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| 1 | Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions显示文摘AIM:To evaluate the efficacy of computer-assisted color analysis of colorectal lesions using a novel auto-fluorescence imaging(AFI)system to distinguish neoplastic lesions from non-neoplastic lesions and to predict the depth of invasion.METHODS:From January 2013 to April 2013,consecutive patients with known polyps greater than 5 mm in size who were scheduled to undergo endoscopic treatment at The Jikei University Hospital were prospectively recruited for this study.All lesions were evaluated using a novel AFI system,and color-tone sampling was performed in a region of interest determined from narrow band imaging or from chromoendoscopy findings without magnification.The green/red(G/R)ratio for each lesion on the AFI images was calculated automatically using a computer-assisted color analysis system that permits real-time color analysis during endoscopic procedures.RESULTS:A total of 88 patients with 163 lesions were enrolled in this study.There were significant differences in the G/R ratios of hyperplastic polyps(non-neoplastic lesions),adenoma/intramucosal cancer/submucosal(SM)superficial cancer,and SM deep cancer(P<0.0001).The mean±SD G/R ratios were 0.984±0.118in hyperplastic polyps and 0.827±0.081 in neoplastic lesions.The G/R ratios of hyperplastic polyps were significantly higher than those of neoplastic lesions(P<0.001).When a G/R ratio cut-off value of>0.89 was applied to determine non-neoplastic lesions,the sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy were 83.9%,82.6%,53.1%,95.6%and 82.8%,respectively.For neoplastic lesions,the mean G/R ratio was 0.834±0.080 in adenoma/intramucosal cancer/SM superficial cancer and 0.746±0.045 in SM deep cancer.The G/R ratio of adenoma/intramucosal cancer/SM superficial cancer was significantly higher than that of SM deep cancer(P<0.01).When a G/R ratio cut-off value of<0.77 was applied to distinguish SM deep cancers,the sensitivity,specificity,PPV,NPV,and accuracy were80.0%,84.4%,29.6%,98.1%and 84.1%,respectively.CONCLUSION:The novel AFI system with color analysis was effective in distinguishing non-neoplastic lesions from neoplastic lesions and might allow determination of the depth of invasion. | Hiroko Inomata Naoto Tamai Hiroyuki Aihara Kazuki Sumiyama Shoichi Saito Tomohiro Kato Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，41： | 5 |
| 2 | A randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: An interim report显示文摘 | Seigo Kitano Norio Shiraishi Kyuzo Fujii Kazuhiro Yasuda Masafumi Inomata Yosuke Adachi | 2002 | Surgery2002，，1： | 4 |
| 3 | Long‐term outcomes of endoscopic submucosal dissection for early gastric cancer: A single‐center retrospective study显示文摘 | Takashi Kosaka Masaki Endo Yosuke Toya Yukito Abiko Norihiko Kudara Masaaki Inomata Toshimi Chiba Yasuhiro Takikawa Kazuyuki Suzuki Tamotsu Sugai | 2014 | Digestive Endoscopy2014，，2： | 4 |
| 4 | Benefit of laparoscopic liver resection in high body mass index patients显示文摘AIM: To explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).METHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical outcomes.RESULTS: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. There were no signi ficant di fferences in mortali ty and morbidity in two groups. Twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. The operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate analysis.CONCLUSION: The present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients. | Hiroki Uchida Yukio Iwashita Kunihiro Saga Hiroomi Takayama Kiminori Watanabe Yuichi Endo Kazuhiro Yada Masayuki Ohta Masafumi Inomata | 2016 | World Journal of Gastroenterology2016，22，10： | 4 |
| 5 | 腹腔镜右半结肠切除术对比开腹手术治疗结肠癌的临床疗效:一项基于日本国家临床数据库的倾向评分匹配研究显示文摘目的:腹腔镜右半结肠切除术相比开腹手术治疗结肠癌的优势在临床实践中尚存争议,我们可以看到在全球范围内相当一部分患者仍在接受开腹手术。本研究基于日本国家临床数据库资料,对腹腔镜右半结肠切除术与开腹手术治疗结肠癌的临床疗效进行评估与比较。方法:本回顾性分析研究纳入于2014-2018年接受治疗的共计72299例结肠癌患者,其中接受腹腔镜右半结肠切除术的有46084例,接受开腹手术的有26215例。采用倾向评分匹配方法比较两组的短期疗效。 | 牟廷裕 MATSUDA T ENDO H INOMATA M | 2021 | 结直肠肛门外科2021，27，2： | 3 |
| 6 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 7 | Minimally invasive approaches for gastric cancer—Japanese experiences显示文摘 | Tsuyoshi Etoh Masafumi Inomata Norio Shiraishi Seigo Kitano | 2012 | J. Surg. Oncol2012，，3： | 2 |
| 8 | Early and late recurrence after gastrectomy for gastric carcinoma显示文摘 | Shiraishi N Inomata M Osawa N | | 0，，： | 2 |
| 9 | Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan显示文摘AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients. CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Shigeyuki Kobayashi Ken Ariizumi Yasuhiko Abe Katsunori Iijima Akira Imatani Yoshifumi Inomata Katsuaki Kato Daisuke Shibuya Shigemitsu Aida Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，9： | 2 |
| 10 | Long‐Term Outcomes of Pediatric Living Donor Liver Transplantation in Japan: An Analysis of More Than 2200 Cases Listed in the Registry of the Japanese Liver Transplantation Society显示文摘 | M. Kasahara K. Umeshita Y. Inomata S. Uemoto | 2013 | American Journal of Transplantation2013，，7： | 2 |
| 11 | Suppression of tumor growth in human gastric cancer with HER2 overexpressionby an anti-HER2 antibody in a murine model显示文摘 | Yoko Matsui Masafumi Inomata Manabu Tojigamori Kazuya Sonoda Norio Shiraishi Seigo Kitano | 2005 | International Journal of Oncology2005，，3： | 2 |
| 12 | Changes in physicochemical properties of proteins in Kayserian Pastirma made from the M.semimembranosus muscle of cows during traditional processing显示文摘In the current study,we examined the effects of beef processing to produce pastirma on the physicochemical properties of proteins in M.semimembranosus(SEM)muscle.Protein concentrations significantly increased in pastirma muscles(P<0.01),as a result of the salting and curing process.The surface hydrophobicity values of processed samples were higher than those without processing at all guanidine-HCl concentrations,suggesting hydrophobicity increased,which may attribute to the new generated peptides during the traditional pastirma-making process.The metmyoglobin content greatly increased(by as much as 89%)in pastirma samples compared with the unprocessed samples.The images of histology also demonstrate that the pastirma processing had no negative impact on the structure of the muscle.The results from this study suggest that the traditional pastirma-making process catalyzed the enzymatic digestion of muscle proteins,and the differences in some physicochemical parameters between the control and pastirma samples were thus likely to be contributable to protein digestion.Thus,the traditional pastirma-making process results in the degradation of many proteins into peptides,which might then be obtainable as functional components to treat human dietand lifestyle-related diseases such as hypertension,hyperglycemia syndromes or to be used as nutraceuticals.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Abdulatef Mrghni Ahhmed Gen Kaneko Hideki Ushio Tomo Inomata Hasan Yetim Safa Karaman Michio Muguruma Ryoichi Sakata | 2013 | Food Science and Human Wellness2013，2，1： | 2 |
| 13 | Takayasu's arteritis显示文摘 | Numano F Okawara M Inomata | 2000 | Lancet2000，356，9234： | 1 |
| 14 | Ghrelin stimu- lates gastric acid secretion and motility in rats显示文摘 | MASUDA Y TANAKA T INOMATA N | 2000 | Biochem Bio- phys Res Commun2000，276，3： | 1 |
| 15 | The effects ofprostaglandin E1or oral clonidine premedication on blood lossduring paranasal sinus surgery显示文摘 | Okuyama K Inomata S Toyooka H | 2005 | Can J Anaesth2005，52，5： | 1 |
| 16 | Surface and bulkpassivated large area multicrystalline silicon solar cells显示文摘 | FUKUI K OKADA K INOMATA Y | 1997 | Solar Energy Materials and Solar Cells1997，48，： | 1 |
| 17 | A novel discharge source of hydronium ions for proton transfer reaction ionization: Design, characterization, and performance显示文摘 | Inomata S Tanimoto H Aoki N | 2006 | Rapid Communications in Mass Spectrometry2006，20，6： | 1 |
| 18 | Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7α-hydroxylase in the liver of patients with end-stage primary biliary cirrhosis显示文摘 | Takeyama Y Kanegae K Inomata S | | 0，，03： | 1 |
| 19 | Seasonal and spatial variations of enhanced gamma ray dose rates derived from 222 Rn progeny during precipitation in Japan显示文摘 | Inomata Y Chiba M Igarashi Y | | 0，，： | 1 |
| 20 | Tunnel magnetoresistance with improved bias voltage dependence in lattice-matched Fe/spinel MgAl2O4/Fe(001)junctions显示文摘 | Sukegawa H Xiu H.X Ohkubo T Furubayashi T Niizeki T Wang W.H Kasai S Mitani S Inomata K and Hono K | | 0，，21： | 1 |
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