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| 1 | Encapsulating peritoneal sclerosis显示文摘Encapsulating peritoneal sclerosis(EPS) is a debilitating condition characterized by a fibrocollagenous membrane encasing the small intestine, resulting in recurrent small bowel obstructions. EPS is most commonly associated with long-term peritoneal dialysis, though medications, peritoneal infection, and systemic inflammatory disorders have been implicated. Many cases remain idiopathic. Diagnosis is often delayed given the rarity of the disorder combined with non-specific symptoms and laboratory findings. Although cross-sectional imaging with computed tomography of the abdomen can be suggestive of the disorder, many patients undergo exploratory laparotomy for diagnosis. Mortality approaches 50% one year after diagnosis. Treatment for EPS involves treating the underlying condition or eliminating possible inciting agents(i.e. peritoneal dialysis, medications, infections) and nutritional support, frequently with total parenteral nutrition. EPSspecific treatment depends on the disease stage. In the inflammatory stage, corticosteroids are the treatment of choice, while in the fibrotic stage, tamoxifen may be beneficial. In practice, distinguishing between stages may be difficult and both may be used. Surgical intervention, consisting of peritonectomy and enterolysis, is timeconsuming and high-risk and is reserved for situations in which conservative medical therapy fails in institutions with surgical expertise in this area. Herein we review the available literature of the etiology, pathogenesis, diagnosis, and treatment of this rare, but potentially devastating disease. | Christopher J Danford Steven C Lin Martin P Smith Jacqueline L Wolf | 2018 | World Journal of Gastroenterology2018，24，28： | 13 |
| 2 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 3 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 4 | Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer显示文摘AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided CPN.Three received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were sacrificed.The abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS:EUS-guided CPN was successfully performed in all 6 pigs without immediate complication.Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1.The blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group 2.CONCLUSION:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible.The presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. | Keith L Obstein Fernanda P Martins Gloria Fernández-Esparrach Christopher C Thompson | 2010 | World Journal of Gastroenterology2010，16，6： | 3 |
| 5 | Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat显示文摘 | Watkins L R Martin D Ulrich P | 1997 | Pain1997，71，3： | 1 |
| 6 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 7 | Functional characteriza- tion of the EMCV IRES in plants显示文摘 | Urwin P Yi L Martin H | 2000 | The Plant Jour- pal2000，24，： | 1 |
| 8 | Lab Chip 显示文摘 | Abbyad P Tharaux P L Martin J L | 2010 | 10(19): 2505-25122010，10，19： | 1 |
| 9 | Phosphorus diagenesis in lake sediments:investigation using fractionation techniques显示文摘 | Michael R P Martin T A Eric L V | 1995 | Mar Freshwater Res1995，46，： | 1 |
| 10 | 显示文摘 | CALZDA M L MARTIN M J RAMOS P | 1997 | J Phys Chem Solids1997，58，7： | 1 |
| 11 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus 显示文摘 | Thomas D L Thio C L Martin M P | 2009 | Nature2009，461，： | 1 |
| 12 | BMP-7 (Bone morphogenetic protein-7):a future treatment for chronic renal failure显示文摘 | Niksic L Martin P Y | | 0，，08： | 1 |
| 13 | Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3 显示文摘 | Martin M MaBhfer L Temming P | 2013 | Nat Genet2013，45，8： | 1 |
| 14 | Molecular structure of SiO,-incorporated diamond like carbon films; evidence for phase segregation 显示文摘 | RANDENIYA L K BENDAVID A MARTIN P J | 2009 | Diamond Relat Mater2009，18，9： | 1 |
| 15 | Modeling of brazing processes that use coating and interlayers显示文摘 | Liu S Olsen D L Martin G P | 1991 | Welding Journal1991，70，8： | 1 |
| 16 | Hybrid performance in wheat as related to parental diversity显示文摘 | Martin J M Talbert L E Larning S P | 1995 | Crop Sci1995，35，： | 1 |
| 17 | Poly- ethylenimine-graft-poly ( ethylene glycol) copolymers: influ- ence of copolymer block structure on DNA complexation and biological activities as gene delivery system 显示文摘 | PETERSEN H FECHNER P M MARTIN A L | 2002 | Bioconjugate Chem2002，13，4： | 1 |
| 18 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 19 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats 显示文摘 | Andersen M L Martins P G F D'Almeida V | 2004 | Exp Gerontol2004，39，6： | 1 |
| 20 | Multitarget bayes filtering viafirst-order multitarget moments 显示文摘 | MAHLER R P S MARTIN L | 2003 | IEEE Transaction onAerospace and Electronic System2003，39，4： | 1 |
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