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| 1 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease显示文摘 | Uma Mahadevan Douglas C. Wolf Marla Dubinsky Antoine Cortot Scott D. Lee Corey A. Siegel Thomas Ullman Sarah Glover John F. Valentine David T. Rubin Jocelyn Miller Maria T. Abreu | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 2 | DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease显示文摘During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. | Corey Dussold Claire Gerber Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin | 2019 | Bone Research2019，7，2： | 4 |
| 3 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 4 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 5 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | The Lancet . 2006 (9536)2006，，9536： | 2 |
| 6 | 内蒙古鄂尔多斯高原古冰缘遗迹科学考察研究进展显示文摘冰缘遗迹(特别是冷生楔形构造及融冻褶皱)是重建古气候及第四纪晚期多年冻土环境的重要证据。内蒙古鄂尔多斯高原是我国北方地区冰缘现象最为发育的地区之一。为准确了解鄂尔多斯高原冰缘遗迹类型及其分布特征、区域冻土演化历史等,中国科学院西北生态环境资源研究院和荷兰自由大学共同组成科研小组,于2018年5—6月组织了'鄂尔多斯高原冰缘遗迹科学考察'。考察区域涉及靖边—城川—乌审旗—鄂尔多斯东胜区一带约12000km2的范围。考察内容主要包括鄂尔多斯高原冰缘遗迹类型及特征、分布区域、各类型冰缘遗迹所指示的气候条件的初步推断等。结果表明:冻融褶皱和冷生楔体构造是鄂尔多斯高原主要存在的两大类冰缘遗迹。基于本次考察中关于冰缘遗迹的分布与特征等新发现,并综合前人研究成果,初步推断:在气温极低、多年冻土非常发育的时段,有利于形成各类冷生楔状构造,如冰楔假形和大型原生砂楔等;在气候转暖、多年冻土退化,但还没有全部融化完阶段,可能形成融冻褶皱;区域性大面积分布和成群出现的融冻褶皱一般反映较暖气候环境下,多年冻土层上部已退化到一定程度。基于光释光(OSL)年代测试结果,结合冰缘遗迹的特征及其所指示的古气候环境,初步重建了鄂尔多斯5万年以来的冻土环境变化序列。区内多年冻土在多年冻土最大期(LPM,25~19ka BP)时最发育,以大面积连续多年冻土为主;之后,随气温转暖,总趋势呈退化状态,多年冻土分布逐渐变为片状→岛状→零星斑状,直至现今全部融完变为深季节冻土区。 | 何瑞霞 金会军 蒋观利 张泽 陈雪梅 Raul David SERBAN Mihaela SERBAN Jef VANDENBERGHE Valentin V.SPEKTOR Hugh M.FRENCH | 2021 | 冰川冻土2021，43，1： | 2 |
| 7 | All hyped up and no place to go显示文摘 | David Bell Jon Binnie Julia Cream Gill Valentine | 1994 | Gender Place & Culture1994，，1： | 1 |
| 8 | Comparison of acquisition costs of surgical supplies in different health care systems for cataract and glaucomaprocedures显示文摘 | Jeremy Valentine David Zurakowski Ramesh S Ayyala | 2014 | J Glaucoma2014，23，6： | 1 |
| 9 | Biogeochemistry:trouble down the river显示文摘 | David Valentine | 2010 | Nature2010，465，： | 1 |
| 10 | Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS)显示文摘 | Helen M. Colhoun D. John Betteridge Paul N. Durrington Graham A. Hitman H. Andrew W. Neil Shona J. Livingstone Valentine Charlton-Menys David A. DeMicco John H. Fuller | 2009 | American Journal of Kidney Diseases2009，，5： | 1 |
| 11 | Natural gas and temperature structured a microbial community response to the Deepwater Horizon oil spill显示文摘 | Molly C Redmond David L Valentine | 2012 | PNAS2012，109，20： | 1 |
| 12 | Shyness, Sociability, and Parental Support for the College Transition: Relation to Adolescents’ Adjustment显示文摘 | Nina S. Mounts David P. Valentiner Katherine L. Anderson Michelle K. Boswell | 2006 | Journal of Youth and Adolescence2006，，1： | 1 |
| 13 | D/H ratios of fatty acids from marine particulate organic matter in the California Borderland Basins 显示文摘 | Ashley A Jones Alex L Sessions Brian J Campbell Li Chao David L Valentine | 2008 | Organic Geochemistry2008，39，5： | 1 |
| 14 | Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study显示文摘 | Koon K Teo Stephanie Ounpuu Steven Hawken MR Pandey Vicent Valentin David Hunt Rafael Diaz Wafa Rashed Rosario Freeman Lixin Jiang Xiaofei Zhang Salim Yusuf | 2006 | 2006 (9536)2006，，9536： | 1 |
| 15 | Hemodynamic and Neurohumoral Effects of Selective Endothelin A (ETA) Receptor Blockade in Chronic Heart Failure: The Heart Failure ETA Receptor Blockade Trial (HEAT)显示文摘 | Thomas F. Lüscher Frank Enseleit Richard Pacher Veselin Mitrovic Matthias R. Schulze Roland Willenbrock Rainer Dietz Valentin Rousson David Hürlimann Sebastian Philipp Thomas Notter Georg Noll Frank Ruschitzka | 2002 | Circulation: Journal of the American Heart Association2002，，： | 1 |
| 16 | ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | Valentin Fuster Lars E. Rydén David S. Cannom Harry J. Crijns Anne B. Curtis Kenneth A. Ellenbogen Jonathan L. Halperin Jean-Yves Le Heuzey G. Neal Kay James E. Lowe S. Bertil Olsson Eric N. Prystowsky Juan Luis Tamargo Samuel Wann | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 17 | ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee 显示文摘 | Valentin Fuster Lars E. Ryden Richard W. Asinger David S. Cannom Harry J. Crijns Robert L. Frye Jonathan L. Halperin G. Neal Kay Werner W. Klein Samuel Levy Robert L. McNamara Eric N. Prystowsky L. Samuel Wann D. George Wyse Raymond J. Gibbons Elliott M. | 2001 | Circulation: Journal of the American Heart Association2001，，17： | 1 |
| 18 | A review: Challenges and opportunities for artificial intelligence and robotics in the offshore wind sector显示文摘The UK has set plans to increase offshore wind capacity from 22GW to 154GW by 2030. With such tremendous growth, the sector is now looking to Robotics and Artificial Intelligence (RAI) in order to tackle lifecycle service barriers as to support sustainable and profitable offshore wind energy production. Today, RAI applications are predominately being used to support short term objectives in operation and maintenance. However, moving forward, RAI has the potential to play a critical role throughout the full lifecycle of offshore wind infrastructure, from surveying, planning, design, logistics, operational support, training and decommissioning. This paper presents one of the first systematic reviews of RAI for the offshore renewable energy sector. The state-of-the-art in RAI is analyzed with respect to offshore energy requirements, from both industry and academia, in terms of current and future requirements. Our review also includes a detailed evaluation of investment, regulation and skills development required to support the adoption of RAI. The key trends identified through a detailed analysis of patent and academic publication databases provide insights to barriers such as certification of autonomous platforms for safety compliance and reliability, the need for digital architectures for scalability in autonomous fleets, adaptive mission planning for resilient resident operations and optimization of human machine interaction for trusted partnerships between people and autonomous assistants. Our study concludes with identification of technological priorities and outlines their integration into a new ‘symbiotic digital architecture’ to deliver the future of offshore wind farm lifecycle management. | Daniel Mitchell Jamie Blanche Sam Harper Theodore Lim Ranjeetkumar Gupta Osama Zaki Wenshuo Tang Valentin Robu Simon Watson David Flynn | 2022 | Energy and AI2022，8，2： | 1 |
| 19 | Carbon and nitrogen dynamics in elk winter ranges显示文摘 | Romulo S C Menezes Edward T Elliott David W Valentine | 2001 | Journal of Range Management2001，54，4： | 1 |
| 20 | A persistent oxygen anomaly reveals the fate of spilled methane in the deep gulf of Mexico显示文摘 | Kessler John D Valentine David L Redmond Molly C | 2011 | Science2011，31，： | 1 |
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