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| 1 | Prospective postsurgical capsule endoscopy in patients with Crohn's disease显示文摘AIM: To clarify the usefulness of postsurgical capsule endoscopy(CE) in the diagnosis of recurrent small bowel lesions of Crohn's disease(CD). METHODS: This prospective study included 19 patients who underwent ileocolectomy or partial ileal resection for CD. CE was performed 2-3 wk after surgery to check for the presence/absence and severity of lesions remaining in the small bowel, and for any recurrence at the anastomosed area. CE was repeated 6-8 mo after surgery and the findings were compared with those obtained shortly after surgery. The Lewis score (LS) was used to evaluate any inflammatory changes of the small bowel. RESULTS: One patient was excluded from analysis because of insufficient endoscopy data at the initial CE. The total LS shortly after surgery was 428.3 on average(median, 174; range, 8-4264), and was ≥ 135(active stage) in 78%(14 of 18) of the patients. When the remaining unresected small bowel was divided into 3 equal portions according to the transition time(proximal, middle, and distal tertiles), the mean LS was 286.6, 83.0, and 146.7, respectively, without any significant difference. Ulcerous lesions in the anastomosed area were observed in 83% of all patients. In 38% of the 13 patients who could undergo CE again after 6-8 mo, the total LS was higher by ≥ 100 than that recorded shortly after surgery, thus indicating a diagnosis of endoscopic progressive recurrence. CONCLUSION: Our pilot study suggests that CE can be used to objectively evaluate the postoperative recurrence of small bowel lesions after surgery for CD. | Tomoaki Kono Nobuyuki Hida Koji Nogami Masaki Iimuro Yoshio Ohda Yoko Yokoyama Koji Kamikozuru Katsuyuki Tozawa Mikio Kawai Tomohiro Ogawa Kazutoshi Hori Hiroki Ikeuchi Hiroto Miwa Shiro Nakamura Takayuki Matsumoto | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 2 | Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis显示文摘AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. | Junmi Tanaka Hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 5 |
| 3 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 4 | Augmented reality: The use of the PicoLinker smart glasses improves wire insertion under fluoroscopy显示文摘AIM To demonstrate the feasibility of the wearable smart glasses, Pico Linker, in guide wire insertion under fluoroscopic guidance. METHODS Under a fluoroscope, a surgeon inserted 3 mm guide wires into plastic femurs from the lateral cortex to the femoral head center while the surgeon did or did not wear Pico Linker, which are wearable smart glasses where the fluoroscopic video was displayed(10 guide wires each). RESULTS The tip apex distance, radiation exposure time and total insertion time were significantly shorter while wearing the Pico Linker smart glasses. CONCLUSION This study indicated that the Pico Linker smart glasses can improve accuracy, reduce radiation exposure time, and reduce total insertion time. This is due to the fact that the Pico Linker smart glasses enable surgeons to keep their eyes on the operation field. | Takafumi Hiranaka Takaaki Fujishiro Yuichi Hida Yosaku Shibata Masanori Tsubosaka Yuta Nakanishi Kenjiro Okimura Harunobu Uemoto | 2017 | World Journal of Orthopedics2017，8，12： | 3 |
| 5 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 6 | Incidence and Prognostic Value of Early Repolarization Pattern in the 12-Lead Electrocardiogram显示文摘 | Daisuke Haruta Kiyotaka Matsuo Akira Tsuneto Shinichiro Ichimaru Ayumi Hida Nobuko Sera Misa Imaizumi Eiji Nakashima Koji Maemura Masazumi Akahoshi | 2011 | Circulation2011，，25： | 2 |
| 7 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 8 | Cyclooxygenase-2 inhibitor induces apoptosis,and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines显示文摘 | Kozaki K Muramatsu H | 2000 | Clin Cancer Res2000，6，： | 1 |
| 9 | Understanding tumor endothelial cell abnormalities to develop ideal anti-angiogenic therapies显示文摘 | Hida K Hida Y Shindoh M | 2008 | Cancer Sci2008，99，3： | 1 |
| 10 | Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers,specifically in adenocarcinomas 显示文摘 | Hida T Yatabe Y Achiwa H | 1998 | Cancer Res1998，58，： | 1 |
| 11 | Intraoperative measurements of nerve root blood flow during discectomy for lumbar disc herniation显示文摘 | Hida S Naito M Kubo M | 2003 | Spine2003，28，1： | 1 |
| 12 | Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum显示文摘 | Nishino G Hida H Takei N | 2000 | Exp Neurol2000，164，1： | 1 |
| 13 | Acid catalysis of silica-included heteropolyacid in polar reaction media显示文摘 | IZUMI Y HISANO K HIDA T | 1999 | Applied Catalysis A:General1999，181，： | 1 |
| 14 | Rab7 is a critical mediator in vesicular transport of tyrosinase-related protein 1 in melanocytes 显示文摘 | Hida T Sohma H Kokai Y | 2011 | Journal of Dermatology2011，38，5： | 1 |
| 15 | Syringosubarachnoid shunt for syringomyelia associated with Chiari I malformation 显示文摘 | Hida K Iwasaki Y | 2001 | Neurosurg Focus2001，11，1： | 1 |
| 16 | Peripheral bloods levels of matrix metalloproteinase-9 and-2 are elevated in parients with acute coronary syndromes显示文摘 | Hisashi Kai Hisao I koda Hida | 1998 | Am Coll Cardial1998，32，2： | 1 |
| 17 | Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway显示文摘 | Taguchi K Hida M Hasegawa M | 2016 | Mol Nutr Food Res2016，60，3： | 1 |
| 18 | Childhood idiopathic thrombocytopenic purpura associated with human parvovirus B19 infection显示文摘 | Hida M Shimamura Y Ueno E Watanabe J | 2000 | Pediatr Int2000，42，6： | 1 |
| 19 | Mesencephalic neural stem(progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum 显示文摘 | Nishino H Hida H Takei N | 2000 | Exp Neuro12000，164，1： | 1 |
| 20 | Indications for colonic J-pouch reconstruction after anterior resection for rectal cancer显示文摘 | Hida J Yasutomi M Maruyama T | 1998 | Dis Colon Rectum1998，41，5： | 1 |
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