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| 1 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 2 | Split liver transplantation: Current developments显示文摘In 1988, Rudolf Pichlmayr pioneered split liver transplantation(SLT), enabling the transplantation of one donor liver into two recipients-one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. However, a SLT is technically demanding, may cause increased perioperative complications, and may potentially transform an excellent deceased donor organ into two marginal quality grafts. Thus, crucial evaluation of donor organs suitable for splitting and careful screening of potential SLT recipients is warranted. Furthermore, the logistic background of the splitting procedure as well as the organ allocation policy must be adapted to further increase the number and the safety of SLT. Under defined circumstances, in selected patients and at experienced transplant centers, SLT outcomes can be similar to those obtained in full organ LT. Thus, SLT is an important tool to reduce the donor organ shortage and waitlist mortality, especially for pediatric patients and small adults. The present review gives an overview of technical aspects, current developments, and clinical outcomes of SLT. | Christina Hackl Katharina M Schmidt Caner Süsal Bernd Dohler Martin Zidek Hans J Schlitt | 2018 | World Journal of Gastroenterology2018，24，47： | 20 |
| 3 | Current developments in pediatric liver transplantation显示文摘In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attempt an orthotopic liver transplant into a 3 years old patient suffering from biliary atresia. Thus, the first LT in humans was attempted in a disease, which, up until today, remains the main indication for pediatric LT(p LT). During the last sixty years, refinements in diagnostics and surgical technique, the introduction of new immunosuppressive medications and improvements in perioperative pediatric care have established LT as routine procedure for childhood acute and chronic liver failure as well as inherited liver diseases. In contrast to adult recipients, p LT differs greatly in indications for LT, allocation practice, surgical technique, immunosuppression and postoperative life-long aftercare. Many aspects are focus of ongoing preclinical and clinical research. The present review gives an overview of current developments and the clinical outcome of p LT, with a focus on alternatives to full-size deceased-donor organ transplantation. | Christina Hackl Hans J Schlitt Martin Loss Birgit Knoppke Michael Melter | 2015 | World Journal of Hepatology2015，7，11： | 13 |
| 4 | Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats显示文摘瞄准:测试假设这项活动的那改进他我有与周期性的肝损伤联系的纤维发生的过程的氧合酶罐头 interfere,我们调查了在表示上的治疗学的潜力他我在 CCl (4 ) 的 oxygense-1 劝诱了微榴状的肝硬化模型。方法:带老鼠 HO-1 或 GFP 基因的 Recombinant 联系 adeno 的病毒被产生。1x 10 (12 )联系 adeno 的病毒的 vg 在肝的正式就职的时候通过门注射被管理纤维变性。结果:有由 rAAV/HO-1 的 HO-1 的在表示上的老鼠肝显著地增加了的调节以一种稳定的方式的 HO 酶的活动。微榴状的肝硬化的开发显著地作为与控制相比在 rAAV/HO-1-transduced 动物被禁止。门静脉高血压显著地作为与控制相比在 rAAV/HO-1-transduced 动物被减少,而在收缩血压没有重要变化。这发现伴有激活的改进的肝生物化学,更少的渗透的巨噬细胞和更少在 rAAV/HO-1-transduced 肝的肝的星形细胞(HSC ) 。结论:改进惊讶在肝的活动压制肝硬化的发展。 | Tung-Yu Tsui Chi-Keung Lau Jian Ma Gabriel Glockzin Aiman Obed Hans J Schlitt Sheung-Tat Fan | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 5 | Liver transplantation for malignancy:current treatment strategies and future perspectives显示文摘In 1967,Starzl et al performed the first successful liver transplantation for a patient diagnosed with hepatoblastoma.In the following,liver transplantation was considered ideal for complete tumor resection and potential cure from primary hepatic malignancies.Several reports of liver transplantation for primary and metastatic liver cancer however showed disappointing results and the strategy was soon dismissed.In1996,Mazzaferro et al introduced the Milan criteria,offering liver transplantation to patients diagnosed with limited hepatocellular carcinoma.Since then,liver transplantation for malignant disease is an ongoing subject of preclinical and clinical research.In this context,several aspects must be considered:(1)Given the shortage of deceased-donor organs,long-term overall and disease free survival should be comparable with results obtained in patients transplanted for nonmalignant disease;(2)In this regard,living-donor liver transplantation may in selected patients help to solve the ethical dilemma of optimal individual patient treatment vs organ allocation justice;and(3)Ongoing research focusing on perioperative therapy and antiproliferative immunosuppressive regimens may further reduce tumor recurrence in patients transplanted for malignant disease and thus improve overall survival.The present review gives an overview of current indications and future perspectives of liver transplantation for malignant disease. | Christina Hackl Hans J Schlitt Gabriele I Kirchner Birgit Knoppke Martin Loss | 2014 | World Journal of Gastroenterology2014，20，18： | 7 |
| 6 | Survival benefit in patients after palliative resection vs non-resection colon cancer surgery显示文摘AIM: To evaluate survival in patients undergoing pallia- tive resection versus non-resection surgery for primary colorectal cancer in a retrospective analysis. METHODS: Demographics, TNM status, operating de- tails and survival were reviewed for 67 patients under- going surgery for incurable colorectal cancer. Palliative resection of the primary tumor was performed in 46 cases in contrast to 21 patients with non-resection of the primary tumor and bypass surgery. Risk factors for post- operative mortality and poor survival were analyzed with univariate and multivariate analyses.RESULTS: The two groups were comparable in terms of age, gender, preoperative presence of ileus and tumor stage. Multivariate analysis showed that median survival was significantly higher in patients with palliative resec- tion surgery (544 vs 233 d). Differentiation of the tumor and tumor size were additional independent factors that were associated with a significantly poorer survival rate. CONCLUSION: Palliative resection surgery for primary colorectal cancer is associated with a higher median survival rate. Also, the presence of liver metastasis and tumor size are associated with poor survival. Therefore, resection of the primary tumor should be considered in patients with non-curable colon cancer. | A Beham M Rentsch K Püllmann L Mantouvalou H Spatz HJ Schlitt A Obed | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 7 | The potential benefits of rapamycin on renal function,tolerance,fibrosis,and malignancy following transplantation显示文摘 | Geissler E K Schlitt H J | 2010 | Kidney Int2010，78，11： | 1 |
| 8 | Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice显示文摘 | SCHLITT A LIU J YAN D | 2005 | Biochim Biophys Acta2005，1733，23： | 1 |
| 9 | Karydakis flap for recurrent pilo- nidal disease显示文摘 | Iesalnieks I Deimel S Schlitt HJ | 2013 | World J Surg2013，37，： | 1 |
| 10 | Enhanced detection of Theilcr' s virus RNA copy equivalents in the mouse central nervous system by real-time RT-PCR 显示文摘 | Trottier M Schlitt BP l ipton HI | 2002 | Journal of Virological Methods2002，103，： | 1 |
| 11 | High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease 显示文摘 | Schlitt A Biekel C Thumma P | 2003 | Artcrioscler Thromb Vase Biol2003，23，10： | 1 |
| 12 | Mordidity and mortality associated with pancreatogastrostony and pancreatojejunostomy following partial pancreatoduodenectomy显示文摘 | Schlitt HJ Schmidt U Simunec D | 2002 | Br J Surg2002，89，： | 1 |
| 13 | Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease显示文摘 | Schlitt A Blankenberg S Yan D | 2006 | Nutr Metab (Lond)2006，3，： | 1 |
| 14 | Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non‐interventional, multicenter study ( LOBSTER )显示文摘 | Hans J. Schlitt Sven Jonas Tom M. Ganten Gerrit Grannas Christian Moench Falk Rauchfuss Aiman Obed Giuseppe Tisone Antonio D. Pinna Giorgio E. Gerunda Susanne Beckebaum | 2013 | Clin Transplant2013，，3： | 1 |
| 15 | Recurrence patterns ofhepatocellular and fibrolamellar carcinoma after liver transplantation显示文摘 | Schlitt HJ Neipp M Weimann A | 1999 | J Clin Oncol1999，17，1： | 1 |
| 16 | Long-term experience af- ter ex situ liver surgery显示文摘 | Oldhafer KJ Lang H Schlitt HJ | 2000 | Surgery2000，127，5： | 1 |
| 17 | CD14^+ CD16^+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels 显示文摘 | Schlitt A Heine GH Blankenberg S | 2004 | Thromb Haemost2004，92，2： | 1 |
| 18 | Building and analyzing genomewide gene disruption networks 显示文摘 | Rung J Schlitt T Brazama A | 2002 | Bioinformatics2002，2，： | 1 |
| 19 | Preeclampsia: multiple approaches for a multifactorial disease 显示文摘 | Pennington KA Schlitt JM Jackson DL | 2012 | Dis Model Mech2012，5，1： | 1 |
| 20 | Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation显示文摘 | Schlitt HJ Neipp M Weimann A | 1999 | J Clin Oncol1999，17，1： | 1 |
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