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| 1 | Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer显示文摘Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were investigated.After two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was performed.Formalin-fixed,paraffin-embedded sections were evaluated using immunohistochemistry.PCa with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as reference.Immunoreactively-positive cells were counted in at least three areas in cancer tissue.Labeling indices(LI)were calculated as percentage values.Results:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their biopsies.GT cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT cases.However,there was no significant difference in CD20-positive B cells among the types of case.There were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with GT.Conclusions:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy. | Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu Yoshiki Murakumo Shiro Baba Masatsugu Iwamura | 2021 | Asian Journal of Urology2021，8，3： | 1 |
| 2 | Possible underlying machanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury显示文摘 | Hideyasu Kiyomoto Kazi Rafiq | 2008 | J Pharmacol Sci2008，108，4： | 1 |
| 3 | Selective induction of neuropiln-1 by vascular endothelial growth factor显示文摘 | Hideyasu O Hitoshi T Atsushi O | 2002 | Proc Natl Acad Sci USA2002，99，1： | 1 |
| 4 | Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy显示文摘 | Atsushi Sakamoto Kazuaki Nishijima Mihori Kita Hideyasu Oh Akitaka Tsujikawa Nagahisa Yoshimura | 2009 | Graefe’s Archive for Clinical and Experimental Ophthalmology2009，，10： | 1 |
| 5 | Phosphatidylinositol 3-Kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvasculer endothelial cells by governing survivin expression and suppression of caspase-3 aetivity显示文摘 | Hirokazu O Hitoshi Hideyasu O | 2004 | Cire Res2004，94，6： | 1 |
| 6 | Interation among vitminc, vitamin E and B-carotenc显示文摘 | ETSUO N NORIKO N HIDEYASU T | 1995 | Am J Clin Nutr1995，，： | 1 |
| 7 | Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury显示文摘 | Hideyasu Kiyomoto Kazi Rafiq | 2008 | J Pharmacol Sci2008，108，： | 1 |
| 8 | Properties of containing Sn nanoparticles activated carbon fiber for a negative electrode in lithium batteries显示文摘 | MINATO EGASHIRA HIDEYASU TAKATSUJI SHIGE TO OKADA | 2002 | Journal of Power Sources2002，，107： | 1 |
| 9 | Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells显示文摘 | Kumiko Kaiful Hideyasu Kiyomotol Hirofumi Hitomil | 2009 | Nephrol Dial Transplant2009，24，： | 1 |
| 10 | Phosphatidylinositol-3 Kinase/ Akt regulates angiotension II induced inhibition of apoptosis in microvas- cular endothelial cells suppression of caspase-3 activit circ显示文摘 | Hirokazu O Hitoshi T Hideyasu O | 2012 | Antican- cer Res2012，94，： | 1 |
| 11 | Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients treated with chemoradiotherapy for bladder cancer显示文摘 | Shigeru Sakano Yuji Hinoda Miwa Sasaki Takashi Wada Hiroaki Matsumoto Satoshi Eguchi Asano Shinohara Yoshihisa Kawai Tomohiko Hara Kazuhiro Nagao Takahiko Hara Katsusuke Naito Hideyasu Matsuyama | 2010 | Pharmacogenomics2010，，10： | 1 |
| 12 | Stromal cell derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis显示文摘 | Hideyasu Sakihama Taro Masunaga Kenichiro Yamashita Taku Hashimoto Manabu Inobe Satoru Todo | 2004 | Circulation2004，110，： | 1 |
| 13 | Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma显示文摘 | Masahiro Shitani Shigeru Sasaki Noriyuki Akutsu Hideyasu Takagi Hiromu Suzuki Masanori Nojima Hiroyuki Yamamoto Takashi Tokino Koichi Hirata Kohzoh Imai Minoru Toyota Yasuhisa Shinomura | 2012 | Tumor Biology2012，，5： | 1 |
| 14 | White opaque substance represents an intracytoplasmic accumulation of lipid droplets: Immunohistochemical and immunoelectron microscopic investigation of 26 cases显示文摘 | Tetsuya Ueo Hirotoshi Yonemasu Naomi Yada Shinji Yano Tetsuya Ishida Masaki Urabe Ken Takahashi Hideyasu Nagamatsu Ryoichi Narita Kenshi Yao Tsutomu Daa Shigeo Yokoyama | 2012 | Digestive Endoscopy2012，，2： | 1 |
| 15 | In- creased energy absortion in ZnO arrester elements through control of electrode edge margin显示文摘 | Steven Boggs Jinbo Kuang Hideyasu Andoh Susumu | 2000 | IEEC Transaction on Power Delivery2000，15，2： | 1 |
| 16 | Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis显示文摘 | Hideyasu S Taro M Kenichiro Y Taku H Manabu I Satoru T | 2004 | Circulation2004，110，： | 1 |
| 17 | ERCC1 and XRCC1 expression predicts survival in bladder cancer patientsreceiving combined trimodality therapy显示文摘 | Shigeru Sakano Satoshi Ogawa Yoshiaki Yamamoto Jun Nishijima Yoshihiro Miyachika Hiroaki Matsumoto Takahiko Hara Hideyasu Matsuyama | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 18 | Phosphatidylinositol - 3 Kinase/Akt regulates angiotension Ⅱ induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase - 3 active circ显示文摘 | Hirokazu O HitoshiT Hideyasu O | 2004 | 94:7852004，94，： | 1 |
| 19 | A new bioabsorbable sleeve for stapleline reinforcement: report nf a clinical experience 显示文摘 | Yukihito S Hideyasu O | 2002 | Surgery Today2002，32，： | 1 |
| 20 | Total synthesis and revision of absolute configuration of antillatoxin, an ichthyotoxic cyclic lipopeptide of marine origin 显示文摘 | Fumiaki Y Hideyasu F Takayuki S | 1999 | Tetrahedron Lett1999，40，： | 1 |
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