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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Inflammatory myofibroblastic tumor of the liver:A case report and review of literature显示文摘BACKGROUND Inflammatory myofibroblastic tumors of the liver(IMTL)are extremely rare neoplasms and very little is known about their clinical presentation,pathogenesis,and biological behavior.Due to their absolute rarity,it is almost impossible to obtain a definite diagnosis without histological examination.Because of their intermediate biological behavior with the risk for local recurrence and metastases,surgical resection is recommend whenever IMTL is suspect.CASE SUMMARY We herein present a case of an otherwise healthy 32-year-old woman who presented with intermittent fever,unclear anemia,malaise and right flank pain 4 mo postpartum.The liver mass in segment IVa/b was highly FDG avid in the positron emission tomography-computed tomography.Hepatic resection was performed achieving a negative resection margin and an immediate resolution of all clinical symptoms.Histological analysis diagnosed the rare finding of an inflammatory myofibroblastic tumor of the liver and revealed cytoplasmic anaplastic lymphoma kinase expression by immunohistochemistry.Twelve months follow-up magnetic resonance imaging showed no recurrence and no metastases in the fully recovered patient.CONCLUSION IMTLs are extremely rare and difficult to diagnose.Due to their intermediate biological behavior,surgical resection should be perform whenever feasible and patients should be followed-up in order to detect recurrence and metastasis as early as possible. | Alexandra Filips Martin H Maurer Matteo Montani Guido Beldi Anja Lachenmayer | 2020 | World Journal of Hepatology2020，12，4： | 4 |
| 3 | Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique显示文摘AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing outcome.METHODS: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for surgery.CONCLUSION: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow. | Reto Bertolini Christa Meyenberger Paul Martin Putora Franziska Albrecht Martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz | 2016 | World Journal of Gastroenterology2016，22，7： | 3 |
| 4 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 5 | How to Manage Functional Vitamin K Deficiency in CKD显示文摘 | Martin Busch Anja Stein Günter Stein | 2012 | American Journal of Kidney Diseases2012，，1： | 1 |
| 6 | Synthesis of the compatible solutes glucosylglycerol and trehalose by salt-stressed cells of Stenotrophomonas strains显示文摘 | Anja Roder Eik Hoffmann Martin Hagemann Gabriele Berg | 2004 | FEMS Microbiology Letters2004，，1： | 1 |
| 7 | Pierson syndrome in an adolescent girl with nephrotic range proteinuria but a normal GFR显示文摘 | Anja Lehnhardt Albert Lama Kerstin Amann Verena Matejas Martin Zenker Markus Kemper | 2012 | Pediatric Nephrology2012，，5： | 1 |
| 8 | A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens显示文摘 | Silke Lassmann Clemens Kreutz Anja Schoepflin Ulrich Hopt Jens Timmer Martin Werner | 2009 | Journal of Molecular Medicine2009，，2： | 1 |
| 9 | Usefulness of noninvasive cardiac imaging nsing dual-source computed tomography in an unselected population with high prevalence of coronary artery disease显示文摘 | Martin H Christof B Anja R | 2007 | Am J Cardiol2007，100，4： | 1 |
| 10 | Bedeutung der TSH-Rezeptor-Antik?rper für die Diagnose des Morbus Basedow sowie die Prognoseabsch?tzung der Schilddrüsenüberfunktion und der endokrinen Orbitopathie显示文摘 | Anja Eckstein Klaus Mann George J. Kahaly Martin Gru?endorf Christoph Reiners Joachim Feldkamp Beate Quadbeck Andreas Bockisch Prof. Dr. Matthias Schott | 2009 | Medizinische Klinik2009，，5： | 1 |
| 11 | Usefulness of noninvasive car diac imaging using dual-source computed tomography in an unselect ed population with high prevalence of coronary artery disease 显示文摘 | Martin H Christof B Anja R | 2007 | Am J Cardiol2007，100，4： | 1 |
| 12 | Ion transport and barrier function are disturbed in microscopic colitis显示文摘 | Christian Barmeyer Irene Erko Anja Fromm Christian Bojarski Kristina Allers Verena Moos Martin Zeitz Michael Fromm J?rg‐Dieter Schulzke | 2012 | Annals of the New York Academy of Sciences2012，，1： | 1 |
| 13 | Knowledge creation in new product development projects 显示文摘 | Schulze Anja and Hoegl Martin | 2006 | Journal of Management2006，32，2： | 1 |
| 14 | Internal anterior chamber diameter using optical coherence tomography compared with white-to-white distances using automated measurements显示文摘 | Thomas Kohnen Martin Christian Thomala Magdalena Cichocki Anja Strenger | 2006 | Journal of Cataract & Refractive Surgery2006，，11： | 1 |
| 15 | RORγt+ hematopoietic cells are necessary for tumor cell proliferation during colitis‐associated tumorigenesis in mice显示文摘 | Maria Martin Rebecca K. Kesselring Balam Saidou Stefan M. Brunner Gabriela Schiechl Verena F. Mouris Anja K. Wege Petra Rümmele Hans J. Schlitt Edward K. Geissler Stefan Fichtner‐Feigl | 2015 | Eur. J. Immunol2015，，6： | 1 |
| 16 | Electrical and electrochemical characterization of microstructured thin film La1-xZrxCoO3 electrodes 显示文摘 | ANJA B H MARTIN S HARRY L T | 2006 | Solid State Ionics2006，177，1925： | 1 |
| 17 | EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer显示文摘 | Christiane Daniela Fichter Sylvia Timme Julia Alexandra Braun Verena Gudernatsch Anja Sch?pflin Lioudmilla Bogatyreva Helene Geddert Gerhard Faller David Klimstra Laura Tang Dieter Hauschke Martin Werner Silke Lassmann | 2014 | Int J Cancer2014，，7： | 1 |
| 18 | Integrating molecular information into treatment of childhood acute lymphoblastic leukemia—A perspective from the BFM Study Group显示文摘 | Martin Stanulla Gunnar Cario Barbara Meissner André Schrauder Anja M?ricke Hansj?rg Riehm Martin Schrappe | 2007 | Blood Cells Molecules and Diseases2007，，2： | 1 |
| 19 | Discrimination between random and non-random processes in early bacterial colonization on biomaterial surfaces: application of point pattern analysis显示文摘 | Daniel Siegismund Anja Schroeter Claudia Lüdecke Andreas Undisz Klaus D. Jandt Martin Roth Markus Rettenmayr Stefan Schuster Sebastian Germerodt | 2014 | Biofouling2014，，9： | 1 |
| 20 | Organizational knowledge innovation and the generation of new product ideas: a behavioral approach显示文摘 | ANJA SCHULZE MARTIN HOEGL | 2008 | Research Policy2008，，37： | 1 |
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