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| 1 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 2 | A very strong summer monsoon event during 30-40 kaBP in the Qinghai-Xizang (Tibet) Plateau and its relation to precessional cycle显示文摘Guliya ice core records, high lake-level records in the Qinghai-Xizang Plateau and at its north side as well as vegetation succession records indicated that during the period of 30-40 kaBP, namely the later age of the megainterstadial of last glacial period, or the marine oxygen isotope stage 3, the climate of the Qinghai-Xizang Plateau was exceptionally warm and humid, the temperature was 2-4℃ higher than today and the precipitation was 40% to over 100% | Shi, YF Liu, XD Li, BY Yao, TD | 1999 | Chinese Science Bulletin1999，44，20： | 40 |
| 3 | 静脉输注万古霉素的住院患者中万古霉素暴露量及其肾毒性阈值的确定显示文摘采用药时曲线下面积(AUC)进行万古霉素治疗药物监测已获证据支持,但确定AUC上限的数据有限,已发表的关于肾毒性的AUC阈值范围较广。本研究的目的是建立万古霉素AUC与肾毒性的相关性。肾毒性定义为连续血清肌酐值较基线值增加0.5 mg/L或50%。万古霉素暴露量AUC0-48、AUC0-24、AUC24-48经由贝叶斯最大后验概率估算。采用分类回归树(CART)分析发现万古霉素AUC、谷浓度(Cmin)阈值与肾毒性发生率呈正相关。CART和其他候选AUC阈值的预测性通过阳性、阴性预测值和受试者工作特征曲线(ROC)评估。 | ZASOWSKI EJ MURRAY KP TRINH TD 范亚新 刘笑芬 | 2018 | 中国感染与化疗杂志2018，18，6： | 6 |
| 4 | 一种改进的预测连续油管环空摩阻压降的计算方法显示文摘在前期分析计算连续油管管内摩阻压降的基础上,进一步介绍了一种准确确定连续油管环空摩阻压降的计算方法,分析了管道几何尺寸,表面粗糙度,泵排量,流体性能,雷诺数,摩阻系数,偏心度等参数对层流态和紊流太时的环空摩阻压降的影响效果,对各参数的确定,给出了计算公式,并进行了实验验证,还列举了带内管的连续油管环空偏心影响效果的分析方法,较全面地阐述了连续油管的环空水力性能,并给出计算实例。 | Reed.,TD 张和茂 | 1999 | 新疆石油科技信息1999，20，1： | 5 |
| 5 | 百日咳毒素S1亚单位的分子修饰及在重组杆状病毒中的表达显示文摘目的:百日咳毒素既是百日咳杆菌的主要毒性因子,又是重要的保护性抗原,其S1亚单位具有ADP核糖转移酶活性和免疫保护性决定簇。为高效表达前构建的一个丧失酶活性但仍保持保护决定簇的S1变异子,开展了本研究。方法:通过添加人流感病毒血凝素基因信号序列或嵌膜序列的方法,对天然和变异S1亚单位基因片段作了遗传学修饰。然后使用重组杆状病毒技术使这些S1亚单位在昆虫细胞和昆虫幼虫中实现了高水平表达。结果:这些重组S1的表达水平介于每万个昆虫卵细胞018~193μg或每只昆虫幼虫046~498mg之间。天然信号肽和HA信号肽均可完整表达,但后者的切割效率(61%~81%)比前者(16%~19%)更高。所有带信号肽的S1亚单位均呈异质性表达(双带)。结论:重组S1亚单位的表达是高效和正确的,表达的异质性是由于信号肽切割不完全的缘故。 | 于康震 Burnette WN Kaslow HR Mar VL Ahmad S Yilma TD | 1999 | 中国免疫学杂志1999，15，2： | 4 |
| 6 | Clinical and pathological characteristics of brain metastasis resected after failed radiosurgery显示文摘 | Jagannathan J Bourne TD Schlesinger D Yen CP Shaffrey ME Laws ER Jr Sheehan JP. | 2010 | 中国神经肿瘤杂志2010，8，1： | 4 |
| 7 | Ice core study--the past, the present and the future显示文摘ICE core study is a forward interdiscipline research domain. Climatic and environmentalchanges in the past and the present can be reconstructed and monitored through ice core stud-ies. On the basis of analyzing the climatic and environmental parameters recorded in ice cores,the characteristics of climatic and environmental changes in recent years or in the past | Yao, TD Wang, NL | 1997 | Chinese Science Bulletin1997，42，13： | 3 |
| 8 | Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells显示文摘 | Frick AG Joseph TD Pang LY | 2000 | J Immunol2000，164，： | 2 |
| 9 | Purification and characterization of toxins A and B of Clostridium difficile显示文摘 | Sullivan NM Pellet S Wilkins TD | 1982 | Infect Immun1982，35，： | 2 |
| 10 | Connective tissue growth factor (CTGF) expression in rat corneas after photorefractive keratectomy and stimulation by transforming growth factor beta (TGF-β)显示文摘 | Blalock TD Varela JC Goldstein MH | 2001 | Invest Ophthalmol Vis Sci2001，，： | 2 |
| 11 | 奈必洛尔和缬沙坦固定剂量联合治疗高血压的疗效与安全性研究显示文摘任意2类降压药物固定剂量联合降压作用强于单独增加一类药物剂量的作用。该研究评估β受体阻滞剂奈必洛尔(nebivolol)和血管紧张素受体拮抗剂缬沙坦(valsartan)固定剂量联合治疗成人高血压的疗效与安全性。方法:研究人员在美国401个医疗中心进行了为期8周、临床试验3期、多中心、随机、双盲、安慰剂平行对照试验。参与者均为≥18岁的高血压患者(但血压≤180/110mm Hg,1mm Hg=0.133kPa),以15例为一治疗组, | 刘莉 叶鹏 Giles TD Weber MA Basile J Gradman AH Bharucha DB Chen W Pattathil M | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 12 | Detection of connective tissue growth factor in human aqueous humor显示文摘 | van Setten GB Blalock TD Grotendorst G | 2002 | Ophthalmic Res2002，34，： | 2 |
| 13 | 用卡尔多分析中国区域经济增长显示文摘 | 汉森.,TD 罗余才 | 1997 | 经济译文1997，，5： | 2 |
| 14 | A framework for quantifying properties of 3-dimensional movement-based signals显示文摘Understanding how signal properties are optimized for the reliable transmission of information requires accurate descriptionof the signal in time and space. For movement-based signals where movement is restricted to a single plane, measurementsfrom a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations.However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions(3D) are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extentto which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed withsynchronized cameras and the position of the tail tip digitized for both recordings. Camera alignment enabled the construction ofa 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtualenvironment, we were able to film the same signal from multiple viewing positions and using a computational motion analysisalgorithm (gradient detector model) to measure local image velocity in order to predict view dependent differences in signalproperties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolutionthat were previously out of reach [Current Zoology 56 (3): 327-336, 2010]. | Shaun TD NEW Richard A PETERS | 2010 | Current Zoology2010，56，3： | 2 |
| 15 | 计算机断层扫描测定肺气肿程度可预测吸烟患者的病死率显示文摘背景和目的:虽然肺功能测定对于慢性阻塞性肺疾病(简称慢阻肺)的诊断和分级十分重要,但却不能反映慢阻肺的全貌。胸部CT可较好地显示慢阻肺患者的病理解剖学变化(如肺气肿和气道病变),但对其预后价值却知之甚少。本研究假设肺气肿程度及气管壁厚度可预测吸烟慢阻肺患者的病死率,并对此进行验证。 | Johannessen A Skorge TD Bottai M 牟向东 黄俊芳 | 2013 | 中华结核和呼吸杂志2013，36，6： | 2 |
| 16 | A systematic review and meta-analysis of the randomized controlled trails on adjuvant intraperitoneal chemotherapy for advanced gastric cancer显示文摘 | Yah TD Black D Sugarbake PH | 2007 | ASCO Meeting Abstracts2007，25，18： | 1 |
| 17 | Analysis of relative gene expression data using real-time quantitative PCR and the 2^-△△C c method 显示文摘 | Livak K J Schmittgen TD | 2001 | Methods2001，25，： | 1 |
| 18 | Endoscopic transaxillary approach to the thyroid gland: our early experience显示文摘 | Duncan TD Rashid Q Speights F | 2007 | Surg Endosc2007，21，12： | 1 |
| 19 | Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method显示文摘 | Livak KJ Schmittgen TD | 2001 | Methods2001，25，4： | 1 |
| 20 | MDCT Angiography of the spinal vasculature and the artery of Adamkiewicz 显示文摘 | Boll TD Bulow H Blackman KA | 2006 | AJR2006，187，： | 1 |
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