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| 1 | 在子宫癌病人联合应用FDG-PET和增强CT成像对检出盆腔与主动脉旁淋巴结转移的准确性显示文摘本研究的目的是以外科手术和组织病理为标准,评估联合应用18FFDG—PET/增强CT成像对检出子宫癌病人盆腔与主动脉旁淋巴结转移的准确性。45例子宫内膜癌或宫颈癌的病人行PET/CT检查后,行子宫根治术,包括盆腔淋巴结清扫伴或不伴主动脉旁淋巴结切除。PET/CT表现由2位有经验的放射医生解释,并达成一致意见。在PET/CT影像上.以淋巴结示踪剂摄取的增加而非淋巴结的大小作为判断恶性标准。以淋巴结为单位,PET/CT检测淋巴结转移的总体敏感度、 | K. Kitajima K. Murakami E. Yamasaki Y. Kaji K. Sugimura 杨秀娟(译) 刘筠(校) | 2009 | 国际医学放射学杂志2009，32，4： | 17 |
| 2 | Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer显示文摘AIM: To investigate diffusion-weighted imaging (DWI) and positron emission tomography and computed tomography (PET/CT) with Ⅳ contrast for the preoperative evaluation of pelvic lymph node (LN) metastasis in uterine cancer. METHODS: Twenty-five patients with endometrial or cervical cancer who underwent both DWI and PET/CT before pelvic lymphadenectomy were included in this study. For area specific analysis, LNs were divided into eight regions: both common iliac, external iliac, internal iliac areas, and obturator areas. The classification for malignancy on DWI was a focally abnormal signal intensity in a location that corresponded to the LN chains on the T1WI and T2WI. The criterion for malignancy on PET/CT images was increased tracer uptake by the LN.RESULTS: A total of 36 pathologically positive LN areas were found in 9 patients. With DWI, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detecting metastatic LNs on an LN area-by-area analysis were 83.3%, 51.2%, 27.3%, 93.3% and 57.0%, respectively, while the corresponding values for PET/CT were 38.9%, 96.3%, 70.0%, 87.8% and 86.0%. Differences in sensitivity, specificity and accuracy were significant (P < 0.0005). CONCLUSION: DWI showed higher sensitivity and lower specificity than PET/CT. Neither DWI nor PET/CT were sufficiently accurate to replace lymphadenectomy. | Kazuhiro Kitajima Erena Yamasaki Yasushi Kaji Koji Murakami Kazuro Sugimura | 2012 | World Journal of Radiology2012，4，5： | 16 |
| 3 | CYP2E1、GSTT1、GSTM1基因型与食管癌关系显示文摘[目的]研究CYP2E1RsaⅠ、GSTT1、GSTM1基因多态性和烟酒茶嗜好及其相互作用与食管癌易感性的关系。[方法]在食管癌高发区淮安市进行了一个病例对照研究(食管癌144例 ,人群对照233例) ,调查研究对象的烟酒茶嗜好习惯 ,以PCR扩增、RsaⅠ内切酶消化 ,分析CYP2E1的基因型 ,以多重PCR方法分析GSTT1、GSTM1基因型。[结果](1)对照组GSTM1基因型频度及饮茶状况分布与食管癌组之间存在显著差异 ,携带GSTM1正常基因型或有饮茶习惯者发生食管癌的危险性显著降低。(2)在不同烟酒茶嗜好者中 ,CYP2E1、GSTT1和GSTM1基因型对食管癌发生的影响有所不同。[结论](1)携带GSTM1正常基因型或饮茶能降低食管癌发生的危险性。(2) | 高长明 Takezaki Toshiro Sugimura Haruhiko 吴建中 丁建华 刘燕婷 李苏平 苏平 李忠佑 王建东 胡旭 徐天亮 Tajima Kazuo | 2001 | 中国肿瘤2001，10，6： | 12 |
| 4 | 8-羟基鸟嘌呤糖苷酶基因型、生活习惯与食管癌和胃癌显示文摘[目的]研究8 羟基鸟嘌呤糖苷酶基因 (hOGG1)型、生活习惯及其相互作用与食管癌、胃癌易感性的关系。[方法]在上消化道癌高发区淮安市进行了一个病例—对照研究(食管癌93例,胃癌107例 ,人群对照200例),调查研究对象的生活习惯 ,以PCR SSCP方法分析hOGG1基因型。[结果]对照组与食管癌组、胃癌组之间的hOGG1基因型频度分布差异无显著意义。在携带hOGG1Ser326Cys或Cys326Cys基因型者中 ,吸烟显著增加食管癌、胃癌发生的危险性。饮茶习惯能降低食管癌、胃癌发生的危险性 ,这种作用在hOGG1Ser326Ser基因型携带者中更明显。[结论]在不同hOGG1基因型携带者中 ,生活习惯与食管癌、胃癌发生的关系有所不同。这些结果表明 ,食管癌、胃癌的发生与生活习惯、hOGG1基因型以及它们的相互作用有关。 | 高长明 Sugimura Haruhiko Takezaki Toshiro 吴建中 李忠佑 丁建华 刘燕婷 李苏平 苏平 胡旭 徐天亮 Tajima Kazuo | 2001 | 中国肿瘤2001，10，9： | 11 |
| 5 | 血浆亲环蛋白A水平对冠状动脉疾病患者预后的影响显示文摘氧化应激状态下,血管平滑肌细胞、炎症细胞分泌亲环蛋白A(cyclophilin A,CyPA),并激活血小板功能。最近研究表明,血浆CyPA水平是诊断冠状动脉疾病的新型生物标志物。血浆CyPA水平对这些患者的预后是否有影响仍未阐明。方法:连续纳入接受诊断性冠状动脉造影的患者511例,测定血浆CyPA水平、高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)和血浆脑钠尿肽水平, | Ohtsuki T Satoh K Omura J Kikuchi N Satoh T Kurosawa R Nogi M Sunamura S Yaoita N Aoki T Tatebe S Sugimura K Takahashi J Miyata S Shimokawa H 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 9 |
| 6 | CYP2E1 RsaⅠpolymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking显示文摘AIM: To investigate associations between the RsaⅠ polymorphism of CYP2E1 and risk of colorectal cancer. METHODS: A case-control study was conducted with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa Ⅰ. Information on smoking and alcohol drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. RESULTS: The proportional distribution of the CYP2E1 RsaⅠc1/c1, c1/c2 and c2/c2 genotypes were 61.4%, 35.6% and 3.0% in controls, 60.6%, 33.7% and 5.8% in colon cancer cases, and 58.4%, 34.0% and 7.7% in rectal cancer cases, respectively. A significant difference was noted between controls and rectal cancer cases (P = 0.029), the c2/c2 genotype being associated with elevated OR (adjusted age, sex and status of the smoking and alcohol drinking) for rectal cancer (1.64, 95% CI, 1.12-2.41, vs c1 allele carriers), but not for colon cancer. In interaction analysis between the CYP2E1 RsaⅠgenotype and smoking and drinking habits, we found a significant cooperative action between the c2/c2 genotype and alcohol drinking in the sex-, age-adjusted ORs for both colon (4.74, 95% CI, 1.10-20.40) and rectal (5.75, 95% CI, 1.65-20.05) cancers. Among nonsmokers, the CYP2E1 RsaⅠc2/c2 genotype was also associated with elevated ORs in the two sites (1.95, 95% CI, 0.99-3.86 and 2.30, 95% CI, 1.32-3.99). CONCLUSION: The results of the present study suggest that the CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general. | Chang-Ming Gao Toshiro Takezaki Jian-Zhong Wu Min-Bin Chen Yan-Ting Liu Jian-Hua Ding Haruhiko Sugimura Jia Cao Nobuyuki Hamajima Kazuo Tajima | 2007 | World Journal of Gastroenterology2007，13，43： | 9 |
| 7 | Single skip metastasis in sentinel lymph node: In an early gastric cancer显示文摘Lymph node status is considered a key prognostic and predictive factor in patients with gastric cancer(GC).Although there is a practical approach to the intraoperative detection of sentinel lymph nodes(SLNs),such a procedure is not included in the European surgical protocol.In this report,we present a practical approach to SLN mapping in a representative case with early gastric cancer(EGC).A 74-year-old female was hospitalized with an endoscopically observed,superficially ulcerated tumor located in the antral region.Subtotal gastrectomy with D2 lymphadenectomy and SLN mapping was performed by injecting methylene blue dye into the peritumoral submucosal layer.An incidentally detected blue-stained lymph node located along the middle colic artery was also removed.This was detected 40 min after injection of the methylene blue.Histopathologic examination showed a p T1b-staged well-differentiated HER-2-negative adenocarcinoma.All of the 41 LNs located at the first,third,and fifth station of the regional LN compartments were found to be free of tumor cells.The only lymph node with metastasis was located along the middle colicartery and was considered a non-regional lymph node.This incidentally identified skip metastasis indicated stage Ⅳ GC.A classic chemotherapy regimen was given,and no recurrences were observed six months after surgery.In this representative case,low-cost SLN mapping,with a longer intraoperative waiting time,totally changed the stage of the tumor in a patient with EGC. | Tivadar Jr Bara Simona Gurzu Ioan Jung Zoltan Kadar Haruhiko Sugimura Tivadar Bara | 2015 | World Journal of Gastroenterology2015，21，33： | 8 |
| 8 | SSJD14101300023292显示文摘 | Shinya Sugimoto Hidetaka Yamada Masazumi Takahashi Yuichi Morohoshi Naotaka Yamaguchi Yuya Tsunoda Hiroyuki Hayashi Haruhiko Sugimura Hirokazu Komatsu | 2014 | Gastric Cancer2014，，4： | 4 |
| 9 | Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma显示文摘 | Kazunari Yamada Kenta Izaki Koji Sugimoto Hiroshi Mayahara Yoshitaka Morita Eisaku Yoden Shinichi Matsumoto Toshinori Soejima Kazuro Sugimura | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，1： | 3 |
| 10 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 11 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 12 | Circulating miR-200c Levels Significantly Predict Response to Chemotherapy and Prognosis of Patients Undergoing Neoadjuvant Chemotherapy for Esophageal Cancer显示文摘 | Koji Tanaka Hiroshi Miyata Makoto Yamasaki Keijiro Sugimura Tsuyoshi Takahashi Yukinori Kurokawa Kiyokazu Nakajima Shuji Takiguchi Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
| 13 | Tribological properties of α-C : N and α-C films prepared by shielded arc ion plating 显示文摘 | Tajima N Saze H Sugimura H | 2000 | Vacuum2000，59，： | 1 |
| 14 | Genetic and epigenetic alterations in carcinogenesis 显示文摘 | Ushijima T | 2000 | Mutation Res2000，462，2： | 1 |
| 15 | Meehanical response of single-layer tetrahe- dral trusses under shear loading显示文摘 | Yuki Sugimura | 2004 | Mechan Mater2004，36，8： | 1 |
| 16 | Early metaphase Ⅱ oocytes treated with dibutyryl cyclic adenosine monophosphate provide suitable recipient cytoplasm for the production of miniature pig somatic cell nucle- ar trmasfer embryos显示文摘 | SUGIMURA S AKAI T SOMFAI T | 2010 | Anita Sci J2010，81，1： | 1 |
| 17 | 显示文摘 | Sugi Y Tawada S Sugimura T | 1990 | Applied Catalysis A:General1990，189，： | 1 |
| 18 | Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion显示文摘 | ISHII K USUI S SUGIMURA Y | 2001 | Int J Cancer2001，92，1： | 1 |
| 19 | Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonasaeruginosa显示文摘 | Sugimura M Maseda H Hanaki H | | 0，，： | 1 |
| 20 | Transparent ultra water-repellent poly(ethylene terephthalate) substrates fabricated by oxygen plasma treatment and subsequent hydrophobic coating显示文摘 | Katsuya Teshima Hiroyuki Sugimura Yasushi Inoue Osamu Takai Atsushi Takano | 2004 | Applied Surface Science2004，，1： | 1 |
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