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| 1 | 小麦族10种禾草叶片可消化性及矿物质含量的差异显示文摘利用扫描电镜及能量分散型荧光 X射线新技术分析小麦族 10种多年生禾草叶片的可消化性和矿物质含量。结果表明 ,供试草种叶片可消化性的高低顺次是 :老芒麦 >野大麦 >航道冰草 =加拿大披碱草 >蒙农杂种冰草>诺丹冰草 >肥披碱草≥新麦草 =披碱草 >蒙古冰草。叶片中 7种矿物元素含量变幅为 :Mg 0 .2 1%~ 0 .5 7%、Si0 .90 %~ 3.31%、P 0 .2 7%~ 0 .36 %、S 0 .36 %~ 0 .6 0 %、Cl 0 .2 1%~ 0 .5 2 %、K 1.4 4 %~ 3.0 6 %、Ca 0 .4 2 %~0 .98% 。 | 于卓 SAIGA Suguru | 2002 | 草地学报2002，10，1： | 18 |
| 2 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 3 | Improvement of prognosis for unresectable biliary tract cancer显示文摘AIM:To evaluate the chemotherapeutic outcomes and confirm the recent improvement of prognosis for unresectable biliary tract cancer.METHODS:A total of 186 consecutive patients with unresectable biliary tract cancer,who had been treated with chemotherapy between 2000 and 2009 at five institutions in Japan,were retrospectively analyzed.These patients were divided into three groups based on the year beginning chemotherapy:Group A(2000-2003),Group B(2004-2006),and Group C(2007-2009).The data were fixed at the end of December 2011.Overall survival and time-to-progression were analyzed and compared chronologically.RESULTS:No patient characteristics were significantly different among the three groups.The gallbladder was involved in about half of the patients in each group,and metastatic biliary tract cancer was present in three quarters of the enrollees.In Group A,5-fluorouracilbased chemotherapies were primarily selected as firstline chemotherapy,and only 24% were treated with second-line chemotherapy.In Group B,gemcitabine or S-1 monotherapy was mainly introduced as firstline chemotherapy,and 51% of the patients who were refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with monotherapy.In Group C,the combination therapy with gemcitabine and S-1 was mainly chosen as first-line chemotherapy,and 53% of the patients refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with combination therapy.The median timeto-progressions were 4.4 mo,3.5 mo and 5.9 mo in Groups A,B and C,respectively(4.4 mo vs 3.5 mo vs 5.9 mo,P < 0.01).The median overall survivals were 7.1,7.3,and 11.7 mo in Groups A,B and C(7.1 mo vs 7.3 mo vs 11.7 mo,P = 0.03).Induction rates of all three drugs(gemcitabine,platinum analogs,and fluoropyrimidine) in Groups A,B and C were 4%,2% and 27%(4% vs 2% vs 27%,P < 0.01).CONCLUSION:The prognosis of unresectable biliary tract cancer has improved recently.Using three effective drugs(gemcitabine,platinum analogs,and fluoropyrimidine) may improve the prognosis of this cancer. | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Naminatsu Takahara Naoki Sasahira Hirofumi Kogure Suguru Mizuno Hiroshi Yagioka Yukiko Ito Natsuyo Yamamoto Kenji Hirano Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 4 | miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer显示文摘AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of patients.METHODS We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC.We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility.We also investigated the expression levels of the selected miRNA not only in tissue but also in plasma samples.Moreover,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant potential.RESULTS Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric mucosa.Conversely,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC patients.In contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC patients.CONCLUSION miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC. | Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 6 |
| 5 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 6 | 12种牧草叶表面微细构造的差异显示文摘用递真空扫描电镜技术和能量分散型X射线 (EDX)分析方法研究了 12种多年生牧草叶表面的微细构造。结果表明 ,每种草叶的正面和背面都有各自独特的微细构造 ,草种间差异明显 ;将扫描电镜图片贮存在高密度光盘内 ,建立各草种叶表面的微细特征图像库 ,对生育初期牧草种的识别及其分类极为有用 ;蒙古冰草叶背面的白色乳突状结构、新麦草叶正面的白色砖块状结构及其叶背面的白色披针状结构都是由硅质成分积累而成的特殊构造。 | 于卓 SAIGA Suguru | 2001 | 中国草地2001，23，5： | 6 |
| 7 | 意大利黑麦草和高羊茅不同品种的矿物质含量差异显示文摘用能量分散型荧光X射线元素分析仪测定了意大利黑麦草和高羊茅两草种各4个品种不同年度、不同器官、不同刈割时期的矿物质元素含量。结果表明,每个草种的高镁品种都具有较高的Mg含量和低的K/(Ca+Mg)当量比,而且与其他品种之间差异显著;不同刈割时期,5月份Mg含量低而K/(Ca+Mg)当量比高,而且与其他刈割时期差异显著;2003年与2004年相比,K含量、K/(Ca+Mg)当量比高而且差异显著;两草种茎叶干物质中矿物质元素含量高低顺序为:常量元素K>Si>Ca>Mg>Na;叶中微量元素Fe>Mn>Zn>Cu,茎中微量元素Mn>Fe>Zn>Cu。不同器官之间,意大利黑麦草除Zn的含量茎显著高于叶而外,其他11种元素都是叶的含量高于茎;高羊茅P,Cl,Zn的含量茎显著高于叶,其他9种元素都是叶的含量高于茎。 | 乔玉梅 谢甫绨 刘永志 Saiga Suguru | 2007 | 华北农学报2007，22，3： | 5 |
| 8 | Hydrogen Adsorption by Woodceramics Produced from Biomass显示文摘Hydrogen adsorption characteristics of woodceramics,made from radiata pine wood fiber boards carbonized at 1 473 K after impregnation with phenolic resin,with and without chemical treatment in an alkaline(KOH) or an acid(H 2 SO 4) solution were investigated The hydrogen adsorption capacity is improved by chemical treatment.The chemical treatment by KOH improves the adsorption capacity more than by H 2 SO 4.The improvement of the capacity level,in any solution,is dependent on the type of chemical in the solution and its concentration.The maximum hydrogen capacity measured at 93 K is mass fraction about w(H) = 2% for the woodceramics after chemical treatment in a volume fraction = 50% KOH solution,although that is about w(H) = 0.7% for one without chemical treatment.The microscopic condition of pores in the woodceramics is thought to vary after chemical treatment. | TAKASAKI Akito IIJIMA Suguru YAMANE Tomoka OKABE Toshio | 2012 | Journal of Shanghai Jiaotong university(Science)2012，17，3： | 4 |
| 9 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 10 | Surgical Resection of Hilar Cholangiocarcinoma: Analysis of Survival and Postoperative Complications显示文摘 | Suguru Hasegawa Iwao Ikai Hideaki Fujii Etsuro Hatano Yasuyuki Shimahara | 2007 | World Journal of Surgery2007，，6： | 3 |
| 11 | Waxy wheat as a functional food for human consumption显示文摘 | Shuzo Fujita Takako Kumagai Mashimi Yanagimachi Suguru Sakuraba Ryuichi Sanpei Mika Yamoto Haruka Tohara | 2012 | Journal of Cereal Science2012，，3： | 2 |
| 12 | Prognostic Index for Patients with Hepatocellular Carcinoma Combined with Tumor Thrombosis in the Major Portal Vein显示文摘 | Iwao Ikai Etsuro Hatano Suguru Hasegawa Hideaki Fujii Kojiro Taura Naoki Uyama Yasuyuki Shimahara | 2006 | Journal of the American College of Surgeons2006，，3： | 2 |
| 13 | 日本农业生物技术年报(2011年)显示文摘本报告介绍了日本转基因作物的消费、监管、公众认知、研究和生产方面的最新状况。 | Jeffrey Nawn Suguru Sato | 2012 | 生物技术进展2012，2，6： | 2 |
| 14 | 利用酶分解法评价牧草的可消化性显示文摘采用酶分解法分析测定禾本科2个草种8个品种不同刈割时期的细胞组成成分含量,通过公式推算出干物质消化率和可消化养分总量,评价牧草品质。结果表明,意大利黑麦草各品种间可消化性无显著差异,但高Mg的Magnet干物质消化率显著高于Tachiwase。高羊茅的高Mg品种Himag可消化性显著高于其他3个品种,而其他3个品种之间无显著差异。2个草种在10月份的可消化性高于其他刈割时期,意大利黑麦草7月的可消化性最低,高羊茅9月的可消化性最低。 | 乔玉梅 刘永志 谢甫绨 Saiga Suguru | 2005 | 华北农学报2005，20，6： | 2 |
| 15 | Damped Oscillation of Liquid Column in Vertical U-Tube for Newtonian and non-Newtonian Liquids显示文摘在垂直U试管的牛顿的液体的抑制摆动是众所周知的现象和这个液体运动的答案之一因为然而,在圆形的管子中的 laminar 流动政体一般来说被解决,就算由这个答案的 oscillational 运动的时期将近与试验性的结果的被与一致,有由解决的方程的时间的差错的抑制 oscillational 过程的评价不与试验性的结果的一致。因此为牛顿、非牛顿的液体在圆形的 U 试管在 oscillational 运动的速度分布的试验性的结果之上基于, Bingham 塑料流动的速度分发被假定。在直径 D=10mm, 20mm 和 40mm 的垂直 U 试管的免费表面的垂直掉落并且升起的速度的抑制摆动并且也的答案与为牛顿的液体的水和水甘油答案和非牛顿的液体的丙烯酸的共聚物解决方案相比。由新流动模型的这些解决的方程的比较在对试验性的结果的好同意被显示出。上述说的结果详细被描述。 | Akira Ogawa Suguru Tokiwa Masatoshi Mutou Kazutaka Mogi Tonau Sugawara Masahide Watanabe Kouhei Satou Toshikazu Kikawada Keitarou Shishido Naoya Matumoto | 2007 | Journal of Thermal Science2007，16，4： | 2 |
| 16 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 17 | Development of monobloc type high-carbon high-alloyed mils for hot rolling mills 显示文摘 | Kawashima Suguru etc | 1992 | ISIJ International1992，32，11： | 1 |
| 18 | Structure and nonlinearoptical properties of lanthanide borate glasses显示文摘 | Kentaro Terashima Suguru Tamura Sea-Hoon Kim | 1997 | J Am Ceram Soc1997，80，11： | 1 |
| 19 | Clinical usefulness of frac- tional exhaled nitric oxide for diagnosing prolonged cough 显示文摘 | Suguru S Junpei S Yasuko S | 2008 | Respir Med2008，102，10： | 1 |
| 20 | The roughness effect on the frequency of frictional sound显示文摘 | Boyko Stoimenova Suguru Maruyamab Koshi Adachia | 2007 | Tribology International2007，40，4： | 1 |
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