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| 1 | Relationship between sonographically measured median nerve cross-sectional area and presence of peripheral neuropathy in diabetic subjects显示文摘BACKGROUND Neuropathy is a common complication of diabetes mellitus resulting from direct damage by hyperglycemia to the nerves and/or ischemia by microvascular injury to the endoneurial vessels which supply the nerves. Median nerve is one of the peripheral nerves commonly affected in diabetic neuropathy. The median nerve size has been studied in non-Nigerian diabetic populations. In attempt to contribute to existing literature, a study in a Nigerian population is needed.AIM To evaluate the cross-sectional area(CSA) of the median nerve using B-mode ultrasonography(USS) and the presence of peripheral neuropathy(PN) in a cohort of adult diabetic Nigerians.METHODS Demographic and anthropometric data of 85 adult diabetes mellitus(DM) and 85 age-and sex-matched apparently healthy control(HC) subjects were taken. A complete physical examination was performed on all study subjects to determine the presence of PN and modified Michigan Neuropathy Screening Instrument(MNSI) was used to grade its severity. Venous blood was taken from the study subjects for fasting lipid profile(FLP), fasting blood glucose(FBG) and glycated haemoglobin(HbA1 c) while their MN CSA was evaluated at a point 5 cm proximal to(5 cmCATL) and at the carpal tunnel(CATL) by high-resolution Bmode USS. Data was analysed using SPSS version 22.RESULTS The mean MN CSA was significantly thicker in DM subjects compared to the HC at 5 cmCATL(P < 0.01) and at the CATL(P < 0.01) on both sides. The presence of diabetic peripheral neuropathy(DPN) further increased the MN CSA at the CATL(P < 0.05) but not at 5 cmCATL(P > 0.05). However, the severity of DPN had no additional effect on MN CSA 5 cm proximal to and at the CATL. There was no significant association between MN CSA and duration of DM and glycemic control.CONCLUSION Thickening of the MN CSA at 5 cmCATL and CATL is seen in DM. Presence of DPN is associated with worse thickening of the MN CSA at the CATL but not at5 cmCATL. Severity of DPN, duration of DM, and glycemic control had no additional effect on the MN CSA. | Fredrick ANDrew Attah Christianah Mopelola Asaleye Adeleye Dorcas Omisore Babatope Ayodeji Kolawole Adeniyi Sunday Aderibigbe Mathew Alo | 2019 | World Journal of Diabetes2019，10，1： | 8 |
| 2 | In vivo antioxidant effect of aqueous root bark,stem bark and leaves extracts of Vitex doniana in CCl_4 induced liver damage rats显示文摘Objective:The antioxidant effects of aqueous root bark,stem bark and leaves of Vitex doniana(V.doniana)were evaluated in carbon tetrachloride(CCl_4)induced liver damage and non induced liver damage albino rats.Methods:A total of 60 albino rats(36 induced liver damage and 24 non induced liver damage)were assigned into liver damage and non liver damage groups of 6 rats in a group.The animals in the CCl_4 induced liver damage groups,were induced by intraperitoneal injection with a single dose of CCl_4(148mg·ml^(-1)·kg^(-1)body weight)as a 1:1(v/v)solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark,stem bark and leaves extracts of V.doniana and vitamin E as standard drug(100 mg/kg body weighy per day)for 21 d,while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same dose.The administration of CCl_4 was done once a week for a period of three weeks.Results:The liver of CCl_4 induced not treated group showed that the induction with CCl_4,significantly(P<0.05)increased thiobarbituric acid reactive substance(TBARS)and significantly(P<0.05)decreased superoxide dismutase(SOD)and catalase(CAT).However there was no significant(P>0.05)difference between TBARS,SOD and CAT in the liver of the induced treated groups and normal control group.In the kidney.TBARS showed no significant(P>0.05)difference between the normal and the induced groups,SOD was significantly(P<0.05)reduced in the CCl_4 group compared to standard drug and normal control groups,CAT was significantly(P<0.05)increased in root and vitamin E groups when compared to induced not treated group.The studies also showed that when the extracts were administered to normal animals,there was no significant(P>0.05)change in the liver and kidney level of TBARS,SOD and CAT compared with the normal control except in the kidney of animals treated with stem extract where TBARS was significantly(P<0.05)lowered compared to control group.Conclusion:The result of the present study suggests that application of V.doniana plant would play an important role in increasing the antioxidant effect and reducing the oxidative damage that formed both in liver and in kidney tissues.However stem bark has potential to improve renal function in normal rats. | Kadejo Olubukola Adetoro James Dorcas Bolanle Sallau Balarebe Abdullahi Ozigi Abdulrahaman Ahmed | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，5： | 4 |
| 3 | Changes in Antioxidant Status and Biochemical Indices after Acute Administration of Artemether, Artemether‐Lumefantrine and Halofantrine in Rats显示文摘 | Oluwatosin A.Adaramoye Dorcas O.Osaimoje Adewale M.Akinsanya Chiaka M.Nneji Michael A.Fafunso Olusegun G.Ademowo | 2008 | Basic & Clinical Pharmacology & Toxicology2008，，4： | 2 |
| 4 | Hepatocurative potential of Vitex doniana root bark,stem bark and leaves extracts against CCl_4-induced liver damage in rats显示文摘Objective:To evaluate the hepatocurative effects of aqueous root bark,stem bark and leaves of Vitex doniana in carbon tetrachloride(CCl_4)induced liver damage and non induced liver damage albino rats.Methods:A total of 60 albino rats(36 induced liver damage and 24 non induced liver damage)were assigned into liver damage and non liver damage groups of 6 rats in a group.The animals in the CCl_4 induced liver damage groups,were induced by intraperitoneal injection with a single dose of CCl_4(1 mL/kg body weight)as a 1:1(v/v)solution in olive oil and were fasted for 36 h before the subsequent treatment with aqueous root bark,stem bark and leaves extracts of Vitex doniana and vitamin E as standard drug(100 mg/kg body weight per day)for 21 d,while the animals in the non induced groups were only treated with the daily oral administration of these extracts at the same dose.The administration of CCl_4 was done once a week for a period of 3 weeks.Results:There was significant(P<0.05)increase in concentration of all liver marker enzymes,alanine aminotransferase,aspartate aminotransferase and alkaline aminotransferase(ALT,AST and ALP)and significant(P<0.05)decrease in albumin in the CCl_4 induced liver damage control when compared to the normal control.The extracts caused a significant(P<0.05)reduction in the serum activities of liver marker enzymes(ALT,AST and ALP)and a significant(P<0.05)increase in albumin of all the induced treated groups.Only stem bark extract and vitamin E significantly(P<0.05)increased total prolein.All the extracts significantly(P<0.05)lowered serum creatinine whereas only root bark extract significantly(P<0.05)lowered serum level of urea in the rats with CCl_4 induced liver damage.Conclusion:Hepatocurative study shows that all the plant parts(root bark,stem bark and leaves)possess significant hepatocurative properties among other therapeutic values justifying their use in folklore medicine. | James Dorcas Bolanle Kadejo Olubukola Adetoro Sallau Abdullahi Balarabe Owolabi Olumuyiwa Adeyemi | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，6： | 2 |
| 5 | Empirical analysis for the characterization of geo-mechanical strength and pressure regime:Implications on hydraulic fracturing stimulation显示文摘Among the several activities involved in oil exploration are the determination of hydrocarbon in-place and mechanical competency of the oil reservoir.The pressure regimes of the formation have also become vital properties which must be well known to ensure preliminary awareness of the hydraulic fracturing.This study seeks to adopt a prediction strategy of the overall geo-mechanical competency and strength of the formation,using a less stressful computational process and an empirical analysis,developed using three wells from ED BON area in parts of Niger Delta.Elastic constants such as Poisson Ratio,Young's,Shear and Bulk moduli which are the parameters for characterizing rock mechanical properties were estimated,as well as the subsurface formation pressures and the associated fracture gradient using P-wave sonic and density logs.The results from the analysis showed that there is correlation between elastic strength and fracture pressure. | Dorcas S.Eyinla Michael A.Oladunjoye | 2019 | Petroleum2019，5，3： | 2 |
| 6 | Effect of corticosteroids on the clinical course of community - acquired pneumonia: a randomized controlled trial显示文摘 | Fernandez - Serrano S Dorca J Garcia - Vidal C | 2011 | Crti Care2011，15，2： | 1 |
| 7 | High doses of Ketamine- Xylazine anesthesia reduce cardiac isehemia-reperfusion injury in guinea pigs显示文摘 | Ruben C Matthew R Dorcas O | 2011 | J Am Assoe Lab Anita Sci2011，50，3： | 1 |
| 8 | Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia 显示文摘 | Fernandez-Serrano S Dorca J Coromines M | 2003 | Clin Diagn Lab Immunol2003，10，5： | 1 |
| 9 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 10 | Low molecularweight heparin for the prevention of hepatic veno-ocolusive disease (VOD) after hematopoietic stem cell transplantation:a prospectivephase Ⅱ study显示文摘 | Forrest DL Thompson K Dorcas VG | 2003 | Bone Marrow Transplant2003，31，12： | 1 |
| 11 | Effect of corticosteroids on the chnical course of community -acquired pneumonia : a randomized controlled trial显示文摘 | Fern6ndez-Serrano S Dorca J Garcia-Vidal C | 2011 | Crit Care2011，15，2： | 1 |
| 12 | Cross-cultural adaptation of health-related quality of life measures:literature review and proposed guidelines显示文摘 | Francis G Dorcas B | 1993 | J Clin Epidemiol1993，46，12： | 1 |
| 13 | Effects of prey type on specific dynamic action,growth,and mass conversion efficiencies in the homed frog,Ceratophrys cranwelli显示文摘 | Grayson K.L Cook L.W Todd M.J Pierce D Hopkins W.A Gatten R.E Dorcas M.E | | 0，，： | 1 |
| 14 | Community-acquired pneumonia chronic ob structive pulmonary disease显示文摘 | Torres A Dorca J Zalacaim R | 1996 | Am J Respir Cirt Care Med1996，154，5： | 1 |
| 15 | Low molecular weight heparin for the prevention of hepatic veno2occlusive disease (VOD) after hematopoietic stem cell transplantation :a prospective phase II study显示文摘 | Forrest DL Thompson K Dorcas VG | 2003 | Bone Marrow Transplant2003，31，12： | 1 |
| 16 | Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia显示文摘 | Fermandez-serrano S Dorca J Coromines M | 2003 | Clin Diagn Lab Immunol2003，10，5： | 1 |
| 17 | Low molecular weight heparin for the prevention of hepatic veno-ocelusive disease(VOD) after hematopoietic stern cell transplantation; a prospective phase II study 显示文摘 | Forrest DL Thompson K Dorcas VG | 2003 | Bone Marrow Transplant2003，31，12： | 1 |
| 18 | Development, Validation, and Evaluation of a Pediatric Ulcerative Colitis Activity Index: A Prospective Multicenter Study显示文摘 | Dan Turner Anthony R. Otley David Mack Jeffrey Hyams J. de Bruijne Krista Uusoue Thomas D. Walters Mary Zachos Petar Mamula Dorcas E. Beaton A. Hillary Steinhart Anne M. Griffiths | 2007 | Gastroenterology2007，，2： | 1 |
| 19 | Effect of corticoste- roids on the clinical course of community-acquired pneumonia : a ran- domized controlled trial显示文摘 | Fernrndez-Serrano S Dorca J Garcia-Vidal C | 2011 | Crit Care2011，15，2： | 1 |
| 20 | Effect of corticosteroids on the clinical course of community - acquired pneumonia: a randomized controlled trial显示文摘 | Femdndez - Serrano S Dorca J | 2011 | Crit Care2011，1515，2： | 1 |
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