|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 文化的数字丈量:“数字人文”下的人文学科显示文摘如果说变革的意义在于改变生活,那么数字化就是这样一场变革,它急剧地改变了我们生活的方方面面,而且风头正劲。数字化也改变了人文学科,这场变革以“数字人文”为标签,但“数字人文”这一概念正如同许多学科名称一样尚不精确。1960年代,电脑被运用于人文学科研究中,人们将其暂称作“人文计算”。 | Gerhard Lauer 庞娜娜(译) | 2018 | 中国社会科学文摘2018，0，12： | 4 |
| 2 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 3 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz | 2010 | Journal of the American College of Cardiology2010，，23： | 2 |
| 4 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 5 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 6 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 7 | Surface roughness of zirconia for full-contour crowns after clinically simulated grinding and polishing显示文摘The aim of this study was to evaluate the effect of controlled intraoral grinding and polishing on the roughness of full-contour zirconia compared to classical veneered zirconia. Thirty bar-shaped zirconia specimens were fabricated and divided into two groups(n515). Fifteen specimens(group 1) were glazed and 15 specimens(group 2) were veneered with feldspathic ceramic and then glazed. Prior to grinding,maximum roughness depth(Rmax) values were measured using a profilometer, 5 times per specimen. Simulated clinical grinding and polishing were performed on the specimens under water coolant for 15 s and 2 N pressure. For grinding, NTI diamonds burs with grain sizes of 20 mm, 10 mm, and 7.5 mm were used sequentially. The ground surfaces were polished using NTI kits with coarse, medium and fine polishers. After each step, Rmaxvalues were determined. Differences between groups were examined using one-way analysis of variance(ANOVA). The roughness of group 1 was significantly lower than that of group 2. The roughness increased significantly after coarse grinding in both groups. The results after glazing were similar to those obtained after fine grinding for non-veneered zirconia. However, fine-ground veneered zirconia had significantly higher roughness than venerred, glazed zirconia. No significant difference was found between fine-polished and glazed zirconia, but after the fine polishing of veneered zirconia, the roughness was significantly higher than after glazing.It can be concluded that for full-contour zirconia, fewer defects and lower roughness values resulted after grinding and polishing compared to veneered zirconia. After polishing zirconia, lower roughness values were achieved compared to glazing; more interesting was that the grinding of glazed zirconia using the NTI three-step system could deliver smooth surfaces comparable to untreated glazed zirconia surfaces. | Rim Hmaidouch Wolf-Dieter Mller Hans-Christoph Lauer Paul Weigl | 2014 | International Journal of Oral Science2014，6，4： | 2 |
| 8 | A prophylactic hepatitis C virus vaccine: A distant peak still worth climbing显示文摘 | Thomas F. Baumert Catherine Fauvelle Diana Y. Chen Georg M. Lauer | 2014 | Journal of Hepatology2014，，1： | 2 |
| 9 | Inflammation as a Risk Factor for Atrial Fibrillation显示文摘 | Ronnier J. Aviles David O. Martin Carolyn Apperson-Hansen Penny L. Houghtaling Pentti Rautaharju Richard A. Kronmal Russell P. Tracy David R. Van Wagoner Bruce M. Psaty Michael S. Lauer Mina K. Chung | 2003 | Circulation: Journal of the American Heart Association2003，，24： | 2 |
| 10 | Spectrum of electrophysiologic and electropharmacologic characteristics of verapamil-sensitive ventricular tachycardia in patients without strucral heart disease显示文摘 | Lauer MR Young C | 1996 | Am J Cardiol1996，77，8： | 1 |
| 11 | Capillary electrophoresis of proteins in un treated fused silica tubing显示文摘 | Lauer H H McManigill D | 1986 | Anal Chem1986，58，： | 1 |
| 12 | Fracture characteristics of carbonfiber,ceramic and non-palladium endodontic post systems atmonotonously increasing loads显示文摘 | Ottl P Hahn L Lauer HCh | 2002 | J Oral Rehabil2002，29，2： | 1 |
| 13 | Chronotropic incompetence:ready for prime time显示文摘 | Lauer M S | 2004 | J Am Coil Cardiol2004，44，2： | 1 |
| 14 | Hyperbilirubinemia in the newbom显示文摘 | Lauer BJ Spector ND | 2011 | Pe-diatr Rev2011，32，8： | 1 |
| 15 | Exercise electrocardiogram testing:beyond the ST segment显示文摘 | Kligfield P Lauer Ms | | 0，，19： | 1 |
| 16 | Napsin A expression in smallcell carcinoma of the lung: a cytologic study with review of difTerenti-als显示文摘 | Hookim K Kavuri S Lauer SR | 2014 | JASC2014，3，1： | 1 |
| 17 | Deeonvolution With a spatially-variant PSF显示文摘 | Tod R Lauer | 2002 | Proceedings of SPIE2002，4847，： | 1 |
| 18 | Efficacy of computerassited surgery in secondary orbital reconstruction显示文摘 | LAUER G PRADEL W SCHNEIDER M | 2006 | J Craniomaxillofac Surg2006，34，5： | 1 |
| 19 | Fracture characteristics of carbon fiber,ceramic and non-palladium endodontic post systems at monotonously increasimg loads显示文摘 | OttL P Hahn L lauer HCH | 2002 | Oral Rehabil2002，29，2： | 1 |
| 20 | Spectrum of electrophysiologic and electropharmacologic characteristics of verapamil-sensitive ventricular tachycardia in patients without structural heart disease显示文摘 | Lee KL Lauer MR Yong C | 1996 | Am J Cardiol1996，77，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员