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| 1 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 2 | 细胞连接对组织冷冻损伤的作用显示文摘目的 了解在无保护剂条件下细胞连接在组织冷冻损伤中的作用。 方法 采用细胞单层中可形成细胞连接的犬上皮细胞系 (MDCK)细胞和不形成细胞连接的中国仓鼠成纤维细胞系(V79)细胞 ,分为细胞悬液组、贴壁组和单层细胞组分别进行 0~ 40℃之间的梯度冷冻实验 ,然后采用新型的四氮唑盐法和脂溶性细胞活化剂法测定细胞的活力并进行比较。 结果 两种方法测定的结果一致 ,均显示两种细胞的细胞悬液冷冻后活力高于贴壁组和单层细胞组 ;MDCK细胞贴壁组活力高于单层细胞组 ,V79细胞则无明显差异 ;MDCK单层细胞组活力却明显低于V79单层细胞组。 结论 组织细胞间的连接以及细胞与细胞基质的连接对组织冷冻的损伤有重要的作用 ,它们的存在直接影响组织细胞的活力 ,其原因可能与构成细胞连接的细胞骨架系统有关。 | 贾晓明 纪晓峰 Yang Hongyou Ebertz Stacey McGann LocksleZHWK200112000y | 2001 | 中华外科杂志2001，39，12： | 11 |
| 3 | Automatic prediction of time to failure of open pit mine slopes based on radar monitoring and inverse velocity method显示文摘Radar slope monitoring is now widely used across the world, for example, the slope stability radar(SSR)and the movement and surveying radar(MSR) are currently in use in many mines around the world.However, to fully realize the effectiveness of this radar in notifying mine personnel of an impending slope failure, a method that can confidently predict the time of failure is necessary. The model developed in this study is based on the inverse velocity method pioneered by Fukuzono in 1985. The model named the slope failure prediction model(SFPM) was validated with the displacement data from two slope failures monitored with the MSR. The model was found to be very effective in predicting the time to failure while providing adequate evacuation time once the progressive displacement stage is reached. | Osasan K.S. Stacey T.R. | 2014 | International Journal of Mining Science and Technology2014，24，2： | 9 |
| 4 | 破产重整程序中的管理人制度显示文摘中国企业重整程序中的管理人制度尚存有诸多需要用立法或司法解释作出进一步改进的地方。这里主要包括两个大问题,首先是管理人的选任方法、任职资格以及报酬等有关管理人的选任程序相关的问题;其次是管理人的权限、义务等涉及管理人就任后的职责履行方面的规制问题。 | 金春 Stacey Steele Andrew Godwin | 2010 | 政法论坛2010，28，6： | 8 |
| 5 | The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors显示文摘 | Wei Gong Kun He Mike Covington S. R Dinesh-Kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga | 2008 | Molecular Plant2008，1，1： | 7 |
| 6 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 7 | Cancer treatment and survivorship statistics, 2012显示文摘 | Rebecca Siegel Carol DeSantis Katherine Virgo Kevin Stein Angela Mariotto Tenbroeck Smith Dexter Cooper Ted Gansler Catherine Lerro Stacey Fedewa Chunchieh Lin Corinne Leach Rachel Spillers Cannady Hyunsoon Cho Steve Scoppa Mark Hachey Rebecca Kirch Ahmed | 2012 | CA: A Cancer Journal for Clinicians2012，，4： | 6 |
| 8 | Outcomes in randomized controlled trials of exercise interventions in solid organ transplant显示文摘AIM To identify the outcome measures that have been used in randomized controlled trials(RCTs) of exercise training in solid organ transplant(SOT) recipients and to link these outcomes to the International Classification of Functioning, Disability and Health(ICF) framework.METHODS Electronic literature searches of MEDLINE, EMBASE, CINAHL, Cochrane, Scopus, and Web of Science were performed. We sought RCTs that investigated the effect of exercise training in SOT recipients. Reference lists of all eligible publications were searched for other appropriate studies not identified by the electronic search. A complete list of outcome measures used in the RCTs was generated and each of these was linked to an ICF category.RESULTS Four hundred and thirteen articles were retrieved, of which 35 met our inclusion criteria. The studies included were designed to compare the effects of exercise training programs to usual care or to another exercise training program and reported on recipients of heart(n = 21), kidney(n = 9), lung(n = 3) or liver(n = 2) transplant. Of the 126 outcome measures identified, 62 were used as primary outcome measures. The most commonly occurring primary outcomes were aerobic capacity using the peak VO2(n = 13), quality of life using the shortform-36(n = 8), and muscle strength(n = 7). Theseoutcome measures were linked to 113 ICF categories and the majority of outcomes fall into the body function domain(n = 93). CONCLUSION There is little standardization in outcome measures used in RCTs of exercise interventions in SOT recipients. The ICF framework can be used to select a core set of outcomes that cross all domains of ICF and that would be appropriate to all SOT recipients. | Tania Janaudis-Ferreira Sunita Mathur Stacey Konidis Catherine M Tansey Cecile Beaurepaire | 2016 | World Journal of Transplantation2016，6，4： | 4 |
| 9 | Vitamin D Deficiency Is Associated with Ulcerative Colitis Disease Activity显示文摘 | Stacey Blanck Faten Aberra | 2013 | Digestive Diseases and Sciences2013，，6： | 4 |
| 10 | Leaching of dissolved organic matter from seagrass leaf litter and its biogeochemical implications显示文摘Dissolved organic matter(DOM) represents a significant source of nutrients that supports the microbial-based food web in seagrass ecosystems. However, there is little information on how the various fractions of DOM from seagrass leaves contributed to the coastal biogeochemical cycles. To address this gap, we carried out a 30-day laboratory chamber experiment on tropical seagrasses Thalassia hemprichii and Enhalus acoroides. After 30 days of incubation, on average 22% carbon(C), 70% nitrogen(N) and 38% phosphorus(P) of these two species of seagrass leaf litter was released. The average leached dissolved organic carbon(DOC), dissolved organic nitrogen(DON) and dissolved organic phosphorus(DOP) of these two species of seagrass leaf litter accounted for 55%, 95% and 65% of the total C, N and P lost, respectively. In the absence of microbes, about 75% of the total amount of DOC, monosaccharides(MCHO), DON and DOP were quickly released via leaching from both seagrass species in the first 9 days. Subsequently, little DOM was released during the remainder of the experiment. The leaching rates of DOC, DON and DOP were approximately 110, 40 and 0.70 μmol/(g·d). Leaching rates of DOM were attributed to the nonstructural carbohydrates and other labile organic matter within the seagrass leaf. Thalassia hemprichii leached more DOC, DOP and MCHO than E. acoroides. In contrast, E. acoroides leached higher concentrations of DON than T. hemprichii, with the overall leachate also having a higher DON: DOP ratio. These results indicate that there is an overall higher amount of DOM leachate from T. hemprichii than that of E. acoroides that is available to the seagrass ecosystem. According to the logarithmic model for DOM release and the in situ leaf litter production(the Xincun Bay, South China Sea), the seagrass leaf litter of these two seagrass species could release approximately 4×10~3 mol/d DOC, 1.4×10~3 mol/d DON and 25 mol/d DOP into the seawater. In addition to providing readily available nutrients for the microbial food web, the remaining particulate organic matter(POM)from the litter would also enter microbial remineralization processes. What is not remineralized from either DOM or POM fractions has potential to contribute to the permanent carbon stocks. | LIU Songlin JIANG Zhijian ZHOU Chenyuan WU Yunchao ARBI Iman ZHANG Jingping HUANG Xiaoping TREVATHAN-TACKETT Stacey M. | 2018 | Acta Oceanologica Sinica2018，37，8： | 4 |
| 11 | Hemodynamic improvement using methylene blue after calcium channel blocker overdose显示文摘Dear editor,Calcium channel blocker overdoses are often fatal despite standard treatment. Methylene blue is a novel adjunct that should be considered in refractory cases.Currently accepted therapeutic modalities include intravenous fluids, calcium, vasopressors and high-dose insulin euglycemic therapy, however shock may | Sophia Ahmed Stacey Barnes | 2019 | World Journal of Emergency Medicine2019，10，1： | 3 |
| 12 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 13 | FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity显示文摘 | Krishna S. Gunturu Xiaopan Yao Xiangyu Cong Jaykumar R. Thumar Howard S. Hochster Stacey M. Stein Jill Lacy | 2013 | Medical Oncology2013，，1： | 3 |
| 14 | 孕期补充叶酸:不仅仅是预防神经管缺陷显示文摘叶酸(维生素B9)是DNA复制的必需原料,并且是氨基酸合成、维生素代谢中酶促反应的底物之一。由于孕期胎儿的生长发育也需要叶酸,因此孕期对叶酸需求也相应增加。叶酸缺乏会引起母婴异常,孕妇主要有贫血、周围神经病变,而胎儿则有发生先天性畸形的可能。这篇文章综述了叶酸的代谢、孕期如何合理补充叶酸及其潜在的益处,以及补充左旋甲基叶酸对神经管缺陷以外的孕期相关并发症的预防作用。 | James A.Greenberg Stacey J.Bell Yong Guan Yan-hong Yu 高云飞 黄启涛 乔娟(译) | 2012 | 妇产与遗传(电子版)2012，2，3： | 3 |
| 15 | Neuroendocrine tumors of the pancreas显示文摘 | Stacey A. Milan Charles J. Yeo | 2012 | Current Opinion in Oncology2012，，1： | 3 |
| 16 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 17 | The dimensionality of counterproductivity: Are all counterproductive behaviors created equal?显示文摘 | Paul E. Spector Suzy Fox Lisa M. Penney Kari Bruursema Angeline Goh Stacey Kessler | 2005 | Journal of Vocational Behavior2005，，3： | 2 |
| 18 | Statistical issues and approaches in endophenotype research显示文摘The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic component of disease liability can be estimated by fitting multivariate genetic models to twin data. A number of statistical methods have been developed for incorporating endophenotypes in genetic linkage and association analyses with the aim of improving statistical power. The most recent of such methods can handle multiple endophenotypes simultaneously for the greatest increase in power. In addition to increasing statistical power, endophenotype research plays an important role in helping to understand the mechanisms which connect the associated genetic variants with disease occurrence. Novel statistical approaches may be required for the analysis of the complex relationships between endophenotypes at different levels and how they converge to cause the occurrence of disease. | SHAM Pak Chung CHERNY Stacey S HALL Mei-Hua | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 19 | ECT2 and RASAL2 Mediate Mesenchymal-Amoeboid Transition In Human Astrocytoma Cells显示文摘 | Adrienne Weeks Nadia Okolowsky Brian Golbourn Stacey Ivanchuk Christian Smith James T. Rutka | 2012 | The American Journal of Pathology2012，，2： | 2 |
| 20 | The Effect of Perioperative Anemia on Clinical and Functional Outcomes in Patients With Hip Fracture显示文摘 | Ethan A. Halm Jason J. Wang Kenneth Boockvar Joan Penrod Stacey B. Silberzweig Jay Magaziner Kenneth J. Koval Albert L. Siu | 2004 | Journal of Orthopaedic Trauma2004，，6： | 2 |
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