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| 1 | NQ01 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China显示文摘AIM: To investigate the association of the/VQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in North China. METHODS: The NQ01 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 317 cancer patients (193 ESCC and 124 GCA) and 165 unrelated healthy controls. RESULTS: The NQ01 C609T C/C, C/T and T/T genotype frequency among healthy controls was 31.5 %, 52.1% and 16.4 % respectively. The NQ01 T/T genotype frequency among ESCC patients (25.9 %) was significantly higher than that among healthy controls (X^2=4.79, P=0.028). The NQ01 T/T genotype significantly increased the risk for developing ESCC compared with the combination of C/C and C/T genotypes, with an age, sex and smoking status adjusted odds ratio (OR) of 1.78 (1.04-2.98). This increased susceptibility was pronounced in ESCC patients with family histories of upper gastrointestinal cancers (UGIC) (adjusted OR=2.20, 95 % CI=1.18-3.98). Similarly, the susceptibility of the NQ01 T/T genotype to GCA development was also observed among patients with family histories of UGIC, with an adjusted odds ratio of 2.55 (95 % CI=1.21-5.23), whereas no differencein NQ01 genotype distribution was shown among patients without family histories of UGIC .CONCLUSION: Determination of the IVQOIC609T genotype may be used as a stratification marker to predicate the individuals at high risk for developing ESCC and GCA in North China. | Helen Geddert | 2003 | World Journal of Gastroenterology2003，9，7： | 15 |
| 2 | Hypermethylation ofhMLHl,HPP1, pl4(ARF),pl6( INK4A) and APC in primary ade-nocarcinomas of the small bowel 显示文摘 | Bricher BLDM Geddert H Langner C | 2006 | Int J Cancer2006，119，6： | 1 |
| 3 | The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer显示文摘 | Rehfeld N Geddert H Atamna A | | 0，，5： | 1 |
| 4 | Influence of Surface Defects and Aging of Coated Surfaces on Fouling Behavior显示文摘 | Geddert Timo Augustin Wolfgang Scholl Stephan | 2011 | Heat Transfer Engineering2011，32，34： | 1 |
| 5 | Hypermethylation of tumor suppressorgenes (p16INK4A,pl4ARF and APC) in adenocarcinomas of the uppergastrointestinal tract显示文摘 | Geddert H Klump B | 2004 | Int J Cancer2004，111，2： | 1 |
| 6 | The role of p63 and dehaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis 显示文摘 | Geddert H Kiel S Heep HJ | 2003 | Hum Pathol2003，34，9： | 1 |
| 7 | Effect of surface treatment on cleaning of a model food soil 显示文摘 | Saikhwan P Geddert T Augustin W | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 8 | Methylation of RAS association domain family protein 1A as a biomarker of lung cancer显示文摘 | Grote H J Schmiemann V Geddert H | 2006 | Cancer2006，108，2： | 1 |
| 9 | EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goMet eell earcinoids of the appendix 显示文摘 | DIMMLER A GEDDERT H FALLER G | 2014 | Pathol Res Pract2014，210，5： | 1 |
| 10 | EBV-infec- tion in cardiac and non-cardiac gastric adenocarcinomas is asso- ciated with promoter methylation of p16, p14 and APC, but not hMLHI显示文摘 | Geddert H zur Hausen A Gabbert H E | 2011 | CellOncol (Dordr)2011，34，3： | 1 |
| 11 | EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer显示文摘 | Christiane Daniela Fichter Sylvia Timme Julia Alexandra Braun Verena Gudernatsch Anja Sch?pflin Lioudmilla Bogatyreva Helene Geddert Gerhard Faller David Klimstra Laura Tang Dieter Hauschke Martin Werner Silke Lassmann | 2014 | Int J Cancer2014，，7： | 1 |
| 12 | EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16,p14 and APC,but not hMLH1显示文摘 | Geddert H Zur Hausen A Gabbert HE | 2011 | Anal Cell2011，34，3： | 1 |
| 13 | Methylation of RAS association domain family protein 1A as a biomarker of lung cancer 显示文摘 | Grote H J Schmiemann V Geddert H | 2006 | Cancer2006，108，2： | 1 |
| 14 | Polymorphism in Methionine Synthase (A2756G) and Cystathionine β-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract显示文摘 | Ott N Geddert H sarbia M | 2008 | J Cancer Res Clin Oncol2008，134，3： | 1 |
| 15 | The role of p63 and de-ltaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis显示文摘 | Geddert H Kiel S Heep HJ | 2003 | Human Pathology2003，34，： | 1 |
| 16 | The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer显示文摘 | Rehfeld N Geddert H Atarrma A | 2006 | J Carcinog2006，5，： | 1 |
| 17 | Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer显示文摘 | Rohr UP Rehfeld N Geddert H | 2005 | Clin Cancer Res2005，11，1： | 1 |
| 18 | Solitary fibrous tumors/ hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features显示文摘 | Barthelme S Geddert H Boltze C | 2014 | Am J Pathol2014，184，4： | 1 |
| 19 | Extending the Induc tion Period of Crystallization Fouling Through Surface Coat ing显示文摘 | Geddert T Bialuch I Augustin W | 2009 | Heat Transfer Engineering2009，30，： | 1 |
| 20 | Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract显示文摘 | Helene Geddert Sibylle Kiel Rainer B | 2005 | J Cancer Res Clin 0ncol2005，131，12： | 1 |
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