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| 1 | Role of targeted therapy in metastatic colorectal cancer显示文摘Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the world.Improvements of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two decades.The biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage setting.Aflibercept,ramucirumab,and regorafenib are also used in second-line or salvage therapy.Recent retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR therapy.Based on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and characteristics.The aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC. | Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 8 |
| 2 | Recent advances in basic and clinical aspects of inflammatory bowel disease: Which steps in the mucosal inflammation should we block for the treatment of inflammatory bowel disease?显示文摘在从煽动性的肠疾病(IBD ) 的基本、临床的方面的观点的遗传上预先安排的个人在在肠的微生物和粘膜发炎之间的相互作用有四步。第一步经由受体是在肠的微生物或他们的部件和肠的上皮细胞之间的一个相互作用,第二走在巨噬细胞和树枝状的房间和粘膜淋巴细胞之间的一个相互作用,第三走在淋巴细胞和脉管的 endothelial 之间的一个相互作用,并且第四走在生产专业版的淋巴细胞和 granulocytes 之间的一个相互作用煽动性的 cytokines 或自由基和粘膜损坏和修理。为 IBD 的最近的治疗学的途径试图与 IBD 在病人的肠的发炎堵住这四步。 | Hitoshi Asakura Kenji Suzuki Terasu Honma | 2007 | World Journal of Gastroenterology2007，13，15： | 5 |
| 3 | FEM analysis for hot rolling process of AM60 alloy显示文摘<正>The rolling of AM60 sheets for 50%reduction was analyzed with DEFORM to investigate the hot deformation process. The simulated results show that the sheet velocities at the entrance(21 mm/s) and at the exit(37 mm/s) are less and larger than roll velocity,respectively.From the entrance to the neutral point,the velocity at the sheet surface is greater than that at the middle point of sheet in thickness,while that from the neutral point to the exit shows the opposite pattern.The effective strain of the sheet increases from the entrance to the exit due to the continuous reduction in thickness.In addition,the effective strain at the sheet surface reaches to 1.0 and is larger than that of 0.8 at the middle point of sheet.The difference of effective strain in thickness direction has a much stronger effect on the recrystallized fraction than on the recrystallized grain size.The minimum temperature of 347℃is obtained at the surface contacting directly with roll and the maximum temperature 388℃at the middle point of sheet in thickness. | 丁汉材 KANAMORI Nao HONMA Tomoyuki KAMADO Shigeharu KOJIMA Yo | 2008 | 中国有色金属学会会刊:英文版2008，18，A01： | 4 |
| 4 | Effect of Zn additions on the age-hardening of Mg–2.0Gd–1.2Y–0.2Zr alloys显示文摘 | T. Honma T. Ohkubo S. Kamado K. Hono | 2007 | Acta Materialia2007，，12： | 3 |
| 5 | Total-factor energy efficiency of regions in Japan显示文摘 | Satoshi Honma Jin-Li Hu | 2007 | Energy Policy2007，，2： | 2 |
| 6 | Global structure and dynamics of advection-dominated accretion flows around black holes显示文摘 | Narayan R Kato S Honma F | 1997 | Astrophysical Journal1997，476，1： | 1 |
| 7 | Oncocytic adenocarcinoma of the stomach 显示文摘 | Takubo K Honma N Sawabe M | 2002 | Am J Surg Pathol2002，26，4： | 1 |
| 8 | Temperature dependence of kinetics of methanol electro-oxidation on PtSn alloys显示文摘 | Honma I Toda T | 2003 | J Electrochem Society2003，150，12： | 1 |
| 9 | Quasi-solid-state lithium-sulfur battery using room temperature ionic liquidLi-salt-fumed silica nanoparticle composites as electrolytes显示文摘 | Ogawa H Unemoto A Honma I | 2012 | Electrochemistry2012，80，10： | 1 |
| 10 | Improved detection of winter lightning in the Tohoku region of Japan using VAISALA's LS700x technology显示文摘 | Cummins K L Honma N Pifer A E | 2012 | IEEJ Transactions on Power and Energy2012，132，6： | 1 |
| 11 | Prevalence of metabolic syndrome in Japanese psoriasis patients 显示文摘 | Takahashi H Takahashi I Honma M | 2010 | J Dermatol Sci2010，57，2： | 1 |
| 12 | Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy显示文摘 | Kitamura H Torigoe T Honma I Asanuma H Nakazawa E Shi mozawa K | 2006 | Urology2006，67，： | 1 |
| 13 | Preparation and rate capability of Li4Ti5O12 hollow - sphere anode material 显示文摘 | Jiang C H Zhou Y Honma I | 2007 | Journal of Power Sources2007，166，2： | 1 |
| 14 | In situ scanning tunneling microscope observation of InAs wet-ting layer formation on GaAs(001)during molecular beam epitaxy growth at 500℃显示文摘 | HONMA T TSUKAMOTO S ARAKAWA Y | 2006 | Jpn Journal of Appl Phys2006，45，29303132： | 1 |
| 15 | Chromosome painting analysis of spontaneous and methyl methanesulfonate-induced trifluorothymidine-resistant LS178Y cell colonies 显示文摘 | Zhang Ls Honma M Matsuoka A | 1996 | Mutat Res1996，370，34： | 1 |
| 16 | Decomposition of persistent organics in water using a gas-liquid two-phase flow plasma re- actor显示文摘 | Katayama H Honma H Nakagawara N | 2009 | IEEETranson Plasma Science2009，37，6： | 1 |
| 17 | Neutrophil mobilization by surface- glycan altered thlT-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss显示文摘 | Settem RP Honma K Sharma A | 2014 | PLoS One2014，9，9： | 1 |
| 18 | Performance of the Tohoku IMPACT sensor network in winter lightning detection显示文摘 | Honma N | 2012 | IEEJ Transactions on Power and Energy2012，132，66： | 1 |
| 19 | Immediate re- sponse to light of rat pineal melatonin rhythm: analysis by in vivo microdialysis 显示文摘 | Kanematsu N Honma S Katsuno Y | 1994 | American Journal of Physiology1994，266，62： | 1 |
| 20 | Enhanced cyclic performance and lithium storage capacity of SnO2/graphene nanoporous elec- trodes with three-dimensionally delaminated flexible structure 显示文摘 | Paek S M Yoo E Honma I | 2009 | Nano Letters2009，9，1： | 1 |
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