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| 1 | Chemotherapy and molecular targeting therapy for recurrent cervical cancer显示文摘For patients with primary stage IVB, persistent, or recurrent cervical cancer, chemotherapy remains the standard treatment, although it is neither curative nor associated with long-term disease control. In this review, we summarized the history of treatment of recurrent cervical cancer, and the current recommendation for chemotherapy and molecular targeted therapy. Eligible articles were identified by a search of the MEDLINE bibliographical database for the period up to November 30, 2014. The search strategy included the following any or all of the keywords: 'uterine cervical cancer', 'chemotherapy', and 'targeted therapies'. Since cisplatin every 21 days was considered as the historical standard treatment for recurrent cervical cancer, subsequent trials have evaluated and demonstrated activity for other agents including paclitaxel, gemcitabine, topotecan and vinorelbine among others. Accordingly, promising agents were incorporated into phase III trials. To examine the best agent to combine with cisplatin, several landmark phase III clinical trials were conducted by Gynecologic Oncology Group(GOG) and Japan Clinical Oncology Group(JCOG). Through, GOG204 and JCOG0505, paclitaxel/cisplatin(TP) and paclitaxel/carboplatin(TC) are now considered to be the recommended therapies for recurrent cervical cancer patients. However, the prognosis of patients who are already resistant to chemotherapy, are very poor. Therefore new therapeutic strategies are urgently required. Molecular targeted therapy will be the most hopeful candidate of these strategies. From the results of GOG240, bevacizumab combined with TP reached its primary endpoint of improving overall survival(OS). Although, the prognosis for recurrent cervical cancer patients is still poor, the results of GOG240 shed light on the usefulness of molecular target agents to chemotherapy in cancer patients. Recurrent cervical cancer is generally considered incurable and current chemotherapy regiments offer only modest gains in OS, particularly for patients with multiple poor prognostic factors. Therefore, it is crucial to consider not only the survival benefit, but also the minimization of treatment toxicity, and maximization of quality of life(QOL). | Naotake Tsuda Hidemichi Watari Kimio Ushijima | 2016 | Chinese Journal of Cancer Research2016，28，2： | 24 |
| 2 | 多学科与正畸结合治疗重度牙周病及咬合错乱:附1例临床报告显示文摘伴有牙周组织破坏和咬合错乱的患者需要牙周、修复和正畸的结合治疗,对于此种患者正畸矫治是可行的,但同时需要消除炎症以及咬合干扰,为之后适宜的修复体提供良好的牙周环境。对于此种患者的正畸治疗需要稳定的支抗系统、合理的力系使用、稳定的保持以及治疗期间的菌斑控制。本病例报告描述了一位49岁伴有牙周组织破坏严重、多个牙缺失且咬合错乱的女性患者,正畸及牙周治疗后患者的咬合功能及面部美观得到较大改善,治疗中采用了诱导组织再生术、种植体修复以及上颌窦提升术。 | Sachiko Maeda Yoshinobu Maeda Yoshihiro Ono Kimio Nakamura Tokuo 王峰(译) | 2007 | 中国口腔医学继续教育杂志2007，10，4： | 4 |
| 3 | 堰塞坝溃决及防范显示文摘 | Takahisa Mizuyama Shigekiyo Tabata Toshio Mori Fumito Watanabe Kimio Inoue4 宋守度 | 2008 | 水利水电技术2008，39，7： | 3 |
| 4 | Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples显示文摘 | Kimio Yoshimura Tomoyuki Hanaoka Shumpei Ohnami Sumiko Ohnami Takashi Kohno Ying Liu Teruhiko Yoshida Hiromi Sakamoto Shoichiro Tsugane | 2003 | Journal of Human Genetics2003，，12： | 1 |
| 5 | On plurigenera of normal isolated singularities. I显示文摘 | Kimio Watanabe | 1980 | Mathematische Annalen1980，，1： | 1 |
| 6 | Mutation screening of the human Clock gene in circadian rhythm sleep disorders显示文摘 | Toshio Iwase Naofumi Kajimura Makoto Uchiyama Takashi Ebisawa Kimio Yoshimura Yuichi Kamei Kayo Shibui Keiko Kim Yoshinao Kudo Masaaki Katoh Tsuyoshi Watanabe Toru Nakajima Yuji Ozeki Mariko Sugishita Toru Hori Masaaki Ikeda Ryoichi Toyoshima Yuichi Inoue | 2002 | Psychiatry Research2002，，2： | 1 |
| 7 | Mathematical modeling of porosity formationin solidification 显示文摘 | Kimio K Robert D P | 1985 | Metallurgical Transactions1985，16，： | 1 |
| 8 | Progress of eutrophication and change of chironomid fauna in Lake Yamanakako, Japan显示文摘 | Kimio H Kazuya Y Norihiko Y | 2004 | The Japanese Society of Limnology2004，，5： | 1 |
| 9 | An Analysis of a Waveguide T Junction with an Inductive Post显示文摘 | Jiro Kimio Sakurai Makoto Naohisa | 1991 | IEEE transactions on microwave theory and techniques1991，39，3： | 1 |
| 10 | Glycerol conversion in the aqueous solution under hydrogen over Ru/C + an ion-exchange resin and its reaction mechanism显示文摘 | Tomohisa Miyazawa Yohei Kusunoki Kimio Kunimori Keiichi Tomishige | 2006 | Journal of Catalysis2006，，2： | 1 |
| 11 | COMPARISON OF 3 SURGICAL APPROACHES TO LAPAROSCOPIC ADRENALECTOMY: A NONRANDOMIZED, BACKGROUND MATCHED ANALYSIS显示文摘 | KAZUO SUZUKI SHINJI KAGEYAMA YASUHIRO HIRANO TOMOMI USHIYAMA SRINIVAS RAJAMAHANTY KIMIO FUJITA | 2001 | The Journal of Urology2001，，2： | 1 |
| 12 | Allelefrequenciesof singlenucleotide(SNPs)in 40 candidate genesforgene-environment studieson cancer:data from population-basede Japanese random samples显示文摘 | Kimio Y Tomoyuki H Shumpei O et al | 2003 | J Hum Genet2003，48，12： | 1 |
| 13 | Sonographic diagnosis of biliary atresia in pediatric patients using the 'Triangular cord' sign versus gallbladder length and contraction显示文摘 | Kimio KG Yosh AK Eri KM | 2003 | AJR2003，181，5： | 1 |
| 14 | Stable Single-mode Operation of Intracavity-doubled Diode-pumped Nd:YVO4 Lasers Theoretical Study显示文摘 | STEN HELMFRID KIMIO TATSUNO | 1994 | J Opt Soc Am B1994，11，3： | 1 |
| 15 | High prevalence of anxiety and depression in patients with primary open-angle glaucoma显示文摘 | Mabuehi Fumihiko Yoshimura Kimio MD Kashiwagi Kenji | 2008 | Glaucoma2008，17，7： | 1 |
| 16 | Mineral particles collected in China and Japan during the same Asian dust-storm event显示文摘 | Fan Xiao-biao Kikuo Okada Noriko Niimura Kenjikai Kimio Arao Shi Guang-Yu Qin Yuan Yasushi Mitsuta | 1996 | Atmospheric Environment1996，30，2： | 1 |
| 17 | Development of CVT Control System and Its Use for Fuel-effi- cient Operation of Engine显示文摘 | Kazutaka A Yoshimasa O Kimio K | 2006 | Asian Journal of Control2006，，8： | 1 |
| 18 | Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin’s lymphoma in a patient infected with hepatitis C virus显示文摘 | Masahide Yoshikawa Yoshiko Yamane Satoshi Yoneda Shu Iwasawa Kimio Nishimura Hiroshi Kawamoto Hiroshi Nakano Hiroshi Fukui Hirokazu Nakamine | 1998 | Journal of Gastroenterology1998，，6： | 1 |
| 19 | A pseudo-random frequency modulation continuous wave coherent lidar using an optical field correlation detection method 显示文摘 | Kimio Asaka Yoshihito Hirana | 1998 | Optical Review1998，5，5： | 1 |
| 20 | Purifica-tion and Some Properties of Acidstable α-amylase from Shochu koji,(Aspergillus kawachii)显示文摘 | Shigeaki M Kimio I Satoshi S Toyoaki S | | 0，，09： | 1 |
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