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| 1 | 儿童铅中毒102例临床分析显示文摘为了解目前铅中毒门诊患儿的常见症状 ,造成铅暴露的主要原因 ,摸索铅中毒门诊患儿的病史询问及诊疗方案 ,对上海新华医院和上海儿童医学中心半年中门诊患儿的资料进行归纳整理。结果发现铅中毒患儿102例 ,血铅水平几何均数129μg/L ,多数患儿表现为多动和注意力不集中 ,学龄儿童中绝大多数表现为上课时注意力分散、学习困难、成绩差 ,部分患儿伴腹痛和便秘等消化系统症状 ,此外还有贫血及血清锌水平降低等 ;多数患儿能找出铅暴露的危险因素 ,常见因素有饭前洗手不认真 ,日钙摄入量低于DRI的50 % ,常有手 -口动作如啃咬指头、铅笔或玩具 ,父亲吸烟或有被动吸烟史等 ;39例复诊患儿 ,经门诊指导 (包括高危因素分析、环境干预、行为矫正、营养指导 )及住院驱铅后血铅水平均呈不同程度下降 ,几何均数由148μg/L下降到117μg/L ,其中1例极重度铅中毒患儿经住院驱铅治疗后血铅水平显著下降 ,但停药2周开始反跳 ,提示这种病例可能需要多个疗程的驱铅治疗 。 | 颜崇淮 沈晓明 薛敏波 余晓刚 金星明 张燕萍 Markowitz M | 2003 | 临床儿科杂志2003，21，4： | 44 |
| 2 | TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma显示文摘 | Pengyuan Yang Qi-Jing Li Yuxiong Feng Yun Zhang Geoffrey J. Markowitz Shanglei Ning Yuezhen Deng Jiangsha Zhao Shan Jiang Yunfei Yuan Hong-Yang Wang Shu-Qun Cheng Dong Xie Xiao-Fan Wang | 2012 | Cancer Cell2012，，3： | 4 |
| 3 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 4 | Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis显示文摘 | Jeffrey Hyams Lakshmi Damaraju Marion Blank Jewel Johanns Cynthia Guzzo Harland S. Winter Subra Kugathasan Stanley Cohen James Markowitz Johanna C. Escher Gigi Veereman–Wauters Wallace Crandall Robert Baldassano Anne Griffiths | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 3 |
| 5 | Isoenzyme(s)of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study显示文摘 | Seidegard J Pero RW Markowitz MM | 1990 | Carcinogenesis1990，11，： | 2 |
| 6 | Eosinophilic Esophagitis: A 10-Year Experience in 381 Children显示文摘 | Chris A. Liacouras Jonathan M. Spergel Eduardo Ruchelli Ritu Verma Maria Mascarenhas Edisio Semeao Jonathan Flick Janice Kelly Terry Brown–Whitehorn Petar Mamula Jonathan E. Markowitz | 2005 | Clinical Gastroenterology and Hepatology2005，，： | 2 |
| 7 | 炎症对原发性肝细胞肿瘤的生长和免疫微环境的影响(英文)显示文摘原发性肝细胞癌(HCC)的起始和发展与肝脏慢性疾病密切相关.与正常肝脏相比,肝脏慢性疾病引起微环境的剧烈变化,尤其影响免疫细胞的功能.为了研究肝脏疾病对于肿瘤生长的影响以及与肿瘤微环境的互相作用,我们采用两种标准化方法诱导肝脏纤维化,并将肿瘤原位移植到发炎并纤维化的肝脏上模拟人类HCC患者的肝脏状态.与健康对照组相比,肝脏的纤维化显著促进肿瘤生长.在两种诱导纤维化的模型中,浸润肿瘤的免疫细胞也发生显著变化:自然杀伤细胞减少,而免疫抑制的骨髓细胞CD11b+Gr1hi显著增加.此外,存在模型特异的区别:在胆管结扎模型的肿瘤中,CD11b+骨髓细胞和CD4+CD25+T细胞数量增加,但在四氯甲烷模型中没有变化.纤维化能改变移植的肿瘤细胞中的细胞因子产生,可能对免疫功能产生深远的影响.综上所述,本研究揭示了肝脏纤维化诱导结合肿瘤原位移植能显著改变肿瘤微环境以及肿瘤生长动态,提示在动物模型中模拟HCC时需要考虑慢性肝脏疾病对肝脏的重要影响. | Geoffrey J. Markowitz Gregory A. Michelotti Anna Mae Diehl Xiao-Fan Wang | 2015 | Science Bulletin2015，60，8： | 2 |
| 8 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 9 | Adefovir nephrotoxicity: Possible role of mitochondrial DNA depletion显示文摘 | Nozomu Tanji Kurenai Tanji Neeraja Kambham Glen S Markowitz Alvin Bell Vivette D D’Agati | 2001 | Human Pathology2001，，7： | 2 |
| 10 | Tumor‐Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox‐2 Signaling Pathway显示文摘 | Jian Yang Debbie Liao Cong Chen Yan Liu Tsung‐Hsien Chuang Rong Xiang Dorothy Markowitz Ralph A. Reisfeld Yunping Luo | 2013 | STEM CELLS2013，，2： | 2 |
| 11 | Immune Response to Influenza Vaccine in Pediatric Patients With Inflammatory Bowel Disease显示文摘 | Petar Mamula Jonathan E. Markowitz David A. Piccoli Alexander Klimov Louis Cohen Robert N. Baldassano | 2007 | Clinical Gastroenterology and Hepatology2007，，7： | 2 |
| 12 | Portfolio Selection显示文摘 | Markowitz | 1952 | Journal of Finance1952，，3： | 1 |
| 13 | Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-I integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals显示文摘 | Dejesus E Berger D Markowitz M | 2006 | J Acquir Immune Defic Syndr2006，43，1： | 1 |
| 14 | Portfolio selection 显示文摘 | Markowitz H | 1952 | Journal of Finance1952，7，1： | 1 |
| 15 | Foundations of portfolio theory显示文摘 | Markowitz H M | 1991 | Journal of Finance1991，56，46： | 1 |
| 16 | Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study显示文摘 | Seidgard J Pero RW Markowitz MM | 1990 | Carcinogenesis1990，11，： | 1 |
| 17 | Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease显示文摘 | Tanji N Markowitz GS Fu C | 2000 | J Am Soc Nephrol2000，11，： | 1 |
| 18 | Autopsy Patterns of Disease Among Subgroups of an Inner-city Bronx AIDS Population显示文摘 | Markowitz G S Concepcion L Factor S M | 1996 | J Acquir Immune Defic Syndr Hum Retrovirol1996，13，1： | 1 |
| 19 | Portfolio selection显示文摘 | Markowitz H M | 1952 | Journal of Finance1952，7，： | 1 |
| 20 | Portfolio Selection 显示文摘 | Markowitz H M | 1952 | Journal of Finance1952，，： | 1 |
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