Kugiyama Hisao Ogawa Ken Okumura Yoshihiro Ogawa Kazuwa Nakao | 1996 | American Heart Journal1996，，1： | 1 |
| 16 | Risk factors for pancreas-related abscess after total gastrectomy显示文摘 | Hitoshi Katai Kimio Yoshimura Takeo Fukagawa Takeshi Sano Mitsuru Sasako | 2005 | Gastric Cancer2005，，3： | 1 |
| 17 | EphrinA1 Inhibits Vascular Endothelial Growth Factor-Induced Intracellular Signaling and Suppresses Retinal Neovascularization and Blood-Retinal Barrier Breakdown显示文摘 | Tomonari Ojima Hitoshi Takagi Kiyoshi Suzuma Hideyasu Oh Izumi Suzuma Hirokazu Ohashi Daisuke Watanabe Eri Suganami Tomoaki Murakami Masafumi Kurimoto Yoshihito Honda Nagahisa Yoshimura | 2006 | The American Journal of Pathology2006，，1： | 1 |
| 18 | Long-Term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy显示文摘 | Miho Shimizu Kengo Furuichi Tadashi Toyama Shinji Kitajima Akinori Hara Kiyoki Kitagawa Yasunori Iwata Norihiko Sakai Toshinari Takamura Mitsuhiro Yoshimura Hitoshi Yokoyama Shuichi Kaneko Takashi Wada | 2013 | Diabetes Care2013，，11： | 1 |
| 19 | The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer显示文摘 | Koichi Suzuki Sumiko Ohnami Chikako Tanabe Hiroki Sasaki Jun Yasuda Hitoshi Katai Kimio Yoshimura Masaaki Terada Manuel Perucho Teruhiko Yoshida | 2003 | Gastroenterology2003，，5： | 1 |
| 20 | Gastric Carcinoid Tumors Without Autoimmune Gastritis in Japan: A Relationship with Helicobacter pylori Infection显示文摘 | Yuichi Sato Mitsuya Iwafuchi Jun-ichi Ueki Akira Yoshimura Tsutomu Mochizuki Hirotaka Motoyama Kazuhito Sugimura Terasu Honma Rintaro Narisawa Takafumi Ichida Hitoshi Asakura David H. Van Thiel | 2002 | Digestive Diseases and Sciences2002，，3： | 1 |
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