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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | Epidemiology of inflammatory bowel disease in South America: A systematic review显示文摘BACKGROUND The worldwide epidemiology of inflammatory bowel disease(IBD)is rapidly changing.Increasing Crohn’s disease(CD)and ulcerative colitis(UC)incidence and prevalence have been recorded in developing regions such as Asia,Africa and Eastern Europe where it was previously thought to be uncommon.Whether this is also the case in South America is not well known.Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD.AIM To report the incidence,prevalence and disease characteristics of CD and UC within the South American continent.METHODS A systematic review was conducted by searching published studies in major international and regional databases(MEDLINE,EMBASE and Scopus)between January 1990 and December 2018.Outcomes considered were incidence,prevalence,phenotype,environmental and genetic factors,ethnicity and gender.A pair of independent reviewers screened and reviewed all identified articles.RESULTS One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review.The majority of included studies were from Brazil(n=13,72%).The incidence of UC ranged from 4.3-5.3/100000 personyears whilst the incidence of CD ranged from 0.74-3.5/100000 person-years.Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for CD.The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years.Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD.People residing in urban areas were at higher risk of developing both CD and UC.CONCLUSION The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world.There is a paucity of highquality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes. | Sriharan Selvaratnam Santiago Gullino Lisa Shim Eric Lee Alice Lee Sudarshan Paramsothy Rupert W Leong | 2019 | World Journal of Gastroenterology2019，25，47： | 5 |
| 3 | Development of high intensity low emission combustor for achieving flameless combustion ofliquid fuels显示文摘This paper presents the experimental and numerical results for a two stagecombustor capable of achieving flameless combustion with liquid fuels for different thermalheat inputs of 20,30,40 and 60 kW and heat release density of 5-15 MW/m^(3).Combustioncharacteristics and pollutant emissions are studied for three different fuels,kerosene,diesel andgasoline.The influence of droplet diameter on pollutant emissions at all conditions is studied.The fuel and oxidizer are supplied at ambient conditions.The concept of high swirl flows hasbeen adopted to achieve high intemal recirculation rates,residence time and increased dilutionof the fresh reactants in the primary combustion zone,resulting in flameless combustion mode.Air is injected through four tangential injection ports located near the bottom of the combustorand liquid fuel is injected through a centrally mounted pressure swirl injector.Computationalanalysis of the flow features shows that decrease in the exit port diameter of the primarychamber increases the recirculation rate of combustion products and helps in achieving theflameless combustion mode.Based on preliminary computational studies,a 30 mm primarychamber exit pont diameter is chosen for experimental studies.Detailed experimentalinvestigations show that flameless combustion mode was achieved with evenly distributedcombustion reaction zone and unifom temperature distribution in the combustor.Pollutant emissions of CO, NO_(x),C_(x)H_(y) are measured and compared for all operating conditions ofdifferent fuels and different thermal inputs. The acoustic emission levels are reduced by6-8 dB as combustion mode shifts from conventional mode to flameless combustion mode. | V.Mahendra Reddy Sudarshan Kumarn | 2013 | Propulsion and Power Research2013，2，2： | 5 |
| 4 | Metabolic syndrome:A review of the role of vitamin D in mediating susceptibility and outcome显示文摘Despite the well-recognised role of vitamin D in a wide range of physiological processes,hypovitaminosis is common worldwide(prevalence 30%-50%) presumably arising from inadequate exposure to ultraviolet radiation and insufficient consumption.While generally not at the very low levels associated with rickets,hypovitaminosis D has been implicated in various very different,pathophysiological processes.These include putative effects on the pathogenesis of neoplastic change,inflammatory and demyelinating conditions,cardiovascular disease(CVD) and diabetes.This review focuses on the association between hypovitaminosis D and the metabolic syndrome as well as its component characteristics which are central obesity,glucose homeostasis,insulin resistance,hypertension and atherogenic dyslipidaemia.We also consider the effects of hypovitaminosis D on outcomes associated with the metabolic syndrome such as CVD,diabetes and non-alcoholic fatty liver disease.We structure this review into 3 distinct sections; the metabolic syndrome,vitamin D biochemistry and the putative association between hypovitaminosis D,the metabolic syndrome and cardiovascular risk. | Richard C Strange Kate E Shipman Sudarshan Ramachandran | 2015 | World Journal of Diabetes2015，6，7： | 5 |
| 5 | 印度Sukinda铬铁矿区水样的重金属污染、理化性质和微生物的评价(英文)显示文摘分析了Sukinda铬铁矿采石场及其邻近区域水样的重金属污染及理化性质和微生物含量。铬铁矿的水样含有高浓度重金属,其浓度顺序为Cr>Fe>Zn>Ni>Co>Mn,然而该地区的地下水除了Fe以外并没有受到重金属污染。矿井水样的理化参数与正常水的有差别。与相邻矿水样相比,矿井水样含有一些低浓度的微生物种群,包括细菌、真菌和放线菌。金属浓度与相关的理化参数显示了他们之间有正、负响应,而金属浓度和微生物种群之间表现出了负的相关性。从铬铁矿废水中纯化出来的菌株对铬和其他的重金属以及抗生素表现出高的耐受性,可作为重金属污染的指示剂。 | S. DAS S. C. PATNAIK H. K. SAHU A. CHAKRABORTY M. SUDARSHAN H. N. THATOI | 2013 | Transactions of Nonferrous Metals Society of China2013，23，2： | 4 |
| 6 | Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions显示文摘 | Thomas J. Borody Sudarshan Paramsothy Gaurav Agrawal | 2013 | Current Gastroenterology Reports2013，，8： | 3 |
| 7 | Anisotropic Gaussian Schell-model beams: passage through optical systems and associated invariants显示文摘 | Simon R Sudarshan E C G Mukunda N | 1985 | Phys Rev A1985，46，4： | 2 |
| 8 | Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease显示文摘BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula healing.AIM To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough levels.METHODS In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical assessment.Data collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical therapy.The primary outcome was fistula healing,defined as cessation in fistula drainage.The secondary outcome was fistula closure,defined as healing and closure of all external fistula openings.Differences between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U test.RESULTS One hundred and fourteen patients(66 infliximab,48 adalimumab)were included.Forty-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula closure.Thirty-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula closure.Patients who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger age.For patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an immunomodulator.Serum trough levels for patients with and without fistula closure were not significantly different for infliximab[6.9(4.3-10.2)vs 5.5(2.5-8.3)mg/L,P=0.105]or adalimumab[10.0(6.6-12.0)vs 7.8(4.2-10.0)mg/L,P=0.083].CONCLUSION Higher maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. | Bonita Gu Kavya Venkatesh Astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor | 2022 | World Journal of Gastroenterology2022，28，23： | 2 |
| 9 | Structural defect visualization and oxide breakdown in SiC wafers after thermal oxidation 显示文摘 | SUDARSHAN T S SOLOVIEV S KHLEBNIKOV I | 1999 | Mater Sci Eng B1999，6162，： | 2 |
| 10 | Stress-rupture measurements of cast magnesium strengthened by in-situ production of ceramic particles显示文摘We have introduced a polymer precursor into molten magnesium and then in-situ pyrolyzed to produce castings of metal matrix composites(P-MMCs)containing silicon-carbonitride(SiCNO)ceramic particles.Stress-rupture measurements of as-cast P-MMCs was performed at 350 ℃(0.69TM)to 450 ℃(0.78TM)under dead load condition corresponding to tensile stress of 2.5 MPa to 20 MPa.The time-to-fracture data were analyzed using the classical Monkman–Grant equation.The time-to-fracture is thermally activated and follows a power-law stress exponent exhibiting dislocation creep.Fractography analysis revealed that while pure magnesium appears to fracture by dislocation slip,the P-MMCs fail from the nucleation and growth of voids at the grain boundaries. | Nagaraj M.Chelliah Sudarshan Lisa Kraemer Harpreet Singh M.K.Surappa Rishi Raj | 2017 | Journal of Magnesium and Alloys2017，5，2： | 2 |
| 11 | Glutathione- S -transferase family of enzymes显示文摘 | Richard C Strange Monica A Spiteri Sudarshan Ramachandran Anthony A Fryer | 2001 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2001，，1： | 2 |
| 12 | The influence of phosphorus on shrinkage porosity in cast irons显示文摘 | SRIVATSAN T S SUDARSHAN T S | 1999 | Materials Letters1999，41，4： | 2 |
| 13 | Analysis of Alloys by Prompt Gamma-ray Neutron Activation显示文摘 | Nair AGC Sudarshan K Raje N | 2004 | Nuclear Instruments and Methods in Physics Research A2004，516，1： | 1 |
| 14 | Effect of N-acetylcysteine on human diaphragm strength and fatigability显示文摘 | Travaline JM Sudarshan S Roy BG | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 15 | Novel insulator design s for suo erior DC hold-off in bridged vacuum gaps显示文摘 | Jaitly N C Sudarshan T S | 1987 | IEEE Trans on Electrical Insulation1987，22，6： | 1 |
| 16 | Partially coherent beams and a generalized ABCD-law显示文摘 | Simon R Mukunda N Sudarshan E C G | 1988 | Opt Commum1988，65，： | 1 |
| 17 | Synthesis and characterization of nanosilica prepared by precipitation method显示文摘 | Jal P K Sudarshan M Ssha A | 2004 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2004，240，2： | 1 |
| 18 | Intelligent lighting systemusing wireless sensor networks 显示文摘 | KUMAAR A AN SUDARSHAN K G | 2010 | International Journal of Ad hoc Sensor & Ubiquitous Computing (IJASUC)2010，1，4： | 1 |
| 19 | Photon induced positron annihilation spectroscopy:a nondestructive method for assay of defects in large engineering materials显示文摘 | Pujari P K Sudarshan K Tripathi R | 2012 | Nuclear Instruments and Methods in Physics Research2012，270，： | 1 |
| 20 | Therapeutic faecal microbiota transplantation: current status and future developments显示文摘 | Thomas J. Borody Lawrence J. Brandt Sudarshan Paramsothy | 2014 | Current Opinion in Gastroenterology2014，，1： | 1 |
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