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| 1 | 中德初级卫生保健的比较研究显示文摘初级卫生保健无论在发达国家还是发展中国家都是卫生保健系统的一个明显特征。根据Starfield提出的不同国家初级卫生保健发展状况要素,对中德两国的初级卫生保健人员、资金来源和支付方式、服务方式及改革和发展趋势等进行比较研究。通过分析借鉴德国的初级卫生保健和全科医生制度,探讨我国初级卫生保健的实现途径,以促进卫生体制的深化改革。 | 王红妹 李鲁 Martin Beyer Perdinand M.Gerlach | 2004 | 中华医院管理杂志2004，20，3： | 4 |
| 2 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 3 | 佛罗里达涉禽羽毛的汞浓度显示文摘1987~1990年,在美国佛罗里达州奥基乔比湖及其南边的湿地收集了92只涉禽(涉水鸟)的初级飞羽或尾羽。雏鸟羽毛中汞平均浓度检定结果:玫瑰琵鹭(Ajaia ajaja)为 2.0ppm,大蓝鹭(Ardea herodias)为 3.5ppm,大白鹭(Ardea herodias occidentalis)为4.7ppm,巨白鹭(Casmerodius albus)为7.1ppm。大白鹭羽毛中汞的浓度随年龄增长而升高,雏鸟为4.7ppm,幼鸟为6.7ppm,成鸟为8.2ppm。猎食大鱼的鸟类汞浓度最高。林鹳(Mycteriaamericana)羽毛中汞平均浓度为3.3ppm。佛罗里达南部涉禽羽毛中汞浓度比所报道的亚洲涉禽羽毛中的要高。已知25只涉禽肝脏和羽毛中汞浓度。肝脏(湿重)汞浓度(Y)与羽毛汞浓度(X)的回归方程是:log(Y)=1.52log(X)-0.722,相关系数为0.84。如果成鸟羽毛中平均汞浓度达9ppm,就会出现生殖失调,正如从一项已发表的绿头鸭(Anas platyrhynchos)实验室研究成果可以推断的那样,那么,佛罗里达南部汞浓度就高得足以减少涉禽种群的繁殖力。然而,在有把握地指定羽毛中最低中毒浓度以前,需要另外进行对照研究。 | W.Nelson Beyer Marilyn Spalding Doug Morrison 寒江 | 1997 | 人类环境杂志1997，26，2： | 4 |
| 4 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 5 | Heterogeneous populations of neural stem cells contribute to myelin repair显示文摘As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis(MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demonstrated the increasing inability of oligodendrocyte precursor cells(OPCs) to replace lost oligodendrocytes(OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair. | Rainer Akkermann Felix Beyer Patrick Küry | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 6 | Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming显示文摘 | Payman Samavarchi-Tehrani Azadeh Golipour Laurent David Hoon-ki Sung Tobias A. Beyer Alessandro Datti Knut Woltjen Andras Nagy Jeffrey L. Wrana | 2010 | Cell Stem Cell2010，，1： | 3 |
| 7 | Rapid,simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection显示文摘A rapid and simple method for the determination of polyhexamethylene biguanide(polyhexanide,PHMB)in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection(HPLC-DAD)was developed.Best separation was achieved using a cyanopropyl bonded phase(Agilent Zorbax Eclipse XDB-CN column 4.6 mm x 75 mm with particle size of 3.5μm)as well as gradient elution consisting of acetonitrile/deionized water at a flow rate of 1.0mL/min.The optimized and applied chromatographic conditions permitted separation of polyhexanide from interacting matrix with subsequent detection at a wavelength of 235 nm with good sensitivity.The method validation was carried out with regard to the guidelines for analytical procedures demanded by the International Conference on Harmonisation(ICH).Mean recoveries of 102%and 101%for gel-like as well as liquid preparations were obtained.Suitable repeatability as well as intermediate precision could be achieved with limits of detection≤0.004 mg/mL for both formulations,equivalent to≤0.004%PHMB concerning sample preparation.Determination of PHMB was accomplished without tedious sample preparation.Interacting matrix could be eliminated by the chromatographicprocedure with excellent performance of system suitability.All analytical requirements were fulfilled permitting a reliable and precise determination of PHMB in pharmaceuticals.Furthermore,the developed method was applied to stability testing of pharmaceutical preparations containing PHMB. | Markus Küsters Soren Beyer Stephan Kutscher Harald Schlesinger Michael Gerhartz | 2013 | Journal of Pharmaceutical Analysis2013，3，6： | 2 |
| 8 | Fish bioaccumulation and biomarkers in environmental risk assessment: a review显示文摘 | Ron van der Oost Jonny Beyer Nico P.E Vermeulen | 2002 | Environmental Toxicology and Pharmacology2002，，2： | 2 |
| 9 | Structural and functional characterization of the phytoene synthase promoter from Arabidopsis thaliana显示文摘 | Ralf Welsch Joaquin Medina Giovanni Giuliano Peter Beyer Johannes von Lintig | 2003 | Planta2003，，3： | 2 |
| 10 | The financial reporting environment: Review of the recent literature显示文摘 | Anne Beyer Daniel A. Cohen Thomas Z. Lys Beverly R. Walther | 2010 | Journal of Accounting and Economics2010，，2： | 2 |
| 11 | A modular DNA signal translator for the controlled release of a protein by an aptamer显示文摘 | Stefan Beyer Friedrich C Simmel | 2006 | Nucleic Acids Research2006，34，5： | 1 |
| 12 | Levels and effects ofdifferent forms of anxiety during pregnancy after a priormiscarriage显示文摘 | FERTL K I BERGNER A BEYER R | 2009 | Eur J Obstet Gynecol Reprod Biol2009，142，1： | 1 |
| 13 | 显示文摘 | Dolber PC Beyer EC Junker JL | 1992 | J Mol Cell Cardiol1992，24，12： | 1 |
| 14 | Explaining the demand for producer services: is cost-driven externalization the major factor? 显示文摘 | Beyers W B Lindahl D P | 1996 | Regional science1996，75，： | 1 |
| 15 | Evidence for the nature of true Lewis sites in faujasite - type zeolites显示文摘 | JACOBS P A H K BEYER | 1979 | J Phys Chem1979，83，9： | 1 |
| 16 | B-cell epitopes as a screening instrument for persistent cow's milk allergy显示文摘 | Jarvinen K Beyer K Vila L | 2002 | J Allergy clin immunol2002，110，2： | 1 |
| 17 | Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection 显示文摘 | Beyer M Bartz H Horner K | 2004 | J Allergy Clin Immunol2004，113，1： | 1 |
| 18 | Systematic screening at diagnosis of - 5/del (5) ( q31 ) , - 7, or chromosome 8 aneuploidy by interphase fluorescence in situ hybridization in 110 acute myelocytic leukemia and high - risk myelodysplastic syndrome patients : concordances and discrepancies with conventional cytogenetics 显示文摘 | Beyer V Castagne C Muhlematter D | 2004 | Cancer Genet Cytogenet2004，152，： | 1 |
| 19 | Regulatory T cells in cancer 显示文摘 | Beyer M Schultze J L | 2006 | Blood2006，108，3： | 1 |
| 20 | Identification of potato genes induced during colonization by Phytophthora infestans显示文摘 | Beyer K Binder A Boiler T | 2001 | Molecular Plant Pathology2001，2，： | 1 |
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