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| 1 | New insights into the role of PML in tumour suppression显示文摘PML 基因涉及 t (15; 17 ) 尖锐 promyelocytic 白血球过多症(APL ) 的 translocation,它产生 oncogenic 熔化蛋白质 PML (promyelocytic 白血球过多症蛋白质)-retinoic 酸受体高山哈。PML 蛋白质本地化称为 PML 原子领域(PML-ND ) 的原子结构到一个代用品,哪个 PML 是必要结构的部件。在 APL, PML-NDs 被破坏,因此含有在这白血球过多症的致病的这些结构。出人意料地,最近的研究显示 PML 和 PML-ND 玩一个瘤在除了 APL 的人的瘤的几种不同类型的镇压角色。因为 PML 在多重细胞的小径的极端通用性和参与,理解位于它的功能下面的机制,并且因此在瘤抑制的角色,是一项挑战性的任务。在这评论,我们试图非常在这个领域里估价更最近的进展并且建议调查的新大街。 | P Salomoni BJ Ferguson AH Wyllie T Rich | 2008 | Cell Research2008，18，6： | 12 |
| 2 | Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy显示文摘Severe reactions to mesalamine products are rarely seen in pediatric patients. We report a case of a 12-year-old boy who had a severe cardiac reaction to a mesalamine product Asacol. Past medical history is significant for ulcerative colitis (UC) diagnosed at 9 years of age. Colo- noscopy one week prior to admission revealed pancoli- tis. He was treated with Asacol 800 mg three times per day and prednisone 20 mg/d. He was subsequently ad- mitted to the hospital for an exacerbation of his UC and started on intravenous solumedrol. He had improvement of his abdominal pain and diarrhea. The patient com- plained of new onset of chest pain upon initiating Asacol therapy. Electrocardiogram (ECG) revealed non-specific ST-T wave changes with T-wave inversion in the lateral leads. Echocardiogram (ECHO) revealed low-normal to mildly depressed left ventricular systolic function. The left main coronary artery and left anterior descending artery were mildly prominent measuring 5 mm and 4.7 mm, respectively. His chest pain completely resolved within 24-36 h of discontinuing Asacol. A repeat echo- cardiogram performed two days later revealed normal left ventricular function with normal coronary arteries (< 3.5 mm). Onset of chest pain after Asacol and im- mediate improvement of chest pain, as well as improve- ment of echocardiogram and ECG findings after discon- tinuing Asacol suggests that our patient suffered from a rare drug-hypersensitivity reaction to Asacol. | Orhan Atay Kadakkal Radhakrishnan Janine Arruda Robert Wyllie | 2008 | World Journal of Gastroenterology2008，14，27： | 6 |
| 3 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 4 | Glucocorticoid- induced thymocyte apoptosis is associated with endogenous endonuclease activation显示文摘 | Wyllie AH | 1980 | Nature1980，284，5756： | 2 |
| 5 | Application of 1-MCP and propylene to identify ethylene-dependent ripening processes in mature banana fruit显示文摘 | J.B Golding D Shearer S.G Wyllie W.B McGlasson | 1998 | Postharvest Biology and Technology1998，，1： | 2 |
| 6 | Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerr JF Wyllie AH Currie AR | 1972 | Br J Cancer1972，26，： | 2 |
| 7 | 新能源转换系统功率模块驱动可靠性分析与试验显示文摘目前推挽结构的功率模块驱动可通过减小驱动电阻将导致开通、关断时间的缩短,但同时也将导致开关过程中IGBT功率器件电流、电压热应力的增加,从而使功率模块可靠性降低。对此,在分析功率模块失效机理和热模型的基础上,提出一种基于dSPACE的分段控制算法,通过软件和硬件结合分段控制功率模块开、关断速度。通过实验揭示了功率模块的表面温度变化规律,得出表面温度变化的指数曲线,并证明了该控制方法具有良好的驱动和保护功能,在缩短开关时间的同时可以有效抑制电压、电流应力的增加,并能有效减少新能源转换系统中输出电压和电流的谐波、提高电压利用率和波形质量,使新能源转换系统可靠性得到提高。 | 徐盛友 陈民铀 冉立 Peter Wyllie | 2013 | 重庆大学学报(自然科学版)2013，36，10： | 2 |
| 8 | Human papillomavirus type 18 is associated with less apoptosis in fibro blast tumours than human papillornavirus type 16显示文摘 | Arends MJ Wyllie AH Bird CC | 2005 | Br J cancer2005，72，3： | 1 |
| 9 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 10 | Apoptosis and carcinogenesis显示文摘 | 13,Wyllie AH | 1997 | Eur J Cell Bid1997，73，： | 1 |
| 11 | Apoptosis, a basic biological phenomenon with wide-ranging inplifications in tissue kinetics 显示文摘 | Wyllie AH Currie AR | 1972 | Br J Cancer1972，26，4： | 1 |
| 12 | Apoptosis: a basic biologi ca1 phenomenon with wide ranging implications in tissue kinetics显示文摘 | Kerr JF Wyllie AH Currie AR | 1972 | BrJCancer1972，26，4： | 1 |
| 13 | More than one way to go显示文摘 | Wyllie AH Golstein P | 2001 | Proc Natl Acad Sci USA2001，95，1： | 1 |
| 14 | Apoptosis:mechanisms and roles in patholog显示文摘 | Arends M Wyllie JAJ | 1991 | Int Rev Exp Pathol1991，32，： | 1 |
| 15 | Hormone-based approaches:altering the balance显示文摘 | Wyllie MG | 2004 | BJU Int2004，93，3： | 1 |
| 16 | Release of iron from ferritin storage by redox cycling of stilbene andsteroid estrogen metabolites: a mechanism of induction of free radical damage by estrogen 显示文摘 | Wyllie S Liehr JG | 1997 | Arch Blochem Biophy1997，346，： | 1 |
| 17 | Application of 1 - MCP and propylene to identify ethylene dependent ripening processes in mature banana fruit 显示文摘 | Golding J B Shearer D Wyllie S G | 1998 | Postharvest Biol and Technol1998，14，： | 1 |
| 18 | Apoptosis: a basic biological phe- nomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerr JF Wyllie AH Currie AR | 1972 | Br J Can- cer1972，26，4： | 1 |
| 19 | The lateralizing significance of versive head and eye movements during epileptic seizures显示文摘 | Wyllie E Ltt ders H Morris HH | 1986 | Neurology1986，36，： | 1 |
| 20 | Seizure outcome after epi- lepsy surgery in children and adolescents 显示文摘 | Wyllie E ComairYG Kotajgal P | 1998 | Ann Neurol1998，44，： | 1 |
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