|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive and difficult cancers to treat.Despite numerous research efforts,limited success has been achieved in the therapeutic management of patients with this disease.In the current review,we focus on one component of morphogenesis signaling,Hedgehog(Hh),with the aim of developing novel,effective therapies for the treatment of pancreatic cancer.Hh signaling contributes to the induction of a malignant phenotype in pancreatic cancer and is responsible for maintaining pancreatic cancer stem cells.In addition,we propose a novel concept linking Hh signaling and tumor hypoxic conditions,and discuss the effects of Hh inhibitors in clinical trials.The Hh signaling pathway may represent a potential therapeutic target for patients with refractory pancreatic cancer. | Hideya Onishi Mitsuo Katano | 2014 | World Journal of Gastroenterology2014，20，9： | 18 |
| 2 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 3 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 4 | Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis显示文摘Background:Graft inflow modulation(GIM)during adult-to-adult living donor liver transplantation(LDLT)is a common strategy to avoid small-for-size syndrome,and some transplant surgeons attempt small size graft strategy with frequent GIM procedures,which are mostly performed by splenectomy,in LDLT.However,splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy infection.Methods:Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively reviewed.We applied the graft selection criteria,which routinely fulfill graft-to-recipient weight ratio≥0.8%,and consider GIM as a backup strategy for high portal venous pressure(PVP).Results:In our current strategy of LDLT,splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms,but splenectomy for GIM was intended to only one patient(2.1%).The final PVP values≤20 mmHg were achieved in all recipients,and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or not.However,6 of 18 patients with splenectomy(33.3%)developed postsplenectomy portal vein thrombosis(PVT),while none of the 30 patients without splenectomy developed PVT after LDLT.Splenectomy was identified as a risk factor of PVT in this study(P<0.001).Our study revealed that a lower final PVP could be risk factor of postsplenectomy PVT.Conclusions:Using sufficient size grafts was one of the direct solutions to control PVP,and allowed GIM to be reserved as a backup procedure.Splenectomy should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of PVT.In splenectomy cases with a lower final PVP,a close follow-up is required for early detection and treatment of PVT. | Nobuhiko Kurata Yasuhiro Ogura Satoshi Ogiso Yasuharu Onishi Hideya Kamei Yasuhiro Kodera | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 2 |
| 5 | Ag7(MBISA)6 Nanoclusters Conjugated with Quinacrine for FRET-Enhanced Photodynamic Activity under Visible Light Irradiation显示文摘Singlet oxygen(1 O2) plays an important role in various applications, such as in the photodynamic therapy(PDT) of cancers,photodynamic inactivation of microorganisms, photo-degradation of toxic compounds, and photo-oxidation in synthetic chemistry. Recently,water-soluble metal nanoclusters(NCs) have been utilized as photosensitizers for the generation of highly reactive 1 O2 because of their high water solubility, low toxicity, and surface functionalizability for targeted substances. In the case of metal NC-based photosensitizers, the photo-physical properties depend on the core size of the NCs and the core/ligand interfacial structures. A wide range of atomically precise gold NCs have been reported; however, reports on the synthesis of atomically precise silver NCs are limited due to the high reactivity and low photostability(i.e., easy oxidation) of Ag NCs. In addition, there have been few reports on what kinds of metal NCs can generate large amounts of 1 O2. In this study, we developed a new one-pot synthesis method of water-soluble Ag7(MBISA)6(MBISA= 2-mercapto-5-benzimidazolesulfonic acid sodium salt) NCs with highly efficient 1 O2 generation ability under the irradiation of white light emitting diodes(LEDs). The molecular formula and purity were determined by electrospray ionization mass spectrometry and gel electrophoresis. To the best of our knowledge, this is the first report on atomically precise thiolate silver clusters(Agn(SR)m) for efficient 1 O2 generation under visible light irradiation. The 1 O2 generation efficiency of Ag7(MBISA)6 NCs was higher than those of the following known water-soluble metal NCs: bovine serum albumin(BSA)-Au25 NCs,BSA-Ag8 NCs, BSA-Ag14 NCs,Ag25(dihydrolipoic acid)14 NCs,Ag35(glutathione)18 NCs,and Ag75(glutathione)40 NCs. The metal NCs examined in this study showed the following order of 1 O2 generation efficiency under white light irradiation: Ag7(MBISA)6 > BSA-Ag14 > Ag75(SG)40 > Ag35(SG)18 >BSA-Au25 >>BSA-Ags(not detected) and Ag2 s(DHLA)14(not detected). For further improving the 1 O2 generation of Ag7(MBISA)6 NCs, we developed a novel fluorescence resonance energy transfer(FRET) system by conjugating Ag7(MBISA)6 NCs with quinacrine(QC)(molar ratio of Ag NCs to QC is 1 : 0.5). We observed the FRET process,from QC to Ag7(MBISA)6 NCs,occurring in the conjugate. That is,the QC works as a donor chromophore,while the Ag NCs work as an acceptor chromophore in the FRET process. The FRET-mediated process caused a 2.3-fold increase in 1 O2 generation compared to that obtained with Ag7(MBISA)6 NCs alone. This study establishes a general and simple strategy for improving the PDT activity of metal NC-based photosensitizers. | TOMINAGA Chiaki HIKOSOU Dailo OSAKA Issey KAWASAK Hideya | 2018 | 物理化学学报2018，34，7： | 2 |
| 6 | Stability of the DMF-Protected Au Nanoclusters: Photochemical, Dispersion, and Thermal Properties 显示文摘 | Hideya Kawasaki Hiroko Yamamoto | 2010 | Langmuir2010，26，8： | 1 |
| 7 | Extension of frequency-based dissimilarity for retrieving similar plasma waveforms显示文摘 | Teruhisa Hochin Katsumasa Koyama Hideya Nakanishi | 2008 | Fusion Engineering and Design2008，83，23： | 1 |
| 8 | Localization of recombination activating gene 1/green fluorescent protein(RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice显示文摘 | Hideya I Naomi K Kumiko K | 2001 | Blood2001，97，9： | 1 |
| 9 | Indexing of plasma waveforms for accelerating search and retrieval of their subsequences显示文摘 | Teruhisa Hochina Yoshihiro Yamauchia Hideya Nakanishib | 2010 | Fusion Engineering and Design2010，85，5： | 1 |
| 10 | calcification development of new Role of osteoprotegefin inarterial animal model 显示文摘 | Yuichi O Hideya Y Nobuoki K | 2001 | Arteriosclcr Thromb Vase Biol2001，27，： | 1 |
| 11 | Triamcinolone acetonide-assisted peeling of the internal limiting membrane显示文摘 | Hideya Kimura Shinichiro Kuroda Makoto Nagata | 2003 | American Journal of Ophthalmology2003，，1： | 1 |
| 12 | Prognostic Factor Analysis in Pars Plana Vitrectomy for Retinal Detachment Attributable to Macular Hole in High Myopia: A Multicenter Study显示文摘 | Hideo Nakanishi Shoji Kuriyama Isao Saito Morio Okada Mihori Kita Yasuo Kurimoto Hideya Kimura Hitoshi Takagi Nagahisa Yoshimura | 2008 | American Journal of Ophthalmology2008，，2： | 1 |
| 13 | Cutaneous tissue angiotensin-converting enzyme may participate in pathologic scar formation in human skin 显示文摘 | Kiyoshi M Shinji T Hideya T | 2006 | Am Acad Dermatol2006，54，2： | 1 |
| 14 | The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection显示文摘 | Kozo Yoshikawa Mitsuo Shimada Masanori Nishioka Nobuhiro Kurita Takashi Iwata Shinya Morimoto Tomohiko Miyatani Masato Komatsu Hideya Kashihara Chie Mikami | 2012 | Surgery Today2012，，7： | 1 |
| 15 | Potentiation of5-Fluorouracil, chromomycin a3, and bleomycin by amphotericin B or polymyxin B in transformed fibroblastic cells 显示文摘 | Michihiko K Tomoya K Hideya E | 1973 | Antimicrob Agents Chemother1973，3，： | 1 |
| 16 | Significant CMAP decre- ment by repetitive nerve stimulation is more frequent in median than ulnar nerves of patients with amyotrophic lateral sclerosis显示文摘 | Satoshi Y Hideya S Akira M | 2012 | Muscle Nerve2012，45，： | 1 |
| 17 | Correlation betweenthe number of melanosomes,tyrosinase mrna levels,and tyrosinase activityin cultured murine melanoma cells in response to various melanogenesisregulatory agents显示文摘 | HIDEYA ANDO AKIRA ITOH YUTAKA MISHIMA | 1995 | Journal of Cellular Physiology1995，163，3： | 1 |
| 18 | Intratumoral CD8+ T/FOXP3+ cell ratio is a predictive marker for survival in patients with colorectal cancer显示文摘 | Hiroyuki Suzuki Nobuhito Chikazawa Takehiko Tasaka Junji Wada Akio Yamasaki Yoshiki Kitaura Masae Sozaki Masao Tanaka Hideya Onishi Takashi Morisaki Mitsuo Katano | 2010 | Cancer Immunology Immunotherapy2010，，5： | 1 |
| 19 | Characterization of Noncalcified Coronary Plaques and Identification of Culprit Lesions in Patients With Acute Coronary Syndrome by 64-Slice Computed Tomography显示文摘 | Toshiro Kitagawa Hideya Yamamoto Jun Horiguchi Norihiko Ohhashi Futoshi Tadehara Tomoki Shokawa Yoshihiro Dohi Eiji Kunita Hiroto Utsunomiya Nobuoki Kohno Yasuki Kihara | 2009 | JACC: Cardiovascular Imaging2009，，2： | 1 |
| 20 | Reevaluating the effects Of tyrosine Iodination Of recombinant hirudin on its thrombin inhibition kinetics 显示文摘 | Yasuhiko Komatsu and Hideya Hayashi | 1997 | Thrombosis Reseach1997，，87： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员