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| 1 | Gastric adenocarcinoma of the fundic gland(chief cell-predominant type): A review of endoscopic and clinicopathological features显示文摘Gastric adenocarcinoma of the fundic gland(chief cellpredominant type, GA-FG-CCP) is a rare variant of welldifferentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis. | Masaki Miyazawa Mitsuru Matsuda Masaaki Yano Yasumasa Hara Fumitaka Arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda | 2016 | World Journal of Gastroenterology2016，22，48： | 26 |
| 2 | 基于特征点矢量与纹理形变能量参数融合的人脸表情识别显示文摘人脸表情识别是人机交互领域的研究热点和难点之一。为了有效去除由于个体差异而造成的表情特征的差异,该文首先基于特征点矢量提出特征点距离比例系数;其后,又给出纹理形变能量参数的概念;最后,将二者融合用于人脸表情识别。所提方法在Cohn-Kanade数据库及BHU人脸表情数据库进行了测试,实验结果表明该方法较传统的方法在识别率上分别提高了4.5%与3.9%。 | 易积政 毛峡 Ishizuka Mitsuru 薛雨丽 | 2013 | 电子与信息学报2013，35，10： | 23 |
| 3 | Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial显示文摘 | Ilfet Songun Hein Putter Elma Meershoek-Klein Kranenbarg Mitsuru Sasako Cornelis JH van de Velde | 2010 | Lancet Oncology2010，，5： | 20 |
| 4 | Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?显示文摘Helicobacter pylori(H. pylori) antimicrobial resistance is an urgent, global issue. In2017, the World Health Organization designated clarithromycin-resistant H.pylori as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of H.pylori infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion. | Sho Suzuki Mitsuru Esaki Chika Kusano Hisatomo Ikehara Takuji Gotoda | 2019 | World Journal of Gastroenterology2019，25，16： | 17 |
| 5 | Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection显示文摘Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was proposed.We treated five cases of GA-FG with endoscopic submucosal dissection.All tumors were small and located in the upper third of the stomach.Four tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱb.Narrow-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the remainder.All tumors arose from the deep layer of the lamina propria mucosae and showed submucosal invasion.Lymphatic invasion was seen only in one case,while no venous invasion was recognized.All tumors were positive for pepsinogen-Ⅰ and MUC6 by immunohistochemistry.None showed p53 overexpression,and the labeling index of Ki-67 was low in all cases.All cases have been free from recurrence or metastasis.Herein,we discussed the clinicopathological features of GA-FG in comparison with past reports. | Masaki Miyazawa Mitsuru Matsuda Masaaki Yano Yasumasa Hara Fumitaka Arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda | 2015 | World Journal of Gastroenterology2015，21，26： | 16 |
| 6 | Pancreatic stents for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis should be inserted up to the pancreatic body or tail显示文摘AIM To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We dividedthese patients into two groups: 131 patients with a stent inserted into the pancreatic head(head group) and 16 patients with a stent inserted up to the pancreatic body or tail(body/tail group). Patient characteristics and ERCP factors were compared between the groups.RESULTS Pancreatic amylase isoenzyme(p-AMY) levels in the head group were significantly higher than those in the body/tail group [138.5(7.0-2086) vs 78.5(5.0-1266.5), P = 0.03] [median(range)]. No cases of PEP were detected in the body/tail group [head group, 12(9.2%)]. Of the risk factors for post-ERCP hyperamylasemia(≥ p-AMY median, 131 IU/L), procedure time ≥ 60 min [odds ratio(OR) 2.65, 95%CI: 1.17-6.02, P = 0.02) and stent insertion into the pancreatic head(OR 3.80, 95%CI: 1.12-12.9, P = 0.03) were identified as independent risk factors by multivariate analysis.CONCLUSION Stent insertion up to the pancreatic body or tail reduces the risk of post-ERCP hyperamylasemia and may reduce the risk of PEP. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，22： | 13 |
| 7 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 8 | 聚N-异丙基丙烯酰胺-丙烯酸共聚微凝胶与Tb(Ⅲ)相互作用的研究显示文摘 | 肖雨亭 陈明清 陆天虹 MITSURU Akashi 黄晓华 | 2005 | 高分子学报2005，15，3： | 10 |
| 9 | Tb(Ⅲ)与PNIPAM接枝核壳纳米微球相互作用的研究显示文摘利用透射电镜、X射线光电子能谱、动态激光光散射和荧光光谱技术对Tb(Ⅲ)与聚N-异丙基丙烯酰胺(PNIPAM)接枝核壳纳米微球PNIPAM-g-P(NIPAM-co-St)(PNNS)的相互作用进行了研究.结果表明:Tb(Ⅲ)和热敏性的核壳纳米微球PNNS有显著的相互作用.其一,Tb(Ⅲ)可与PNNS中酰胺基团上的氧原子配位形成微球配合物Tb(Ⅲ)-PNNS;其二,Tb(Ⅲ)-PNNS微球配合物兼具热敏性;其三,该配合物在545nm处的荧光强度较Tb(Ⅲ)增大了233倍,Tb(Ⅲ)与PNNS分子间能量传递达到50%,当Tb(Ⅲ)质量分数为12%时荧光强度最大. | 殷伟庆 陈明清 陆天虹 MITSURU Akashi 黄晓华 | 2006 | 化学学报2006，64，20： | 9 |
| 10 | Index-based assessment of agricultural drought in a semi-arid region of Inner Mongolia, China显示文摘Agricultural drought is a type of natural disaster that seriously impacts food security.Because the relationships among short-term rainfall,soil moisture,and crop growth are complex,accurate identification of a drought situation is difficult.In this study,using a conceptual model based on the relationship between water deficit and crop yield reduction,we evaluated the drought process in a typical rainfed agricultural region,Hailar county in Inner Mongolia autonomous region,China.To quantify drought,we used the precipitation-based Standardized Precipitation Index(SPI),the soil moisture-based Crop Moisture Index(CMI),as well as the Normalized Difference Vegetation Index(NDVI).Correlation analysis was conducted to examine the relationships between dekad-scale drought indices during the growing season(May–September)and final yield,according to data collection from 2000 to 2010.The results show that crop yield has positive relationships with CMI from mid-June to mid-July and with the NDVI anomaly throughout July,but no correlation with SPI.Further analysis of the relationship between the two drought indices shows that the NDVI anomaly responds to CMI with a lag of 1 dekad,particularly in July.To examine the feasibility of employing these indices for monitoring the drought process at a dekad time scale,a detailed drought assessment was carried out for selected drought years.The results confirm that the soil moisture-based vegetation indices in the late vegetative to early reproductive growth stages can be used to detect agricultural drought in the study area.Therefore,the framework of the conceptual model developed for drought monitoring can be employed to support drought mitigation in the rainfed agricultural region of Northern China. | Rui LI Atsushi TSUNEKAWA Mitsuru TSUBO | 2014 | Journal of Arid Land2014，6，1： | 8 |
| 11 | Laparoscopic approach to suspected T1 and T2 gallbladder carcinoma显示文摘AIM To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer(GBC).METHODS We performed 50 cases of laparoscopic whole-layer cholecystectomy(LCWL) and 13 cases of laparoscopic gallbladder bed resection(LCGB) for those gallbladder lesions from April 2010 to November 2016. We analyzed the short-term and long-term results of our laparoscopic approach. RESULTS The median operation time was 108 min for LCWL and 211 min for LCGB. The median blood loss was minimal for LCWL and 28 ml for LCGB. No severe morbidity occurred in either procedure. Nine patients who underwent LCWL and 7 who underwent LCGB were postoperatively diagnosed with GBC. One of these patients had undergone LCGB for pathologically diagnosed T2 GBC after LCWL. All of the final surgical margins were negative. Three of these 15 patients underwent additional open surgery. The mean follow-up period was 26 mo, and only one patient developed recurrence.CONCLUSION LCWL and LCGB are safe and useful procedures that allow complete resection of highly suspected or earlystage cancer and achieve good short-term and longterm results. | Yusuke Ome Kazuki Hashida Mitsuru Yokota Yoshio Nagahisa Michio Okabe Kazuyuki Kawamoto | 2017 | World Journal of Gastroenterology2017，23，14： | 8 |
| 12 | Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering (SERS) and basic applications of SERS biological sensing显示文摘我们考察最近我们在有试图识别使用的改进和眨眼的机制的实验上的强调的散布的提高表面的拉曼(重量的单位) 的基本学习的结果挑选 nanoparticle dimers 依附染分子的 Ag。这些结果是在电磁的机制的框架讨论的份量上。我们也考察最近我们在为在单个房间和单个分子下面的关于房间表面分子和疾病标记分子的区别的察觉的生物察觉到的基本重量的单位应用的结果铺平。 | Yuko S. Yamamoto Mitsuru Ishikawa Yukihiro Ozaki Tamitake Itoh | 2014 | Frontiers of physics2014，9，1： | 8 |
| 13 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 14 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 8 |
| 15 | Endoscopic diagnosis and treatment of superficial nonampullary duodenal tumors显示文摘The diagnostic and treatment guidelines of superficial non-ampullary duodenal tumors have not been standardized due to their low prevalence.Previous reports suggested that a superficial adenocarcinoma(SAC) should be treated via local resection because of its low risk of lymph node metastasis,whereas a highgrade adenoma(HGA) should be resected because of its high risk of progression to adenocarcinoma.Therefore,pretreatment diagnosis of SAC or HGA is important to determine the appropriate treatment strategy.There are certain endoscopic features known to be associated with SAC or HGA,and current practice prioritizes the endoscopic and biopsy diagnosis of these conditions.Surgical treatment of these duodenal lesions is often related to high risk of morbidity,and therefore endoscopic resection has become increasingly common in recent years.Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) are the commonly performed endoscopic resection methods.EMR is preferred due to its lower risk of adverse events;however,it has a higher risk of recurrence than ESD.Recently,a new and safer endoscopic procedure that reduces adverse events from EMR or ESD has been reported. | Mitsuru Esaki Sho Suzuki Hisatomo Ikehara Chika Kusano Takuji Gotoda | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 16 | Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers显示文摘 | Takuji Gotoda Akio Yanagisawa Mitsuru Sasako Hiroyuki Ono Yukihiro Nakanishi Tadakazu Shimoda Yo Kato | 2000 | Gastric Cancer2000，，4： | 7 |
| 17 | Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading显示文摘AIM: To evaluate the efficacy of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) for grading pancreatic neuroendocrine tumors(PNETs).METHODS: A total of 22 patients were diagnosed with PNET by EUS-FNA between October 2001 and December 2013 at Fukushima Medical University Hospital.Among these cases,we targeted 10 PNET patients who were evaluated according to the World Health Organization(WHO) 2010 classification.Surgery was performed in eight patients,and chemotherapy was performed in two patients due to multiple liver metastases.Specimens obtained by EUS-FNA were first stained with hematoxylin and eosin and then stained with chromogranin,synaptophysin,CD56,and Ki-67.The specimens were graded by the Ki-67 index according to the WHO 2010 classification.Specimens obtained by surgery were graded by the Ki-67 indexand mitotic count(WHO 2010 classification).For the eight specimens obtained by EUS-FNA,the Ki-67 index results were compared with those obtained by surgery.In the two cases treated with chemotherapy,the effects and prognoses were evaluated.RESULTS: The sampling rate for histological diagnosis by EUS-FNA was 100%.No adverse effects were observed.The concordance rate between specimens obtained by EUS-FNA and surgery was 87.5%(7/8).Fo r t h e t w o c a s e s t re a t e d w i t h c h e m o t h e ra p y,case 1 received somatostatin analog therapy and transcatheter arterial infusion(TAI) targeting multiple liver metastases.Subsequent treatment consisted of everolimus.During chemotherapy,the primary tumor remained unconfirmed,although the multiple liver metastases diminished dramatically.Case 2 was classified as neuroendocrine carcinoma(NEC) according to the Ki-67 index of a specimen obtained by EUS-FNA; therefore,cisplatin and irinotecan therapy was started.However,severe adverse effects,including renal failure and diarrhea,were observed,and the therapy regimen was changed to cisplatin and etoposide.TAI targeting multiple liver metastases was performed.Although the liver metastases diminished,the primary tumor remained unconfirmed.These chemotherapy regimens had immediate effects for both unresectable neuroendocrine tumor(NET) and NEC cases.These two subjects are still alive.CONCLUSION: EUS-FNA was effective for PNET diagnosis and Ki-67 index grading for WHO 2010 classification,enabling informed decisions on unresectable PNET treatment by identifying NET or NEC. | Mitsuru Sugimoto Tadayuki Takagi Takuto Hikichi Rei Suzuki Ko Watanabe Jun Nakamura Hitomi Kikuchi Naoki Konno Yuichi Waragai Hiroyuki Asama Mika Takasumi Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 18 | Patterns of plant diversity at high altitudes on the Qinghai-Tibetan Plateau显示文摘To describe the biodiversity patterns of plants along an altitudinal gradient on the Qinghai-Tibetan Plateau and to clarify the bias in plant specimen records at high altitude.Methods We conducted a large-scale investigation of vegetation at a wide range of altitudes,focusing on a high-altitudinal range(3200-5200 m)at different locations on the Qinghai-Tibetan Plateau.We then compared the altitudinal distribution of plant species obtained from our field investigation with that in plant specimen records from published sources and an online database.Important Findings Our data provide evidence that altitude plays a large role in regulating species composition on the Qinghai-Tibetan Plateau.We could not,however,detect a clear relationship between altitude and species richness,although a weak monotonically increasing trend of richness was detected with increasing altitude.According to specimen records,most species have been sampled at a wide range of altitudes,and the average range of 145 species is>2000 m.Despite this wide range,more than half of the species we observed were at higher altitudes than the specimen records indicate.High-altitude areas have probably been so poorly sampled that only a small fraction of the resident species has been recorded.This study clearly shows the regional bias of specimen records in the Qinghai-Tibetan Plateau. | Ayako Shimono Huakun Zhou Haihua Shen Mitsuru Hirota Toshiyuki Ohtsuka Yanhong Tang | 2010 | Journal of Plant Ecology2010，3，1： | 6 |
| 19 | Dynamics and hotspots of soil erosion and management scenarios of the Central Rift Valley of Ethiopia显示文摘大多数在埃塞俄比亚的中央裂缝山谷的低地干旱或半干旱并且在降级,与干旱的经常的出现。土壤侵蚀走水路在雨季期间是在这个区域的一个严重问题,导致为水身体的衰退农业生产,减少的食物安全,和沉积风险。然而,没有这个问题或可能的管理答案的系统的学习。满足这需要,我们分析了侵蚀从 1973 ~ 2006 评估的土壤,识别侵蚀热点,和建议可能的土壤保存情形。我们用通用土壤损失方程和地理信息系统软件估计了土壤损失 dynamicity,就在下列三个时期的陆地使用变化而言:1973, 1985 和 2006。我们以识别热点的侵蚀严厉,地形学,和陆地使用描绘了分水岭并且求婚,当模特儿,并且评估了各种各样的分水岭管理情形减轻这个问题。分别地,土壤侵蚀由于植被降级并且特别地从 1973 ~ 2006 显著地增加了,与在 1973, 1985,和 2006 的 31, 38,和 56 t ha1 的年度率几千公顷进农田的森林或树林的变换。观察土壤侵蚀率远离这个国家的土壤损失的可容忍的率并且因此要求迫切土壤保存干预,特别在热点区域。我们建议为减少的八种情形玷污损失并且评估了他们的有效性。恢复降级的土地(使用的 exclosures 和种的植被) 和在农田的安装石头侵蚀控制结构(石头东亚各国之堤岸) 分别地在 12.6% 和 63.8% 减少了全部的土壤损失。由综合管理(侵蚀控制结构和 exclosures ) 与超过 20 t ha1 的年度土壤损失对待热点区域是最有效的途径,减少在 87.8% 的土壤损失。 | Derege Tsegaye MESHESHA Atsushi TSUNEKAWA Mitsuru TSUBO Nigussie HAREGEWEYN | 2012 | International Journal of Sediment Research2012，27，1： | 6 |
| 20 | Expression of Angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannoma显示文摘AIM: To investigate the role of angiopoietin (Ang) -1, -2 and -4 and its receptors, Tie-1 and -2, in the growth and differentiation of gastrointestinal stromal tumors (GISTs).METHODS: Thirty GISTs, seventeen leiomyomas and six schwannomas were examined by immunohistochemistry in this study.RESULTS: Ang-1, -2 and -4 proteins were expressed in the cytoplasm of tumor cells, and Tie-1 and -2 were expressed both in the cytoplasm and on the membrane of all tumors. Immunohistochemical staining revealed that 66.7% of GISTs (20 of 30), 76.5% of leiomyomas (13 of 17) and 83.3% of schwannomas (5 of 6) were positive for Ang-1. 83.3% of GISTs (25 of 30), 82.4% of leiomyomas (14 of 17) and 100% of schwannomas (6 of 6) were positive for Ang-2. 36.7% of GISTs (11 of 30), 58.8% of leiomyomas (10 of 17) and 83.3% of schwannomas (5 of 6) were positive for Ang-4. 60.0% of GISTs (18 of 30), 82.4% of leiomyomas and 100% of schwannomas (6 of 6) were positive for Tie-1. 10.0% of GISTs (3 of 30), 94.1% of leiomyomas (16 of 17) and 33.3% of schwannomas (2 of 6) were positive for Tie-2. Tie-2 expression was statistically different between GISTs and leiomyomas (P < 0.001). However, there was no correlation between expression of angiopoietin pathway components and clinical risk categories.CONCLUSION: Our results suggest that the angiopoietin pathway plays an important role in the differentiation of GISTs, leiomyomas and schwannomas. | Toshiyuki Nakayama Maki Inaba Shinji Naito Yumi Mihara Shiro Miura Mitsuru Taba Ayumi Yoshizaki Chun-Yang Wen Ichiro Sekine | 2007 | World Journal of Gastroenterology2007，13，33： | 6 |
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