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| 1 | Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies显示文摘 | Lehmann Brian D Bauer Joshua A Chen Xi Sanders Melinda E Chakravarthy A Bapsi Shyr Yu Pietenpol Jennifer A | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 2 | Paracrine activation of hepatic stellate cells in platelet‐derived growth factor C transgenic mice: Evidence for stromal induction of hepatocellular carcinoma显示文摘 | Jocelyn H. Wright Melissa M. Johnson Masami Shimizu‐Albergine Renay L. Bauer Brian J. Hayes James Surapisitchat Kelly L. Hudkins Kimberly J. Riehle Simon C. Johnson Matthew M. Yeh Theodor K. Bammler Richard P. Beyer Debra G. Gilbertson Charles E. Alpers N | 2014 | Int. J. Cancer2014，，4： | 1 |
| 3 | Evaluating Natural Attractions for Tourism 显示文摘 | Jinyang Deng Brian King Thomas Bauer | 2002 | Annals of Tourism Research2002，29，2： | 1 |
| 4 | Evaluating natural attractions for tourism显示文摘 | Jinyang Deng Brian King Thomas Bauer | 2002 | Annals of Tourism Research2002，29，2： | 1 |
| 5 | Identification of human triple-negative breast cancer subtypes end Targets of Triple-negative Breast Cancer 显示文摘 | Brian D Lehmann Joshua A Bauer Xi Chen | 2011 | Journal of Clinical Investigation2011，121，7： | 1 |
| 6 | Processes of StateFormation in the Inca Heartland (Cuzco, Peru) 显示文摘 | BRIAN S BAUER RAC | 2002 | American anthropologist2002，104，3： | 1 |
| 7 | 2012 White Paper on Recent Issues in Bioanalysis and Alignment of Multiple Guidelines显示文摘 | Binodh DeSilva Fabio Garofolo Mario Rocci Suzanne Martinez Isabelle Dumont France Landry Catherine Dicaire Gabriella Szekely-Klepser Russell Weiner Mark Arnold Surendra Bansal Kevin Bateman Ronald Bauer Brian Booth Scott Davis Sherri Dudal Dominique Gouty | 2012 | Bioanalysis2012，，18： | 1 |
| 8 | Evaluating national attractions for tourism显示文摘 | Jinyang Deng Brian King Thomas Bauer | 2002 | Annals of Tourism Research2002，，2： | 1 |
| 9 | 2011 White Paper on Recent Issues in Bioanalysis and Regulatory Findings from Audits and Inspections显示文摘 | Fabio Garofolo Mario L Rocci Isabelle Dumont Suzanne Martinez Steve Lowes Eric Woolf Peter van Amsterdam Surendra Bansal Ariadna Cristina Gomes Barra Ronald Bauer Brian P Booth Montserrat Carrasco-Triguero Binodh DeSilva John Dunn Keith Gallicano Dominiqu | 2011 | Bioanalysis2011，，18： | 1 |
| 10 | Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer显示文摘 | Todd W. Bauer MD Francis R. Spitz MD Linda S. Callans MD Abass Alavi MD Rosemarie Mick MS Susan P. Weinstein MD Isabelle Bedrosian MD Douglas L. Fraker MD Thomas L. Bauer MD Brian J. Czerniecki MD PhD | 2002 | Annals of Surgical Oncology2002，，2： | 1 |
| 11 | Land cover classification and change analysis of the Twin Cities (Minnesota) Metropolitan Area by multitemporal Landsat remote sensing显示文摘 | Fei Yuan Kali E. Sawaya Brian C. Loeffelholz Marvin E. Bauer | 2005 | Remote Sensing of Environment2005，，2： | 1 |
| 12 | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-a-MSH and setmelanotide显示文摘The melanocortin-4 receptor(MC4R),a hypothalamic master regulator of energy homeostasis and appetite,is a class A G-protein-coupled receptor and a prime target for the pharmacological treatment of obesity.Here,we present cryo-electron microscopy structures of MC4R-Gs-protein complexes with two drugs recently approved by the FDA,the peptide agonists NDP-a-MSH and setmelanotide,with 2.9 A and 2.6 A resolution.Together with signaling data from structure-derived MC4R mutants,the complex structures reveal the agonist-induced origin of transmembrane helix(TM)6-regulated receptor activation.The ligand-binding modes of NDP-a-MSH,a high-affinity linear variant of the endogenous agonist a-MSH,and setmelanotide,a cyclic anti-obesity drug with biased signaling toward Gq/11,underline the key role of TM3 in ligand-specific interactions and of calcium ion as a ligand-adaptable cofactor.The agonist-specific TM3 interplay subsequently impacts receptor-Gs-protein interfaces at intracellular loop 2,which also regulates the G-protein coupling profile of this promiscuous receptor.Finally,our structures reveal mechanistic details of MC4R activation/inhibition,and provide important insights into the regulation of the receptor signaling profile which will facilitate the development of tailored anti-obesity drugs. | Nicolas A.Heyder Gunnar Kleinau David Speck Andrea Schmidt Sarah Paisdzior Michal Szczepek Brian Bauer Anja Koch Monique Gallandi Dennis Kwiatkowski Jorg Burger Thorsten Mielke Annette G.Beck-Sickinger Peter W.Hildebrand Christian M.T.Spahn Daniel Hilger Magdalena Schacherl Heike Biebermann Tarek Hilal Peter Kuhnen Brian K.Kobilka Patrick Scheerer | 2021 | Cell Research2021，31，11： | 0 |
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