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| 1 | Fat:A matter of disturbance for the immune system显示文摘Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as 'a matter of disturbance for the immune system' with a focus on hepatic steatosis. | Alessandro Federico Elena D’Aiuto Francesco Borriello Giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma | 2010 | World Journal of Gastroenterology2010，16，38： | 12 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy. | Carthage P Moran Barra Neary Glen A Doherty | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 3 |
| 4 | Hereditary gastric cancer:Three rules to reduce missed diagnoses显示文摘Gastric cancer remains one of the most lethal cancers.The incidence and mortality rates are quite similar.The main reason for the high mortality is diagnosis at advanced stages of disease,when treatment options are poor.One of the supposed strategies to overcome late-stage diagnosis is identifying people at high risk with the aim of establishing rigorous clinical control,including routine endoscopy and biopsies.Hereditary gastric cancer(HGC)syndromes,though representing a sizeable group to monitor for prevention or,at least,for early diagnosis,are apparently extremely rare.The low rate of HGC diagnosis might be related to the low rates of suspicion,insufficient familiarity about clinical diagnosis criteria,and the supposed conditional necessity of a molecular diagnosis.In this review,we will discuss simple measures to increase HGC diagnosis by applying three rules that might provide an opportunity for precision care to benefit the families affected by this disease. | Paula Assumpcao Taíssa Araújo André Khayat Geraldo Ishak Sidney Santos Williams Barra Joao Felipe Acioli Benedito Rossi Paulo Assumpcao | 2020 | World Journal of Gastroenterology2020，26，13： | 3 |
| 5 | 有 atrial 纤维性颤动的病人的风险层化: Biomarkers 和其它未来观点显示文摘 Risk stratification of atrial fibrillation (AF) and adequate thromboembolism prophylaxis is the cornerstone of treatment in patients with AF. Current risk stratification schemes such as the CHADS 2 and CHA 2 DS 2 -VASc scores are based on clinical risk factors and suboptimally weight the risk/benefit of anticoagulation. Recently, the potential of biomarkers (troponin and NT-proBNP) in the RE-LY biomarker sub-analysis has been demonstrated. Echocardiography is also being evaluated as a possible approach to improve risk score performance. The authors present an overview on AF risk stratification and discuss future potential developments that may be introduced into our current risk stratification schemes. | Rui Providência Luís Paiva Sérgio Barra | 2012 | World Journal of Cardiology2012，4，6： | 3 |
| 6 | Deep Learning and Time Series-to-Image Encoding for Financial Forecasting显示文摘In the last decade,market financial forecasting has attracted high interests amongst the researchers in pattern recognition.Usually,the data used for analysing the market,and then gamble on its future trend,are provided as time series;this aspect,along with the high fluctuation of this kind of data,cuts out the use of very efficient classification tools,very popular in the state of the art,like the well known convolutional neural networks(CNNs)models such as Inception,Res Net,Alex Net,and so on.This forces the researchers to train new tools from scratch.Such operations could be very time consuming.This paper exploits an ensemble of CNNs,trained over Gramian angular fields(GAF)images,generated from time series related to the Standard&Poor's 500 index future;the aim is the prediction of the future trend of the U.S.market.A multi-resolution imaging approach is used to feed each CNN,enabling the analysis of different time intervals for a single observation.A simple trading system based on the ensemble forecaster is used to evaluate the quality of the proposed approach.Our method outperforms the buyand-hold(B&H)strategy in a time frame where the latter provides excellent returns.Both quantitative and qualitative results are provided. | Silvio Barra Salvatore Mario Carta Andrea Corriga Alessandro Sebastian Podda Diego Reforgiato Recupero | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，3： | 2 |
| 7 | Chemical analysis of French beans ( Phaseolus vulgaris L.) by headspace solid phase microextraction (HS-SPME) and simultaneous distillation/extraction (SDE)显示文摘 | A. Barra N. Baldovini A.-M. Loiseau L. Albino C. Lesecq L. Lizzani Cuvelier | 2006 | Food Chemistry2006，，3： | 2 |
| 8 | Influence of amount of recycled coarse aggregates and production process on properties of recycled aggregate concrete显示文摘 | M. Etxeberria E. Vázquez A. Marí M. Barra | 2007 | Cement and Concrete Research2007，，5： | 2 |
| 9 | Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma: Recurrence Pathway and Prognostic Factors显示文摘 | B. Pérez-Saborido S. Jiménez de los Galanes J.C. Menéu-Díaz C. Jiménez Romero A. Moreno Elola-Olaso Y. Fundora Suárez V. Barra Valencia E. Moreno-González | 2007 | Transplantation Proceedings2007，，7： | 2 |
| 10 | Hematopoietic stem cell transplantation for severe and refractory lupus.Analysis after five years and fifteen patients显示文摘 | Traynor AE Barra WG Rosa RM | | 0，，： | 2 |
| 11 | Influence of amount of recycled coarse aggregates and production process on properties of recycled aggregate concrete显示文摘 | M. Etxeberria E. Vázquez A. Marí M. Barra | 2007 | Cement and Concrete Research2007，，5： | 2 |
| 12 | 氢能技术的现状与未来(上)显示文摘氢是自然界里最轻的元素,其分子量为2.016。在一个大气压和20℃下的密度为83.764g/m^3,其液化温度大约为-253℃。由于这种特性,如按它的能量密度算,氢是难于以适当的形式来贮存的,而且有时还要消耗很多的能量。 相反,氢作为燃料却有很好的特性;低热值大约是 33.3kWh/kg或3kWh/标m^3,燃烧时只产生水。当与空气发生燃烧时则会产生氮氧化物,但可以适当控制燃烧温度来减少氮氧化物。如果氢用在燃料电池上来产生电能的话,不会有污染物排放。所以说,氢是一种有利于环境的理想燃料。 不幸的是,氢不以游离状态存在,而是以化合物的形态存在,其中最为常见的是水。如果氢可用对环境无害的能源(太阳能、风能、生物质、水力等)来生产。 | Luciano Barra 周鑫发 | 1995 | 能源工程1995，，2： | 2 |
| 13 | Heat recirculation and heat transfer in porous burners显示文摘 | Barra A J Ellzey J L | 2004 | Combustion and Flame2004，137，12： | 1 |
| 14 | Fracture initiation,growth and effect on stress field:a numerical investigation显示文摘 | Barra I G | 1998 | J Struct Geol1998，20，12： | 1 |
| 15 | Involvement of 5-hydroxytryptamine(HT) 7 receptors in the 5-HT excitatory effects on the rat urinary bladder显示文摘 | Palea S Lluel P Barras M | 2004 | BJU Int2004，94，7： | 1 |
| 16 | Data collection in a livemass casualty incident simulation: automated RFID technologyversus manually recorded system显示文摘 | Ngrassia P L Carenzo L Barra F L | 2012 | Eur J Emerg Med2012，191，： | 1 |
| 17 | Therapeutic Monitoring of Vancomycin in Adult Patients:A Consensus Review of the American Society of Health-SystemPharmacists, the Infectious Diseases Society of America, and thesociety of Infectious Dis- eases Pharmacists显示文摘 | Martin JH Norris R Barras M | 2010 | Clin Biochem Rev2010，31，2： | 1 |
| 18 | Spinal gout in a young pa- tient with involvement of thoracic, lumbar and sacroiliac re- gions显示文摘 | Kwan BY Osman S Barra L | 2013 | Joint Bone Spine2013，80，6： | 1 |
| 19 | Reproductionand growth of the deep-sea benthic foraminifer bu-limina marginata under different laboratory conditions显示文摘 | Barras C Geslin E Duplessy J C | 2009 | The Journal of Foraminiferal Research2009，39，3： | 1 |
| 20 | Dual graph representation of transport networks显示文摘 | Afiez J De La Barra T Pérez B | 1996 | Transportation Research Part B:Methodological1996，30，3： | 1 |
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