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| 1 | BRCA1 affects global DNA methylation through regulation of DNMT1显示文摘在 CpG 岛的全球 DNA hypomethylation 结合了本地 hypermethylation 是为乳癌的一个特点,然而,位于这个变化下面的机制留下逃犯。在这研究,我们证明 DNMT1,编码 methylation 维护酶,是 BRCA1 的一个 transcriptional 目标。BRCA1 通过一个潜在的 OCT1 地点和绑定绑在 DNMT1 基因的倡导者为维持 transcriptional 被要求在老鼠和人的房间的倡导者的活跃配置。我们进一步证明 BRCA1 的那损害功能在在 premaligant 阶段在一个 BRCA1 变异的老鼠模型检验的纸巾的几种类型导致全球 DNA hypomethylation,印的 genomic 的损失,和一种开的染色质配置。BRCA1 缺乏也与几 protooncogenes 的显著地增加的表达式层次被联系,包括 c-Fos,哈地岬,和 c-Myc,与在肿瘤的一个更高的表达式,当时乳房的上皮的房间显示了的 premalignant 在肿瘤和控制之间的一个中间的状态。在人的临床的样品,有 DNMT1 的减少的层次的 BRCA1 相互关联的减少的表示,和 CpG 岛的减少的 methylation。因此, BRCA1 通过断然调整 DNMT1 表示阻止全球 DNA hypomethylation,并且这为联系 BRCA1 的乳癌形成提供机制之一。 | Vivek Shukla Xavier Coumoul Tyler Lahusen Rui-Hong Wang Xiaoling Xu Athanassios Vassilopoulos Cuiying Xiao Mi-Hye Lee Yan-Gao Man Mutsuko Ouchi Toru Ouchi Chu-Xia Deng | 2010 | Cell Research2010，20，11： | 5 |
| 2 | Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse显示文摘背景雌激素受体 alpha (嗯一)是最重要的内分泌的治疗应答预言者因为有对内分泌的治疗的反应的预言的胸 cancer.The 精确性的女人被认为被包含雌激素受体 coregulatory 蛋白质和串音在之间影响嗯并且另外的生长发信号因素的 networks.Nuclear corepressor 1 ( NCOR1 )是学习客观的抄写 repressor.The 是在蛋白质 le 调查 NCOR1 | ZHANG Zhen-huan Hiroko Yamashita Tatsuya Toyama Yutaka Yamamoto Teru Kawasoe Mutsuko lbusuki Saori Tomita Hiroshi Sugiura Shunzo Kobayashi Yoshitaka Fujii Hirotaka Iwase | 2009 | Chinese Medical Journal2009，，15： | 4 |
| 3 | Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction显示文摘 | Mariko Matsumoto Mutsuko Hirata-Koizumi Makoto Ema | 2007 | Regulatory Toxicology and Pharmacology2007，，1： | 2 |
| 4 | Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals显示文摘 | Kenichi Ikejima Hajime Honda Mutsuko Yoshikawa Miyoko Hirose Tsuneo Kitamura Yoshiyuki Takei Nobuhiro Sato | 2001 | Hepatology2001，，2： | 2 |
| 5 | Cu2O as a photocatalyst for overall water spilling under visible-light irradiation显示文摘 | Michikazu Hara Takeshi Kondo Mutsuko Komoda | 1998 | Chem Commun1998，3，： | 1 |
| 6 | Failure in the Detection of Aberrant mRNA from the Heterozygotic Splice Site Mutant Allele for Protein S in a Patient with Protein S Deficiency显示文摘 | Hiroko lida Mutsuko Nakahara Kimihiro Komori | 2001 | Thrombosis Research2001，102，： | 1 |
| 7 | Two-generation reproductive toxicity study of the flame retardant hexabromocyclododecane in rats显示文摘 | Makoto Ema Sakiko Fujii Mutsuko Hirata-Koizumi Mariko Matsumoto | 2007 | Reproductive Toxicology2007，，3： | 1 |
| 8 | Potential adverse effects of phthalic acid esters on human health:A review of recent studies on reproduction显示文摘 | Mariko M Mutsuko HK Makoto E | | 0，，： | 1 |
| 9 | A Novel Splice Acceptor Site Mutation of Protein S Gene in Affected Individuals with Type 1 Protein S Deficiency: Allelic Exclusion of the Mutant Gene显示文摘 | Mutsuko Nakahara Hiroko lida Michiyo Urata | 2001 | Thrombosis Research2001，101，： | 1 |
| 10 | Inhibition of in vitro cell invasion by Ginsenoside Rg3显示文摘 | Kiyoko SK Hitoshi A Mutsuko M | 1996 | Jpn J Cancer Res1996，87，4： | 1 |
| 11 | Bietti Crystalline Corneoretinal Dystrophy Is Caused by Mutations in the Novel Gene CYP4V2显示文摘 | Anren Li Xiaodong Jiao Francis L. Munier Daniel F. Schorderet Wenliang Yao Fumino Iwata Mutsuko Hayakawa Atsushi Kanai Muh Shy Chen Richard Alan Lewis John Heckenlively Richard G. Weleber Elias I. Traboulsi Qingjiong Zhang Xueshan Xiao Muriel Kaiser-Kupfe | 2004 | The American Journal of Human Genetics2004，，5： | 1 |
| 12 | Diagnostic accuracy of the 13 C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study显示文摘 | Seiichi Kato Kyoko Ozawa Mutsuko Konno Hitoshi Tajiri Norikazu Yoshimura Toshiaki Shimizu Takuji Fujisawa Daiki Abukawa Takanori Minoura Kazuie Iinuma | 2002 | The American Journal of Gastroenterology2002，，： | 1 |
| 13 | Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction显示文摘 | MARIKO M MUTSUKO H K MAKOTO E | 2008 | Regulatory Toxicology and Pharmacology2008，50，1： | 1 |
| 14 | Genetic Linkage of Bietti Crystallin Corneoretinal Dystrophy to Chromosome 4q35显示文摘 | Xiaodong Jiao Francis L. Munier Fumino Iwata Mutsuko Hayakawa Atsushi Kanai June Lee Daniel F. Schorderet Muh-Shy Chen Muriel Kaiser-Kupfer J. Fielding Hejtmancik | 2000 | The American Journal of Human Genetics2000，，5： | 1 |
| 15 | Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction显示文摘 | Mariko Matsumoto Mutsuko Hirata-Koizumi Makoto Ema | 2007 | Regulatory Toxicology and Pharmacology2007，，1： | 1 |
| 16 | Postoperative detection of a-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellnlar carcinoma显示文摘 | Mutsuko M Naoshi N | 2001 | Gastroenterol Hepatol2001，16，4： | 1 |
| 17 | Inhibition of epi- dermal growth factor induced RhoA translocation and inva- sion of human pancreatic cancer cells by 3 Hydroxy-3 meth- ylglutaryl-coenzyme a reduetase inhibitors显示文摘 | Toshiyuki K Mutsuko M Teruo I | 2001 | Cancer Res2001，61，12： | 1 |
| 18 | Potential adverse effects of phthalic acid esters on human health: A review of recent studies on reproduction 显示文摘 | Mariko M Mutsuko H K Makoto E | 2008 | Regulatory Toxicolo- gy and Pharmacology2008，50，1： | 1 |
| 19 | Postoperative detec tion of a-fetoprotein mRNA in blood as a predictor for metastas tic recurrence of hepatocellular carcinoma显示文摘 | Mutsuko M Naoshi N Toshiki K | 2001 | J Gastroenterol Hepatol2001，16，4： | 1 |
| 20 | Postoperative detection of a-fetoprotein mRNA in blood as a predictor for metastatic recurrence of hepatocellular carcinoma显示文摘 | Mutsuko M Naoshi N | | 0，，： | 1 |
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