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| 1 | Gut microbiome in primary sclerosing cholangitis:A review显示文摘Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing.Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease(IBD)and the“gut-liver”axis is an emerging area of interest.A growing number of studies have begun to elucidate the role of the gut microbiota,its metabolites and its influence on host immune responses in the development of PSC and PSCIBD.Studies of the fecal microbiota have highlighted enriched levels of certain species,including Veillonella,Streptococcus and Enterococcus,among others.A heightened immune response to enteric dysbiosis and bacterial translocation have also been implicated.For example,Klebsiella pneumoniae strains derived from gnotobiotic mice transplanted with PSC-IBD microbiota were found to induce pore formation in human intestinal epithelial cells and enhanced Th17 responses.Gut microbes have additionally been hypothesized to be implicated in PSC pathogenesis through their role in the synthesis of various metabolites,including bile acids(BAs),which function as signaling molecules with important gut and hepatic effects.An expanded knowledge of the gut microbiome as it relates to PSC offers critical insight into the development of microbe-altering therapeutic interventions,such as antibiotics,nutritional interventions and fecal microbial transplantation.Some of these have already shown some preliminary evidence of benefit.Despite exciting progress in the field,much work remains to be done;areas that are particularly lacking include functional characterization of the microbiome and examination of pediatric populations.In this review,we summarize studies that have investigated the microbiome in PSC and PSC-IBD as well as putative mechanisms,including the potential role of metabolites,such as BAs.We then briefly review the evidence for interventions with microbe-altering properties for treating PSC. | Rebecca Little Eytan Wine Binita M Kamath Anne M Griffiths Amanda Ricciuto | 2020 | World Journal of Gastroenterology2020，26，21： | 5 |
| 2 | Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis显示文摘 | Jeffrey Hyams Lakshmi Damaraju Marion Blank Jewel Johanns Cynthia Guzzo Harland S. Winter Subra Kugathasan Stanley Cohen James Markowitz Johanna C. Escher Gigi Veereman–Wauters Wallace Crandall Robert Baldassano Anne Griffiths | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 3 |
| 3 | Information Technology and the Changing Fabric of Organization显示文摘 | Raymond F. Zammuto Terri L. Griffith Ann Majchrzak Deborah J. Dougherty Samer Faraj | 2007 | Organization Science2007，，5： | 2 |
| 4 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology显示文摘 | Geoffrey C. Nguyen Charles N. Bernstein Alain Bitton Anthony K. Chan Anne M. Griffiths Grigorios I. Leontiadis William Geerts Brian Bressler J. Decker Butzner Marc Carrier Nilesh Chande John K. Marshall Chadwick Williams Clive Kearon | 2014 | Gastroenterology2014，，3： | 2 |
| 5 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 6 | Pharmacokinetics of Infliximab in Children with Moderate-to-Severe Ulcerative Colitis: Results from a Randomized, Multicenter, Open-label, Phase 3 Study显示文摘 | Omoniyi J. Adedokun Zhenhua Xu Lakshmi Padgett Marion Blank Jewel Johanns Anne Griffiths Joyce Ford Honghui Zhou Cynthia Guzzo Hugh M. Davis Jeffrey Hyams | 2013 | Inflammatory Bowel Diseases2013，，13： | 1 |
| 7 | Information technology and the changing fabric oforganization 显示文摘 | RAYMOND F ZAMMUTO TERRI L GRIFFITH ANN MA-JCHRZAK | 2007 | Organization Science2007，，5： | 1 |
| 8 | Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，： | 1 |
| 9 | <ce:link locator='fx1'/> Response to Corticosteroids in Severe Ulcerative Colitis: A Systematic Review of the Literature and a Meta-Regression显示文摘 | Dan Turner Catharine M. Walsh A. Hillary Steinhart Anne M. Griffiths | 2007 | Clinical Gastroenterology and Hepatology2007，，1： | 1 |
| 10 | Endoscopic and Clinical Variables that Predict Sustained Remission in Children with Ulcerative Colitis Treated With Infliximab显示文摘 | Dan Turner Anne M. Griffiths Gigi Veerman Jewel Johanns Lakshmi Damaraju Marion Blank Jeffrey Hyams | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 11 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 12 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 13 | Evidence and Implications of Recent Climate Change in Northern Alaska and Other Arctic Regions显示文摘 | Larry D. Hinzman Neil D. Bettez W. Robert Bolton F. Stuart Chapin Mark B. Dyurgerov Chris L. Fastie Brad Griffith Robert D. Hollister Allen Hope Henry P. Huntington Anne M. Jensen Gensuo J. Jia Torre Jorgenson Douglas L. Kane David R. Klein Gary Kofinas A | 2005 | Climatic Change2005，，3： | 1 |
| 14 | A Two-Year Longitudinal Study of Persistent Lean Tissue Deficits in Children With Crohn’s Disease显示文摘 | Francisco A. Sylvester Scott Leopold Miriam Lincoln Jeffrey S. Hyams Anne M. Griffiths Trudy Lerer | 2009 | Clinical Gastroenterology and Hepatology2009，，4： | 1 |
| 15 | Growth Abnormalities Persist in Newly Diagnosed Children With Crohn Disease Despite Current Treatment Paradigms显示文摘 | Marian Pfefferkorn Georgine Burke Anne Griffiths James Markowitz Joel Rosh David Mack Anthony Otley Subra Kugathasan Jonathan Evans Athos Bousvaros M Susan Moyer Robert Wyllie Maria Oliva-Hemker Ryan Carvalho Wallace Crandall David Keljo TD Walters Neal L | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，2： | 1 |
| 16 | Beta‐blockers in cirrhosis patients with refractory ascites显示文摘 | Anne Robins Anne Bowden William Watson Fiona Smith William Gelson William Griffiths | 2014 | Hepatology2014，，5： | 1 |
| 17 | Evidence and Implications of Recent Climate Change in Northern Alaska and Other Arctic Regions显示文摘 | Larry D. Hinzman Neil D. Bettez W. Robert Bolton F. Stuart Chapin Mark B. Dyurgerov Chris L. Fastie Brad Griffith Robert D. Hollister Allen Hope Henry P. Huntington Anne M. Jensen Gensuo J. Jia Torre Jorgenson Douglas L. Kane David R. Klein Gary Kofinas A | 2005 | Climatic Change2005，，3： | 1 |
| 18 | Outcomes of Pediatric Inflammatory Bowel Disease: Socioeconomic Status Disparity in a Universal-Access Healthcare System显示文摘 | Eric I. Benchimol Teresa To Anne M. Griffiths Linda Rabeneck Astrid Guttmann | 2011 | The Journal of Pediatrics2011，，6： | 1 |
| 19 | Severe Pediatric Ulcerative Colitis: A Prospective Multicenter Study of Outcomes and Predictors of Response显示文摘 | Dan Turner David Mack Neal Leleiko Thomas D. Walters Krista Uusoue Steven T. Leach Andrew S. Day Wallace Crandall Mark S. Silverberg James Markowitz Anthony R. Otley David Keljo Petar Mamula Subra Kugathasan Jeffrey Hyams Anne M. Griffiths | 2010 | Gastroenterology2010，，7： | 1 |
| 20 | Transition of the Patient With Inflammatory Bowel Disease From Pediatric to Adult Care: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition显示文摘 | Robert Baldassano George Ferry Anne Griffiths David Mack James Markowitz Harland Winter | 2002 | Journal of Pediatric Gastroenterology and Nutrition2002，，3： | 1 |
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