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| 1 | 质子重离子肿瘤放疗的临床注册试验初步报告显示文摘目的探讨IONTRIS粒子放疗设备临床应用的安全性和有效性。方法2014年6月至2014年8月间共有35例肿瘤患者入组,其中男性31例,女性4例:年龄36~80岁,中位年龄69岁。头颈肿瘤10例(均为手术后复发),胸部肿瘤4例,原发性肝癌1例,腹膜后肉瘤术后复发1例.前列腺癌19例。碳离子照射剂量为2.74—10GyE/次,质子照射剂量为2—5.5GyE/次,5次/周。放疗前对每个放射野进行水箱剂量验证。结果碳离子照射22例,质子照射13例。放疗后1年,35例患者全部生存。在16例头颈部、胸部和腹盆腔肿瘤患者中,完全缓解2例,部分缓解1例,疾病稳定12例,疾病进展1例,1年无进展生存率为93.8%(15/16)。19例前列腺癌患者的1年无生化复发生存率为100%。35例患者对粒子放疗的耐受性良好,放疗期间的美国东部肿瘤协作组评分和体重无明显改变。25例(71.4%)患者发生了与粒子放疗相关的急性不良事件(AE)33例次,均为1级.在放疗1年时急性AE全部消失。有6例(17.1%)患者在放疗后1年发生后期AE6例次,全部为1级。结论采用IONTRIS设备治疗肿瘤患者安全、有效。 | 陆嘉德 叶明 郭小毛 傅深 Moyers F. Michael 章青 茅静芳 孔琳 HSI Wen Chien Shahnazi Kambiz 赵静芳 章真 马秀梅 来松涛 张晓萌 麻宁一 高云生 蔡昕 管西寅 张军华 吴斌 程竞仪 盛尹祥子 任炜 赵俊 孙力宁 蒋国梁 | 2018 | 中华肿瘤杂志2018，40，1： | 7 |
| 2 | Protective effects ofLactobacillus plantarum against epithelial barrier dysfunction of human colon cell line NCM460显示文摘AIM: To investigate the effects of Lactobacillus plantarum (L. plantarum ) in the intestinal permeability and expression of tight junction (TJ) using the normal human colon cell line NCM460. METHODS: Paracellular permeability of NCM460 monolayers was determined by transepithelial electrical resistance and dextran permeability. Expression of TJ proteins in NCM460 cell monolayers was detected by Western blotting and quantitative real-time polymerase chain reaction.RESULTS: L. plantarum played an important role in increasing transepithelial electrical resistance and decreasing the permeability to macromolecules of NCM460 monolayers against the disruption caused by enteropathogenic Escherichia coli (E. coli ) or enteroinvasive E. coli . L. plantarum also prevented the decrease in the expression of TJ proteins and F-actin in NCM460 cells.CONCLUSION: L. plantarum can protect against dysfunction of NCM460 intestinal epithelial barrier caused by enteropathogenic E. coli or enteroinvasive E. coli , and thus can be a potential candidate of therapeutic agents for the treatment of intestinal diseases. | Mary Pat Moyer | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 3 | Mdm proteins: critical regulators of embryogenesis and hornoeostasis显示文摘 | Sydney M. Moyer Connie A. Larsson Guillermina Lozano | 2017 | Journal of Molecular Cell Biology2017，9，1： | 5 |
| 4 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 5 | Endoscopic and Radiographic Evaluation of the Small Bowel in 2012显示文摘 | Charles E. Dye Ryan R. Gaffney Thomas M. Dykes Matthew T. Moyer | 2012 | The American Journal of Medicine2012，，12： | 2 |
| 6 | Screening for Cervical Cancer: U.S. Preventive Services Task Force Recommendation Statement显示文摘 | Virginia A. Moyer | 2012 | Annals of Internal Medicine2012，，12： | 2 |
| 7 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 8 | Parameters affecting the efficacy of a sustained release polymeric implant of leuprolide显示文摘 | Ravivarapu HB Moyer KL Dunn RL | 2000 | Int J Pharm2000，194，2： | 1 |
| 9 | Conservative management of renal artery embolus 显示文摘 | Moyer J D Rao C N Widrich W C | 1973 | J Urol1973，109，2： | 1 |
| 10 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 11 | The pathogenesis of Newcastle disease:a comparison of seleted Newcastle disease virus wild-type strains and their infectious clones显示文摘 | Myers T M Smallwood S Moyer S A | | 0，，： | 1 |
| 12 | Therapist influence on client language duringmotivational interviewing sessions 显示文摘 | Moyers TB Martin T | 2006 | Journal of Substance AbuseTreatment2006，30，3： | 1 |
| 13 | An order-disorder transition in Sr2IrD5: Evidence for square pyramidal IrD5 units from powder neutron diffraction data 显示文摘 | ZHUANG J HASTINGS J M CORLISS L M BAU R WEI C Y MOYER R O J | 1981 | J Solid State Chem1981，40，： | 1 |
| 14 | Cytotoxic T lymphocyte-assisted suicide: Caspase 3 activation is primarily the result of the direct action of granzyme B 显示文摘 | Barry M Darmon AJ Shostak I Turner PC Moyer RW Bleackley RC | 1998 | J Biol Chem1998，273，21： | 1 |
| 15 | Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering显示文摘 | An Y Chen C Y Moyer B | 2009 | J Mol Biol2009，391，1： | 1 |
| 16 | Exposure to cocaine dynamically regulates the intrinsic membrane excitability of nucleus accumbens neurons显示文摘 | Mu P Moyer JT Ishikawa M | 2010 | J Neurosci2010，30，10： | 1 |
| 17 | Multiple systems organ fail- ure : 1W Imbalances in plasma amion acids associated with exogenous albumin in the trauma-septic patient显示文摘 | Moyer ED Border JR Cerra FB | 1981 | J Trauma1981，21，7： | 1 |
| 18 | Guideline for the evaluation of cholestatic jaundice in infants:recommendations of the North American Society for Pediatric Gastroenterology,Hepatology and Nutrition显示文摘 | Moyer V Freese DK Whitington PF | 2004 | J Pediatr Gastroenterol Nutr2004，39，2： | 1 |
| 19 | Clinical problem-solving, The heart of the matter 显示文摘 | Tarter L Yazdany J Moyers B | 2013 | N Engl J Med2013，368，10： | 1 |
| 20 | Isolation of complementary DNA clones encoding pathogenesis-related proteins P and Q, two acidic chitinases from tobacco 显示文摘 | Payne G Ahl P Moyer M | 1990 | Proc Nail Acad Sci USA1990，87，1： | 1 |
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