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| 1 | Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition显示文摘瞄准:在肝细胞癌(HCC ) 的早阶段期间调查 survivin 的表示。方法:在肝肿瘤和从 17 个病人拿的非肿瘤织物标本的 survivin 的 Immunohistochemical 表示被比较。另外,在早阶段 HCC 响应反癌症药决定 survivin 表示, survivin 表示在 hypoxic 文化条件下面与反癌症药在 HCC 房间的治疗以后被决定。结果:Survivin 蛋白质在早 HCC 标本在 64.7% 房间被表示。在在 peritumoral hepatocytes 的 survivin 表示率和在 HCC 标本(低率的组对高率的组) 的表示的率之间的关联被观察。在 HCC 房间的 survivin 蛋白质集中被组织缺氧和反癌症药的联合增加。结论:这研究建议 survivin 能在早 HCC 被用作一个治疗学的目标。 | Satoshi Mamori Tadashi Asakura Kiyoshi Ohkawa Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，40： | 8 |
| 2 | Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs显示文摘AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. | Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi | 2005 | World Journal of Gastroenterology2005，11，44： | 8 |
| 3 | Recent research progress on mixed valence state tungsten based materials显示文摘Synthesis and characterization of tungsten based mixed valence state nanoparticles and their novel applications are reviewed.The mixed valence state tungsten based homogeneous nanomaterials such as bronze structure M_(x)WO_(3)(M=Na^(+),K^(+),Rb^(+),Cs^(+),NH_(4)^(+),etc.)and tungsten sub-oxide W_(18)O_(49) possess excellent infrared(IR)light shielding property,implying their great potential applications on heat ray shielding and indoor energy saving effect in summer season.Also,some novel properties such as electric conductivity,bio thermal therapy function and electrochromic properties of mixed valence state tungsten based materials are introduced.The design of components,formation of composites and structure control of thin films are expected to realize the property enhancement and candidates for practice application as window materials.The multifunc-tionality of the mixed valence state based composites also implies great potential on novel applications of various building materials. | Shu Yin Yusuke Asakura | 2019 | Tungsten2019，1，1： | 6 |
| 4 | Recent advances in basic and clinical aspects of inflammatory bowel disease: Which steps in the mucosal inflammation should we block for the treatment of inflammatory bowel disease?显示文摘在从煽动性的肠疾病(IBD ) 的基本、临床的方面的观点的遗传上预先安排的个人在在肠的微生物和粘膜发炎之间的相互作用有四步。第一步经由受体是在肠的微生物或他们的部件和肠的上皮细胞之间的一个相互作用,第二走在巨噬细胞和树枝状的房间和粘膜淋巴细胞之间的一个相互作用,第三走在淋巴细胞和脉管的 endothelial 之间的一个相互作用,并且第四走在生产专业版的淋巴细胞和 granulocytes 之间的一个相互作用煽动性的 cytokines 或自由基和粘膜损坏和修理。为 IBD 的最近的治疗学的途径试图与 IBD 在病人的肠的发炎堵住这四步。 | Hitoshi Asakura Kenji Suzuki Terasu Honma | 2007 | World Journal of Gastroenterology2007，13，15： | 5 |
| 5 | Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis显示文摘AIM To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis(UC). METHODS We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical activity of UC was assessed with the partial Mayo score(PMS). Relapse was defined as increase of PMS by 2 points or more in stool frequency or rectal bleeding subscore. The endoscopic and histologic activities of UC were evaluated in 50 patients within a 2-mo period from fecal sampling. Endoscopic activity was determined by Mayo endoscopic subscore, Rachmilewitz endoscopic index, and ulcerative colitis endoscopic index of severity. The histologic grade of inflammation was evaluated with biopsy specimens obtained from the endoscopically most severely inflamed site, according to the scheme by Matts grade and Riley's score.RESULTS Fecal calprotectin levels varied from 1-20783 μg/g. There was a significant correlation between the partial Mayo score and fecal calprotectin levels(r = 0.548, P < 0.001). In 50 patients who underwent colonoscopy with biopsy, levels were significantly correlated with the Mayo endoscopic subscore(r = 0.574, P < 0.001), Rachmilewitz endoscopic index(r = 0.628, P < 0.001), ulcerative colitis endoscopic index of severity(r = 0.613, P < 0.001), Riley's histologic score(r = 0.400, P = 0.006), and Matts grade(r = 0.586, P < 0.001). Receiver-operating characteristic analyses identified the best cut-off value for the prediction of endoscopic remission as 288 μg/g, with an area under the curve of 0.777 or 0.823, while that for histologic remission was 123 or 125 μg/g, with an AUC of 0.881 or 0918, respectively. Of the 131 study patients, 88 patients in clinical remission were followed up 6 mo. During the follow-up period, 19 patients relapsed. The best fecal calprotectin cut-off value for predicting relapse was 175 μg/g.CONCLUSION Fecal calprotectin is a predictive biomarker for endoscopic and histologic remission in Japanese patients with UC. | Jun Urushikubo Shunichi Yanai Shotaro Nakamura Keisuke Kawasaki Risaburo Akasaka Kunihiko Sato Yosuke Toya Kensuke Asakura Takahiro Gonai Tamotsu Sugai Takayuki Matsumoto | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 6 | 超细水泥的分散特性对悬浮薄浆可灌性的影响显示文摘以前人们认为悬浮薄浆很难灌入由细小料粒组成的地基中(例如 Mori等人,1991年),但是近年来,在日本随着市政建设的发展,增强改善这种类型地基的需求也日益增长。本文中作者对一些造成薄浆灌入困难的主要因素进行了研究,并提出了一些确保安全灌入的对策。 | 刘新菊 Etsuro ASAKURA | 1999 | 国外建材科技1999，20，1： | 2 |
| 7 | Continuous ethanol extration by pervaporation from a membrane bioreacter显示文摘 | Saito F Nakao S Asakura T Toda K | 1989 | Nittogiho1989，27，： | 2 |
| 8 | H elicobacter pylori outer membrane protein HopQ identified as a novel T4SS ‐associated virulence factor显示文摘 | Elena Belogolova Bianca Bauer Malvika Pompaiah Hiroshi Asakura Volker Brinkman Claudia Ertl Sina Bartfeld Taras Y. Nechitaylo Rainer Haas Nikolaus Machuy Nina Salama Yuri Churin Thomas F. Meyer | 2013 | Cell Microbiol2013，，11： | 2 |
| 9 | Mechanism of glucose oxidase immobilization with silk fibroin显示文摘 | ASAKURA T YOSHIMIZU H KAZUHARA A | 1988 | Nippin Sanshigaku Zasshi1988，57，3： | 2 |
| 10 | Immobilization of peroxidase with a bombyx mori silk fibroin membrane and its application to biophotosensors显示文摘 | DEMURA M ASAKURA T NAKAMURA E | 1989 | Biotechnol1989，10，2： | 2 |
| 11 | Mercury emissions from a coal-fired power plant in Japan显示文摘 | Yokoyama T Asakura K Matsuda H | 2000 | The Science of the Total Environment2000，259，13： | 1 |
| 12 | Lamrl functional retroposen causes right ventricular dysplasia in mice 显示文摘 | Asano Y Takashima S Asakura M | 2004 | Nat Genet2004，36，2： | 1 |
| 13 | Molecular and functional characterization of ERG,KCNQ,and KCNE subtypes in rat stomach smooth muscle显示文摘 | Ohya S Asakura K Muraki K | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，2： | 1 |
| 14 | Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation显示文摘 | Asakura A Komaki M Rudnicki M | 2001 | Differentiation2001，68，45： | 1 |
| 15 | Impact of adenosine receptor signaling and metabolism on pathophysiology in patients with chronic heart failure显示文摘 | Asakura M Asauuma H Kim J | 2007 | Hypertens Res2007，30，9： | 1 |
| 16 | Sensingcharacteristics of an optical fiber sensor for hyarogen leak显示文摘 | Okazaki S Nakagawa H Asakura S | 2003 | Sensors and Actuators B:Chemical2003，93，13： | 1 |
| 17 | Preinfaction angina as a major predictor of left ventricular function and long term prognosis after a first Q wave myocardiol infarction显示文摘 | Anzai T Yoshikawa T Asakura R | 1995 | J Am Coll Cardiol1995，28，： | 1 |
| 18 | Human atrial natriuretic peptide and nicorandil as adiuncts to reperfusion treatment for acute myocardial infarction (J-WIND) : two randomised trials显示文摘 | Kitakaze M Asakura M Kim J | 2007 | Lancet2007，370，9597： | 1 |
| 19 | Mycophenolate Mofetil Is Effective and Well Tolerated in the Treatment of Refractory Acute and Chronic Graft-versus-Host Disease显示文摘 | Akiyoshi Takami Kanako Mochizuki Hirokazu Okumura Hirohito Yamazaki Masahide Yamazaki Yukio Kondo Hidesaku Asakura Shinji Nakao Satsuki Ito Yukio Suga | 2006 | International Journal of Hematology2006，，1： | 1 |
| 20 | Evaluation of new Japa- nese diagnostic criteria for disseminated int ravascular coagulation in critically ill patients显示文摘 | Gando S Wada H Asakura H | 2005 | Clin Appl Thromb Hemost2005，11，1： | 1 |
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