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| 1 | Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection显示文摘AIM:To characterize the impact of the Pringle ma-neuver (PM) and ischemic preconditioning (IP) on total blood supply to the liver following hepatectomies. METHODS: Sixty one consecutive patients who un-derwent hepatic resection under in flow occlusion were randomized either to receive PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liver perfusion was measured by Doppler probes at the hepatic artery and portal vein at various time points after reperfusion of remnant livers. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal vein flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% vs baseline) was observed. In accordance with a better postischemic blood supply of the liver, hepatocellular injury, as measured by alanine aminotransferase (ALT) levels on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I vs 550 ± 650 U/I, P < 0.05). Additionally, ALT levels were significantly correlated to the hepatic artery in flow.CONCLUSION: IP prevents postischemic flow reduction of the portal vein and simultaneously increases arterial perfusion, suggesting that improved hepatic macrocirculation is a protective mechanism following hepatectomy. | Oleg Heizmann Georgios Meimarakis Andreas Volk Daniel Matz Daniel Oertli Rolf J Schauer | 2010 | World Journal of Gastroenterology2010，16，15： | 12 |
| 2 | Transplant benefit for patients with hepatocellular carcinoma显示文摘Although liver transplantation is theoretically the best treatment for hepatocellular carcinoma(HCC),it is limited by the realities of perioperative complications,and the shortage of donor organs.Furthermore,in many cases there are available alternative treatments such as resection or locoregional therapy.Deciding upon the best option for a patient with HCC is complicated,involving numerous ethical principles including:urgency,utility,intention-to-treat survival,transplant benefit,harm to candidates on waiting list,and harm to living donors.The potential contrast between different principles is particularly relevant for patients with HCC for several reasons:(1)HCC candidates to liver transplantation are increasing;(2)the great prognostic heterogeneity within the HCC population;(3)in HCC patients tumor progression before liver transplantation may significantly impair post transplant outcome;and(4)effective alternative therapies are often available for HCC candidates to liver transplantation.In this paper we suggest that allocating organs by transplant benefit could help balance these competing principles,and also introduce equity between patients with HCC and nonmalignant liver disease.We also propose a triangular equipoise model to help decide between deceased donor liver transplantation,living donor liver transplantation,or alternative therapies. | Alessandro Vitale Michael Volk Umberto Cillo | 2013 | World Journal of Gastroenterology2013，19，48： | 6 |
| 3 | Oil-bearing fluid inclusions from the Palaeoproterozoic:A review of biogeochemical results from time-capsules >2.0 Ga old显示文摘The observation of oil inclusions trapped prior to 2.0 Ga in Palaeoproterozoic rocks and the ability to obtain detailed molecular geochemical information from them provide a robust way for understanding the early biogeochemical evolution of the Earth. Oil-bearing fluid inclusions (FI) in ca. 2.45 Ga fluvial metaconglomerate of the Matinenda Formation at Elliot Lake, Canada were trapped in quartz and feldspar during diagenesis and early metamorphism of the host rock, probably before ca. 2.2 Ga. The 2.1 Ga FA Formation sandstone of the Franceville Basin in Gabon that hosts the Oklo natural fission reactors has also been discovered to contain abundant Palaeoproterozoic oil-bearing FIs. This oil occurs within H2O and CO2-dominated inclusions trapped in syntaxial quartz overgrowths and intragranular and transgranular microfractures in detrital quartz, and was most likely trapped 2.1-1.98 Ga. Molecular geochemical analyses of both FI oils reveal a wide range of compounds, including n-alkanes, isoprenoids, monomethylalkanes, aromatic hydrocarbons, and trace amounts of complex multi-ring biomarkers including terpanes, hopanes, methylhopanes, steranes and diasteranes. To ensure a reliable interpretation of oil inclusions, a comprehensive series of outside-rinse blanks and procedural system blanks was analysed by gas chromatography-mass spectrometry; quantitative amounts of the hydrocarbons in these blanks were compared to the FI extracts, so as to provide confidence limits on the experimental integrity of each compound class. Maturity ratios based on reliably detected compound classes show that the FI oils were generated in the oil window, with no evidence of extensive thermal cracking. The presence of biomarkers for cyanobacteria and eukaryotes derived from and trapped in rocks deposited prior to 2.0 Ga is consistent with early evolution of oxygenic photosynthesis and suggests that some aquatic settings had become sufficiently oxygenated for sterol biosynthesis by this time. The extraction of biomarker molecules from Palaeoproterozoic oil-bearing FIs thus establishes a new method, using low detection limits and system blank levels, to trace evolution through Earth's early history that avoids the potential contamination problems affecting shale-hosted hydrocarbons. | Simon C. GEORGE Adriana DUTKIEWICZ Herbert VOLK John RIDLEY David J. MOSSMAN Roger BUICK | 2009 | Science China Earth Sciences2009，52，1： | 3 |
| 4 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos)显示文摘 | Jutta Keller Christiane Fibbe Frank Volke Jeremy Gerber Alexander C. Mosse Meike Reimann-Zawadzki Elisha Rabinovitz Peter Layer Daniel Schmitt Viola Andresen Ulrich Rosien Paul Swain | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 6 | Is MRCP equivalent to ERCP for diagnosing biliary obstruction in orthotopic liver transplant recipients? A meta-analysis显示文摘 | Jennifer E. Jorgensen Akbar K. Waljee Michael L. Volk Christopher J. Sonnenday Grace H. Elta Mahmoud M. Al-Hawary Amit G. Singal Jason R. Taylor B. Joseph Elmunzer | 2011 | Gastrointestinal Endoscopy2011，，5： | 2 |
| 7 | The function of abscisic acid in bryophytes 显示文摘 | HARTUNG W HELLWEGE E M VOLK O K | 1994 | J Hattori Bot Lab1994，76，： | 2 |
| 8 | Geochemistry of oil in fluid inclusions in a middle Proterozoic igneous intrusion: implications for the source of hydrocarbons in crystalline rocks 显示文摘 | Dutkiewicz A Volk H Ridley J | 2004 | Organic Geochemistry2004，35，8： | 1 |
| 9 | Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photo emission computerized tomography 显示文摘 | Volk SA Kaendler SH Weber R | 1992 | Acta Psychiatr Scand1992，86，3： | 1 |
| 10 | Postoperative epidural anesthesia preserves lymphocyte, but not monocyte, immune function after major spine surgery 显示文摘 | Volk T Sehenk M Voigt K | 2004 | Anesth Analg2004，98，4： | 1 |
| 11 | Towards predicting relative belt edge endurance with the finite element method显示文摘 | Eskinazi J Z Ishihara K Volk H | 1990 | Tire Science and Technology1990，18，4： | 1 |
| 12 | Immunomodulatory therapies in sepsis 显示文摘 | Kox W J Volk T Kox SN | 2000 | Intensive Care Med2000，26，1： | 1 |
| 13 | Cloning, expression, and in vitro activity of human endostatin 显示文摘 | Dhanabal M Volk R Ramchandran R | 1999 | Biochem Biophys Res Commun1999，258，2： | 1 |
| 14 | Elevatedsoluble CD14 receptors and altered cytokines in chronic heartfailure 显示文摘 | ANKER S D EGERER K R VOLK H D | 1997 | Am J Cardiol1997，79，10： | 1 |
| 15 | Solution structure and antibody binding studies of the envelope protein domain Ⅲ from the New York strain of West Nile virus 显示文摘 | Volk DE Beasley DW Kallick DA | 2004 | J Biol Chem2004，279，38： | 1 |
| 16 | The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by mi-croRNAs显示文摘 | Abrahante JE Daul AL Li M Volk ML Tennessen JM MillerEA | 2003 | Dev Cell2003，4，5： | 1 |
| 17 | Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features 显示文摘 | Curley AA Arion D Volk DW | 2011 | Am J Psychiatry2011，168，9： | 1 |
| 18 | Monocytc deactivationraonale for a new therapeutic strategy in sepsis显示文摘 | Volk HD Reinke P Krausch D | 1996 | Intensive Care Med1996，22，4： | 1 |
| 19 | Influence of different gases and intraperitoneal instillation of antiadherent or cytotoxic agents on peritoneal tumor cell growth and implantation with laparoscopic surgery in a rat model显示文摘 | Wildbrett P Volk T | 1999 | Surg Endosc1999，13，： | 1 |
| 20 | The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane显示文摘 | Rocchi E Khodjakov A Volk EL | 2000 | Biochem Biophys Res Commun2000，271，1： | 1 |
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