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| 1 | Characteristics and prognosis of synchronous multiple early gastric cancer显示文摘AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative survival.Tumors were classified into groups on the basis of location and histology.Smoking habits were evaluated using the Brinkman index.Clinical and pathological factors were compared using either Fisher’s exact test or Pearson’sχ2test.Logistic regression analysis was performed to identify independent risk factors.Survival rate was calculated using the Kaplan-Meier method.RESULTS:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and drinkers.These tumors were typically macroscopically elevated and histologically differentiated.There were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant cancer.CONCLUSION:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases. | Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi Kazuo Shirouzu | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 2 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 3 | Status of colitis-associated cancer in ulcerative colitis显示文摘Surgical therapy for ulcerative colitis(UC) depends on the medical therapy administered for the patient's condition. UC is a benign disease. However, it has been reported that the rare cases of cancer in UC patients are increasing, and such cases have a worse prognosis. Recently, surgical therapy has greatly changed, there has been quite an increase in the number of UC patients with high-grade dysplasia and/or cancer. These lesions are known as colitis-associated cancer(CAC). The relationship between inflammation and tumorigenesis is well-established, and in the last decade, a great deal of supporting evidence has been obtained from genetic, pharmacological, and epidemiological studies. Inflammatory bowel disease, especially UC, is an important risk factor for the development of colon cancer. We should determine the risk factors for UC patients with cancer based on a large body of data, and we should attempt to prevent the increase in the number of such patients using these newly identified risk factors in the near future. Actively introducing the surgical treatment in addition to medical treatment should be considered. Several physicians should analyze UC from their unique perspectives in order to establish new clinically relevant diagnostic and treatment methods in the future. This article discusses CAC, including its etiology, mechanism, diagnosis, and treatment in UC patients. | Tetsushi Kinugasa Yoshito Akagi | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 11 |
| 4 | Surgically treated diaphragmatic perforation after radiofrequency ablation for hepatocellular carcinoma显示文摘We review 6 cases of diaphragmatic perforation, with and without herniation, treated in our institution. All patients with diaphragmatic perforation underwent radiofrequency ablation(RFA) treatments for hepatocellular carcinoma(HCC) performed at Kurume University Hospital and Tobata Kyoritsu Hospital. We investigated the clinical profiles of the 6 patients between January 2003 and December 2013. We further describe the clinical presentation, diagnosis, and treatment of diaphragmatic perforation. The change in the volume of liver and the change in the Child-Pugh score from just after the RFA to the onset of perforation was evaluated using a paired t-test. At the time of perforation, 4 patients had herniation of the viscera, while the other 2 patients had no herniation. The majority of ablated tumors were located adjacent to the diaphragm, in segments 4, 6, and 8. The average interval from RFA to the onset of perforation was 12.8 mo(range, 6-21 mo). The median Child-Pugh score at the onset of perforation(8.2) was significantly higher compared to the median Child-Pugh score just after RFA(6.5)(P = 0.031). All patients underwent laparotomy and direct suture of the diaphragm defect, with uneventful post-surgical recovery. Diaphragmatic perforation after RFA is not a matter that can be ignored. Clinicians should carefully address this complication by performing RFA for HCC adjacent to diaphragm. | Sachiko Nagasu Koji Okuda Ryoko Kuromatsu Yoriko Nomura Takuji Torimura Yoshito Akagi | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 3 |
| 5 | Vascular endothelial growth factor C(VEGF C)expression in human colorectal cancer tissues显示文摘 | Akagi K Ikeda Y Miyazaki M | | 0，，： | 3 |
| 6 | 土压盾构施工引起的土层应力-变形分析显示文摘为对土压盾构施工过程中土的应力-变形进行研究,利用大型有限元分析软件PLAXIS建立了关于土压盾构机在隧道开挖过程中对地表沉降的影响模型,并运用该模型对盾构过程中土层的应力状态和排水情况进行分析,并在此基础上通过考虑盾构机的推进速度、土的固结系数、隧道的覆土厚度和隧道断面4个因素,通过参数试验得出关于判断隧道开挖过程中土层排水情况的方程,并根据具体的隧道工程和地质条件进行数值模拟对方程进行验证。结果表明,地表沉降预测值与实测值吻合较好。 | 郑晨 李莹 Akagi Hirokazu | 2016 | 施工技术2016，45，17： | 3 |
| 7 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 8 | A study of active power filters using quad-series voltage-source PWM converters for harmonic compensation显示文摘 | Peng F Z Akagi H Nabae A | 1990 | IEEE Transactions on Power Electronics1990，5，1： | 2 |
| 9 | New trends in active filters for power conditioning显示文摘 | Akagi H | 1996 | IEEE Transactions on Industry Applications1996，32，6： | 2 |
| 10 | Control strategy and site selection of a shunt active filter for damping of harmonic propagation in power distribution systems显示文摘 | Akagi H | 1997 | IEEE Transactions on Power Delivery1997，12，1： | 2 |
| 11 | Microsatellite DNA markers for rice chromosomes 显示文摘 | Akagi H Yokozeki Y Inagaki A | 1996 | Theor Appl Genet1996，93，： | 2 |
| 12 | New trends in active filters for power conditioning显示文摘 | Akagi H | 1996 | IEEE Trans on Industry Applications1996，32，6： | 2 |
| 13 | New trends in active filters for power conditioning显示文摘 | Akagi H | 1996 | IEEE Trans Ind Appl1996，32，6： | 2 |
| 14 | Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites显示文摘 | Brian K. Zebrowski MD Wenbiao Liu MD Karen Ramirez BS Yoshito Akagi MD Gordon B. Mills MD Lee M. Ellis MD | 1999 | Annals of Surgical Oncology1999，，4： | 2 |
| 15 | A New Approach to Harmonic Compensation in Power Systems-A Combined System of Shunt Passive and Series Active Filters 显示文摘 | Fangzheng Peng Hirofumi Akagi Akira Nabae | 1990 | IEEE Transactions on Industry Application1990，，6： | 2 |
| 16 | Highly polymorphic microsatellites of rice consist of AT repeats, and a classification of closely related cultivars with these microsatellite loci 显示文摘 | AKAGI H YOKOZEKI Y INAGAKI A | 1997 | Theor Appl Genet1997，94，： | 1 |
| 17 | A practical approach to harmonic compensation in power systems-series connection of passive and active filters显示文摘 | Fujita H Akagi H | 1991 | IEEE Transactions on Industry Applications1991，27，6： | 1 |
| 18 | New trends in active filters for power conditioning 显示文摘 | Akagi H | 1996 | IEEE Trans on Industry Applications1996，32，6： | 1 |
| 19 | The p-q Theory in Three-phase Systems under Nonsinusoidal Conditions显示文摘 | AKAGI H NABAE A | 1993 | European Trans Electrical Power Engineering1993，3，1： | 1 |
| 20 | Instantaneous reactive power compensators comprising switching devices without energy storage components显示文摘 | AKAGI H KANAZAWA Y NABAE A | 1984 | IEEE Trans Ind Appl1984，20，3： | 1 |
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