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| 1 | Comparison of endoscopic stenting for malignant biliary obstruction: A single-center study显示文摘AIM: To evaluate the efficacy and safety of single-step endoscopic placement of self-expandable metallic stents(SEMS) for treatment of obstructive jaundice.METHODS: A retrospective study was performed among 90 patients who underwent transpapillary biliary metallic stent placement for malignant biliary obstruction(MBO) between April 2005 and October 2012. The diagnosis of primary disease and MBO was based on abdominal ultrasound, computed tomography, magnetic resonance imaging, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography with brush cytology, biopsy, and/or a combination of these modalities. The type of SEMS(covered or non-covered, 8 mm or 10 mm in diameter) was determined by the endoscopist. Ninety patients were divided into two groups: group 1(49 patients) who underwent a singlestep SEMS placement and group 2(41 patients) who underwent a two-step SEMS placement. The technical success rate, complication rate, stent patency, and patient survival rate were compared between the groups. In addition, to identify the clinical prognostic factors associated with patient survival, the following variables were evaluated in Cox-regression analysis: gender, age, etiology of MBO(pancreatic cancer or nonpancreatic cancer), clinical stage(Ⅳb; with distant metastases or Ⅳa >; without distant metastases), chemotherapy(with or without), patency of the stent, and the use of single-step or two-step SEMS. RESULTS: Immediate technical success was achieved in 93.9%(46/49) in group 1 and in 95.1%(39/41) in group 2, with no significant difference(P = 1.0). Similarly, there was no difference in the complication rates between the groups(group 1, 4.1% and group 2, 4.9%; P = 0.62). Stent failure was observed in 10 cases in group 1(20.4%) and in 16 cases in group 2(39.0%). The patency of stent and patient survival revealed no difference between the two groups with Kaplan-Meier analysis, with a mean patency of 111 ± 17 d in group 1 and 137 ± 19 d in group 2(P = 0.91), and a mean survival of 178 ± 35 d in group 1 and 222 ± 23 d in group 2(P = 0.57). On the contrary, the number of days of hospitalization associated with first-time SEMS placement in group 1 was shorter when compared with that number in group 2(28 vs 39 d; P < 0.05). Multivariate analysis revealed that a clinical stage of Ⅳa >(P = 0.0055), chemotherapy(P = 0.0048), and no patency of the stent(P = 0.011) were independent prognostic factors associated with patient survival.CONCLUSION: Our results showed that single-step endoscopic metal stent placement was safe and effective for treating obstructive jaundice secondary to various inoperable malignancies. | Ryuichi Yamamoto Masatomo Takahashi Yasuyo Osafune Katsuya Chinen Shingo Kato Sumiko Nagoshi Koji Yakabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 12 |
| 2 | Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin显示文摘AIM:To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin- induced peptic ulcer. METHODS:Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin(81 or 100 mg/day).The endoscopic findings were classified according to the Lanza score,and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used.In another study,31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled.The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group.The administration of low-dose aspirin was continued concomitantly,and endoscopic examinations were performed 8 wk later. RESULTS:The Lanza scores(mean±SD)of the gastro-mucosal lesions were 1.0±1.9 and 1.9±2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA,respectively.Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy(4.7±1.0)and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3±1.6).In the prospective study,18 and 13 patients received a PPI and an H2RA,respectively.Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%)in the H2RA-treated group;no significant differences were observed between the groups. CONCLUSION:H2RA therapy was effective for both the prevention and treatment of low-dose aspirin- induced peptic ulcer,similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration. | Sayaka Nakashima Shinichi Ota Shin Arai Kiyoko Yoshino Mie Inao Keiko Ishikawa Nobuaki Nakayama Yukinori Imai Sumiko Nagoshi Satoshi Mochida | 2009 | World Journal of Gastroenterology2009，15，6： | 11 |
| 3 | 桃果实水孔蛋白cDNA的分离显示文摘使用逆转录聚合酶链失反应(RT-PCR)技术从桃果实的果皮组织中分离出来2个编码水孔蛋白部分cDNA克隆。比较结果表明,其推导的氨基酸序列与从其他一些植物体中分离出来的液泡膜内在蛋白有很高的同源性。数量PCR分析表明,编码水孔蛋白基因pWC1在果实发育早期表达,而pWC2在果实发育期间全过程均有表达。 | Sumiko Sugaya Hiroshi Gemma Shuichi Iwahori 刘广树 | 2000 | 园艺学报2000，27，z1： | 2 |
| 4 | Sequence andlysis of the genome of Bombyx mori nucleoplly-hedrovirus Journal of general 显示文摘 | Sumiko Gomi Kei Majima Susumu Maeda | 1999 | Virology1999，80，： | 1 |
| 5 | Mechanism of oxidative DNA damage induced by carcinogenic allyl isothiocyanate显示文摘 | Mariko Murata Nauto Yamashita Sumiko Inoue | 2000 | Free Radical Biology and Medicine2000，28，5： | 1 |
| 6 | Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples显示文摘 | Kimio Yoshimura Tomoyuki Hanaoka Shumpei Ohnami Sumiko Ohnami Takashi Kohno Ying Liu Teruhiko Yoshida Hiromi Sakamoto Shoichiro Tsugane | 2003 | Journal of Human Genetics2003，，12： | 1 |
| 7 | Application of molecular techniques to evaluate the methanogenic archaea and anaerobic bacteria in the presence of oxygen with different COD:Sulfate ratios in a UASB reactor显示文摘 | Julia Sumiko Hirasawa Arnaldo Sarti Nora Katia Saavedra Del Aguila Maria Bernadete A. Varesche | 2008 | Anaerobe2008，，4： | 1 |
| 8 | Cyclic Variation and Solar Forcing of Holocene Climate in the Alaskan Sub arctic 显示文摘 | Feng Sheng Hu Darrell Kaufman Sumiko Yoneji | 2003 | Science2003，301，： | 1 |
| 9 | A Functional Single Nucleotide Polymorphism in Mucin 1 , at Chromosome 1q22, Determines Susceptibility to Diffuse-Type Gastric Cancer显示文摘 | Norihisa Saeki Akira Saito Il Ju Choi Keitaro Matsuo Sumiko Ohnami Hirohiko Totsuka Suenori Chiku Aya Kuchiba Yeon–Su Lee Kyong–Ah Yoon Myeong–Cherl Kook Sook Ryun Park Young–Woo Kim Hideo Tanaka Kazuo Tajima Hiroshi Hirose Fumihiko Tanioka Yoshihiro Mats | 2011 | Gastroenterology2011，，3： | 1 |
| 10 | Drug interaction between voriconazole and tacrolimus and its association with the bioavailability of oral voriconazole in recipients of allogeneic hematopoietic stem cell transplantation显示文摘 | Takehiko Mori Jun Kato Akiko Yamane Masatoshi Sakurai Sumiko Kohashi Taku Kikuchi Yukako Ono Shinichiro Okamoto | 2012 | International Journal of Hematology2012，，5： | 1 |
| 11 | Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus显示文摘 | Gomi Sumiko Kei Majima Maeda S | 1999 | J Gen Virol1999，80，： | 1 |
| 12 | BMP4 expression in the developing rat retina显示文摘 | Yuka M Sumiko M Yoshihiro H | 2006 | Brain Res2006，1122，1： | 1 |
| 13 | Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas显示文摘 | Rumiko Kawashima Satoshi Mochida Atsushi Matsui YuSuFu YouLuTuZ Keiko Ishikawa Keiko Toshima Fumio Yamanobe Mie Inao Hitoshi Ikeda Akihiko Ohno Sumiko Nagoshi Toshimitsu Uede Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 14 | The p53-Independent,Nuclear Translocation of Cyclin G1 in Degenerating Neurons by Ischemic and Traumatic Insults显示文摘 | Mitsuyo Maeda Kei-Ichi Ampo Sumiko Kiryu-Seo | 2005 | Experimental Neurology2005，193，2： | 1 |
| 15 | Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax,a homeobox gene显示文摘 | Yoko T Yasuo O Haruyuki K Toshiya M Ken-ichi A Sumiko W | 2004 | Mol Cell Biol2004，24，10： | 1 |
| 16 | Protein-protein interaction in neurotransmitter rel-ease显示文摘 | Sumiko Mochida | 2000 | Neuroscience Research2000，36，： | 1 |
| 17 | Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus显示文摘 | Gomi Sumiko Kei Majima Maeda S | 1999 | J Gen Virol1999，80，： | 1 |
| 18 | Application of maxwell solvers to PD propagation-part Ⅲ:PD propagation in GIS显示文摘 | SUMIKO SAKAGUCHI MITSUTOSHI OYAMA | 2003 | IEEE Electrical Insulation Magazine2003，19，1： | 1 |
| 19 | Influence of physicochemical properties of rice flour on oil uptake of tempura frying batter显示文摘 | Sumiko NAKAMURA Ken'ichi OHTSUBO | 2010 | Bioscience biotechnology and biochemistry2010，74，12： | 1 |
| 20 | The p53 - independent nuclear translocation of Cyclin G1 in degenerating neurons by ischemic and traumatic insult 显示文摘 | Mitsuyo Maeda Kei-lehi Ampo Sumiko Kiryu-Seo | 2005 | Exp Neurol2005，193，2： | 1 |
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