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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Erosion problem in tool steel using cold box core-making process显示文摘This paper presents the erosion results of the AISI H13 steel impinged by resin-bonded silica sand, using a testing rig that closely simulates the real blowing conditions during industrial core-making. Steel specimens were heat treated to obtain hardness of 294, 445 and 595 HV200 (29, 45 and 55 HRC). Erosion tests were carried out at impingement angles from 20° to 90° and air drag pressures of 1.38, 2.07 and 2.76 bar (20, 30 and 40 psi). The main results are summarized as follows:(i) The harder material, the lower erosion;(ii) the maximum erosion rate is at 30°;(iii) Little difference in erosion rate at impact angle of 60° and 90° for a constant pressure tested regardless of the hardness level;(iv) As the pressure increases, so does the erosion rate, being more sensitive for low impact angles. Finally, a differential form of the general erosion equation is applied on a practical core-making case to evaluate the erosion rate of the H13 steel at 30° and 90° impingement angles. | Eduardo Rodríguez Alberto Pérez Rafael David Mercado-Solis Velasco-Téllez Abraham Omar Jimenez Martin Flores Marco Aurelio Gonzalez Jesus Ibarra | 2019 | China Foundry2019，16，3： | 2 |
| 3 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 4 | Sustained release of vascular endothelial growth factor from mineralized poly (lactide-co-glycolide) scaffolds for tissue engineering显示文摘 | WILLIAM L M MARTIN C P DAVID H | 2000 | Biomaterials2000，21，： | 1 |
| 5 | Practical application of on-line hot strip inspection system at hoogovens 显示文摘 | DAVID G P MARTIN P L HANEGHEM A V | 1995 | Iron and Steel Engineer1995，72，7： | 1 |
| 6 | Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequence that determine recognitional specificity in Cf-4 and Cf-9 显示文摘 | DAVID A J MARTIN P | 1997 | The Pant Cell1997，9，12： | 1 |
| 7 | Dose rate and static/dynamic bias effects on CCDs显示文摘 | MARTIN E DAVID J P NUNS T | 2011 | IEEE Transcations on Nuclear Science2011，58，3： | 1 |
| 8 | Pro-and Anti-inflammatory Cytokine Gene Expression in Rat Sciatic Nerve Chronic Constriction Injury Model of Neuropathic Pain显示文摘 | Kunihisa Okamoto David P Martin | 2001 | Experimental Neurology2001，169，： | 1 |
| 9 | IMS updated recommendations on postmenopausal hormone therapy 显示文摘 | Amos P David W Martin H | 2007 | Climacteric2007，0，： | 1 |
| 10 | Evaluation of machine geometry显示文摘 | Leleu S David J M Diolez G Martin P | 2003 | Recent Advantages in Integrated Design and Manufacturing in Mechanical Engineering2003，，： | 1 |
| 11 | Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials显示文摘 | Julia Bohlius Kurt Schmidlin Corinne Brillant Guido Schwarzer Sven Trelle Jerome Seidenfeld Marcel Zwahlen Michael Clarke Olaf Weingart Sabine Kluge Margaret Piper Dirk Rades David P Steensma Benjamin Djulbegovic Martin F Fey Isabelle Ray-Coquard Mitchell | 2009 | The Lancet2009，，9674： | 1 |
| 12 | Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting显示文摘 | Westenskow Peter D Kurihara Toshihide Aguilar Edith Scheppke Elizabeth L Moreno Stacey K Wittgrove Carli Marchetti Valentina Michael Iacovos P Anand Sudarshan Nagy Andras Cheresh David Friedlander Martin | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 13 | Proteosome-adjuvanted intranasal influenza vaccines: advantages, progress and future considerations 显示文摘 | David B Corey M Martin P | 2011 | Expert Rev Vaccines2011，10，3： | 1 |
| 14 | PHA application:addressing the price performance issue tissue engineering显示文摘 | Simon F Williams David P Martin Daniel M Horowitz | 1999 | International Journal of Biological Macromole-cules1999，25，： | 1 |
| 15 | Physiologic Concentrations of Exogenously Infused Ghrelin Reduces Insulin Secretion Without Affecting Insulin Sensitivity in Healthy Humans显示文摘 | Jenny Tong Ronald L. Prigeon Harold W. Davis Martin Bidlingmaier Matthias H. Tsch?p David D?Alessio | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，6： | 1 |
| 16 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 17 | Obesity and Non-Alcoholic Fatty Liver Disease in Chronic Hepatitis C显示文摘 | Zobair M Younossi Arthur J McCullough Janus P Ong David S Barnes Anthony Post Anthony Tavill Diane Bringman Lisa M Martin Jennifer Assmann Terry Gramlich Kevin D Mullen Robert O’Shea William D Carey Roy Ferguson | 2004 | Journal of Clinical Gastroenterology2004，，8： | 1 |
| 18 | Ribosome Association and Stability of the Nascent Polypeptide-Associated Complex Is Dependent Upon Its Own Ubiquitination显示文摘 | Panasenko Olesya O David Fabrice P A Collart Martine A | 2009 | Genetics2009，，2： | 1 |
| 19 | New Measures of Job Control, Cognitive Demand, and Production Responsibility显示文摘 | Jackson P R Wall T D Martin R David K | 1993 | Journal of Applied Psychology1993，，78： | 1 |
| 20 | Mineral surface control of organ-ic carbon in black shale显示文摘 | Martin J K David R P Ronald J H | 2002 | Science2002，295，： | 1 |
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