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| 1 | 以肝脏为靶器官的基因治疗时重组腺病毒引起的急性肝炎显示文摘目的 研究腺病毒为载体的基因治疗时淋巴细胞在肝组织免疫反应中的作用,探讨免疫抑制疗法在腺病毒载体基因治疗中的可行性。 方法 取8只恒河猴,经不同路径输入携带大肠杆菌lacZ基因或荧火虫荧光素酶基因luc的重组腺病毒6只。其中4只进行免疫抑制治疗。将含lacZ的质粒DNA注入2只动物作为对照。用免疫组织化学法检测β2-MG、HLA-DR、CD3、CD4、CD8及CD20。 结果 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多。腺病毒载体和转基因均与肝损害有关, 表现为一过性, 呈轻、中度无黄疸性肝炎。免疫抑制的动物只要处于免疫抑制状态下就没有肝炎的表现,基因表达的时间延长。质粒介导的基因转导效果差, 无肝损害及免疫反应。所有动物B淋巴细胞抗原CD20始终阴性。 结论 腺病毒介导的基因治疗时肝脏的β2-MG、HLA-DR、CD3、CD4及CD8阳性细胞明显增多, 造成轻、中度一过性肝损害。使用免疫抑制药物可避免肝损害的发生并延长基因表达的时间。 | 鲁慧英 Deborah Sullivan Srikanta Dash Michael A Gerber | 2001 | 中华肝脏病杂志2001，9，5： | 3 |
| 2 | Regulation of Wnt/β-catenin signaling by herpesviruses显示文摘The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda. | Kevin J Zwezdaryk Joseph A Combs Cindy A Morris Deborah E Sullivan | 2016 | World Journal of Virology2016，5，4： | 2 |
| 3 | Blood Transfusion and Infection After Cardiac Surgery显示文摘 | Keith A. Horvath Michael A. Acker Helena Chang Emilia Bagiella Peter K. Smith Alexander Iribarne Irving L. Kron Pamela Lackner Michael Argenziano Deborah D. Ascheim Annetine C. Gelijns Robert E. Michler Danielle Van Patten John D. Puskas Karen O’Sullivan | 2013 | The Annals of Thoracic Surgery2013，，6： | 1 |
| 4 | The Role of MITF Phosphorylation Sites During Coat Color and Eye Development in Mice Analyzed by Bacterial Artificial Chromosome Transgene Rescue显示文摘 | Bauer Georg L Praetorius Christian Bergsteinsdóttir Kristín Hallsson Jón H Gísladóttir Bryndís K Schepsky Alexander Swing Deborah A O’Sullivan T Norene Arnheiter Heinz Bismuth Keren Debbache Julien Fletcher Colin Warming S?ren Copeland Neal | 2009 | Genetics2009，，2： | 1 |
| 5 | 以肝脏为靶器官的基因治疗时腺病毒引起的急性肝炎(英文)显示文摘目的 确定以肝脏为靶器官的基因治疗时急性肝炎的机制。方法 用HE法和免疫组织化学法对 8只恒河猴通过不同径路接受以腺病毒或Lipofectamine为载体的基因治疗时的免疫反应进行了研究。结果 经静脉或胆管注入除去E1,携带lacZ基因的腺病毒后 1至 3周发生了轻到中度急性肝炎。有病变的肝脏内CD3+,CD4 +和CD8+T细胞明显增多而B细胞缺如。肝细胞表面 β2 MG和HLA DR也增多。免疫抑制治疗使急性肝炎和伴随的免疫反应延迟。结论 腺病毒介导的基因治疗时肝脏的免疫反应是T细胞介导的 ,主要受I型MHC限制。腺病毒载体和转基因均与肝损害有关。肝脏损害呈轻、中度 ,是可逆的。免疫抑制药物可延迟免疫性肝损害的发生并延长基因表达的时间。 | 鲁慧英 Deborah Sullivan Michael A Gerbera Srikanta Dash | 2002 | Chinese Medical Journal2002，，5： | 1 |
| 6 | Integrin-linked kinase: A hypoxia-induced anti-apoptotic factor exploitedby cancer cells显示文摘 | Elizabeth Abboud Seth Coffelt Yanira Figueroa Kevin Zwezdaryk Anne Nelson Deborah Sullivan Cindy Morris Yan Tang Barbara Beckman Aline Scandurro | 2007 | International Journal of Oncology2007，，1： | 1 |
| 7 | Quality and safety education for advanced nursing practice显示文摘 | Linda Cronenwett Gwen Sherwood Joanne Pohl Jane Barnsteiner Shirley Moore Doff Taylor Sullivan Deborah Ward Judith Warren | 2009 | Nursing Outlook2009，，6： | 1 |
| 8 | Scripps Oceanography to Build Fleet of Data-Collecting Robotic Ocean Floats显示文摘A US$53 million federal grant will enable Scripps Institution of Oceanography and other organizations to build a fleet of robotic sensors to monitor conditions in oceans around the world.The robotic fleet will survey water from the surface to a depth of 2,000 meters.They will continuously collect data that scientists use to observe ocean ecosystems and monitor elemental cycles of carbon. | Deborah Sullivan Brennan | 2021 | 空中英语教室(中级版)2021，，4： | 0 |
| 9 | 科学家和渔民致力于拯救棱皮龟显示文摘美国西岸虽然实施了严格的保护措施,饺皮电在太平洋其他地区却依然面临危险,科学家和渔民住一场专为这种加州官方指定的海洋爬行动物而召集的研讨会上指出。这种动物的数量在20世纪80年代以来已减少了超过90%,它们现在被列为绝种风险最高的八种海洋生物之一,美国国家海洋和大气管理局的国家海洋渔业服务中心指出。 | Deborah Sullivan Brennan | 2017 | 空中英语教室(高级版.彭蒙惠英语)2017，0，11： | 0 |
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