|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita显示文摘Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes. | Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte | 2019 | Molecular Plant2019，12，4： | 9 |
| 3 | IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location显示文摘AIM: To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-α and the interleukin (IL)-10 in childhood Crohn’s disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes. METHODS: Ten variants in GR, TNF-α and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin. RESULTS: For the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5’flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians (GCC, ACC and ATA) and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of fi ve polymorphisms in the promoter region of the TNF-α gene (-1031 T > C, -863 A > C, -857 T > C, -308 A > G and -238 A > G) revealed a significant overrepresentation of homozygous -1031 CC among CD patients (OR = 9.9) and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUSION: This is one of the fi rst studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD. | Rocio Sanchez Emile Levy Florin Costea Daniel Sinnett | 2009 | World Journal of Gastroenterology2009，15，30： | 9 |
| 4 | A software-defined networking approach for handover management with real-time video in WLANs显示文摘To achieve high performance and reliability in video streaming over wireless local area networks (WLANs), one must jointly consider both optimized association to access points (APs) and handover management based on dynamic scanning of alternate APs. In this article, we propose a new architecture within the software-defined networking (SDN) framework, which allows stations to be connected to several APs simultaneously and to switch fast between them. We evaluate our system in a real-time testbed and demonstrate that our SDN-based handover mechanism significantly reduces the number and duration of video freeze events and allows for smaller playout buffers. | Peter Dely Andreas Kassler Lawrence Chow Nicholas Bambos Nico Bayer Hans Einsiedler Christoph Peylo Daniel Mellado Miguel Sanchez | 2013 | Journal of Modern Transportation2013，21，1： | 3 |
| 5 | Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions显示文摘 | Silvina G. Castro Sergio F. Sanchez Bruni Lucí a P. Urbizu Alejandra Confalonieri Laura Ceballos Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2013 | Pharmaceutical Development and Technology2013，，2： | 2 |
| 6 | Improved Albendazole Dissolution Rate in Pluronic 188 Solid Dispersions显示文摘 | Silvina G. Castro Sergio Sanchez Bruni Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2010 | AAPS PharmSciTech2010，，4： | 2 |
| 7 | Projected effectiveness of HIV detection during early infection and rapid ART initiation among MSM and transgender women in Peru: A modeling study显示文摘Background:The Sabes study,a treatment as prevention intervention in Peru,tested the hypothesis that initiating antiretroviral therapy(ART)early in HIV infection when viral load is high,would markedly reduce onward HIV transmission among high-risk men who have sex with men(MSM)and transgender women(TW).We investigated the potential population-level benefits of detection of HIV early after acquisition and rapid initiation of ART.Methods:We designed a transmission dynamic model to simulate the HIV epidemic among MSM and TW in Peru,calibrated to data on HIV prevalence and ART coverage from 2004 to 2011.We assessed the impact of an intervention starting in 2018 in which up to 50%of the new infections were diagnosed within three months of acquisition and initiated on ART within 1 month of diagnosis.We estimated the impact of the intervention over 20 years using the cumulative prevented fraction of new HIV infections compared to scenarios without intervention.Findings:Our model suggests that only 19%of the infected MSM and TW are virally suppressed in 2018 and 35%e40%of the new HIV infections are transmitted from contacts with acutely-infected partners.An intervention reaching 10%of all acutely infected MSM and TW is projected to prevent 13.3%[Uncertainty interval:11.9%e14.3%]of the new infections over 20 years and reduce HIV incidence in 2038 by 24%.Reaching 50%of all acutely infected MSM and TWwill increase the prevalence of viral suppression in 2038 to 59%and prevent 41%of expected infections over 20 years.Reaching 50%of the high-risk MSM and TW in acute phase would reduce HIV incidence in 2038 by 60%and prevent 36%of new infections between 2018 and 2038.Conclusions:Early detection of HIV infections and rapid initiation of ART among MSM is desirable as it would increase the effectiveness of the HIV prevention program in Peru.Targeting high-risk MSM and TW will be highly efficient. | Dobromir Dimitrov Daniel Wood Angela Ulrich David A.Swan Blythe Adamson Javier R.Lama Jorge Sanchez Ann Duerr | 2019 | Infectious Disease Modelling2019，4，1： | 2 |
| 8 | Energy and environment comparison of two - stage solu- tions for commercial refrigeration at low temperature: Fluids and systems显示文摘 | Rodrigo Liopis Daniel Sanchez Sanz- Kock Carlos | 2015 | Applied Energy2015，138，： | 1 |
| 9 | Fuzzy Association Rules :General Model and Applications显示文摘 | Miguel Delgado Nicolas Marín Daniel Sanchez | 2003 | IEEE Transactions on2003，11，2： | 1 |
| 10 | Serial measurement of N-terminal pro–B-type natriuretic peptide and cardiac troponin T for cardiovascular disease risk assessment in the Multi-Ethnic Study of Atherosclerosis (MESA)显示文摘 | Lori B. Daniels Paul Clopton Christopher R. deFilippi Otto A. Sanchez Hossein Bahrami Joao A.C. Lima Russell P. Tracy David Siscovick Alain G. Bertoni Philip Greenland Mary Cushman Alan S. Maisel Michael H. Criqui | 2015 | American Heart Journal2015，，6： | 1 |
| 11 | A Fuzzy Language显示文摘 | Daniel Sanchez Alvarez Antonio F Gomez Skarme ta | 2004 | Fuzzy Sets and Systems2004，141，： | 1 |
| 12 | A fuzzy language显示文摘 | Daniel Sanchez Alvarez Antonio F Gomez Skarmeta | 2004 | Fuzzy Sets and Systems2004，141，： | 1 |
| 13 | Heterogeneity of Total Factor Productivity Across Latin American Countries: Evidence from Manufacturing Firms 显示文摘 | Daniel KAPP Alan SANCHEZ | 2012 | CES Working Paper2012，，34： | 1 |
| 14 | Rotavirus vaccines: considerations for successful implementation in Europe显示文摘 | Pierre Van Damme Marie Van der Wielen Filippo Ansaldi Daniel Desgrandchamps Javier Diez Domingo Francisco Gimenez Sanchez Jim Gray Martin Haditsch Kari Johansen Paula Lorgelly Mathie Lorrot Nathalie Parez Volkmar Reschke Markus Rose | 2006 | The Lancet Infectious Diseases2006，，12： | 1 |
| 15 | Pediatric cardiomyopathies: causes, epidemiology, clinical course, preventive strategies and therapies显示文摘 | Steven E Lipshultz Thomas R Cochran David A Briston Stefanie R Brown Peter J Sambatakos Tracie L Miller Adriana A Carrillo Liat Corcia Janine E Sanchez Melissa B Diamond Michael Freundlich Danielle Harake Tamara Gayle William G Harmon Paolo G Rusconi Sati | 2013 | Future Cardiol2013，，6： | 1 |
| 16 | A simple method to cure established tumors by inflammatory killing of normal cells显示文摘 | DANIELS G A SANCHEZ PEREZ L DIAZ R M | 2004 | Nat Biotechnol2004，22，9： | 1 |
| 17 | Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis显示文摘 | Marcia Cruz–Correa Daniel A. Shoskes Patricia Sanchez Rhongua Zhao Linda M. Hylind Steven D. Wexner Francis M. Giardiello | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 18 | Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis显示文摘 | Marcia Cruz–Correa Daniel A. Shoskes Patricia Sanchez Rhongua Zhao Linda M. Hylind Steven D. Wexner Francis M. Giardiello | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 19 | New approach for obtaining the C-factor of RUSLE considering the seasonal effect of rainfalls on vegetation cover显示文摘We present a new approach for calculating the C-factor of RUSLE considering the effect of low-reflectance vegetation cover areas on the reduction of the effects on erosion caused by rainfall seasonality.For this,we propose the coefficients Cr2(rescaled 2)and C-PC(Precipitation Correction),which represent the Cfactor,and an adaptation in NDVI calculation,according to the seasonality of precipitation(NDVI-PC).The Cr2 factor is used when there is no seasonal effect of rainfall on vegetation,while the C-PC factor is calculated for localities under the influence of seasonality,from NDVI-PC.The proposed approaches were tested using different satellites images in the Palmares-Ribeir~ao do Saco watershed,Rio de Janeiro,Brazil.The values of Cr2 and C-PC factors were compared to the Cr factor(rescaled)and to mean values from the literature for different land covers.Our results indicated that the Cr2 factor represents an improvement in accuracy in relation to Cr by considering specific values of the studied area to normalize the data without generalizations.Furthermore,the C-PC factor is able to simulate the effect of seasonality,providing more realistics values of soil loss by the RUSLE as a function of the proportion of area affected by the rainfall seasonality obtained from NDVI-PC.We conclude that both Cr2 and C-PC factors generate values similar of the C-factor observed in the literature,and therefore are able to provide better soil loss estimation than that using the Cr factor. | Pietro Menezes Sanchez Macedo Paulo Tarso Sanches Oliveira Mauro Antonio Homem Antunes Valdemir Lucio Durigon Elaine Cristina Cardoso Fidalgo Daniel Fonseca de Carvalho | 2021 | International Soil and Water Conservation Research2021，9，2： | 1 |
| 20 | A transport network reliability model for the efficient assignment of resources 显示文摘 | SANCHEZ S M DANIELS M LLERASA G | 2005 | Transportation Research Part B2005，39，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员