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| 1 | Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples显示文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. | Satoshi Mamori Keisuke Nagatsuma Tomokazu Matsuura Kiyoshi Ohkawa Hiroshi Hano Masaharu Fukunaga Masato Matsushima Yoshifumi Masui Nao Fushiya Hiroshi Onoda Yasuyuki Searashi Ichiro Takagi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，21： | 20 |
| 2 | Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C显示文摘瞄准:估计自体免疫的血小板减少的贡献到丙肝病毒相关的肝肝硬化(类型 C 肝硬化) ,我们在联系血小板的免疫球蛋白 G (PAIgG ) 层次和血小板数字之上评估了脾切除术的影响。方法:PAIgG 乳头 ers 和有免疫力的标记与一口未经触动的怒气与一口未经触动的怒气,提交到脾切除术的 17 个类型 C 肝脏硬化症的病人,和 21 non-C 肝硬化在 24 个类型 C 肝脏硬化症的病人被决定。结果:血小板减少(PLT <
15 x 10 (4 )/microL ) 在类型 C,肝硬化与一口未经触动的怒气在所有病人被诊断,提交到脾切除术的 8 个病人,并且在有未经触动的怒气的 19 non-C 肝硬化。在超过 25.0 ng/10 (7 ) 的 PAIgG 的提高的乳头 ers 房间除了一个 splenectomized 病人在所有肝脏硬化症的病人被检测。PAIgG 乳头 ers (ng/10 (7 ) 房间) 与 splenectomized 病人(125.6+/-87.8 ) 或 non-C 肝硬化(152.4+/-127.4 ) 相比在有一口未经触动的怒气(247.9+/-197.0 ) 的类型 C 肝硬化是显著地更高的。PAIgG 乳头 ers 否定地与一口未经触动的怒气在类型 C 肝脏硬化症的病人与血小板计数被相关。与有一口未经触动的怒气的类型 C 肝硬化比较, splenectomized 病人有减少的 CD4/CD8 比率和浆液 neopterin 层次。怒气索引(cm2 ) 否定地在 non-C 肝硬化,然而并非在类型 C 肝硬化与血小板计数被相关。结论:我们的数据显示自体免疫的机制在由 HCV 积极的肝硬化复杂的血小板增多起一个重要作用。另外,脾切除术可以损害 T 房间功能通过,至少部分地, CD4/CD8 比率的减小,因而压制 PAIgG 生产。 | Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，8： | 16 |
| 3 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 4 | Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis:Case report and literature review显示文摘肝的煽动性的假肿瘤(IPT ) 是煽动性的房间渗入的增殖的纤维组织描绘的稀罕良性的非肿瘤的损害。IPT 的准确病原学仍然保持不清楚。尽管有全身的煽动性的混乱的 IPT 的协会很好被建立了,有胆管炎的一种特殊关系是显然稀罕的。我们与主要胆汁性肝硬变(PBC ) 报导肝的 IPT 的自发的回归的一个案例。迄今为止,仅仅有 PBC 的 IPT 的二个案例被报导了。在我们的情况中,然而, IPT 在有效治疗导致的 PBC 的胆管炎的改进的功课期间发展了,不同于二个以前报导的案例。我们的案例显示 IPT 的发展也不联系到胆管炎或亢奋的 gamma-globulinemia 的活动,自从我们的案例被证实当胆汁的酶和免疫球蛋白比承认上的相应价值高得多时,没有 IPT 的放射线学的联盟者。我们有二个以前报导的案例的案例的比较建议与 PBC 发生的 IPT 不代表一样的疾病实体或是为 PBC 的一个旁观者。 | Hiroshi Koide Ken Sato Toshio Fukusato Kenji Kashiwabara Noriaki Sunaga Takafumi Tsuchiya Saeko Morino Naondo Sohara Satoru Kakizaki Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，10： | 12 |
| 5 | 云南南部野外与村内蚊虫群落特征的比较研究显示文摘目的 研究云南南部西双版纳州景洪市一亻爱伲族村寨野外及村内蚊虫群落结构 ,探讨蚊类群落在不同环境条件下的分布和种类组成。方法 采用人诱和牛诱 ( 8m× 8m× 2m蚊帐 )通宵捕蚊 ,用群落生态学方法计算群落结构、多样性和均匀性指数。结果 村内群落捕获蚊虫 2亚科 6属 11个亚属 3 6种 2 14 2 6只 ,野外群落捕获 2亚科 4属 10个亚属 3 8种 12 2 19只。两群落优势蚊种基本一致为三带喙库蚊、棕头库蚊、伪杂鳞库蚊、中华按蚊、菲律宾按蚊、克氏按蚊、乌头按蚊和可赫按蚊。优势度村内群落分别为 70 .73、3 1.3 7、2 9.92、3 6.11、2 5 .67、2 7.80、2 1.60、15 .5 8,野外群落分别为 5 8.18、3 1.86、2 9.13、3 4.91、16.5 5、2 6.77、2 4.0 6、2 1.45。多样性指数、均匀性指数和优势集中指数村内分别为 1.78、0 .45和 0 .83 ,野外分别为 2 .0 9、0 .5 8和 0 .81。结论 野外群落较村内丰富 ,两群落组成结构复杂 ,优势蚊种分布均匀。 | 王学忠 杜尊伟 卢勇荣 朱国君 黄荣 顾云安 Masahiro TAKAGI Yoshio TSUDA | 2003 | 中国媒介生物学及控制杂志2003，14，5： | 12 |
| 6 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 7 | S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial显示文摘 | Wasaburo Koizumi Hiroyuki Narahara Takuo Hara Akinori Takagane Toshikazu Akiya Masakazu Takagi Kosei Miyashita Takashi Nishizaki Osamu Kobayashi Wataru Takiyama Yasushi Toh Takashi Nagaie Seiichi Takagi Yoshitaka Yamamura Kimihiko Yanaoka Hiroyuki Orita M | 2008 | Lancet Oncology2008，，3： | 12 |
| 8 | Efficacy of acupuncture during post-acute phase of rehabilitation after total knee arthroplasty显示文摘OBJECTIVE:The purpose of this study was to determine whether acupuncture is effective in reducing pain and swelling around the knee and improving range of motion(ROM) during the post-acute phase of rehabilitation after total knee arthroplasty(TKA).METHODS:Following TKA,80 knees in 80 patients were randomly assigned to either an acupuncture treatment group(Group A) or a control group(Group C).In Group A,the complementary treatment of acupuncture was performed three times/week from postoperative day 7 until postoperative day 21.Outcome measures were:i) pain as assessed by a visual analog scale;ii) reduction of swelling around the knee as indicated by its circumference at the center of the patella;and iii) ROM of the affected knee.RESULTS:Group A patients had significantly reduced pain and swelling around the knees and earlier recovery of ROM than did those in Group C.CONCLUSION:Acupuncture provides effective treatment during the post-acute phase of rehabilitation after TKA with respect to pain relief,reduction of swelling around the knee,and early recovery of ROM. | Yoshinori Mikashima Tadashi Takagi Taisuke Tomatsu Mariko Horikosh Katsunori Ikari Shigeki Momohara | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 11 |
| 9 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 10 | Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats显示文摘AIM: To investigate the protective effect of lansoprazoleon ischemia and reperfusion (I/R)-induced rat intestinalmucosal injury in vivo.METHODS: Intestinal damage was induced by clampingboth the superior mesenteric artery and the celiac trunkfor 30 rain followed by reperfusion in male Sprague-Dawleyrats. lansoprazole was given to rats intraperitoneally 1 hbefore vascular clamping.RESULTS: Both the intraluminal hemoglobin and proteinlevels, as indices of mucosal damage, significantlyincreased in I/R-groups comparion with those of sham-operation groups. These increases in intraluminal hemoglobinand protein levels were significantly inhibited by the treatmentwith lansoprazole at a dose of 1 mg/kg. Small intestineexposed to I/R resulted in mucosal inflammation that wascharacterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associatedmyeloperoxidase activity (MPO), and mucosal content of ratcytokine-induced neutrophil chemoattractant-1 (CINC-1).These increases in TBARS, MPO activities and CINC-1 contentin the intestinal mucosa after I/R were all inhibited bypretreatment with lansoprazole at a dose of 1 mg/kg.Furthermore, the CINC-1 mRNA expression was increasedduring intestinal I/R, and this increase in mRNA expressionwas inhibited by treatment with lansoprazole.CONCLUSION: Lansoprazole inhibits lipid peroxidation andreduces development of intestinal mucosal inflammationinduced by I/R in rats, suggesting that lansoprazole mayhave a therapeutic potential for I/R injury. | Hiroshi Ichikawa Norimasa Yoshida Tomohisa Takagi Naoya Tomatsuri Kazuhiro Katada Yutaka Isozaki Kazuhiko Uchiyama Yuji Naito Takeshi Okanoue Toshikazu Yoshikawa | 2004 | World Journal of Gastroenterology2004，10，19： | 10 |
| 11 | 中国东北地区兴安落叶松林树干呼吸的研究(英文)显示文摘树干呼吸是森林碳平衡估计中的一个重要项目同时还能够显示树木的活力.对于如何准确估计森林树干呼吸释放CO2总量还存在争论.在本项研究中,2001~2002连续两年在一个33年生的兴安落叶松(Larix gmelini Rupr.)人工林内对树干呼吸进行了测定,同时测定了不同高度树干呼吸、呼吸的日变化、同龄落叶松林内不同个体的树干呼吸以及相关生长状态因子、水分因子和温度因子.结果显示:1)树干上部的呼吸速率在不同季节都高于下部呼吸速率,树干温度的差异能够一定程度上解释这种差异;2)树干呼吸有午间降低的现象,上午的测定结果树干温度与树干呼吸速率紧密相关,而下午则温度依赖性很小,土壤、空气、小枝木质部水势、叶片蒸腾速率和气孔导度都显示下午植物水分亏缺下午较上午严重,呼吸的这种上下午温度相关性的差异可能受这种水分亏缺的影响;3)在同龄林内,树木个体生长状态包括平均生长速率和树冠投影面积与树干呼吸速率有显著相关关系,而树干温度与之相关性很小.幂指数模型和S曲线模型能够产生较好的拟合效果;4)树干呼吸季节变化明显,7月份出现最大值,但同一月份的年间差异较大.自然指数模型能够较好地拟合温度与树干呼吸的季节变化规律.Q10值在2.22(2001年)和3.53(2002年)之间,与以往研究的结果相当.从以上结果可以看出,通过单一的Q10值估计森林树干呼吸总量会产生偏差,要想得到准确的估计,至少应该考虑生长状态的差异和水分状态的差异. | 王文杰 杨逢建 祖元刚 王慧梅 TAKAGI Kentaro SASA Kaichiro KOIKE Takayoshi | 2003 | Acta Botanica Sinica2003，45，12： | 10 |
| 12 | Efficacy of balloon-occluded retrograde transvenous obliteration, percutaneous transhepatic obliteration and combined techniques for the management of gastric fundal varices显示文摘瞄准:评估为胃的静脉曲张的处理包含 transvenous 涂去的三个 interventional 处理的效果,并且比较功效和这些方法的不利效果。方法:从 1995 ~ 2004,有胃的底的静脉曲张的 93 个病人经历了 interventional 在我们的医院的放射线学的 embolotherapy。93 个病人, 75 被对待与堵塞汽球后退 transvenous 涂去(BRTO ) 过程;8 与经皮的 transhepatic 涂去(PTO ) 是过程;并且 10 与联合 BRTO 和 PTO 治疗。后续评估检验了幸存的率,复发并且胃的静脉曲张重新流血,在每个组食道的静脉曲张和复杂并发症变得更坏。结果:BRTO, PTO,和联合治疗在 81% 是技术上成功的(75/93 ) , 44%(8/18 ) ,并且 100%(10/10 ) 病人分别地。胃的静脉曲张的复发在 PTO 组在 BRTO 组并且在 3 个病人在 3 个病人被发现。重新流血在 PTO 组在 BRTO 组并且在 1 个病人在 1 个病人被观察。没有肝细胞癌(HCC ) , 1 年、 3 年的幸存率在在 PTO 组的 BRTO 组, 100% 和 100% 在病人是 98% 和 87% ,并且 90% 和 75% 分别地在联合治疗组织。结论:尽管有我们的学习的限制,联合 BRTO 和 PTO 治疗可以与与 BRTO 或 PTO 仍然是甚至术后疗法的控制不了的胃的底的静脉曲张救盒子,包括在在 BRTO, PTO 和联合治疗组之间的样品尺寸的回顾的自然和差异。 | Hirotaka Arai Takehiko Abe Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，24： | 9 |
| 13 | Cell sheet technology for regeneration of esophageal mucosa显示文摘The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD. | Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo Takaaki Ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano | 2012 | World Journal of Gastroenterology2012，18，37： | 9 |
| 14 | Analysis and Improvement of Authenticatable Ring Signcryption Scheme显示文摘We show that the Zhang-Yang-Zhu-Zhang identity-based authenticatable ring signcryption scheme is not secure against chosen plaintext attacks.Furthermore, we propose an improved scheme that remedies the weakness of the Zhang-Yang-Zhu-Zhang scheme.The improved scheme has shorter ciphertext size than the Zhang-Yang-Zhu-Zhang scheme.We then prove that the improved scheme satisfies confidentiality, unforgeability, anonymity and authenticatability. | 李发根 Shirase Masaaki Takagi Tsuyoshi | 2008 | Journal of Shanghai Jiaotong university(Science)2008，13，6： | 9 |
| 15 | Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”显示文摘MK615, a compound extracted from the Japanese apricot 'Prunus mume ' has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis appeared.Sorafenib was administered, but was not effective.Then, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects. | Takashi Hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 16 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 17 | 抗主密钥泄露和连续泄露的双态仿射函数加密显示文摘抗密钥泄露安全的加密系统保证在攻击者获得(主)密钥部分信息的情况下仍具有语义安全性.文中设计了一个抗密钥泄露的双态仿射函数加密方案,该方案中加密策略和解密角色定义为仿射空间,并且具有再次委托能力.在双系统加密模型下,实现了自适应安全的抗有界的主密钥泄露和用户密钥连续泄露的加密方案,在标准模型下基于静态子群判定假设证明了该方案的安全性.同时,分析了方案中的主密钥和用户密钥的泄露界和泄露率,通过参数调整可以达到接近73%的泄露率,具有较好的抗泄露性质. | 张明武 杨波 TAKAGI Tsuyoshi | 2012 | 计算机学报2012，35，9： | 7 |
| 18 | Single-Walled Carbon Nanotube Growth with Non-Iron- Group “Catalysts” by Chemical Vapor Deposition显示文摘Various materials have been found to“catalyze”carbon nanotube growth in chemical vapor deposition(CVD)when they become nano-sized particles.These involve not only metals,such as Pd,Pt,Au,Ag,and Cu,but also semiconductors,such as Si,Ge,and SiC.Alumina and diamond nanoparticles also produce carbon nanotubes.These“catalysts”,which are better called“seeds”,can be categorized into two types:one type forms a eutectic liquid or highly-mobile alloy with carbon,and carbon atoms precipitate from the eutectic alloy;the other type remains as a solid phase and form a carbon surface layer during CVD growth.In this paper,we review recent studies of SWCNT growth with these non-iron-group materials and highlight the mechanisms involved. | Yoshikazu Homma Huaping Liu Daisuke Takagi Yoshihiro Kobayashi | 2009 | Nano Research2009，2，10： | 6 |
| 19 | Cryptanalysis of efficient proxy signature schemes for mobile communication显示文摘In a proxy signature scheme, an original signer is allowed to delegate his signing power to a designated person, called the proxy signer and the proxy signer is able to sign the messages on behalf of the original signer. Recently, Lu, Dong and Cao proposed two proxy signature schemes for mobile communication (see Sci China Ser F-Inf Sci, 2008, 51(2): 183–195). Although they proved that their schemes are secure in the random oracle model, we disprove their claim and show that their schemes are not secure. | LI FaGen SHIRASE Masaaki TAKAGI Tsuyoshi | 2010 | Science China(Information Sciences)2010，53，10： | 6 |
| 20 | Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading显示文摘AIM: To evaluate the efficacy of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) for grading pancreatic neuroendocrine tumors(PNETs).METHODS: A total of 22 patients were diagnosed with PNET by EUS-FNA between October 2001 and December 2013 at Fukushima Medical University Hospital.Among these cases,we targeted 10 PNET patients who were evaluated according to the World Health Organization(WHO) 2010 classification.Surgery was performed in eight patients,and chemotherapy was performed in two patients due to multiple liver metastases.Specimens obtained by EUS-FNA were first stained with hematoxylin and eosin and then stained with chromogranin,synaptophysin,CD56,and Ki-67.The specimens were graded by the Ki-67 index according to the WHO 2010 classification.Specimens obtained by surgery were graded by the Ki-67 indexand mitotic count(WHO 2010 classification).For the eight specimens obtained by EUS-FNA,the Ki-67 index results were compared with those obtained by surgery.In the two cases treated with chemotherapy,the effects and prognoses were evaluated.RESULTS: The sampling rate for histological diagnosis by EUS-FNA was 100%.No adverse effects were observed.The concordance rate between specimens obtained by EUS-FNA and surgery was 87.5%(7/8).Fo r t h e t w o c a s e s t re a t e d w i t h c h e m o t h e ra p y,case 1 received somatostatin analog therapy and transcatheter arterial infusion(TAI) targeting multiple liver metastases.Subsequent treatment consisted of everolimus.During chemotherapy,the primary tumor remained unconfirmed,although the multiple liver metastases diminished dramatically.Case 2 was classified as neuroendocrine carcinoma(NEC) according to the Ki-67 index of a specimen obtained by EUS-FNA; therefore,cisplatin and irinotecan therapy was started.However,severe adverse effects,including renal failure and diarrhea,were observed,and the therapy regimen was changed to cisplatin and etoposide.TAI targeting multiple liver metastases was performed.Although the liver metastases diminished,the primary tumor remained unconfirmed.These chemotherapy regimens had immediate effects for both unresectable neuroendocrine tumor(NET) and NEC cases.These two subjects are still alive.CONCLUSION: EUS-FNA was effective for PNET diagnosis and Ki-67 index grading for WHO 2010 classification,enabling informed decisions on unresectable PNET treatment by identifying NET or NEC. | Mitsuru Sugimoto Tadayuki Takagi Takuto Hikichi Rei Suzuki Ko Watanabe Jun Nakamura Hitomi Kikuchi Naoki Konno Yuichi Waragai Hiroyuki Asama Mika Takasumi Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
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