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| 1 | The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway显示文摘Inflammasomes 为维持肠的动态平衡是重要的,并且 dysbiosis 贡献煽动性的肠疾病(IBD ) 的病理并且为 colorectal 癌症增加风险。Inflammasome 缺点贡献长期的肠的发炎并且在老鼠增加危险性到大肠炎。然而,在黑瘤 2 不在的 inflammasome 传感器(AIM2 ) 通过 DNA 依赖的蛋白质 kinase 和 Akt 小径以一种 inflammasome 独立的方式免于 colorectal 癌症。然而,在 IBD 和 colorectal 癌症的早阶段的 AIM2 inflammasome 的角色留下不清楚。这里,我们证明 AIM2 inflammasome 在肠有一个保护的角色。在稳定的状态期间, Aim2 删除导致 IL-18 分泌物的损失,在肠的上皮的房间和 STAT3 依赖的抗菌剂肽(安培) 的作为结果的损失的 IL-22 有约束力的蛋白质(IL-22BP ) 的抑制 Reg3β并且 Reg3γ,它支持连接 dysbiosis 的大肠炎。在葡聚糖硫酸盐期间导致钠的大肠炎,不正常的 IL-18/在 Aim2 −/− 老鼠的 IL-22BP 小径支持过多的 IL-22 生产和提高的 STAT3 激活。Aim2 −/− 鼠标进一步在提高的 Reg3b 和 Reg3g 表示造成的大肠炎的分辨率期间展出持续 STAT3 和 Akt 激活。这恋职的机制支持肠的地窟房间的增长并且多半在 Aim2 −/− 老鼠的危险性贡献最近描述的增加到 colorectal 癌症。一起,我们的结果在通过 IL-18/ 的规定阻止 dysbiosis 和肠的发炎为 AIM2 inflammasome 表明一个中央角色; IL-22BP/ IL-22 和 STAT3 小径和精选安培的表示。 | Rojo A Ratsimandresy Mohanalaxmi Indramohan Andrea Dorfleutner Christian Stehlik | 2017 | Cellular & Molecular Immunology2017，14，1： | 27 |
| 2 | Challenges and perspectives on high and intermediate-temperature sodium batteries显示文摘 | Karina B. Hueso Veronica Palomares Michel Armand Teofilo Rojo | 2017 | Nano Research2017，10，12： | 12 |
| 3 | Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography显示文摘 | Robert P. Myers Aaron Pollett Richard Kirsch Gilles Pomier‐Layrargues Melanie Beaton Mark Levstik Andres Duarte‐Rojo David Wong Pam Crotty Magdy Elkashab | 2012 | Liver Int2012，，6： | 4 |
| 4 | Challenges in microRNAs’ targetome prediction and validation显示文摘MicroRNAs(miRNAs)are small RNA molecules with important roles in post-transcriptional regulation of gene expression.In recent years,the predicted number of miRNAs has skyrocketed,largely as a consequence of high-throughput sequencing technologies becoming ubiquitous.This dramatic increase in miRNA candidates poses multiple challenges in terms of data deposition,curation,and validation.Although multiple databases containing miRNA annotations and targets have been developed,ensuring data quality by validating miRNA-target interactions requires the efforts of the research community.In order to generate databases containing biologically active miRNAs,it is imperative to overcome a multitude of hurdles,including restricted miRNA expression patterns,distinct miRNA biogenesis machineries,and divergent miRNA-mRNA interaction dynamics.In the present review,we discuss recent advances and limitations in miRNA prediction,identification,and validation.Lastly,we focus on the most enriched neuronal miRNA,miR-124,and its gene regulatory network in human neurons,which has been revealed using a combined computational and experimental approach. | Jesus Eduardo Rojo Arias Volker Busskamp | 2019 | Neural Regeneration Research2019，14，10： | 3 |
| 5 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 6 | Android fat ditribution as predictor of severity in acute pancreatitis 显示文摘 | Mery CM Rubio V Duarte - Rojo A | 2002 | Pancreatology2002，2，6： | 1 |
| 7 | The Role of Neuroimmunomodulation in Alzheimer's Disease显示文摘 | Maccioni RB Rojo LE Ferndndez JA | 2009 | Ann N Y Acad Sci2009，1153，： | 1 |
| 8 | The role of neuroimmunomodulation in Alzheimer′s disease显示文摘 | MACCIONI R B ROJO L E FERNNDEZ J A | 2009 | Ann N Y Acad Sci2009，1153，： | 1 |
| 9 | TACE is required for the activation of the EGFR by TGF-alpha in tumors 显示文摘 | Borrell-Pags M Rojo F Albanell J | 2003 | EMBO J2003，22，5： | 1 |
| 10 | Combined antidepres- sant: clinical experience 显示文摘 | Rojo JE Ros S Agtiera L | 2005 | Acta Psychiatr Stand Suppl2005，36，： | 1 |
| 11 | Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease显示文摘 | Rojo AI Innamorato NG Martin-Moreno AM | 2010 | Glia2010，58，： | 1 |
| 12 | Expression and clinical significance of pepsinogen C in epithelial ovarian carcinomas显示文摘 | Rojo J V Merino A M Gonzalez L O | 2002 | Eur J Obstet Gynecol Reprod Biol2002，104，1： | 1 |
| 13 | Effects of exogenous amylases from Bacillus licheniformis and Aspergillus niger on ruminal starch digestion and lamb performance显示文摘 | ROJO R MENDOZA G D GONZALEZ S S | 2005 | Anim Feed Sci Technol2005，124，： | 1 |
| 14 | Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor显示文摘 | Vanhoefer U Tewes M Rojo F | 2004 | J Clin Oncol2004，22，1： | 1 |
| 15 | Cervical cancer: Current view of its epidemiology and risk factors显示文摘 | Torres Lobaton A Rojo Herrera G Torres Rojo A | 2004 | Ginecol Obstet Mex2004，72，9： | 1 |
| 16 | Efficacy of second-generation-antipsychotics in the treatment of negative symptoms of schizophrenia:a meta-analysis of randomized clinical trials显示文摘 | Darbà J Minoves A Rojo E | 2011 | Rev Psiquiatr Salud Ment2011，4，3： | 1 |
| 17 | Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics显示文摘 | Cécile Sauvanet Stéphane Duvezin-Caubet Jean-Paul di Rago Manuel Rojo | 2010 | Seminars in Cell and Developmental Biology2010，，6： | 1 |
| 18 | European retirees on the Costa del Sol:Across-national comparison显示文摘 | RODRIGUEZ V FEMAILDEZ-MAYORALAS G ROJO F | 1998 | lnternational journal of population geography1998，4，1： | 1 |
| 19 | Homozygous HLA-G·0105N Healthy Individuals Indicate that Membrane associated HLA G1 Molecule is not Necessary for Survival显示文摘 | Casro M J Morales P Rojo Amigo R | 2000 | Tissue Antigens2000，56，3： | 1 |
| 20 | Macrocyclic peptidomimetic inhibitors of fl-secretase ( BACE ) : First X-ray structure of a macrocyclic peptidomimetic-BACE complex 显示文摘 | ROJO I MARTIN J A BROUGHTON H | 2006 | Bioorg Med Chem Lett2006，16，1： | 1 |
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