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| 1 | Site effects by generalized inversion technique using strong motion recordings of the 2008 Wenchuan earthquake显示文摘The generalized inversion of S-wave amplitude spectra from the free-field strong motion recordings of the China National Strong Motion Observation Network System (NSMONS) are used to evaluate the site effects in the Wenchuan area. In this regard, a total of 602 recordings from 96 aftershocks of the Wenchuan earthquake with magnitudes of M3.7-M6.5 were selected as a dataset. These recordings were obtained from 28 stations at a hypocenter distance ranging from 30 km to 150 km. The inversion results have been verified as reliable by comparing the site response at station 62WUD using the Generalized Inversion Technique (GIT) and the Standard Spectral Ratio method (SSR). For all 28 stations, the site predominant frequency Fp and the average site amplification in different frequency bands of 1.0-5.0Hz, 5.0-10.0Hz and 1.0-10.0 Hz have been calculated based on the inversion results. Compared with the results from the horizontal-to-vertical spectral ratio (HVSR) method, it shows that the HVSR method can reasonably estimate the site predominant frequency but underestimates the site amplification. The linear fitting between the average site amplification for each frequency band and the Vs20 (the average uppermost-20 m shear wave velocity) shows good correlation. A distance measurement called the asperity distance DAspt is proposed to reasonably characterize the source-to-site distance for large earthquakes. Finally, the inversed site response is used to identify the soil nonlinearity in the main shock and aftershocks of Wenchuan earthquake. In ten of the 28 stations analyzed in the main shock, the soil behaved nonlinearly, where the ground motion level is apparently beyond a threshold of PGA > 300cm/s2 or PGV > 20cm/s, and only one station coded 51SFB has evidence of soil nonlinear behavior in the aftershocks. | Ren Yefei Wen Ruizhi Hiroaki Yamanaka Toshihide Kashima | 2013 | Earthquake Engineering and Engineering Vibration2013，12，2： | 20 |
| 2 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 3 | Pseudolymphoma of the liver associated with primary biliary cirrhosis:A case report and review of literature显示文摘We report a case of two pseudolymphomas of the liver in a 63-year-old Japanese woman with primary biliary cirrhosis.One of the lesions was found incidentally during a medical examination,presenting as a 10 mm hypodense nodule that revealed hyperdensity in the early phase and hypodensity in the late phase in computed tomography(CT)after injection of contrast medium.Retrospectively,the 10 mm nodule had first been discovered as a 4 mm nodule during CT 4 years previously.Superparamagnetic iron oxide-enhanced MRI revealed another 4 mm hyperintense nodule in segment 6 in addition to the 10 mm hyperintense nodule in segment 7.CT during arterial portography revealed two hypointense nodules.Findings with other imaging modalities such as ultrasonography,magnetic resonance imaging,and hepatic angiography were consistent with hepatocellular carcinoma.A right posterior segmentectomy was performed,and the lesions were microscopically diagnosed as pseudolymphoma.To the best of our knowledge,only 31 other cases of this disease have ever been reported,with a highly asymmetrical male:female ratio of 1:9.7.Although we could find only one case of transformation of hepaticpseudolymphoma into lymphoma in the liver,the exact nature of development from benign pseudolymphoma to malignant lymphoma is still not fully understood and cases of hepatic lymphoma need to be followed carefully. | Toshihide Okada Hiroshi Mibayashi Kenkei Hasatani Yoshiaki Hayashi Shigetsugu Tsuji Yoshibumi Kaneko Masashi Yoshimitsu Takashi Tani Yoh Zen Masakazu Yamagishi | 2009 | World Journal of Gastroenterology2009，15，36： | 8 |
| 4 | Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats显示文摘AIM:To elucidate the role of neuropilin-1(Nrp-1) and semaphorin 3A(Sema3A) in sinusoidal remodeling during liver regeneration in rats.METHODS:Male Wistar/ST rats at 7 wk of age,weighing about 200 g,were used for all animal experiments.In vivo,at 24,48,72,96,144 and 192 h after twothirds partial hepatectomy(PHx),the remnant livers were removed.Liver tissues were immunohistochemically stained for Nrp-1,Sema3A and SE-1,a liver sinusoidal endothelial cell(SEC) marker.Total RNA of the liver tissue was extracted and reversely transcribed into cDNA.The mRNA expression of Sema3A was analyzed by quantitative real-time polymerase chain reaction and normalized to that of ribosomal protein S18.In vitro,SECs were isolated from rat liver and cultured in endothelial growth medium containing 20 ng/mL vascular endothelial cell growth factor.Migration of SECs in primary culture was assessed by cell transwell assay with or without recombinant Sema3A.Apoptotic cells were determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling method.RESULTS:In vitro,immunohistochemistry study revealed that Sema3A and Nrp-1 were constitutively expressed in hepatocytes and SECs,respectively,in normal rat liver tissues.Nrp-1 expression in SECs was quantified by the percentage of immunostained area with antiNrp-1 antibody in relation to the area stained with SE-1.Between 24 h and 96 h following resection of liver,Nrp-1 expression in SECs was transiently increased.Compared with the baseline(5.2% ± 0.1%),Nrp-1 expression in SECs significantly increased at 24 h(17.3% ± 0.7%,P < 0.05),48 h(39.1% ± 0.6%,P < 0.01),72 h(46.9% ± 4.5%,P < 0.01) and 96 h(29.9% ± 3.8%,P < 0.01) after PHx,then returned to the basal level at termination of liver regeneration.Interestingly,the expression of Sema3A was inversely associated with that of Nrp-1 in liver after PHx.Sema3A mRNA expression was significantly reduced by about 75% over the period 24-144 h after PHx(P < 0.05),and returned to basal levels at 192 h after PHx.In vitro,SECs isolated from rats after PHx(PHx-SECs) were observed to migrate to the lower chamber of the cell transwell system after incubation for 24 h,but not cells from normal rats(CONT-SECs),indicating that mobility of PHx-SECs increases as compared with that of CONT-SECs.Moreover,recombinant Sema3A significantly attenuated migration in PHx-SECs in primary culture(vehicle-treated 100% ± 7.9% vs Sema3A-treated 42.6% ± 5.4%,P < 0.01),but not in CONT-SECs.Compared with CONTSECs,the apoptotic rate of PHx-SECs decreased by 78.3%(P < 0.05).There was no difference in apoptosis between CONT-SECs that were treated with vehicle and Sema3A.However,in PHx-SECs,apoptosis was induced by the presence of 5 nmol Sema3A for 24 h(vehicle-treated 21.7% ± 7.6% vs Sema3A-treated 104.3% ± 8.9%,P < 0.05).In addition,immunohistochemistry confirmed the increased expression of Nrp-1 in PHx-SECs,while it was noted to a lesser extent in CONT-SECs.CONCLUSION:The interplay of Nrp-1 and Sema3A shown in our results may lead to a better understanding of interaction between sinusoidal remodeling and SECs during liver regeneration. | Ling Fu Tsuneo Kitamura Kazuhisa Iwabuchi Syozo Ichinose Mitsuaki Yanagida Hideoki Ogawa Sumio Watanabe Toshihide Maruyama Masafumi Suyama Kenji Takamori | 2012 | World Journal of Gastroenterology2012，18，36： | 5 |
| 5 | 鸡氨肽酶H在大肠杆菌中的表达、纯化与部分酶学性质分析显示文摘氨肽酶H(Aminopeptidase H,APH))是生物组织内一种常见的氨基内肽酶,但因为天然材料中含量很低,基本无法深入研究其催化机理、功能与结构的关系及其在生物体内的确切功能。从鸡肝组织克隆了APH的全基因序列,并把该序列亚克隆到载体pET22b(+)上,然后转化大肠杆菌Rosetta(DE3),构建了APH的表达菌株。该菌株经IPTG诱导,在SDS-PAGE上明显出现一条与天然APH理论分子量一致的新增蛋白带,该条带的浓度随着表达时间的延长逐渐加深;6h基本达到平衡,此时重组蛋白占总蛋白的16.7%,表达水平高达94.7mg/L。对表达产物进行了活性检测、纯化和酶学性质分析,发现重组蛋白在亚基构成,热稳定性,最适pH等方面与天然APH基本相同,据此可以确认表达产物确实是APH,发酵液总活力达到1636u/L。这些结果为APH的催化机理及其在生物体内的功能的阐明奠定了重要的物质基础。 | 赖庆安 刘树滔 卢菀华 陈莉 Toshihide NISHIMURA 饶平凡 | 2008 | 生物工程学报2008，24，3： | 5 |
| 6 | Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions显示文摘AIM To investigate daclatasvir(DCV) and asunaprevir(ASV) efficacy in hepatitis C(HCV) patients, with respect to resistance-associated substitutions(RASs).METHODS A total of 392 HCV-infected patients from multiple centers were included in this study. We evaluated their clinical courses and sustained virologic responses(SVR) according to pretreatment factors(gender, age, history of interferon-based regimens, platelet counts, level of viremia, pretreatment NA5A:L31, and Y93 substitutions). We also analyzed the pretreatment and post-treatment major RASs of NS3:D168, NS5A:L31 and Y93 substitutions using a direct-sequencing method in 17 patients who were unable to achieve SVR at 12 wk after treatment completion(SVR12).RESULTS The overall SVR12 rate was 88.3%. Thirty-one patients discontinued treatment before 24 wk because of adverse events, 23 of whom achieved SVR12. There were no significant differences in SVR12 rates with respect to gender, age, history of interferon-based regimens, and platelet counts. The SVR12 rate in patients with viral loads of ≥ 6.0 log IU/m L was significantly lower than those with viral loads of < 6.0 log IU/m L(P < 0.001). The SVR12 rate in patients with Y93 substitution-positive was significantly lower than those with Y93 substitution-negative(P < 0.001). The L31 substitution-positive group showed a lower SVR12 rate than the L31 substitution-negative group, but the difference was not statistically significant. Seventeen patients who did not achieve SVR12 and had available pretreatment and post-treatment sera had additional RASs in NS3:D168, NS5:L31, and Y93 substitution at treatment failure.CONCLUSION Combination of DCV and ASV is associated with a high SVR rate. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure. | Hideki Fujii Atsushi Umemura Taichiro Nishikawa Kanji Yamaguchi Michihisa Moriguchi Hideki Nakamura Kohichiroh Yasui Masahito Minami Saiyu Tanaka Hiroki Ishikawa Hiroyuki Kimura Shiro Takami Yasuyuki Nagao Toshihide Shima Yoshito Itoh | 2017 | World Journal of Hepatology2017，9，25： | 3 |
| 7 | A High-Precision US-Guided Robot-Assisted HIFU Treatment System for Breast Cancer显示文摘乳腺癌是女性中最常见的癌症。高强度聚焦超声(波)(HIFU)是一种很有前景的非介入式治疗方法。为了提高HIFU治疗的精确度和降低治疗成本,开发了一套基于超声引导(US)的五自由度辅助HIFU系统。搭建了一套功能齐全的样机,它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU自动照射等功能。利用线模型实现点定位,并且在异构组织模型上对凝固区域进行评估。在超声引导下,HIFU治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗,本系统有足够的准确性。 | Tianhan Tang Takashi Azuma Toshihide Iwahashi Hideki Takeuchi Etsuko Kobayashi Ichiro Sakuma | 2018 | Engineering2018，4，5： | 3 |
| 8 | Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?显示文摘 | Kazuhiro Miwa Hisashi Doyama Renma Ito Hiroyoshi Nakanishi Katsura Hirano Satoko Inagaki Kei Tominaga Naohiro Yoshida Kenichi Takemura Shinya Yamada Yoshibumi Kaneko Kazuyoshi Katayanagi Hiroshi Kurumaya Toshihide Okada Masakazu Yamagishi | 2012 | Gastric Cancer2012，，2： | 3 |
| 9 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 10 | Use of omentum or falciform ligament does not decrease complications after pancreaticoduodenectomy: Nationwide survey of the Japanese Society of Pancreatic Surgery显示文摘 | Masaji Tani Manabu Kawai Seiko Hirono Takashi Hatori Toshihide Imaizumi Akimasa Nakao Shinichi Egawa Takehide Asano Takukazu Nagakawa Hiroki Yamaue | 2012 | Surgery2012，，2： | 2 |
| 11 | Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study显示文摘 | Kazuaki Kitajima Takahiro Fujimori Shigehiko Fujii Jun Takeda Yasuo Ohkura Hitoshi Kawamata Toshihide Kumamoto Shingo Ishiguro Yo Kato Tadakazu Shimoda Akinori Iwashita Yoichi Ajioka Hidenobu Watanabe Toshiaki Watanabe Tetsuichiro Muto Ko Nagasako | 2004 | Journal of Gastroenterology2004，，6： | 2 |
| 12 | Intracranial malignant solitary fibrous tumor metastasized to the chest wall:A case report and review of literature显示文摘BACKGROUND Solitary fibrous tumor(SFT)is a rare fibroblastic mesenchymal neoplasm that affects spindle cell soft tissues with broad-spectrum biological behavior;it is predominantly benign,and rarely metastasizes.SFT occurs mainly in the tissue structure of the serosa in the pleura and the thorax,and can be found throughout the body,though extra-thoracic localization,including the cephalic region,is uncommon.We reported the first case of intracranial malignant SFT metastasized to the chest wall.CASE SUMMARY An 81-year-old Japanese man was referred to our hospital due to progressive gait disturbance and appetite loss.His medical history included partial resection due to brain tumor,four times,and 50-Gray radiation therapy at another hospital,starting when he was 74 years old.An unenhanced head computed tomography(CT)scan revealed an 8 cm×5.1 cm×6.5 cm mixed-density mass at the left frontal lobe,accompanying a midline shift,and an unenhanced chest-abdomen CT scan revealed a 6 cm×4.1 cm×6.5 cm low-density mass in the left chest wall.A CT-guided percutaneous lung biopsy was performed,and the pathological findings were SFT corresponding to brain tumor.Finally,the correct diagnosis of his brain tumor in history of past illness revealed to be SFT,and the unremovable tumor,namely present brain lesions enlarged and metastasized to the chest wall.We established a definitive diagnosis of intracranial malignant SFT metastasized to the chest wall.We notified him and his family of the disease,and offered palliative care.He passed away on the 29 th hospital day.CONCLUSION This case suggests the need for careful,detailed examination,and careful followup when encountering patients presenting with a mass. | Daisuke Usuda Shinya Yamada Toshihide Izumida Ryusho Sangen Toshihiro Higashikawa Ken Nakagawa Masaharu Iguchi Yuji Kasamaki | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 13 | Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma显示文摘 | Kohichiroh Yasui Etsuko Hashimoto Yasuji Komorizono Kazuhiko Koike Shigeki Arii Yasuharu Imai Toshihide Shima Yoshihiro Kanbara Toshiji Saibara Takahiro Mori Sumio Kawata Hirofumi Uto Shiro Takami Yoshio Sumida Toshinari Takamura Miwa Kawanaka Takeshi Oka | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 14 | Case of a tumor comprising gastric cancer and duodenal neuroendocrine tumor显示文摘The present report describes a rare case of a tumor composed of early gastric cancer and a duodenal neuroendocrine tumor(NET). A 78-year-old woman underwent esophagogastroduodenoscopy at a local institution for screening of the upper gastrointestinal tract which revealed a protruded tumor through the pyloric ring from the pyloric antrum. The tumor was too large to treat at the facility; consequently, she was referred to our hospital for further management. Esophagogastroduodenoscopy with tumor biopsy of the lesion revealed the diagnosis of early gastric cancer. Endoscopic submucosal dissection was performed with sufficient free margins in both vertical and horizontal directions. Histopathological findings showed NET confined to the submucosal layer and covered by welldifferentiated adenocarcinoma. Immunohistochemical stainings showed that the two lesions existed continuously. While the possibility of a collision cancer was considered, it was suggested that the two lesions existed continuously. Finally, the tumor was diagnosed as gastric cancer composed of duodenal NET G1, with a lymphatic invasion of NET component. | Hiroaki Kaneko Akio Miyake Yasuaki Ishii Soichiro Sue Haruo Miwa Tomohiko Sasaki Toshihide Tamura Masaaki Kondo Shin Maeda | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 15 | 1-Hexene isomerization and n-hexane cracking over HMCM-22显示文摘 | ANUP K T KRISHNA G B TOSHIHIDE B | 2001 | Applied Catalysis A:General2001，213，2： | 1 |
| 16 | Intraoperative radiotherapy for resectable extrahepatic bile duct cancer显示文摘 | Hiromasa K Katsuyuki K Toshihide K | 1999 | Int J Radiat Oncol Biol phys1999，45，3： | 1 |
| 17 | Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity显示文摘 | Ayumi Yoshizaki Kazuhiro Komura Yohei Iwata Fumihide Ogawa Toshihide Hara Eiji Muroi Motoi Takenaka Kazuhiro Shimizu Minoru Hasegawa Manabu Fujimoto Shinichi Sato | 2009 | Journal of Clinical Immunology2009，，2： | 1 |
| 18 | Palladium/P(t-Bu)3-catalyzed synthesis of N-aryl azoles and application to t-he synthesis of 4,4′,4″-tris(N-azolyl)triphenylamines显示文摘 | Makoto W Masakazu N Toshihide Y | 2000 | Tetrahedron Letters2000，41，： | 1 |
| 19 | Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat显示文摘 | Toshihide | 2000 | Molecular Brain Res2000，78，12： | 1 |
| 20 | Improvement of corrosion resistance of magnesium metal by rare earth elements显示文摘 | Toshihide Takenaka Takami Ono Yuji Narazaki | 2007 | Eleetroehimica Aeta2007，53，1： | 1 |
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